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1 September 2009
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Paclitaxel is an antimicrotubule agent that is known to target β-tubulin subunits. Ferlini and colleagues have demonstrated that paclitaxel also interacts with Bcl-2, and is able to convert its function from antiapoptotic to proapoptotic. The direct interaction was proven with surface plasmon resonance technology (biosensogram, bottom panel ). Using bioinformatics, modeling of the interaction was obtained (top panel ) and, through this approach, the authors discovered an extraordinary homology between the binding site in both paclitaxel targets (Bcl-2 and β-tubulin). This finding suggests the possibility that paclitaxel is a peptide-mimicking drug. The authors assessed this possibility and discovered that the mimicked protein is Nur77, a factor known for its ability to convert Bcl-2 from a protector to a cell killer. This discovery could lead to the development of better clinical use of paclitaxel, as well as a novel generation of anticancer agents sharing this mechanism of action. For additional information, please see the article by Ferlini and colleagues on page 6906 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Issue Sections
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Point-Counterpoint Reviews
Meeting Report
Cell, Tumor, and Stem Cell Biology
Ectopic Runx2 Expression in Mammary Epithelial Cells Disrupts Formation of Normal Acini Structure: Implications for Breast Cancer Progression
Jitesh Pratap; Karen M. Imbalzano; Jean M. Underwood; Nathalie Cohet; Karthiga Gokul; Jacqueline Akech; Andre J. van Wijnen; Janet L. Stein; Anthony N. Imbalzano; Jeffrey A. Nickerson; Jane B. Lian; Gary S. Stein
Clinical Research
Endocrinology
Epidemiology
The CHRNA5-CHRNA3-CHRNB4 Nicotinic Receptor Subunit Gene Cluster Affects Risk for Nicotine Dependence in African-Americans and in European-Americans
Nancy L. Saccone; Jen C. Wang; Naomi Breslau; Eric O. Johnson; Dorothy Hatsukami; Scott F. Saccone; Richard A. Grucza; Lingwei Sun; Weimin Duan; John Budde; Robert C. Culverhouse; Louis Fox; Anthony L. Hinrichs; Joseph Henry Steinbach; Meng Wu; John P. Rice; Alison M. Goate; Laura J. Bierut
Polymorphisms in DNA Repair Genes, Smoking, and Bladder Cancer Risk: Findings from the International Consortium of Bladder Cancer
Mariana C. Stern; Jie Lin; Jonine D. Figueroa; Karl T. Kelsey; Anne E. Kiltie; Jian-Min Yuan; Giuseppe Matullo; Tony Fletcher; Simone Benhamou; Jack A. Taylor; Donatella Placidi; Zuo-Feng Zhang; Gunnar Steineck; Nathaniel Rothman; Manolis Kogevinas; Debra Silverman; Nuria Malats; Stephen Chanock; Xifeng Wu; Margaret R. Karagas; Angeline S. Andrew; Heather H. Nelson; D. Timothy Bishop; Sei Chung Sak; Ananya Choudhury; Jennifer H. Barrett; Faye Elliot; Román Corral; Amit D. Joshi; Manuela Gago-Dominguez; Victoria K. Cortessis; Yong-Bing Xiang; Yu-Tang Gao; Paolo Vineis; Carlotta Sacerdote; Simonetta Guarrera; Silvia Polidoro; Alessandra Allione; Eugen Gurzau; Kvetoslava Koppova; Rajiv Kumar; Peter Rudnai; Stefano Porru; Angela Carta; Marcello Campagna; Cecilia Arici; Sung Shim Lani Park; Montserrat Garcia-Closas; for the International Consortium of Bladder Cancer
Experimental Therapeutics, Molecular Targets, and Chemical Biology
Fyn and Src Are Effectors of Oncogenic Epidermal Growth Factor Receptor Signaling in Glioblastoma Patients
Kan V. Lu; Shaojun Zhu; Anna Cvrljevic; Tiffany T. Huang; Shawn Sarkaria; David Ahkavan; Julie Dang; Eduard B. Dinca; Seema B. Plaisier; Isaac Oderberg; Yohan Lee; Zugen Chen; Jeremy S. Caldwell; Yongmin Xie; Joseph A. Loo; David Seligson; Arnab Chakravari; Francis Y. Lee; Roberto Weinmann; Timothy F. Cloughesy; Stanley F. Nelson; Gabriele Bergers; Thomas Graeber; Frank B. Furnari; C. David James; Webster K. Cavenee; Terrance G. Johns; Paul S. Mischel
Targeting Sphingosine Kinase 1 Inhibits Akt Signaling, Induces Apoptosis, and Suppresses Growth of Human Glioblastoma Cells and Xenografts
Dmitri Kapitonov; Jeremy C. Allegood; Clint Mitchell; Nitai C. Hait; Jorge A. Almenara; Jeffrey K. Adams; Robert E. Zipkin; Paul Dent; Tomasz Kordula; Sheldon Milstien; Sarah Spiegel
c-Jun NH2-Terminal Kinase Activation Is Essential for DRAM-Dependent Induction of Autophagy and Apoptosis in 2-Methoxyestradiol–Treated Ewing Sarcoma Cells
Séverine Lorin; Amélie Borges; Lisandra Ribeiro Dos Santos; Sylvie Souquère; Gérard Pierron; Kevin M. Ryan; Patrice Codogno; Mojgan Djavaheri-Mergny
Preclinical Evaluation of Novel Glutamate-Urea-Lysine Analogues That Target Prostate-Specific Membrane Antigen as Molecular Imaging Pharmaceuticals for Prostate Cancer
Shawn M. Hillier; Kevin P. Maresca; Frank J. Femia; John C. Marquis; Catherine A. Foss; Nghi Nguyen; Craig N. Zimmerman; John A. Barrett; William C. Eckelman; Martin G. Pomper; John L. Joyal; John W. Babich
Inhibitors of Deacetylases Suppress Oncogenic KIT Signaling, Acetylate HSP90, and Induce Apoptosis in Gastrointestinal Stromal Tumors
Thomas Mühlenberg; Yixiang Zhang; Andrew J. Wagner; Florian Grabellus; James Bradner; Georg Taeger; Hauke Lang; Takahiro Taguchi; Martin Schuler; Jonathan A. Fletcher; Sebastian Bauer
Distinct Concentration-Dependent Effects of the Polo-like Kinase 1–Specific Inhibitor GSK461364A, Including Differential Effect on Apoptosis
Aidan G. Gilmartin; Maureen R. Bleam; Mark C. Richter; Symon G. Erskine; Ryan G. Kruger; Lenore Madden; Daniel F. Hassler; Gary K. Smith; Richard R. Gontarek; Mary P. Courtney; David Sutton; Melody A. Diamond; Jeffrey R. Jackson; Sylvie G. Laquerre
Immunology
Molecular Biology, Pathobiology, and Genetics
MicroRNA Expression, Chromosomal Alterations, and Immunoglobulin Variable Heavy Chain Hypermutations in Mantle Cell Lymphomas
Alba Navarro; Sílvia Beà; Verónica Fernández; Miriam Prieto; Itziar Salaverria; Pedro Jares; Elena Hartmann; Anna Mozos; Armando López-Guillermo; Neus Villamor; Dolors Colomer; Xavier Puig; German Ott; Francesc Solé; Sergi Serrano; Andreas Rosenwald; Elías Campo; Luis Hernández
Chromobox Protein Homologue 7 Protein, with Decreased Expression in Human Carcinomas, Positively Regulates E-Cadherin Expression by Interacting with the Histone Deacetylase 2 Protein
Antonella Federico; Pierlorenzo Pallante; Mimma Bianco; Angelo Ferraro; Francesco Esposito; Maria Monti; Marianna Cozzolino; Simona Keller; Monica Fedele; Vincenza Leone; Giancarlo Troncone; Lorenzo Chiariotti; Piero Pucci; Alfredo Fusco
Prevention
Chemopreventive Effects of Gefitinib on Nonsmoking-Related Lung Tumorigenesis in Activating Epidermal Growth Factor Receptor Transgenic Mice
Kadoaki Ohashi; Nagio Takigawa; Masahiro Osawa; Eiki Ichihara; Hiromasa Takeda; Toshio Kubo; Seiki Hirano; Tadashi Yoshino; Minoru Takata; Mitsune Tanimoto; Katsuyuki Kiura
Systems Biology and Emerging Technologies
Tumor Microenvironment
Corrections
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