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15 April 2008
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It has become clear that the initiation and progression of carcinomas depend not only on alterations in epithelial cells, but also on changes in their microenvironment. However, the functional interplay between carcinomas and their stoma is still poorly understood. In this report Hawsawi and colleagues present clear evidence that breast carcinoma–associated fibroblasts (CAFs) and their tumor counterpart fibroblasts (TCFs) present tumor-associated features. Using the immunohistochemistry technique, it has been shown that while normal breast fibroblasts (NBFs) from plastic surgery do not express the a-smooth muscle antigen (a-SMA), both CAFs and TCFs from the same patients are positive for this antigen and, therefore, are myofibroblasts (bottom panel, lower row). Also using immunohistochemistry, the authors show that Ki-67 protein is highly expressed not only in epithelial cells, but also in their corresponding stromal fibroblasts from the same tissue (top panel). The expression of Ki-67 in both cell types suggests that the increase in the proliferation rate is not restricted to breast carcinomas but is present in their stromal fibroblasts as well, which may enable tumor cells to grow and spread. In addition, using the two-dimensional gel electrophoresis technique, it has been shown that CAF, TCF, and NBF cells present different proteome profiles, with many proteins differentially expressed between these cells (bottom panel, upper row). Thisindicates that breast CAFs and their corresponding adjacent counterparts present different genetic alterations that need to be identified and characterized in order to further comprehend the role of stromal fibroblasts in the development and spread of breast cancer. Further characterization is also required for the development of novel therapeutic approaches that specifically target these cells to improve the treatment ofdifferent types of carcinoma. For details, see the article by Hawsawi and colleagues on page 2717 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Reviews
Priority Reports
Molecular Biology, Pathobiology, and Genetics
The Signatures of Autozygosity among Patients with Colorectal Cancer
Manny D. Bacolod; Gunter S. Schemmann; Shuang Wang; Richard Shattock; Sarah F. Giardina; Zhaoshi Zeng; Jinru Shia; Robert F. Stengel; Norman Gerry; Josephine Hoh; Tomas Kirchhoff; Bert Gold; Michael F. Christman; Kenneth Offit; William L. Gerald; Daniel A. Notterman; Jurg Ott; Philip B. Paty; Francis Barany
Bile Acid Exposure Up-regulates Tuberous Sclerosis Complex 1/Mammalian Target of Rapamycin Pathway in Barrett's-Associated Esophageal Adenocarcinoma
Chia-Jui Yen; Julie G. Izzo; Dung-Fang Lee; Sushovan Guha; Yongkun Wei; Tsung-Teh Wu; Chun-Te Chen; Hsu-Ping Kuo; Jung-Mao Hsu; Hui-Lung Sun; Chao-Kai Chou; Navtej S. Buttar; Kenneth K. Wang; Peng Huang; Jaffer Ajani; Mien-Chie Hung
Genome-Wide Promoter Analysis Uncovers Portions of the Cancer Methylome
Mohammad Obaidul Hoque; Myoung Sook Kim; Kimberly Laskie Ostrow; Junwei Liu; G. Bea A. Wisman; Hannah Lui Park; Maria Luana Poeta; Carmen Jeronimo; Rui Henrique; Ágnes Lendvai; Ed Schuuring; Shahnaz Begum; Eli Rosenbaum; Maté Ongenaert; Keishi Yamashita; Joseph Califano; William Westra; Ate G.J. van der Zee; Wim Van Criekinge; David Sidransky
Novel and Highly Recurrent Chromosomal Alterations in Sézary Syndrome
Maarten H. Vermeer; Remco van Doorn; Remco Dijkman; Xin Mao; Sean Whittaker; Pieter C. van Voorst Vader; Marie-Jeanne P. Gerritsen; Marie-Louise Geerts; Sylke Gellrich; Ola Söderberg; Karl-Johan Leuchowius; Ulf Landegren; Jacoba J. Out-Luiting; Jeroen Knijnenburg; Marije IJszenga; Karoly Szuhai; Rein Willemze; Cornelis P. Tensen
DNA Methyltransferase 1 and 3B Activate BAG-1 Expression via Recruitment of CTCFL/BORIS and Modulation of Promoter Histone Methylation
Lunching Sun; Lei Huang; Phuongmai Nguyen; Kheem S. Bisht; Gil Bar-Sela; Allen S. Ho; C. Matthew Bradbury; Wenqiang Yu; Hengmi Cui; Sunmin Lee; Jane B. Trepel; Andrew P. Feinberg; David Gius
Cell, Tumor, and Stem Cell Biology
Genistein Induces the p21WAF1/CIP1 and p16INK4a Tumor Suppressor Genes in Prostate Cancer Cells by Epigenetic Mechanisms Involving Active Chromatin Modification
Shahana Majid; Nobuyuki Kikuno; Jason Nelles; Emily Noonan; Yuichiro Tanaka; Ken Kawamoto; Hiroshi Hirata; Long C. Li; Hong Zhao; Steve T. Okino; Robert F. Place; Deepa Pookot; Rajvir Dahiya
The Promyelocytic Leukemia Zinc Finger–MicroRNA-221/-222 Pathway Controls Melanoma Progression through Multiple Oncogenic Mechanisms
Federica Felicetti; M. Cristina Errico; Lisabianca Bottero; Patrizia Segnalini; Antonella Stoppacciaro; Mauro Biffoni; Nadia Felli; Gianfranco Mattia; Marina Petrini; Mario P. Colombo; Cesare Peschle; Alessandra Carè
Matrix Metalloproteinase-8 Functions as a Metastasis Suppressor through Modulation of Tumor Cell Adhesion and Invasion
Ana Gutiérrez-Fernández; Antonio Fueyo; Alicia R. Folgueras; Cecilia Garabaya; Caroline J. Pennington; Simon Pilgrim; Dylan R. Edwards; Deborah L. Holliday; J. Louise Jones; Paul N. Span; Fred C.G.J. Sweep; Xose S. Puente; Carlos López-Otín
Epigenetic Inactivation of the Canonical Wnt Antagonist SRY-Box Containing Gene 17 in Colorectal Cancer
Wei Zhang; Sabine C. Glöckner; Mingzhou Guo; Emi Ota Machida; David H. Wang; Hariharan Easwaran; Leander Van Neste; James G. Herman; Kornel E. Schuebel; D. Neil Watkins; Nita Ahuja; Stephen B. Baylin
Experimental Therapeutics, Molecular Targets, and Chemical Biology
Targeting Endoplasmic Reticulum Stress and Akt with OSU-03012 and Gefitinib or Erlotinib to Overcome Resistance to Epidermal Growth Factor Receptor Inhibitors
Yu-Chieh Wang; Samuel K. Kulp; Dasheng Wang; Chih-Cheng Yang; Aaron M. Sargeant; Jui-Hsiang Hung; Yoko Kashida; Mamoru Yamaguchi; Geen-Dong Chang; Ching-Shih Chen
Coordinated Epidermal Growth Factor Receptor Pathway Gene Overexpression Predicts Epidermal Growth Factor Receptor Inhibitor Sensitivity in Pancreatic Cancer
Antonio Jimeno; Aik Choon Tan; Jordy Coffa; N.V. Rajeshkumar; Peter Kulesza; Belen Rubio-Viqueira; Jenna Wheelhouse; Begoña Diosdado; Wells A. Messersmith; Christine Iacobuzio-Donahue; Anirban Maitra; Marileila Varella-Garcia; Fred R. Hirsch; Gerrit A. Meijer; Manuel Hidalgo
NVP-AUY922: A Novel Heat Shock Protein 90 Inhibitor Active against Xenograft Tumor Growth, Angiogenesis, and Metastasis
Suzanne A. Eccles; Andy Massey; Florence I. Raynaud; Swee Y. Sharp; Gary Box; Melanie Valenti; Lisa Patterson; Alexis de Haven Brandon; Sharon Gowan; Frances Boxall; Wynne Aherne; Martin Rowlands; Angela Hayes; Vanessa Martins; Frederique Urban; Kathy Boxall; Chrisostomos Prodromou; Laurence Pearl; Karen James; Thomas P. Matthews; Kwai-Ming Cheung; Andrew Kalusa; Keith Jones; Edward McDonald; Xavier Barril; Paul A. Brough; Julie E. Cansfield; Brian Dymock; Martin J. Drysdale; Harry Finch; Rob Howes; Roderick E. Hubbard; Alan Surgenor; Paul Webb; Mike Wood; Lisa Wright; Paul Workman
Immunology
Interleukin-15/Interleukin-15Rα Complexes Promote Destruction of Established Tumors by Reviving Tumor-Resident CD8+ T Cells
Mathieu Epardaud; Kutlu G. Elpek; Mark P. Rubinstein; Ai-ris Yonekura; Angelique Bellemare-Pelletier; Roderick Bronson; Jessica A. Hamerman; Ananda W. Goldrath; Shannon J. Turley
Endocrinology
Clinical Research
Epidemiology
Double-Strand Break Damage and Associated DNA Repair Genes Predispose Smokers to Gene Methylation
Shuguang Leng; Christine A. Stidley; Randy Willink; Amanda Bernauer; Kieu Do; Maria A. Picchi; Xin Sheng; Melissa A. Frasco; David Van Den Berg; Frank D. Gilliland; Christopher Zima; Richard E. Crowell; Steven A. Belinsky
Prevention
Letters to the Editor
Corrections
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