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1 December 2008
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Bile acids, an end-product of cholesterol catabolism, are synthesized in the liver, stored in the gallbladder, and secreted into the duodenum in response to a meal to allow the absorption of dietary lipids and fat-soluble vitamins. Epidemiological studies have shown a correlation between high levels of intestinal bile acids and colorectal cancer progression. In this study, Modica and colleagues have investigated the role of the Farnesoid X Receptor (FXR), the transcriptional mediator of the physiological effects of bile acid, in the context of intestinal tumorigenesis. First, the authors demonstrate that FXR expression is dramatically reduced in human and mouse intestinal neoplasia. Second, they provide evidence that the reduced expression of FXR in the intestine further promotes inflammation and tumor progression in mouse models. Finally, using in vivo and in vitro studies, the authors suggest a protective role of FXR in intestinal tumorigenesis via induction of apoptosis and propose therapies aimed at reactivating FXR for the management of colorectal cancer. For details, see the article by Modica and colleagues on page 9589 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Reviews
Meeting Reports
Priority Reports
Cell, Tumor, and Stem Cell Biology
Endocrinology
Bidirectional Crosstalk between Leptin and Insulin-like Growth Factor-I Signaling Promotes Invasion and Migration of Breast Cancer Cells via Transactivation of Epidermal Growth Factor Receptor
Neeraj K. Saxena; LaTonia Taliaferro-Smith; Brandi B. Knight; Didier Merlin; Frank A. Anania; Ruth M. O'Regan; Dipali Sharma
Epidemiology
Experimental Therapeutics, Molecular Targets, and Chemical Biology
ODC1 Is a Critical Determinant of MYCN Oncogenesis and a Therapeutic Target in Neuroblastoma
Michael D. Hogarty; Murray D. Norris; Kimberly Davis; Xueyuan Liu; Nicholas F. Evageliou; Candace S. Hayes; Bruce Pawel; Rong Guo; Huaqing Zhao; Eric Sekyere; Joanna Keating; Wayne Thomas; Ngan Ching Cheng; Jayne Murray; Janice Smith; Rosemary Sutton; Nicola Venn; Wendy B. London; Allen Buxton; Susan K. Gilmour; Glenn M. Marshall; Michelle Haber
Glutathione Peroxidase 2 Inhibits Cyclooxygenase-2–Mediated Migration and Invasion of HT-29 Adenocarcinoma Cells but Supports Their Growth as Tumors in Nude Mice
Antje Banning; Anna Kipp; Stephanie Schmitmeier; Maria Löwinger; Simone Florian; Susanne Krehl; Sophie Thalmann; René Thierbach; Pablo Steinberg; Regina Brigelius-Flohé
Inhibition of Repair of Radiation-Induced DNA Damage Enhances Gene Expression from Replication-Defective Adenoviral Vectors
Mohan Hingorani; Christine L. White; Andrew Merron; Inge Peerlinck; Martin E. Gore; Andrew Slade; Simon D. Scott; Christopher M. Nutting; Hardev S. Pandha; Alan A. Melcher; Richard G. Vile; Georges Vassaux; Kevin J. Harrington
Atu027, a Liposomal Small Interfering RNA Formulation Targeting Protein Kinase N3, Inhibits Cancer Progression
Manuela Aleku; Petra Schulz; Oliver Keil; Ansgar Santel; Ute Schaeper; Britta Dieckhoff; Oliver Janke; Jens Endruschat; Birgit Durieux; Nadine Röder; Kathrin Löffler; Christian Lange; Melanie Fechtner; Kristin Möpert; Gerald Fisch; Sibylle Dames; Wolfgang Arnold; Karin Jochims; Klaus Giese; Bertram Wiedenmann; Arne Scholz; Jörg Kaufmann
Evidence that Resistance to Nilotinib May Be Due to BCR-ABL, Pgp, or Src Kinase Overexpression
François-Xavier Mahon; Sandrine Hayette; Valérie Lagarde; Francis Belloc; Béatrice Turcq; Franck Nicolini; Coralie Belanger; Paul W. Manley; Cédric Leroy; Gabriel Etienne; Serge Roche; Jean-Max Pasquet
Anti–Glypican 3 Antibody as a Potential Antitumor Agent for Human Liver Cancer
Takahiro Ishiguro; Masamichi Sugimoto; Yasuko Kinoshita; Yoko Miyazaki; Kiyotaka Nakano; Hiroyuki Tsunoda; Izumi Sugo; Iwao Ohizumi; Hiroyuki Aburatani; Takao Hamakubo; Tatsuhiko Kodama; Masayuki Tsuchiya; Hisafumi Yamada-Okabe
F14512, a Potent Antitumor Agent Targeting Topoisomerase II Vectored into Cancer Cells via the Polyamine Transport System
Jean-Marc Barret; Anna Kruczynski; Stéphane Vispé; Jean-Philippe Annereau; Viviane Brel; Yves Guminski; Jean-Guy Delcros; Amélie Lansiaux; Nicolas Guilbaud; Thierry Imbert; Christian Bailly
Immunology
ICAM-1 Has a Critical Role in the Regulation of Metastatic Melanoma Tumor Susceptibility to CTL Lysis by Interfering with PI3K/AKT Pathway
Ahmed Hamaï; Franck Meslin; Houssem Benlalam; Abdelali Jalil; Maryam Mehrpour; Florence Faure; Yann Lecluse; Philipe Vielh; Marie-Françoise Avril; Caroline Robert; Salem Chouaib
Preventive Vaccination with Telomerase Controls Tumor Growth in Genetically Engineered and Carcinogen-Induced Mouse Models of Cancer
Carmela Mennuni; Stefano Ugel; Federica Mori; Barbara Cipriani; Manuela Iezzi; Tania Pannellini; Domenico Lazzaro; Gennaro Ciliberto; Nicola La Monica; Paola Zanovello; Vincenzo Bronte; Elisa Scarselli
Overcoming Immunoescape Mechanisms of BCL1 Leukemia and Induction of CD8+ T-Cell–Mediated BCL1-Specific Resistance in Mice Cured by Targeted Polymer-Bound Doxorubicin
Marek Kovar; Jakub Tomala; Helena Chmelova; Lubomir Kovar; Tomas Mrkvan; Radka Joskova; Zuzana Zakostelska; Tomas Etrych; Jiri Strohalm; Karel Ulbrich; Milada Sirova; Blanka Rihova
Molecular Biology, Pathobiology, and Genetics
Chromosome 12p Deletions in TEL-AML1 Childhood Acute Lymphoblastic Leukemia Are Associated with Retrotransposon Elements and Occur Postnatally
Joseph L. Wiemels; Jerry Hofmann; Michelle Kang; Rebecca Selzer; Roland Green; Mi Zhou; Sheng Zhong; Luoping Zhang; Martyn T. Smith; Carmen Marsit; Mignon Loh; Patricia Buffler; Ru-Fang Yeh
A Range of Cancers Is Associated with the rs6983267 Marker on Chromosome 8
Dominika Wokołorczyk; Bartłomiej Gliniewicz; Andrzej Sikorski; Elżbieta Złowocka; Bartłomiej Masojć; Tadeusz Dębniak; Joanna Matyjasik; Marek Mierzejewski; Krzysztof Mędrek; Dorota Oszutowska; Janina Suchy; Jacek Gronwald; Urszula Teodorczyk; Tomasz Huzarski; Tomasz Byrski; Anna Jakubowska; Bohdan Górski; Thierry van de Wetering; Swietłana Walczak; Steven A. Narod; Jan Lubiński; Cezary Cybulski
Tumor Microenvironment
Interstitial Doppler Optical Coherence Tomography as a Local Tumor Necrosis Predictor in Photodynamic Therapy of Prostatic Carcinoma: An In vivo Study
Beau A. Standish; Kenneth K.C. Lee; Xiao Jin; Adrian Mariampillai; Nigel R. Munce; Michael F.G. Wood; Brian C. Wilson; I. Alex Vitkin; Victor X.D. Yang
Coevolution of Prostate Cancer and Bone Stroma in Three-Dimensional Coculture: Implications for Cancer Growth and Metastasis
Shian-Ying Sung; Chia-Ling Hsieh; Andrew Law; Haiyen E. Zhau; Sen Pathak; Asha S. Multani; Sharon Lim; Ilsa M. Coleman; Li-Chin Wu; William D. Figg; William L. Dahut; Peter Nelson; Jae K. Lee; Mahul B. Amin; Robert Lyles; Peter A.J. Johnstone; Fray F. Marshall; Leland W.K. Chung
Obituary
Corrections
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