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15 December 2009
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Cover Image
Cover Image
Early detection provides the best outcome for lung cancer patients. Although there is a large at-risk population of smokers and ex-smokers, there is presently no easily applied, noninvasive test for early-stage lung cancer. Showe and colleagues have examined gene expression in peripheral blood samples to detect a signature for the presence of early-stage NSCLC in the peripheral immune system. The authors carried out microarray studies on blood samples from 137 NSCLC patients and 91 patients with nonmalignant lung disease that were at high-risk for developing lung cancer. They identified a 29-gene signature that distinguishes these two groups with 86% accuracy. They also show that this 29-gene signature diminishes or disappears in blood samples taken 2–5 months after surgical removal of the tumor in a subset of patients. The cover image shows a heat map of the mRNA expression array analysis of the 29 genes on the 228 samples. The pathway figure indicates the most significant pathways found to be deregulated in the peripheral immune system between the cancer and control patients in the gene expression analysis. Future studies will focus on streamlining the sample collection process and understanding the gene expression changes postsurgery. For details, see the article by Showe and colleagues on page 9202 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Issue Sections
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Reviews
Priority Reports
Cell, Tumor, and Stem Cell Biology
WNT16B Is a New Marker of Cellular Senescence That Regulates p53 Activity and the Phosphoinositide 3-Kinase/AKT Pathway
Romuald Binet; Damien Ythier; Ana I. Robles; Manuel Collado; Delphine Larrieu; Claire Fonti; Elisabeth Brambilla; Christian Brambilla; Manuel Serrano; Curtis C. Harris; Rémy Pedeux
Gene Expression Profiles in Peripheral Blood Mononuclear Cells Can Distinguish Patients with Non–Small Cell Lung Cancer from Patients with Nonmalignant Lung Disease
Michael K. Showe; Anil Vachani; Andrew V. Kossenkov; Malik Yousef; Calen Nichols; Elena V. Nikonova; Celia Chang; John Kucharczuk; Bao Tran; Elliot Wakeam; Ting An Yie; David Speicher; William N. Rom; Steven Albelda; Louise C. Showe
Endocrinology
Epidemiology
Experimental Therapeutics, Molecular Targets, and Chemical Biology
Disruption of Sphingosine 1-Phosphate Lyase Confers Resistance to Chemotherapy and Promotes Oncogenesis through Bcl-2/Bcl-xL Upregulation
Sandra Colié; Paul P. Van Veldhoven; Blandine Kedjouar; Carmen Bedia; Virginie Albinet; Sonia-Caroline Sorli; Virginie Garcia; Mojgan Djavaheri-Mergny; Chantal Bauvy; Patrice Codogno; Thierry Levade; Nathalie Andrieu-Abadie
Immunology
Folate Receptor β Is Expressed by Tumor-Associated Macrophages and Constitutes a Marker for M2 Anti-inflammatory/Regulatory Macrophages
Amaya Puig-Kröger; Elena Sierra-Filardi; Angeles Domínguez-Soto; Rafael Samaniego; María Teresa Corcuera; Fernando Gómez-Aguado; Manohar Ratnam; Paloma Sánchez-Mateos; Angel L. Corbí
Molecular Biology, Pathobiology, and Genetics
Prevention
Systems Biology and Emerging Technologies
Tumor Microenvironment and Immunobiology
Letter to the Editor
Acknowledgment to Reviewers
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