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1 August 2009
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Cover Image
Cover Image
Disorganized tumor vasculature leads to poor perfusion and hypoxia, both contributing to cytoxic treatment failure. The authors show that treatment of tumors with drugs that target EGFR-ras-PI3K-AKT signaling (STIs) improves vascular function. The image from a tumor treated with Nefinavir shows in blue the Hoechst dye indicating perfusion seen between the GFP labelled tumor cells and the red stained vessels. Quantitation of such images revealed that STI treatment improved blood flow, enhanced vascular maturation and eliminated hypoxia. This could create a new paradigm for the use of STIs to condition tumors for therapy with drugs or radiation. For details, see the article by Qayum and colleagues on page 6347 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Issue Sections
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Reviews
Meeting Report
Priority Reports
Cell, Tumor, and Stem Cell Biology
Clinical Research
Endocrinology
Androgen Receptor Inhibits Estrogen Receptor-α Activity and Is Prognostic in Breast Cancer
Amelia A. Peters; Grant Buchanan; Carmela Ricciardelli; Tina Bianco-Miotto; Margaret M. Centenera; Jonathan M. Harris; Shalini Jindal; Davendra Segara; Li Jia; Nicole L. Moore; Susan M. Henshall; Stephen N. Birrell; Gerhard A. Coetzee; Robert L. Sutherland; Lisa M. Butler; Wayne D. Tilley
Epidemiology
Experimental Therapeutics, Molecular Targets, and Chemical Biology
Comparison of Human and Rat Uterine Leiomyomata: Identification of a Dysregulated Mammalian Target of Rapamycin Pathway
Judy S. Crabtree; Scott A. Jelinsky; Heather A. Harris; Sung E. Choe; Monette M. Cotreau; Michelle L. Kimberland; Ewa Wilson; Kathryn A. Saraf; Wei Liu; Adrienne S. McCampbell; Bhuvanesh Dave; Russell R. Broaddus; Eugene L. Brown; Wenling Kao; Jerauld S. Skotnicki; Magid Abou-Gharbia; Richard C. Winneker; Cheryl L. Walker
The Development of a Selective Cyclin-Dependent Kinase Inhibitor That Shows Antitumor Activity
Simak Ali; Dean A. Heathcote; Sebastian H.B. Kroll; Ashutosh S. Jogalekar; Bodo Scheiper; Hetal Patel; Jan Brackow; Alekasandra Siwicka; Matthew J. Fuchter; Manikandan Periyasamy; Robert S. Tolhurst; Seshu K. Kanneganti; James P. Snyder; Dennis C. Liotta; Eric O. Aboagye; Anthony G.M. Barrett; R. Charles Coombes
Biochemical, Cellular, and In vivo Activity of Novel ATP-Competitive and Selective Inhibitors of the Mammalian Target of Rapamycin
Ker Yu; Lourdes Toral-Barza; Celine Shi; Wei-Guo Zhang; Judy Lucas; Boris Shor; Jamie Kim; Jeroen Verheijen; Kevin Curran; David J. Malwitz; Derek C. Cole; John Ellingboe; Semiramis Ayral-Kaloustian; Tarek S. Mansour; James J. Gibbons; Robert T. Abraham; Pawel Nowak; Arie Zask
Immunology
Intratumoral Induction of CD103 Triggers Tumor-Specific CTL Function and CCR5-Dependent T-Cell Retention
Katarzyna Franciszkiewicz; Audrey Le Floc'h; Abdelali Jalil; Frédéric Vigant; Thomas Robert; Isabelle Vergnon; Andrzej Mackiewicz; Karim Benihoud; Pierre Validire; Salem Chouaib; Christophe Combadière; Fathia Mami-Chouaib
Immunity to Murine Prostatic Tumors: Continuous Provision of T-Cell Help Prevents CD8 T-Cell Tolerance and Activates Tumor-Infiltrating Dendritic Cells
Kimberly A. Shafer-Weaver; Stephanie K. Watkins; Michael J. Anderson; Lauren J. Draper; Anatoli Malyguine; W. Gregory Alvord; Norman M. Greenberg; Arthur A. Hurwitz
Inhibition of Superoxide Generation upon T-Cell Receptor Engagement Rescues Mart-127-35–Reactive T Cells from Activation-Induced Cell Death
Håkan Norell; Telma Martins da Palma; Aaron Lesher; Navtej Kaur; Meenal Mehrotra; Osama S. Naga; Natalie Spivey; Seye Olafimihan; Nitya G. Chakraborty; Christina Voelkel-Johnson; Michael I. Nishimura; Bijay Mukherji; Shikhar Mehrotra
Molecular Biology, Pathobiology, and Genetics
3-Phosphoinositide–Dependent Kinase 1 Potentiates Upstream Lesions on the Phosphatidylinositol 3-Kinase Pathway in Breast Carcinoma
Matthew Maurer; Tao Su; Lao H. Saal; Susan Koujak; Benjamin D. Hopkins; Christina R. Barkley; Jiaping Wu; Subhadra Nandula; Bhaskar Dutta; Yuli Xie; Y. Rebecca Chin; Da-In Kim; Jennifer S. Ferris; Sofia K. Gruvberger-Saal; Mervi Laakso; Xiaomei Wang; Lorenzo Memeo; Albert Rojtman; Tulio Matos; Jennifer S. Yu; Carlos Cordon-Cardo; Jorma Isola; Mary Beth Terry; Alex Toker; Gordon B. Mills; Jean J. Zhao; Vundavalli V.V.S. Murty; Hanina Hibshoosh; Ramon Parsons
Differentiation of Lung Adenocarcinoma, Pleural Mesothelioma, and Nonmalignant Pulmonary Tissues Using DNA Methylation Profiles
Brock C. Christensen; Carmen J. Marsit; E. Andres Houseman; John J. Godleski; Jennifer L. Longacker; Shichun Zheng; Ru-Fang Yeh; Margaret R. Wrensch; Joseph L. Wiemels; Margaret R. Karagas; Raphael Bueno; David J. Sugarbaker; Heather H. Nelson; John K. Wiencke; Karl T. Kelsey
Tumor Microenvironment
Letters to the Editor
Corrections
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