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15 April 2007
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Cover Image
Peritoneal metastases are usually disseminated throughout the abdominal cavity and therefore difficult to see during surgery. Fluorescent molecular imaging can help identify such lesions, but conventional imaging probes produce high background signal which can obscure peritoneal implants. To achieve high sensitivity and specificity, a two-step activatable fluorescent probe set was synthesized in which the tumor is first pretargeted with a biotinylated antibody and then a subsequently administered optical probe, neutravidin-BODIPY-FL, is activated via the molecular interaction of the fluorophore with biotin. A single antibody can be loaded with more than 10 biotin molecules. The fluorescence of the probe is increased approximately 10-fold after it binds to the biotinylated antibody leading to high sensitivity for peritoneal implants and reduced background signal of the unbound probe. Using this two-step pretargeting strategy, it was possible to detect submillimeter nodules disseminated within the peritoneal cavity in a mouse model of ovarian cancer with high sensitivity and specificity. This two-step activation strategy for molecular optical imaging is potentially widely applicable to other tumor types and other anatomic sites. For details, see the article by Hama et al. on page 3809 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Issue Sections
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Reviews
Perspectives in Cancer Research
Priority Reports
Identification of Their Epitope Reveals the Structural Basis for the Mechanism of Action of the Immunosuppressive Antibodies Basiliximab and Daclizumab
Mascha Binder; Friederike-Nora Vögtle; Stefan Michelfelder; Fabian Müller; Gerald Illerhaus; Sangeeth Sundararajan; Roland Mertelsmann; Martin Trepel
Mutations in BRAF and KRAS Differentially Distinguish Serrated versus Non-Serrated Hyperplastic Aberrant Crypt Foci in Humans
Daniel W. Rosenberg; Shi Yang; Devon C. Pleau; Emily J. Greenspan; Richard G. Stevens; Thiruchandurai V. Rajan; Christopher D. Heinen; Joel Levine; Yijian Zhou; Michael J. O'Brien
Shared MHC Class II–Dependent Melanoma Ribosomal Protein L8 Identified by Phage Display
Rolf K. Swoboda; Rajasekharan Somasundaram; Laura Caputo; Elizabeth M. Ochoa; Phyllis A. Gimotty; Francesco M. Marincola; Patricia Van Belle; Stephen Barth; David Elder; DuPont Guerry; Brian Czerniecki; Lynn Schuchter; Robert H. Vonderheide; Dorothee Herlyn
Molecular Biology, Pathobiology, and Genetics
Cell, Tumor, and Stem Cell Biology
Androgen-Independent Growth and Tumorigenesis of Prostate Cancer Cells Are Enhanced by the Presence of PKA-Differentiated Neuroendocrine Cells
Paul D. Deeble; Michael E. Cox; Henry F. Frierson, Jr.; Robert A. Sikes; Jodie B. Palmer; Robert J. Davidson; Eli V. Casarez; George P. Amorino; Sarah J. Parsons
Experimental Therapeutics, Molecular Targets, and Chemical Biology
Proteomic Analysis of Waldenstrom Macroglobulinemia
Evdoxia Hatjiharissi; Hai Ngo; Alexey A. Leontovich; Xavier Leleu; Michael Timm; Mona Melhem; Diane George; Ganwei Lu; Joanna Ghobrial; Yazan Alsayed; Steven Zeismer; Miguel Cabanela; Alex Nehme; Xiaoying Jia; Anne Sophie Moreau; Steven P. Treon; Rafael Fonseca; Morie A. Gertz; Kenneth C. Anderson; Thomas E. Witzig; Irene M. Ghobrial
Curcumin Potentiates Antitumor Activity of Gemcitabine in an Orthotopic Model of Pancreatic Cancer through Suppression of Proliferation, Angiogenesis, and Inhibition of Nuclear Factor-κB–Regulated Gene Products
Ajaikumar B. Kunnumakkara; Sushovan Guha; Sunil Krishnan; Parmeswaran Diagaradjane; Juri Gelovani; Bharat B. Aggarwal
Immunology
Selective Targeting and Potent Control of Tumor Growth Using an EphA2/CD3-Bispecific Single-Chain Antibody Construct
Scott A. Hammond; Ralf Lutterbuese; Shannon Roff; Petra Lutterbuese; Bernd Schlereth; Elizabeth Bruckheimer; Michael S. Kinch; Steve Coats; Patrick A. Baeuerle; Peter Kufer; Peter A. Kiener
Endocrinology
M3 Muscarinic Receptor Antagonists Inhibit Small Cell Lung Carcinoma Growth and Mitogen-Activated Protein Kinase Phosphorylation Induced by Acetylcholine Secretion
Pingfang Song; Harmanjatinder S. Sekhon; Allison Lu; Juan Arredondo; David Sauer; Courtney Gravett; Gregory P. Mark; Sergei A. Grando; Eliot R. Spindel
Aromatase Localization in Human Breast Cancer Tissues: Possible Interactions between Intratumoral Stromal and Parenchymal Cells
Yasuhiro Miki; Takashi Suzuki; Chika Tazawa; Yuri Yamaguchi; Kunio Kitada; Seijiro Honma; Takuya Moriya; Hisashi Hirakawa; Dean B. Evans; Shin-ichi Hayashi; Noriaki Ohuchi; Hironobu Sasano
Clinical Research
Epidemiology and Prevention
Letters to the Editor
Correction
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