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1 November 2009
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Cover Image
Cover Image
Disruption of the circadian rhythms has a profound influence on human health and has been linked to several major diseases, including cancer. It has been demonstrated that the proliferation of tumor cells follows autonomous circadian patterns that are out of phase with nontumor cells. Taniguchi and colleagues have identified that the BMAL1 gene, a major component of the endogenous clock, undergoes promoter CpG island methylation-mediated silencing in hematological malignancies, in which it might prevent the development of the physiological circadian rhythm. These findings suggest a chromatin-based explanation for the lack of rhythmic expression of clock-target genes in tumors, and might be useful for the design of successful chronotherapy strategies. The image shows staining for the BMAL1 protein in unmethylated leukemia cells. For details, see the article by Taniguchi and colleagues on page 8447 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Issue Sections
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Reviews
Priority Reports
Cell, Tumor, and Stem Cell Biology
Activation of the PI3K/AKT Pathway Induces Urothelial Carcinoma of the Renal Pelvis: Identification in Human Tumors and Confirmation in Animal Models
Chao-Nan Qian; Kyle A. Furge; Jared Knol; Dan Huang; Jindong Chen; Karl J. Dykema; Eric J. Kort; Aaron Massie; Sok Kean Khoo; Kristin Vanden Beldt; James H. Resau; John Anema; Richard J. Kahnoski; Hans Morreau; Philippe Camparo; Eva Comperat; Mathilde Sibony; Yves Denoux; Vincent Molinie; Annick Vieillefond; Charis Eng; Bart O. Williams; Bin Tean Teh
Deletion of PTEN Promotes Tumorigenic Signaling, Resistance to Anoikis, and Altered Response to Chemotherapeutic Agents in Human Mammary Epithelial Cells
Michele I. Vitolo; Michele B. Weiss; Marta Szmacinski; Khola Tahir; Todd Waldman; Ben Ho Park; Stuart S. Martin; David J. Weber; Kurtis E. Bachman
Clinical Research
Enhanced Leukemia Cell Detection Using a Novel Magnetic Needle and Nanoparticles
Jason E. Jaetao; Kimberly S. Butler; Natalie L. Adolphi; Debbie M. Lovato; Howard C. Bryant; Ian Rabinowitz; Stuart S. Winter; Trace E. Tessier; Helen J. Hathaway; Christian Bergemann; Edward R. Flynn; Richard S. Larson
Endocrinology
Epidemiology
Lung Adenocarcinoma with EGFR Amplification Has Distinct Clinicopathologic and Molecular Features in Never-Smokers
Lynette M. Sholl; Beow Y. Yeap; A. John Iafrate; Alison J. Holmes-Tisch; Yi-Ping Chou; Ming-Tsang Wu; Yih-Gang Goan; Li Su; Elisa Benedettini; Jian Yu; Massimo Loda; Pasi A. Jänne; David C. Christiani; Lucian R. Chirieac
Experimental Therapeutics, Molecular Targets, and Chemical Biology
The Cell Death–Inducing Activity of the Peptide Containing Noxa Mitochondrial-Targeting Domain Is Associated with Calcium Release
Young-Woo Seo; Ha-Na Woo; Sujan Piya; Ae Ran Moon; Jae-Wook Oh; Cheol-Won Yun; Kyung-Keun Kim; Ji-Young Min; Seon-Yong Jeong; Seyung Chung; Peter I. Song; Seong-Yun Jeong; Eun Kyung Choi; Dai-Wu Seol; Tae-Hyoung Kim
The Novel Tubulin-Targeting Agent Pyrrolo-1,5-Benzoxazepine-15 Induces Apoptosis in Poor Prognostic Subgroups of Chronic Lymphocytic Leukemia
Anthony M. McElligott; Elaina N. Maginn; Lisa M. Greene; Siobhan McGuckin; Amjad Hayat; Paul V. Browne; Stefania Butini; Giuseppe Campiani; Mark A. Catherwood; Elisabeth Vandenberghe; D. Clive Williams; Daniela M. Zisterer; Mark Lawler
Immunology
Intratumoral Cytokines and Tumor Cell Biology Determine Spontaneous Breast Cancer–Specific Immune Responses and Their Correlation to Prognosis
Christoph Domschke; Florian Schuetz; Yingzi Ge; Tobias Seibel; Christine Falk; Benedikt Brors; Israel Vlodavsky; Nora Sommerfeldt; Hans-Peter Sinn; Marie-Christine Kühnle; Andreas Schneeweiss; Alexander Scharf; Christof Sohn; Volker Schirrmacher; Gerhard Moldenhauer; Frank Momburg; Philipp Beckhove
Molecular Biology, Pathobiology, and Genetics
Whole-Body Sleeping Beauty Mutagenesis Can Cause Penetrant Leukemia/Lymphoma and Rare High-Grade Glioma without Associated Embryonic Lethality
Lara S. Collier; David J. Adams; Christopher S. Hackett; Laura E. Bendzick; Keiko Akagi; Michael N. Davies; Miechaleen D. Diers; Fausto J. Rodriguez; Aaron M. Bender; Christina Tieu; Ilze Matise; Adam J. Dupuy; Neal G. Copeland; Nancy A. Jenkins; J. Graeme Hodgson; William A. Weiss; Robert B. Jenkins; David A. Largaespada
Identification of Key Regions and Genes Important in the Pathogenesis of Sézary Syndrome by Combining Genomic and Expression Microarrays
Elisabetta Caprini; Cristina Cristofoletti; Diego Arcelli; Paolo Fadda; Mauro Helmer Citterich; Francesca Sampogna; Armando Magrelli; Federica Censi; Paola Torreri; Marina Frontani; Enrico Scala; Maria Cristina Picchio; Paola Temperani; Alessandro Monopoli; Giuseppe Alfonso Lombardo; Domenica Taruscio; Maria Grazia Narducci; Giandomenico Russo
Distinct MicroRNA Alterations Characterize High- and Low-Grade Bladder Cancer
James W.F. Catto; Saiful Miah; Helen C. Owen; Helen Bryant; Katie Myers; Ewa Dudziec; Stéphane Larré; Marta Milo; Ishtiaq Rehman; Derek J. Rosario; Erica Di Martino; Margaret A. Knowles; Mark Meuth; Adrian L. Harris; Freddie C. Hamdy
Progressive Chromatin Repression and Promoter Methylation of CTNNA1 Associated with Advanced Myeloid Malignancies
Ying Ye; Michael A. McDevitt; Mingzhou Guo; Wei Zhang; Oliver Galm; Steven D. Gore; Judith E. Karp; Jaroslaw P. Maciejewski; Jeanne Kowalski; Hua-Ling Tsai; Lukasz P. Gondek; Hsing-Chen Tsai; Xiaofei Wang; Craig Hooker; B. Douglas Smith; Hetty E. Carraway; James G. Herman
Systems Biology and Emerging Technologies
Tumor Microenvironment and Immunobiology
Corrections
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