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1 December 2009
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Cover Image
Cover Image
Many tumors contain a subset of neoplastic cells with stem cell–like properties that are resistant to radiation and chemotherapy. The susceptibility of these cells to antitumor effector mechanisms operative in T-cell–mediated therapies has not been examined in detail. In this report, the authors examine a panel of primary human brain tumor stem-like initiating cells expanded from high-grade gliomas to evaluate their HLA Class I antigen presentation pathways for CD8+ T-cell recognition, target cell susceptibility to cytolytic perforin-based killing mechanisms, and their triggering of effector cytokine production. The cover image shows mouse brain sections stained with H&E (left panel) or a human-specific antibody (anti-B23; right panel) which were injected with stem cell–like glioma-initiating cells in the presence (bottom row) or absence (top row) of antigen-specific CD8+ T cells. This orthotopic glioma engraftment model demonstrates the capacity of CD8+ T cells to eradicate the tumor-initiating activity of primary stem-like glioma cells in an antigen-specific manner. These findings suggest that brain tumor stem-like cells are targets for T-cell recognition and killing, and lay the foundation for developing immunotherapeutic approaches to eradicate this otherwise therapeutically resistant tumor cell population. For details, see the article by Brown and colleagues on page 8886 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Issue Sections
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Reviews
Cell, Tumor, and Stem Cell Biology
Differential Enhancement of Breast Cancer Cell Motility and Metastasis by Helical and Kinase Domain Mutations of Class IA Phosphoinositide 3-Kinase
Huan Pang; Rory Flinn; Antonia Patsialou; Jeffrey Wyckoff; Evanthia T. Roussos; Haiyan Wu; Maria Pozzuto; Sumanta Goswami; John S. Condeelis; Anne R. Bresnick; Jeffrey E. Segall; Jonathan M. Backer
Endocrinology
Epidemiology
Experimental Therapeutics, Molecular Targets, and Chemical Biology
De novo Discovery of a γ-Secretase Inhibitor Response Signature Using a Novel In vivo Breast Tumor Model
James W. Watters; Chun Cheng; Pradip K. Majumder; Ruojie Wang; Sireesha Yalavarthi; Carol Meeske; Lingxin Kong; Wenping Sun; Jie Lin; Joerg Heyer; Chris Ware; Christopher Winter; John F. Reilly; Tim Demuth; Steve Clark; M. Isabel Chiu; Murray O. Robinson; Nancy Kohl; Karuppiah Kannan
Absence of Both Cytochrome P450 3A and P-glycoprotein Dramatically Increases Docetaxel Oral Bioavailability and Risk of Intestinal Toxicity
Robert A.B. van Waterschoot; Jurjen S. Lagas; Els Wagenaar; Cornelia M.M. van der Kruijssen; Antonius E. van Herwaarden; Ji-Ying Song; Rogier W. Rooswinkel; Olaf van Tellingen; Hilde Rosing; Jos H. Beijnen; Alfred H. Schinkel
Immunology
Molecular Biology, Pathobiology, and Genetics
Intrinsic Gene Expression Profiles of Gliomas Are a Better Predictor of Survival than Histology
Lonneke A.M. Gravendeel; Mathilde C.M. Kouwenhoven; Olivier Gevaert; Johan J. de Rooi; Andrew P. Stubbs; J. Elza Duijm; Anneleen Daemen; Fonnet E. Bleeker; Linda B.C. Bralten; Nanne K. Kloosterhof; Bart De Moor; Paul H.C. Eilers; Peter J. van der Spek; Johan M. Kros; Peter A.E. Sillevis Smitt; Martin J. van den Bent; Pim J. French
Epigenetic Profiles Distinguish Malignant Pleural Mesothelioma from Lung Adenocarcinoma
Yasuhiro Goto; Keiko Shinjo; Yutaka Kondo; Lanlan Shen; Minoru Toyota; Hiromu Suzuki; Wentao Gao; Byonggu An; Makiko Fujii; Hideki Murakami; Hirotaka Osada; Tetsuo Taniguchi; Noriyasu Usami; Masashi Kondo; Yoshinori Hasegawa; Kaoru Shimokata; Keitaro Matsuo; Toyoaki Hida; Nobukazu Fujimoto; Takumi Kishimoto; Jean-Pierre J. Issa; Yoshitaka Sekido
Prevention
Systems Biology and Emerging Technologies
Prognostic Significance of Growth Kinetics in Newly Diagnosed Glioblastomas Revealed by Combining Serial Imaging with a Novel Biomathematical Model
Christina H. Wang; Jason K. Rockhill; Maciej Mrugala; Danielle L. Peacock; Albert Lai; Katy Jusenius; Joanna M. Wardlaw; Timothy Cloughesy; Alexander M. Spence; Russ Rockne; Ellsworth C. Alvord, Jr.; Kristin R. Swanson
Tumor Microenvironment and Immunobiology
Corrections
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