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15 March 2008
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A large number of somatic mutations accumulate during the process of tumorigenesis. A subset of these mutations contributes to tumor progression (known as “driver” mutations) while the majority of these mutations are effectively neutral (known as “passenger” mutations). The ability to differentiate between drivers and passengers will be critical to the success of upcoming large-scale cancer DNA resequencing projects. In this issue, Torkamani and Schork describe a method capable of discriminating between drivers and passengers in the most frequently cancer-associated protein family, protein kinases. The structural distribution of predicted cancer drivers is depicted as a heat map overlayed on the crystal structure of PKA, with red being the highest density of drivers, followed by yellow, green, and blue. Identification of cancer drivers is a crucial first step towards customizing or individualizing the treatment of a cancer patient based on his or her specific tumorigenic profile. With this knowledge, kinase inhibitors can be redesigned to target tumor-promoting mutant protein kinases more effectively. For details, see the article by Torkamani and Schork on page 1675 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Reviews
Priority Reports
Molecular Biology, Pathobiology, and Genetics
Human Tumor Antigens Tn and Sialyl Tn Arise from Mutations in Cosmc
Tongzhong Ju; Grainger S. Lanneau; Tripti Gautam; Yingchun Wang; Baoyun Xia; Sean R. Stowell; Margaret T. Willard; Wenyi Wang; Jonathan Y. Xia; Rosemary E. Zuna; Zoltan Laszik; Doris M. Benbrook; Marie H. Hanigan; Richard D. Cummings
Bin3 Deletion Causes Cataracts and Increased Susceptibility to Lymphoma during Aging
Arivudainambi Ramalingam; James B. Duhadaway; Erika Sutanto-Ward; Yan Wang; Joseph Dinchuk; Minzhou Huang; Preston S. Donover; Janette Boulden; Lois M. McNally; Alejandro P. Soler; Alexander J. Muller; Melinda K. Duncan; George C. Prendergast
Cell, Tumor, and Stem Cell Biology
Lipid Bodies Are Reservoirs of Cyclooxygenase-2 and Sites of Prostaglandin-E2 Synthesis in Colon Cancer Cells
Maria T. Accioly; Patricia Pacheco; Clarissa M. Maya-Monteiro; Nina Carrossini; Bruno K. Robbs; Silvia S. Oliveira; Cristiane Kaufmann; José A. Morgado-Diaz; Patricia T. Bozza; João P.B. Viola
The Smo/Smo Model: Hedgehog-Induced Medulloblastoma with 90% Incidence and Leptomeningeal Spread
Beryl A. Hatton; Elisabeth H. Villavicencio; Karen D. Tsuchiya; Joel I. Pritchard; Sally Ditzler; Barbara Pullar; Stacey Hansen; Sue E. Knoblaugh; Donghoon Lee; Charles G. Eberhart; Andrew R. Hallahan; James M. Olson
Epithelial Progeny of Estrogen-Exposed Breast Progenitor Cells Display a Cancer-like Methylome
Alfred S.L. Cheng; Aedín C. Culhane; Michael W.Y. Chan; Chinnambally R. Venkataramu; Mathias Ehrich; Aejaz Nasir; Benjamin A.T. Rodriguez; Joseph Liu; Pearlly S. Yan; John Quackenbush; Kenneth P. Nephew; Timothy J. Yeatman; Tim H-M. Huang
Deletion of Yin Yang 1 Protein in Osteosarcoma Cells on Cell Invasion and CXCR4/Angiogenesis and Metastasis
Filomena de Nigris; Raffaele Rossiello; Concetta Schiano; Claudio Arra; Sharon Williams-Ignarro; Antonio Barbieri; Alessandro Lanza; Antonio Balestrieri; Maria Teresa Giuliano; Louis J. Ignarro; Claudio Napoli
Tumor Microenvironment
Experimental Therapeutics, Molecular Targets, and Chemical Biology
Hypoxia-Inducible Factor-1 Target Genes as Indicators of Tumor Vessel Response to Vascular Endothelial Growth Factor Inhibition
Duyen T. Dang; Sang Y. Chun; Kyunghee Burkitt; Masako Abe; Shaowei Chen; Pamela Havre; Nicola J. Mabjeesh; Elisabeth I. Heath; Nicholas J. Vogelzang; Marcia Cruz-Correa; Douglas W. Blayney; William D. Ensminger; Brad St. Croix; Nam H. Dang; Long H. Dang
NOTCH3 Signaling Pathway Plays Crucial Roles in the Proliferation of ErbB2-Negative Human Breast Cancer Cells
Noritaka Yamaguchi; Tetsunari Oyama; Emi Ito; Hitoshi Satoh; Sakura Azuma; Mitsuhiro Hayashi; Ken Shimizu; Reiko Honma; Yuka Yanagisawa; Akira Nishikawa; Mika Kawamura; Jun-ichi Imai; Susumu Ohwada; Kuniaki Tatsuta; Jun-ichiro Inoue; Kentaro Semba; Shinya Watanabe
Adjuvant Therapy with Small Hairpin RNA Interference Prevents Non–Small Cell Lung Cancer Metastasis Development in Mice
Etmar Bulk; Antje Hascher; Ruediger Liersch; Rolf M. Mesters; Sven Diederichs; Bülent Sargin; Volker Gerke; Marc Hotfilder; Josef Vormoor; Wolfgang E. Berdel; Hubert Serve; Carsten Müller-Tidow
Enzastaurin, a Protein Kinase Cβ Inhibitor, Suppresses Signaling through the Ribosomal S6 Kinase and Bad Pathways and Induces Apoptosis in Human Gastric Cancer Cells
Keun-Wook Lee; Sang Gyun Kim; Hwang-Phill Kim; Euna Kwon; Jiran You; Hyung-Jun Choi; Jung-Hyun Park; Byeong-Cheol Kang; Seock-Ah Im; Tae-You Kim; Woo Ho Kim; Yung-Jue Bang
Antitumor Activity and Pharmacology of a Selective Focal Adhesion Kinase Inhibitor, PF-562,271
Walter Gregory Roberts; Ethan Ung; Pamela Whalen; Beth Cooper; Catherine Hulford; Christofer Autry; Daniel Richter; Earling Emerson; Jing Lin; John Kath; Kevin Coleman; Lili Yao; Luis Martinez-Alsina; Marianne Lorenzen; Martin Berliner; Michael Luzzio; Nandini Patel; Erika Schmitt; Susan LaGreca; Jitesh Jani; Matt Wessel; Eric Marr; Matt Griffor; Felix Vajdos
PIK3CA Mutation/PTEN Expression Status Predicts Response of Colon Cancer Cells to the Epidermal Growth Factor Receptor Inhibitor Cetuximab
Minaxi Jhawer; Sanjay Goel; Andrew J. Wilson; Cristina Montagna; Yi-He Ling; Do-Sun Byun; Shannon Nasser; Diego Arango; Joongho Shin; Lidija Klampfer; Leonard H. Augenlicht; Roman Perez Soler; John M. Mariadason
Targeted Delivery of Gemcitabine to Pancreatic Adenocarcinoma Using Cetuximab as a Targeting Agent
Chitta Ranjan Patra; Resham Bhattacharya; Enfeng Wang; Aaron Katarya; Julie S. Lau; Shamit Dutta; Michael Muders; Shanfeng Wang; Sarah A. Buhrow; Stephanie L. Safgren; Michael J. Yaszemski; Joel M. Reid; Matthew M. Ames; Priyabrata Mukherjee; Debabrata Mukhopadhyay
Systems Biology and Emerging Technologies
Immunology
Prevention
Corrections
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