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1 April 2008
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Current modalities for predicting prostate cancer outcome are largely based on clinical features of tumors, whereas molecular markers that distinguish indolent versus aggressive tumors are lacking. Using an integrative approach that combines gene expression profiling of a mouse model with expression validation using human prostate cancer tissue microarrays, we find that the AP-1 transcription factors c-Fos and c-Jun are markers of advanced prostate cancer and in particular that c-Jun is associated with disease recurrence. Our findings provide a striking example of how accurate mouse models can inform on molecular processes involved in the progression and recurrence of human cancer. For details, see the article by Ouyang and colleagues on page 2132 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Reviews
Priority Reports
Molecular Biology, Pathobiology, and Genetics
Activator Protein-1 Transcription Factors Are Associated with Progression and Recurrence of Prostate Cancer
Xuesong Ouyang; Walter J. Jessen; Hikmat Al-Ahmadie; Angel M. Serio; Yong Lin; Weichung-Joseph Shih; Victor E. Reuter; Peter T. Scardino; Michael M. Shen; Bruce J. Aronow; Andrew J. Vickers; William L. Gerald; Cory Abate-Shen
Origins and Prevalence of the American Founder Mutation of MSH2
Mark Clendenning; Mark E. Baze; Shuying Sun; Kyle Walsh; Sandya Liyanarachchi; Dan Fix; Victoria Schunemann; Ilene Comeras; Molly Deacon; Jane F. Lynch; Gordon Gong; Brittany C. Thomas; Stephen N. Thibodeau; Henry T. Lynch; Heather Hampel; Albert de la Chapelle
Frequency of the CHEK2 1100delC Mutation among Women with Breast Cancer: An International Study
Shiyu Zhang; Catherine M. Phelan; Phil Zhang; Francois Rousseau; Parviz Ghadirian; Andre Robidoux; William Foulkes; Nancy Hamel; David McCready; Maureen Trudeau; Henry Lynch; Douglas Horsman; Maria Lourdes Leon De Matsuda; Zeba Aziz; Magda Gomes; Mauricio Magalhaes Costa; Alexander Liede; Aletta Poll; Ping Sun; Steven A. Narod
Cell, Tumor, and Stem Cell Biology
Hypoxia Down-regulates CCAAT/Enhancer Binding Protein-α Expression in Breast Cancer Cells
Ramzi Seifeddine; Anne Dreiem; Etienne Blanc; Marie-Claude Fulchignoni-Lataud; Marie-Aude Le Frère Belda; Fabrice Lecuru; Thérèse Hervèe Mayi; Nathalie Mazure; Vincent Favaudon; Charbel Massaad; Robert Barouki; Liliane Massaad-Massade
c-Jun NH2-Terminal Kinase Activating Kinase 1/Mitogen-Activated Protein Kinase Kinase 4–Mediated Inhibition of SKOV3ip.1 Ovarian Cancer Metastasis Involves Growth Arrest and p21 Up-regulation
Tamara Lotan; Jonathan Hickson; Jeffrey Souris; Dezheng Huo; Jennifer Taylor; Terry Li; Kristen Otto; Seiko Diane Yamada; Kay Macleod; Carrie W. Rinker-Schaeffer
Regulation of Id1 Expression by Src: Implications for Targeting of the Bone Morphogenetic Protein Pathway in Cancer
Oliver Gautschi; Clifford G. Tepper; Phillip R. Purnell; Yoshihiro Izumiya; Christopher P. Evans; Tim P. Green; Pierre Y. Desprez; Primo N. Lara; David R. Gandara; Philip C. Mack; Hsing-Jien Kung
Tumor Microenvironment
Experimental Therapeutics, Molecular Targets, and Chemical Biology
Blood Vessel Maturation and Response to Vascular-Disrupting Therapy in Single Vascular Endothelial Growth Factor-A Isoform–Producing Tumors
Gillian M. Tozer; Simon Akerman; Neil A. Cross; Paul R. Barber; Meit A. Björndahl; Olga Greco; Sheila Harris; Sally A. Hill; Davina J. Honess; Christopher R. Ireson; Katie L. Pettyjohn; Vivien E. Prise; Constantino C. Reyes-Aldasoro; Christiana Ruhrberg; David T. Shima; Chryso Kanthou
Loss of E-Cadherin Promotes Ovarian Cancer Metastasis via α5-Integrin, which Is a Therapeutic Target
Kenjiro Sawada; Anirban K. Mitra; A. Reza Radjabi; Vinay Bhaskar; Emily O. Kistner; Maria Tretiakova; Sujatha Jagadeeswaran; Anthony Montag; Amy Becker; Hilary A. Kenny; Marcus E. Peter; Vanitha Ramakrishnan; S. Diane Yamada; Ernst Lengyel
Characterization of an Akt Kinase Inhibitor with Potent Pharmacodynamic and Antitumor Activity
Nelson Rhodes; Dirk A. Heerding; Derek R. Duckett; Derek J. Eberwein; Victoria B. Knick; Timothy J. Lansing; Randy T. McConnell; Tona M. Gilmer; Shu-Yun Zhang; Kimberly Robell; Jason A. Kahana; Robert S. Geske; Elena V. Kleymenova; Anthony E. Choudhry; Zhihong Lai; Jack D. Leber; Elisabeth A. Minthorn; Susan L. Strum; Edgar R. Wood; Pearl S. Huang; Robert A. Copeland; Rakesh Kumar
Immunology
Conjugation of Human Topoisomerase 2α with Small Ubiquitin-like Modifiers 2/3 in Response to Topoisomerase Inhibitors: Cell Cycle Stage and Chromosome Domain Specificity
Marta Agostinho; Vera Santos; Fernando Ferreira; Rafael Costa; Joana Cardoso; Inês Pinheiro; José Rino; Ellis Jaffray; Ronald T. Hay; João Ferreira
A Cryptic Vascular Endothelial Growth Factor T-Cell Epitope: Identification and Characterization by Mass Spectrometry and T-Cell Assays
Andreas O. Weinzierl; Dominik Maurer; Florian Altenberend; Nicole Schneiderhan-Marra; Karin Klingel; Oliver Schoor; Dorothee Wernet; Thomas Joos; Hans-Georg Rammensee; Stefan Stevanović
Endocrinology
Insulin-like Growth Factor-I–Dependent Up-regulation of ZEB1 Drives Epithelial-to-Mesenchymal Transition in Human Prostate Cancer Cells
Tisheeka R. Graham; Haiyen E. Zhau; Valerie A. Odero-Marah; Adeboye O. Osunkoya; K. Sean Kimbro; Mourad Tighiouart; Tongrui Liu; Jonathan W. Simons; Ruth M. O'Regan
Clinical Research
Epidemiology
Prevention
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