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15 March 2007
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Cover Image
The use of multiphoton imaging in living undissected mammary tumors reveals that macrophages initiate invasion and intravasation using paracrine signaling pathways that have been correlated with metastatic outcome. These results indicate that perivascular macrophages determine the metastatic potential of tumor cells and are an important drug target for cancer therapy. Figures counterclockwise from the top show: a 300-μm-thick reconstruction of a mammary tumor of the mouse showing blood vessels in red and macropages in green; green perivascular macrophages surrounding a blood vessel; and a high magnification image of a single perivascular macrophage with engulfed red dextran particles. For details, see the article by Wyckoff et al. on page 2649 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Review
Meeting Report
Priority Reports
Mutant p53 Enhances Nuclear Factor κB Activation by Tumor Necrosis Factor α in Cancer Cells
Lilach Weisz; Alexander Damalas; Michalis Liontos; Panagiotis Karakaidos; Giulia Fontemaggi; Revital Maor-Aloni; Marina Kalis; Massimo Levrero; Sabrina Strano; Vassilis G. Gorgoulis; Varda Rotter; Giovanni Blandino; Moshe Oren
Molecular Biology, Pathobiology, and Genetics
Anaplastic, Plasmablastic, and Plasmacytic Plasmacytomas of Mice: Relationships to Human Plasma Cell Neoplasms and Late-Stage Differentiation of Normal B Cells
Chen-Feng Qi; Jeff X. Zhou; Chang Hoon Lee; Zohreh Naghashfar; Shao Xiang; Alexander L. Kovalchuk; Torgny N. Fredrickson; Janet W. Hartley; Derry C. Roopenian; Wendy F. Davidson; Siegfried Janz; Herbert C. Morse, III
Destabilized Adhesion in the Gastric Proliferative Zone and c-Src Kinase Activation Mark the Development of Early Diffuse Gastric Cancer
Bostjan Humar; Ryuji Fukuzawa; Vanessa Blair; Anita Dunbier; Helen More; Amanda Charlton; Han Kwang Yang; Woo Ho Kim; Anthony E. Reeve; Iain Martin; Parry Guilford
Inactivation of Apc in the Mouse Prostate Causes Prostate Carcinoma
Katia J. Bruxvoort; Holli M. Charbonneau; Troy A. Giambernardi; James C. Goolsby; Chao-Nan Qian; Cassandra R. Zylstra; Daniel R. Robinson; Pradip Roy-Burman; Aubie K. Shaw; Bree D. Buckner-Berghuis; Robert E. Sigler; James H. Resau; Ruth Sullivan; Wade Bushman; Bart O. Williams
Dikkopf-1 as a Novel Serologic and Prognostic Biomarker for Lung and Esophageal Carcinomas
Takumi Yamabuki; Atsushi Takano; Satoshi Hayama; Nobuhisa Ishikawa; Tatsuya Kato; Masaki Miyamoto; Tomoo Ito; Hiroyuki Ito; Yohei Miyagi; Haruhiko Nakayama; Masahiro Fujita; Masao Hosokawa; Eiju Tsuchiya; Nobuoki Kohno; Satoshi Kondo; Yusuke Nakamura; Yataro Daigo
Association of CYP1B1 Germ Line Mutations with Hepatocyte Nuclear Factor 1α–Mutated Hepatocellular Adenoma
Emmanuelle Jeannot; Karine Poussin; Laurence Chiche; Yannick Bacq; Nathalie Sturm; Jean-Yves Scoazec; Catherine Buffet; Jeanne Tran Van Nhieu; Christine Bellanné-Chantelot; Claudia de Toma; Pierre Laurent-Puig; Paulette Bioulac-Sage; Jessica Zucman-Rossi
Oncogenic Activation of the RAS/RAF Signaling Pathway Impairs the Response of Metastatic Colorectal Cancers to Anti–Epidermal Growth Factor Receptor Antibody Therapies
Silvia Benvenuti; Andrea Sartore-Bianchi; Federica Di Nicolantonio; Carlo Zanon; Mauro Moroni; Silvio Veronese; Salvatore Siena; Alberto Bardelli
Cell, Tumor, and Stem Cell Biology
Molecular Cloning of hMena (ENAH) and Its Splice Variant hMena+11a: Epidermal Growth Factor Increases Their Expression and Stimulates hMena+11a Phosphorylation in Breast Cancer Cell Lines
Francesca Di Modugno; Lucia DeMonte; Michele Balsamo; Giovanna Bronzi; Maria Rita Nicotra; Massimo Alessio; Elke Jager; John S. Condeelis; Angela Santoni; Pier Giorgio Natali; Paola Nisticò
Metallothionein Expression Is Suppressed in Primary Human Hepatocellular Carcinomas and Is Mediated through Inactivation of CCAAT/Enhancer Binding Protein α by Phosphatidylinositol 3-Kinase Signaling Cascade
Jharna Datta; Sarmila Majumder; Huban Kutay; Tasneem Motiwala; Wendy Frankel; Robert Costa; Hyuk C. Cha; Ormond A. MacDougald; Samson T. Jacob; Kalpana Ghoshal
Mullerian-Inhibiting Substance Induces Gro-β Expression in Breast Cancer Cells through a Nuclear Factor-κB–Dependent and Smad1-Dependent Mechanism
Vandana Gupta; Giminna Yeo; Hirofumi Kawakubo; Vivek Rangnekar; Preethi Ramaswamy; Tetsu Hayashida; David T. MacLaughlin; Patricia K. Donahoe; Shyamala Maheswaran
Experimental Therapeutics, Molecular Targets, and Chemical Biology
Radionuclide Therapy of HER2-Positive Microxenografts Using a 177Lu-Labeled HER2-Specific Affibody Molecule
Vladimir Tolmachev; Anna Orlova; Rikard Pehrson; Joakim Galli; Barbro Baastrup; Karl Andersson; Mattias Sandström; Daniel Rosik; Jörgen Carlsson; Hans Lundqvist; Anders Wennborg; Fredrik Y. Nilsson
A Target Cell–Specific Activatable Fluorescence Probe for In vivo Molecular Imaging of Cancer Based on a Self-Quenched Avidin-Rhodamine Conjugate
Yukihiro Hama; Yasuteru Urano; Yoshinori Koyama; Mako Kamiya; Marcelino Bernardo; Ronald S. Paik; In Soo Shin; Chang H. Paik; Peter L. Choyke; Hisataka Kobayashi
Dasatinib Inhibits Migration and Invasion in Diverse Human Sarcoma Cell Lines and Induces Apoptosis in Bone Sarcoma Cells Dependent on Src Kinase for Survival
Audrey C. Shor; Elizabeth A. Keschman; Francis Y. Lee; Carlos Muro-Cacho; G. Douglas Letson; Jonathan C. Trent; W. Jack Pledger; Richard Jove
Functional Neoangiogenesis Imaging of Genetically Engineered Mouse Prostate Cancer Using Three-Dimensional Power Doppler Ultrasound
Jim W. Xuan; Michael Bygrave; Hongyi Jiang; Fatma Valiyeva; Joy Dunmore-Buyze; David W. Holdsworth; Jonathan I. Izawa; Glenn Bauman; Madeleine Moussa; Scott F. Winter; Norman M. Greenberg; Joseph L. Chin; Maria Drangova; Aaron Fenster; James C. Lacefield
Sensitization of Mesothelioma Cells to Tumor Necrosis Factor–Related Apoptosis–Inducing Ligand–Induced Apoptosis by Heat Stress via the Inhibition of the 3-Phosphoinositide-Dependent Kinase 1/Akt Pathway
Melissa H. Pespeni; Maki Hodnett; Keith S. Abayasiriwardana; Jérémie Roux; Marybeth Howard; V. Courtney Broaddus; Jean-François Pittet
Immunology
Combining Adoptive Cellular and Immunocytokine Therapies to Improve Treatment of B-Lineage Malignancy
Harjeet Singh; Lisa Marie Serrano; Timothy Pfeiffer; Simon Olivares; George McNamara; David D. Smith; Zaid Al-Kadhimi; Stephen J. Forman; Stephen D. Gillies; Michael C. Jensen; David Colcher; Andrew Raubitschek; Laurence J.N. Cooper
Clinical Research
Letters to the Editor
Correction
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