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15 May 2009
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Cover Image
RSK2 plays a key role in proliferation and cell transformation by regulating downstream targets that include transcription factors and protein kinases. Kaempferol, a natural compound that is abundant in many foods such as green onion (∼800 mg/kg), was identified as an RSK2 inhibitor. The authors provide evidence showing that kaempferol inhibits the N-terminal, but not C-terminal, kinase activity of RSK2 by interacting with Val82 and Lys100, which are critical amino acids for RSK2 activity. Computational modeling showed that kaempferol occupies the active pocket by direct binding with the backbone of Asp148 and Leu150 and forming a hydrogen bond with Lys100 and a hydrophobic interaction with Val82 and Leu147. The cover shows the interacting amino acids of the RSK2 N-terminal kinase domain and kaempferol. For details, see the article by Cho and colleagues on page 4398 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Issue Sections
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Reviews
Priority Reports
RIP1 Activates PI3K-Akt via a Dual Mechanism Involving NF-κB–Mediated Inhibition of the mTOR-S6K-IRS1 Negative Feedback Loop and Down-regulation of PTEN
Seongmi Park; Dawen Zhao; Kimmo J. Hatanpaa; Bruce E. Mickey; Debabrata Saha; David A. Boothman; Michael D. Story; Eric T. Wong; Sandeep Burma; Maria-Magdalena Georgescu; Vivek M. Rangnekar; Sandili S. Chauncey; Amyn A. Habib
A Multicenter, Double-Blinded Validation Study of Methylation Biomarkers for Progression Prediction in Barrett's Esophagus
Zhe Jin; Yulan Cheng; Wen Gu; Yingye Zheng; Fumiaki Sato; Yuriko Mori; Alexandru V. Olaru; Bogdan C. Paun; Jian Yang; Takatsugu Kan; Tetsuo Ito; James P. Hamilton; Florin M. Selaru; Rachana Agarwal; Stefan David; John M. Abraham; Herbert C. Wolfsen; Michael B. Wallace; Nicholas J. Shaheen; Kay Washington; Jean Wang; Marcia Irene Canto; Achyut Bhattacharyya; Mark A. Nelson; Paul D. Wagner; Yvonne Romero; Kenneth K. Wang; Ziding Feng; Richard E. Sampliner; Stephen J. Meltzer
Cell, Tumor, and Stem Cell Biology
Characterization of a Naturally Occurring Breast Cancer Subset Enriched in Epithelial-to-Mesenchymal Transition and Stem Cell Characteristics
Bryan T. Hennessy; Ana-Maria Gonzalez-Angulo; Katherine Stemke-Hale; Michael Z. Gilcrease; Savitri Krishnamurthy; Ju-Seog Lee; Jane Fridlyand; Aysegul Sahin; Roshan Agarwal; Corwin Joy; Wenbin Liu; David Stivers; Keith Baggerly; Mark Carey; Ana Lluch; Carlos Monteagudo; Xiaping He; Victor Weigman; Cheng Fan; Juan Palazzo; Gabriel N. Hortobagyi; Laura K. Nolden; Nicholas J. Wang; Vicente Valero; Joe W. Gray; Charles M. Perou; Gordon B. Mills
Clinical Research
Endocrinology
Loss of Phosphatase and Tensin Homologue Deleted on Chromosome 10 Engages ErbB3 and Insulin-Like Growth Factor-I Receptor Signaling to Promote Antiestrogen Resistance in Breast Cancer
Todd W. Miller; Marianela Pérez-Torres; Archana Narasanna; Marta Guix; Olle Stål; Gizeh Pérez-Tenorio; Ana M. Gonzalez-Angulo; Bryan T. Hennessy; Gordon B. Mills; J. Phillip Kennedy; Craig W. Lindsley; Carlos L. Arteaga
Epidemiology
Genetic Variation in B-Cell–Activating Factor Is Associated with an Increased Risk of Developing B-Cell Non–Hodgkin Lymphoma
Anne J. Novak; Susan L. Slager; Zachary S. Fredericksen; Alice H. Wang; Michelle M. Manske; Steven Ziesmer; Mark Liebow; William R. Macon; Stacey R. Dillon; Thomas E. Witzig; James R. Cerhan; Stephen M. Ansell
Experimental Therapeutics, Molecular Targets, and Chemical Biology
Proteasome Inhibition Potentiates Antitumor Effects of Photodynamic Therapy in Mice through Induction of Endoplasmic Reticulum Stress and Unfolded Protein Response
Angelika Szokalska; Marcin Makowski; Dominika Nowis; Grzegorz M. Wilczyński; Marek Kujawa; Cezary Wójcik; Izabela Młynarczuk-Biały; Pawel Salwa; Jacek Bil; Sylwia Janowska; Patrizia Agostinis; Tom Verfaillie; Marek Bugajski; Jan Gietka; Tadeusz Issat; Eliza Głodkowska; Piotr Mrówka; Tomasz Stoklosa; Michael R. Hamblin; Paweł Mróz; Marek Jakóbisiak; Jakub Golab
EGFRvIII and DNA Double-Strand Break Repair: A Molecular Mechanism for Radioresistance in Glioblastoma
Bipasha Mukherjee; Brian McEllin; Cristel V. Camacho; Nozomi Tomimatsu; Shyam Sirasanagandala; Suraj Nannepaga; Kimmo J. Hatanpaa; Bruce Mickey; Christopher Madden; Elizabeth Maher; David A. Boothman; Frank Furnari; Webster K. Cavenee; Robert M. Bachoo; Sandeep Burma
Epithelial-to-Mesenchymal Transition and Resistance to Ingenol 3-Angelate, a Novel Protein Kinase C Modulator, in Colon Cancer Cells
Aïda Ghoul; Maria Serova; Lucile Astorgues-Xerri; Ivan Bieche; Guilhem Bousquet; Mariana Varna; Michel Vidaud; Edelmira Phillips; Sophie Weill; Karim A. Benhadji; François Lokiec; Esteban Cvitkovic; Sandrine Faivre; Eric Raymond
A New Class of Quinoline-Based DNA Hypomethylating Agents Reactivates Tumor Suppressor Genes by Blocking DNA Methyltransferase 1 Activity and Inducing Its Degradation
Jharna Datta; Kalpana Ghoshal; William A. Denny; Swarna A. Gamage; Darby G. Brooke; Pasit Phiasivongsa; Sanjeev Redkar; Samson T. Jacob
Immunology
Cyclophosphamide Augments Antitumor Immunity: Studies in an Autochthonous Prostate Cancer Model
Satoshi Wada; Kiyoshi Yoshimura; Edward L. Hipkiss; Tim J. Harris; Hung-Rong Yen; Monica V. Goldberg; Joseph F. Grosso; Derese Getnet; Angelo M. Demarzo; George J. Netto; Robert Anders; Drew M. Pardoll; Charles G. Drake
Cancer Vaccine Enhanced, Non–Tumor-Reactive CD8+ T Cells Exhibit a Distinct Molecular Program Associated with “Division Arrest Anergy”
Marc Beyer; Julia Karbach; Michael R. Mallmann; Thomas Zander; Daniela Eggle; Sabine Classen; Svenja Debey-Pascher; Michael Famulok; Elke Jäger; Joachim L. Schultze
Molecular Biology, Pathobiology, and Genetics
Loss of the SMRT/NCoR2 Corepressor Correlates with JAG2 Overexpression in Multiple Myeloma
Pushpankur Ghoshal; Alain J. Nganga; Joseph Moran-Giuati; Angela Szafranek; Timothy R. Johnson; Ashley J. Bigelow; Christiane M. Houde; Herve Avet-Loiseau; Dominic J. Smiraglia; Noreen Ersing; Asher A. Chanan-Khan; Lionel J. Coignet
Identification of PDE4D as a Proliferation Promoting Factor in Prostate Cancer Using a Sleeping Beauty Transposon-Based Somatic Mutagenesis Screen
Eric P. Rahrmann; Lara S. Collier; Todd P. Knutson; Meghan E. Doyal; Sheri L. Kuslak; Laura E. Green; Rita L. Malinowski; Laura Roethe; Keiko Akagi; Michelle Waknitz; Wei Huang; David A. Largaespada; Paul C. Marker
Association between Transcriptional Activity, Local Chromatin Structure, and the Efficiencies of Both Subpathways of Nucleotide Excision Repair of Melphalan Adducts
Hara Episkopou; Soterios A. Kyrtopoulos; Petros P. Sfikakis; Maria Fousteri; Meletios A. Dimopoulos; Leon H.F. Mullenders; Vassilis L. Souliotis
Treatment-Dependent Androgen Receptor Mutations in Prostate Cancer Exploit Multiple Mechanisms to Evade Therapy
Mara P. Steinkamp; Orla A. O'Mahony; Michele Brogley; Haniya Rehman; Elizabeth W. LaPensee; Saravana Dhanasekaran; Matthias D. Hofer; Rainer Kuefer; Arul Chinnaiyan; Mark A. Rubin; Kenneth J. Pienta; Diane M. Robins
Epigenetic Silencing of the Tumor Suppressor MicroRNA Hsa-miR-124a Regulates CDK6 Expression and Confers a Poor Prognosis in Acute Lymphoblastic Leukemia
Xabier Agirre; Amaia Vilas-Zornoza; Antonio Jiménez-Velasco; José Ignacio Martin-Subero; Lucia Cordeu; Leire Gárate; Edurne San José-Eneriz; Gloria Abizanda; Paula Rodríguez-Otero; Puri Fortes; José Rifón; Eva Bandrés; María José Calasanz; Vanesa Martín; Anabel Heiniger; Antonio Torres; Reiner Siebert; José Román-Gomez; Felipe Prósper
Prevention
Association between Rectal Optical Signatures and Colonic Neoplasia: Potential Applications for Screening
Hemant K. Roy; Vladimir Turzhitsky; Young Kim; Michael J. Goldberg; Patrice Watson; Jeremy D. Rogers; Andrew J. Gomes; Alexey Kromine; Randall E. Brand; Mohammed Jameel; Andrej Bogovejic; Prabhakar Pradhan; Vadim Backman
Systems Biology and Emerging Technologies
Quantitative Metrics of Net Proliferation and Invasion Link Biological Aggressiveness Assessed by MRI with Hypoxia Assessed by FMISO-PET in Newly Diagnosed Glioblastomas
Mindy D. Szeto; Gargi Chakraborty; Jennifer Hadley; Russ Rockne; Mark Muzi; Ellsworth C. Alvord, Jr.; Kenneth A. Krohn; Alexander M. Spence; Kristin R. Swanson
Tumor Microenvironment
Up-regulation of L1CAM in Pancreatic Duct Cells Is Transforming Growth Factor β1– and Slug-Dependent: Role in Malignant Transformation of Pancreatic Cancer
Claudia Geismann; Mascha Morscheck; Dorothee Koch; Frank Bergmann; Hendrik Ungefroren; Alexander Arlt; Ming-Sound Tsao; Max G. Bachem; Peter Altevogt; Bence Sipos; Ulrich R. Fölsch; Heiner Schäfer; Susanne Sebens Müerköster
VEGF-A Induces Angiogenesis by Perturbing the Cathepsin-Cysteine Protease Inhibitor Balance in Venules, Causing Basement Membrane Degradation and Mother Vessel Formation
Sung-Hee Chang; Keizo Kanasaki; Vasilena Gocheva; Galia Blum; Jay Harper; Marsha A. Moses; Shou-Ching Shih; Janice A. Nagy; Johanna Joyce; Matthew Bogyo; Raghu Kalluri; Harold F. Dvorak
Corrections
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