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15 May 2008
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Recurrent gene fusions between the androgen-regulated genes TMPRSS2 and the ETS transcription family members ERG, ETV1, and ETV4 have been implicated in the majority of clinically localized prostate cancers. To determine if these fusions are also present in androgen-independent metastatic prostate cancer, a previously validated fluorescent in situ hybridization (FISH) split probe strategy was used to analyze the frequency and mechanism of these gene fusions in samples isolated from 30 prostate cancer patients. The results indicate that the high frequency of TMPRSS2-ETS rearrangements is maintained during progression to an androgen-independent state. The most common gene fusion, TMPRSS2-ERG, was associated with interstitial deletion (Edel) in 39% to 60% of clinically localized disease and in all of the androgen-independent metastatic prostate sites. Furthermore, multiple sites from an individual case harbored the same gene fusion molecular subtype suggesting clonal expansion of disease. These findings suggest that TMPRSSE-ERG with Edel is an aggressive and, in this study, uniformly lethal molecular subtype of prostate cancer associated with androgen-independent disease. For details, see the article by Mehra et al. on page 3584 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Reviews
Priority Reports
Molecular Biology, Pathobiology, and Genetics
Cell, Tumor, and Stem Cell Biology
Reversible Dysfunction of Wild-Type p53 following Homeodomain-Interacting Protein Kinase-2 Knockdown
Rosa Puca; Lavinia Nardinocchi; Hilah Gal; Gideon Rechavi; Ninette Amariglio; Eytan Domany; Daniel A. Notterman; Marco Scarsella; Carlo Leonetti; Ada Sacchi; Giovanni Blandino; David Givol; Gabriella D'Orazi
Experimental Therapeutics, Molecular Targets, and Chemical Biology
Constitutive Activation of Signal Transducers and Activators of Transcription Predicts Vorinostat Resistance in Cutaneous T-Cell Lymphoma
Valeria R. Fantin; Andrey Loboda; Cloud P. Paweletz; Ronald C. Hendrickson; Jacqueline W. Pierce; Jennifer A. Roth; Lixia Li; Frank Gooden; Susan Korenchuk; Xiaoli S. Hou; Elizabeth A. Harrington; Sophia Randolph; John F. Reilly; Christopher M. Ware; Marshall E. Kadin; Stanley R. Frankel; Victoria M. Richon
An Anti–Transforming Growth Factor β Antibody Suppresses Metastasis via Cooperative Effects on Multiple Cell Compartments
Jeong-Seok Nam; Masaki Terabe; Mizuko Mamura; Mi-Jin Kang; Helen Chae; Christina Stuelten; Ethan Kohn; Binwu Tang; Helen Sabzevari; Miriam R. Anver; Scott Lawrence; David Danielpour; Scott Lonning; Jay A. Berzofsky; Lalage M. Wakefield
Immunology
The Soluble α Chain of Interleukin-15 Receptor: A Proinflammatory Molecule Associated with Tumor Progression in Head and Neck Cancer
Cécile Badoual; Grégory Bouchaud; Nour El Houda Agueznay; Erwan Mortier; Stéphane Hans; Alain Gey; Fahima Fernani; Séverine Peyrard; Pierre Laurent -Puig; Patrick Bruneval; Xavier Sastre; Ariane Plet; Laure Garrigue-Antar; Françoise Quintin-Colonna; Wolf H. Fridman; Daniel Brasnu; Yannick Jacques; Eric Tartour
Transforming Growth Factor β Subverts the Immune System into Directly Promoting Tumor Growth through Interleukin-17
Jeong-Seok Nam; Masaki Terabe; Mi-Jin Kang; Helen Chae; Nga Voong; Yu-an Yang; Arian Laurence; Aleksandra Michalowska; Mizuko Mamura; Scott Lonning; Jay A. Berzofsky; Lalage M. Wakefield
Endocrinology
Clinical Research
Rap1GAP Promotes Invasion via Induction of Matrix Metalloproteinase 9 Secretion, Which Is Associated with Poor Survival in Low N-Stage Squamous Cell Carcinoma
Raj S. Mitra; Mitsuo Goto; Julia S. Lee; Diana Maldonado; Jeremy M.G. Taylor; Quintin Pan; Thomas E. Carey; Carol R. Bradford; Mark E. Prince; Kitrina G. Cordell; Keith L. Kirkwood; Nisha J. D'Silva
Epidemiology
Prevention
Letters to the Editor
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