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1 July 2008
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Defective mismatch repair (MMR) in humans causes hereditary nonpolyposis colorectal cancer. This genetic predisposition to colon cancer is linked to heterozygous familial mutations, and loss-of-heterozygosity is necessary for tumor development. Existing mouse knockout models show only partial overlap in the tumor spectrum. Novel zebrafish knockout mutants for the MMR genes msh6, msh2 and mlh1 were generated by target-selected mutagenesis. These fish were found to display microsatellite instability and to develop tumors. Although the tumor spectrum is different from the mouse, it does partially resemble the spectrum of rare patient cases with biallelic MMR mutations. MMR-deficient fish develop predominantly neurofibromas/malignant peripheral nerve sheath tumors, but several other tumor types were also found. The image shows high (first row) and medium (second row) magnifications of histological cross sections (third row) as well as macroscopical images (fourth row) of an ocular neurofibroma (first column), an olfactory neuroblastoma (second column), a primitive neuroectodermal tumor in the brain (third column), and a hemangiosarcoma (fourth column) that were identified in msh6-/- and mlh1-/- fish. Our work shows that the zebrafish is a useful cancer model that provides new insights and experimental possibilities, and complements studies in mouse models and humans. For details, see the article by Feitsma et al. on page 5059 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Issue Sections
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Reviews
Meeting Report
Priority Reports
Identification of Novel Isoforms of the EML4-ALK Transforming Gene in Non–Small Cell Lung Cancer
Young Lim Choi; Kengo Takeuchi; Manabu Soda; Kentaro Inamura; Yuki Togashi; Satoko Hatano; Munehiro Enomoto; Toru Hamada; Hidenori Haruta; Hideki Watanabe; Kentaro Kurashina; Hisashi Hatanaka; Toshihide Ueno; Shuji Takada; Yoshihiro Yamashita; Yukihiko Sugiyama; Yuichi Ishikawa; Hiroyuki Mano
Transporter-Mediated Protection against Thiopurine-Induced Hematopoietic Toxicity
Partha Krishnamurthy; Matthias Schwab; Kazumasa Takenaka; Deepa Nachagari; Jessica Morgan; Mark Leslie; Weinan Du; Kelli Boyd; Meyling Cheok; Hiromitsu Nakauchi; Catia Marzolini; Richard B. Kim; Balasubramanian Poonkuzhali; Erin Schuetz; William Evans; Mary Relling; John D. Schuetz
Complement-Dependent Tumor Cell Lysis Triggered by Combinations of Epidermal Growth Factor Receptor Antibodies
Michael Dechant; Wencke Weisner; Sven Berger; Matthias Peipp; Thomas Beyer; Tanja Schneider-Merck; Jeroen J. Lammerts van Bueren; Wim K. Bleeker; Paul W.H.I. Parren; Jan G.J. van de Winkel; Thomas Valerius
Molecular Biology, Pathobiology, and Genetics
15-Hydroxyprostaglandin Dehydrogenase is a Target of Hepatocyte Nuclear Factor 3β and a Tumor Suppressor in Lung Cancer
Guosheng Huang; Rosana Eisenberg; Min Yan; Stefano Monti; Earl Lawrence; Pingfu Fu; Jaclyn Walbroehl; Ester Löwenberg; Todd Golub; Jaime Merchan; Daniel G. Tenen; Sanford D. Markowitz; Balazs Halmos
Cell, Tumor, and Stem Cell Biology
Genomic and Proteomic Analysis Reveals a Threshold Level of MYC Required for Tumor Maintenance
Catherine M. Shachaf; Andrew J. Gentles; Sailaja Elchuri; Debashis Sahoo; Yoav Soen; Orr Sharpe; Omar D. Perez; Maria Chang; Dennis Mitchel; William H. Robinson; David Dill; Garry P. Nolan; Sylvia K. Plevritis; Dean W. Felsher
NO Signaling Confers Cytoprotectivity through the Survivin Network in Ovarian Carcinomas
Knut Engels; Shirley K. Knauer; Sibylle Loibl; Verena Fetz; Philipp Harter; Andrea Schweitzer; Annette Fisseler-Eckhoff; Friedrich Kommoss; Lars Hanker; Valentina Nekljudova; Iris Hermanns; Hartmut Kleinert; Wolf Mann; Andreas du Bois; Roland H. Stauber
Tumor Microenvironment
Experimental Therapeutics, Molecular Targets, and Chemical Biology
Aplidin, a Marine Organism–Derived Compound with Potent Antimyeloma Activity In vitro and In vivo
Constantine S. Mitsiades; Enrique M. Ocio; Atanasio Pandiella; Patricia Maiso; Consuelo Gajate; Mercedes Garayoa; David Vilanova; Juan Carlos Montero; Nicholas Mitsiades; Ciaran J. McMullan; Nikhil C. Munshi; Teru Hideshima; Dharminder Chauhan; Pablo Aviles; Gabriel Otero; Glynn Faircloth; M. Victoria Mateos; Paul G. Richardson; Faustino Mollinedo; Jesus F. San-Miguel; Kenneth C. Anderson
Cross-talk between Notch and the Estrogen Receptor in Breast Cancer Suggests Novel Therapeutic Approaches
Paola Rizzo; Haixi Miao; Gwendolyn D'Souza; Clodia Osipo; Jieun Yun; Huiping Zhao; Joaquina Mascarenhas; Debra Wyatt; Giovanni Antico; Lu Hao; Katharine Yao; Prabha Rajan; Chindo Hicks; Kalliopi Siziopikou; Suzanne Selvaggi; Amina Bashir; Deepali Bhandari; Adriano Marchese; Urban Lendahl; Jian-Zhong Qin; Debra A. Tonetti; Kathy Albain; Brian J. Nickoloff; Lucio Miele
Improved Cellular Pharmacokinetics and Pharmacodynamics Underlie the Wide Anticancer Activity of Sagopilone
Jens Hoffmann; Ilio Vitale; Bernd Buchmann; Lorenzo Galluzzi; Wolfgang Schwede; Laura Senovilla; Werner Skuballa; Sonia Vivet; Rosemarie B. Lichtner; José M. Vicencio; Theocharis Panaretakis; Gerhard Siemeister; Hermann Lage; Lisa Nanty; Stefanie Hammer; Kevin Mittelstaedt; Sebastian Winsel; Julia Eschenbrenner; Maria Castedo; Carine Demarche; Ulrich Klar; Guido Kroemer
Increasing Melanoma Cell Death Using Inhibitors of Protein Disulfide Isomerases to Abrogate Survival Responses to Endoplasmic Reticulum Stress
Penny E. Lovat; Marco Corazzari; Jane L. Armstrong; Shaun Martin; Vittoria Pagliarini; David Hill; Anna M. Brown; Mauro Piacentini; Mark A. Birch-Machin; Christopher P.F. Redfern
Systems Biology and Emerging Technologies
Immunology
Endocrinology
Clinical Research
Prevention
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