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1 June 2008
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Cytoreductive surgery followed by platinum/taxane results in complete response in 70&percent; of ovarian cancer patients, but most patients will relapse with drug-resistant disease within 18 months. An emerging model for the development of drug-resistant tumors invokes a pool of self-renewing malignant progenitors known as cancer-initiating cells. Zhang and colleagues identify and characterize a subpopulation of ovarian cancer–initiating cells (OCICs) capable of serial propagation of their original tumor phenotype in animals. Stemness properties of OCICs include enhanced chemoresistance to cisplatin or paclitaxel and upregulation of stem cell markers Bmi-1, stem cell factor, Notch-1, Nanog, nestin, ABCG2, and Oct-4. To identify an OCIC cell surface phenotype, immunostaining showed significant up-regulation of the hyaluronate acid receptor CD44 and stem cell factor receptor CD117, a tyrosine kinase oncoprotein. Isolated CD44+CD117+ cells could also serially propagate theiroriginal tumor phenotype in animals. These findings suggest that epithelial ovarian cancers derive from a subpopulation of CD44+CD117+ cells, thus representing a possible therapeutic target for this devastating disease. For details, see the article by Zhang et al. on page 4311 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Issue Sections
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Reviews
Meeting Report
Priority Reports
Molecular Biology, Pathobiology, and Genetics
Polo-like Kinase 3 Functions as a Tumor Suppressor and Is a Negative Regulator of Hypoxia-Inducible Factor-1α under Hypoxic Conditions
Yali Yang; Jingxiang Bai; Rulong Shen; Sharron A.N. Brown; Elena Komissarova; Ying Huang; Ning Jiang; Gregory F. Alberts; Max Costa; Luo Lu; Jeffrey A. Winkles; Wei Dai
Epigenetic Inactivation of the Groucho Homologue Gene TLE1 in Hematologic Malignancies
Mario F. Fraga; Maria Berdasco; Esteban Ballestar; Santiago Ropero; Pilar Lopez-Nieva; Lidia Lopez-Serra; José I. Martín-Subero; Maria J. Calasanz; Isabel Lopez de Silanes; Fernando Setien; Sara Casado; Agustin F. Fernandez; Reiner Siebert; Stefano Stifani; Manel Esteller
Genome-Wide Copy Number Analysis in Esophageal Adenocarcinoma Using High-Density Single-Nucleotide Polymorphism Arrays
Derek J. Nancarrow; Herlina Y. Handoko; B. Mark Smithers; David C. Gotley; Paul A. Drew; David I. Watson; Andrew D. Clouston; Nicholas K. Hayward; David C. Whiteman; for the Australian Cancer Study and the Study of Digestive Health
RET/PTC-Induced Cell Growth Is Mediated in Part by Epidermal Growth Factor Receptor (EGFR) Activation: Evidence for Molecular and Functional Interactions between RET and EGFR
Michelle Croyle; Nagako Akeno; Jeffrey A. Knauf; Doriano Fabbro; Xu Chen; Jacqueline E. Baumgartner; Heidi A. Lane; James A. Fagin
Cell, Tumor, and Stem Cell Biology
Dual-Specificity Phosphatase 1 Ubiquitination in Extracellular Signal-Regulated Kinase–Mediated Control of Growth in Human Hepatocellular Carcinoma
Diego F. Calvisi; Federico Pinna; Floriana Meloni; Sara Ladu; Rossella Pellegrino; Marcella Sini; Lucia Daino; Maria M. Simile; Maria R. De Miglio; Patrizia Virdis; Maddalena Frau; Maria L. Tomasi; Maria A. Seddaiu; Maria R. Muroni; Francesco Feo; Rosa M. Pascale
Functional and Clinical Evidence for NDRG2 as a Candidate Suppressor of Liver Cancer Metastasis
Dong Chul Lee; Yun Kyung Kang; Woo Ho Kim; Ye Jin Jang; Dong Joon Kim; In Young Park; Bo Hwa Sohn; Hyun Ahm Sohn; Hee Gu Lee; Jong Seok Lim; Jae Wha Kim; Eun Young Song; Dong Min Kim; Mi-Ni Lee; Goo Taeg Oh; Soo Jung Kim; Kyung Chan Park; Hyang Sook Yoo; Jong Young Choi; Young Il Yeom
Pediatric Malignant Germ Cell Tumors Show Characteristic Transcriptome Profiles
Roger D. Palmer; Nuno L. Barbosa-Morais; Emma L. Gooding; Balaji Muralidhar; Claire M. Thornton; Mark R. Pett; Ian Roberts; Dominik T. Schneider; Natalie Thorne; Simon Tavaré; James C. Nicholson; Nicholas Coleman; on behalf of Children's Cancer and Leukaemia Group
Defective Claudin-7 Regulation by Tcf-4 and Sox-9 Disrupts the Polarity and Increases the Tumorigenicity of Colorectal Cancer Cells
Charbel Darido; Michael Buchert; Julie Pannequin; Pauline Bastide; Hassan Zalzali; Theo Mantamadiotis; Jean-François Bourgaux; Véronique Garambois; Philippe Jay; Philippe Blache; Dominique Joubert; Frédéric Hollande
Inhibition of Gastric Cancer Invasion and Metastasis by PLA2G2A, a Novel β-Catenin/TCF Target Gene
Kumaresan Ganesan; Tatiana Ivanova; Yonghui Wu; Vikneswari Rajasegaran; Jeanie Wu; Ming Hui Lee; Kun Yu; Sun Young Rha; Hyun Cheol Chung; Bauke Ylstra; Gerrit Meijer; Kon Oi Lian; Heike Grabsch; Patrick Tan
Histone Deacetylase Inhibitors Reverse SS18-SSX–Mediated Polycomb Silencing of the Tumor Suppressor Early Growth Response 1 in Synovial Sarcoma
Joanna M. Lubieniecka; Diederik R.H. de Bruijn; Le Su; Anke H.A. van Dijk; Subbaya Subramanian; Matt van de Rijn; Neal Poulin; Ad Geurts van Kessel; Torsten O. Nielsen
Tumor Microenvironment
Experimental Therapeutics, Molecular Targets, and Chemical Biology
MetMAb, the One-Armed 5D5 Anti-c-Met Antibody, Inhibits Orthotopic Pancreatic Tumor Growth and Improves Survival
Hongkui Jin; Renhui Yang; Zhong Zheng; Mally Romero; Jed Ross; Hani Bou-Reslan; Richard A.D. Carano; Ian Kasman; Elaine Mai; Judy Young; Jiping Zha; Zemin Zhang; Sarajane Ross; Ralph Schwall; Gail Colbern; Mark Merchant
Systems Biology and Emerging Technologies
Immunology
Endocrinology
Epidemiology
Correction
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