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15 November 2009
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Cover Image
Cover Image
During breast conserving surgery (lumpectomy) procedures, the status (positive, close, negative) of the surgical tumor margin is the most important factor for determining local recurrence. Too often, repeat surgeries are required for complete resection. Margin status is currently assessed microscopically using postoperative histopathology, with limited sampling of visually suspicious areas. In this report, the authors perform intraoperative optical coherence tomography (OCT) for the real-time point-of-care microscopic assessment of surgical margins during lumpectomy procedures. From a study involving 37 patients, comprising training and study groups, a sensitivity of 100% and a specificity of 82% was found for determining margin status using intraoperative OCT, compared to standard postoperative histopathology. Positive and close margins were identified by the presence and pattern of dense, high-scattering regions, indicative of tumor cells, compared to lowscattering adipocytes from negative margins. These results suggest the future use of OCT as an intraoperative imaging modality for the comprehensive real-time microscopic assessment of tumor margins, which offers the potential to increase the microscopic sampling and visualization of the tissue, and significantly reduce reoperation rates. The cover shows a series of OCT images acquired across a three-dimensional surgical margin that is positive for tumor. Identified regions of tumor cells along the surgical margin appear as bright yellow. For details, see the article by Nguyen and colleagues on page 8790 of this issue. - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Issue Sections
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Reviews
Priority Report
Cell, Tumor, and Stem Cell Biology
Clinical Research
Epidemiology
Pattern of Antioxidant and DNA Repair Gene Expression in Normal Airway Epithelium Associated with Lung Cancer Diagnosis
Thomas Blomquist; Erin L. Crawford; D'Anna Mullins; Youngsook Yoon; Dawn-Alita Hernandez; Sadik Khuder; Patricia L. Ruppel; Elizabeth Peters; David J. Oldfield; Brad Austermiller; John C. Anders; James C. Willey
Experimental Therapeutics, Molecular Targets, and Chemical Biology
Repression of NHE1 Expression by PPARγ Activation Is a Potential New Approach for Specific Inhibition of the Growth of Tumor Cells In vitro and In vivo
Alan Prem Kumar; Ai Li Quake; Michelle Ker Xing Chang; Ting Zhou; Kelly Swee Ying Lim; Rajeev Singh; Robert Edwin Hewitt; Manuel Salto-Tellez; Shazib Pervaiz; Marie-Véronique Clément
Constitutive Activation of the DNA Damage Signaling Pathway in Acute Myeloid Leukemia with Complex Karyotype: Potential Importance for Checkpoint Targeting Therapy
Cindy Cavelier; Christine Didier; Naïs Prade; Véronique Mansat-De Mas; Stéphane Manenti; Christian Recher; Cécile Demur; Bernard Ducommun
Immunology
Enhanced Antitumor Activity Induced by Adoptive T-Cell Transfer and Adjunctive Use of the Histone Deacetylase Inhibitor LAQ824
Dan D. Vo; Robert M. Prins; Jonathan L. Begley; Timothy R. Donahue; Lilah F. Morris; Kevin W. Bruhn; Pilar de la Rocha; Meng-Yin Yang; Stephen Mok; Hermes J. Garban; Noah Craft; James S. Economou; Francesco M. Marincola; Ena Wang; Antoni Ribas
Interleukin 12 Stimulates IFN-γ–Mediated Inhibition of Tumor-Induced Regulatory T-Cell Proliferation and Enhances Tumor Clearance
Xuefang Cao; Karen Leonard; Lynne I. Collins; Sheng F. Cai; Joshua C. Mayer; Jacqueline E. Payton; Michael J. Walter; David Piwnica-Worms; Robert D. Schreiber; Timothy J. Ley
Molecular Biology, Pathobiology, and Genetics
Systems Biology and Emerging Technologies
Microenvironmental Independence Associated with Tumor Progression
Alexander R.A. Anderson; Mohamed Hassanein; Kevin M. Branch; Jenny Lu; Nichole A. Lobdell; Julie Maier; David Basanta; Brandy Weidow; Archana Narasanna; Carlos L. Arteaga; Albert B. Reynolds; Vito Quaranta; Lourdes Estrada; Alissa M. Weaver
Tumor Microenvironment and Immunobiology
Letters to the Editor
Corrections
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