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Volume 67, Issue 6
15 March 2007
Cancer Research Cover Image for Volume 67, Issue 6
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  • Cover Image

    Cover Image

    Issue cover image
    The use of multiphoton imaging in living undissected mammary tumors reveals that macrophages initiate invasion and intravasation using paracrine signaling pathways that have been correlated with metastatic outcome. These results indicate that perivascular macrophages determine the metastatic potential of tumor cells and are an important drug target for cancer therapy. Figures counterclockwise from the top show: a 300-μm-thick reconstruction of a mammary tumor of the mouse showing blood vessels in red and macropages in green; green perivascular macrophages surrounding a blood vessel; and a high magnification image of a single perivascular macrophage with engulfed red dextran particles. For details, see the article by Wyckoff et al. on page 2649 of this issue.
  • PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445

Cancer Research

Table of Contents


Review

The Obesity-Cancer Link: Lessons Learned from a Fatless Mouse
Stephen D. Hursting; Nomeli P. Nunez; Lyuba Varticovski; Charles Vinson
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Meeting Report

A Tribute to George F. Vande Woude, a Man of Character: 2006 Scientific Symposium Winning the War against Cancer: From Genomics to Bedside and Back
Bin T. Teh; Nicholas S. Duesbery
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Priority Reports

Mutant p53 Enhances Nuclear Factor κB Activation by Tumor Necrosis Factor α in Cancer Cells
Lilach Weisz; Alexander Damalas; Michalis Liontos; Panagiotis Karakaidos; Giulia Fontemaggi; Revital Maor-Aloni; Marina Kalis; Massimo Levrero; Sabrina Strano; Vassilis G. Gorgoulis; Varda Rotter; Giovanni Blandino; Moshe Oren
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Purging of the Neuroblastoma Stem Cell Compartment and Tumor Regression on Exposure to Hypoxia or Cytotoxic Treatment
Ilaria Marzi; Massimo D'Amico; Tiziana Biagiotti; Serena Giunti; Maria Vittoria Carbone; David Fredducci; Enzo Wanke; Massimo Olivotto
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RAD001 (Everolimus) Delays Tumor Onset and Progression in a Transgenic Mouse Model of Ovarian Cancer
Seiji Mabuchi; Deborah A. Altomare; Denise C. Connolly; Andres Klein-Szanto; Samuel Litwin; Matthew K. Hoelzle; Harvey H. Hensley; Thomas C. Hamilton; Joseph R. Testa
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The Synthetic Triterpenoids CDDO-Methyl Ester and CDDO-Ethyl Amide Prevent Lung Cancer Induced by Vinyl Carbamate in A/J Mice
Karen Liby; Darlene B. Royce; Charlotte R. Williams; Renee Risingsong; Mark M. Yore; Tadashi Honda; Gordon W. Gribble; Ethan Dmitrovsky; Thomas A. Sporn; Michael B. Sporn
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Protein-Tyrosine Phosphatase 1B Is Required for HER2/Neu–Induced Breast Cancer
Mohamed Bentires-Alj; Benjamin G. Neel
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Extrathymic Generation of Tumor-Specific T Cells from Genetically Engineered Human Hematopoietic Stem Cells via Notch Signaling
Yangbing Zhao; Maria R. Parkhurst; Zhili Zheng; Cyrille J. Cohen; John P. Riley; Luca Gattinoni; Nicholas P. Restifo; Steven A. Rosenberg; Richard A. Morgan
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Molecular Biology, Pathobiology, and Genetics

Dominant-Negative Activator Protein 1 (TAM67) Targets Cyclooxygenase-2 and Osteopontin under Conditions in which It Specifically Inhibits Tumorigenesis
Connie P. Matthews; Alysia M. Birkholz; Alyson R. Baker; Christine M. Perella; George R. Beck, Jr.; Matthew R. Young; Nancy H. Colburn
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Anaplastic, Plasmablastic, and Plasmacytic Plasmacytomas of Mice: Relationships to Human Plasma Cell Neoplasms and Late-Stage Differentiation of Normal B Cells
Chen-Feng Qi; Jeff X. Zhou; Chang Hoon Lee; Zohreh Naghashfar; Shao Xiang; Alexander L. Kovalchuk; Torgny N. Fredrickson; Janet W. Hartley; Derry C. Roopenian; Wendy F. Davidson; Siegfried Janz; Herbert C. Morse, III
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MYCN-Directed Centrosome Amplification Requires MDM2-Mediated Suppression of p53 Activity in Neuroblastoma Cells
Andrew D. Slack; Zaowen Chen; Andrew D. Ludwig; John Hicks; Jason M. Shohet
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Characterization of MicroRNA Expression Levels and Their Biological Correlates in Human Cancer Cell Lines
Arti Gaur; David A. Jewell; Yu Liang; Dana Ridzon; Jason H. Moore; Caifu Chen; Victor R. Ambros; Mark A. Israel
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Activation of Tumor-Specific Splice Variant Rac1b by Dishevelled Promotes Canonical Wnt Signaling and Decreased Adhesion of Colorectal Cancer Cells
Susmita Esufali; George S. Charames; Vaijayanti V. Pethe; Pinella Buongiorno; Bharati Bapat
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Destabilized Adhesion in the Gastric Proliferative Zone and c-Src Kinase Activation Mark the Development of Early Diffuse Gastric Cancer
Bostjan Humar; Ryuji Fukuzawa; Vanessa Blair; Anita Dunbier; Helen More; Amanda Charlton; Han Kwang Yang; Woo Ho Kim; Anthony E. Reeve; Iain Martin; Parry Guilford
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Inactivation of Apc in the Mouse Prostate Causes Prostate Carcinoma
Katia J. Bruxvoort; Holli M. Charbonneau; Troy A. Giambernardi; James C. Goolsby; Chao-Nan Qian; Cassandra R. Zylstra; Daniel R. Robinson; Pradip Roy-Burman; Aubie K. Shaw; Bree D. Buckner-Berghuis; Robert E. Sigler; James H. Resau; Ruth Sullivan; Wade Bushman; Bart O. Williams
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Concomitant Activation of the JAK/STAT, PI3K/AKT, and ERK Signaling Is Involved in Leptin-Mediated Promotion of Invasion and Migration of Hepatocellular Carcinoma Cells
Neeraj K. Saxena; Dipali Sharma; Xiaokun Ding; Songbai Lin; Fabio Marra; Didier Merlin; Frank A. Anania
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Fine Mapping and Candidate Gene Analyses of Pulmonary Adenoma Resistance 1, a Major Genetic Determinant of Mouse Lung Adenoma Resistance
Min Wang; Zhongqiu Zhang; Zhuo Zhang; Haris Vikis; Ying Yan; Yian Wang; Ming You
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Dikkopf-1 as a Novel Serologic and Prognostic Biomarker for Lung and Esophageal Carcinomas
Takumi Yamabuki; Atsushi Takano; Satoshi Hayama; Nobuhisa Ishikawa; Tatsuya Kato; Masaki Miyamoto; Tomoo Ito; Hiroyuki Ito; Yohei Miyagi; Haruhiko Nakayama; Masahiro Fujita; Masao Hosokawa; Eiju Tsuchiya; Nobuoki Kohno; Satoshi Kondo; Yusuke Nakamura; Yataro Daigo
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Long-term XPC Silencing Reduces DNA Double-Strand Break Repair
Emmanuelle Despras; Petra Pfeiffer; Bernard Salles; Patrick Calsou; Steffi Kuhfittig-Kulle; Jaime F. Angulo; Denis S.F. Biard
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Involvement of IFN Regulatory Factor (IRF)-1 and IRF-2 in the Formation and Progression of Human Esophageal Cancers
Yan Wang; Dong-Ping Liu; Ping-Ping Chen; H. Phillip Koeffler; Xiang-Jun Tong; Dong Xie
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Genome-Wide, High-Resolution Detection of Copy Number, Loss of Heterozygosity, and Genotypes from Formalin-Fixed, Paraffin-Embedded Tumor Tissue Using Microarrays
Sharoni Jacobs; Ella R. Thompson; Yasuhito Nannya; Go Yamamoto; Raji Pillai; Seishi Ogawa; Dione K. Bailey; Ian G. Campbell
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Inhibitor of Growth 4 Suppresses Cell Spreading and Cell Migration by Interacting with a Novel Binding Partner, Liprin α1
Jiang-Cheng Shen; Motoko Unoki; Damien Ythier; Alain Duperray; Lyuba Varticovski; Kensuke Kumamoto; Remy Pedeux; Curtis C. Harris
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Lens Epithelium-Derived Growth Factor Is an Hsp70-2 Regulated Guardian of Lysosomal Stability in Human Cancer
Mads Daugaard; Thomas Kirkegaard-Sørensen; Marie Stampe Ostenfeld; Mads Aaboe; Maria Høyer-Hansen; Torben Falck Ørntoft; Mikkel Rohde; Marja Jäättelä
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Oncogenic Role of KIAA0101 Interacting with Proliferating Cell Nuclear Antigen in Pancreatic Cancer
Masayo Hosokawa; Akio Takehara; Koichi Matsuda; Hidetoshi Eguchi; Hiroaki Ohigashi; Osamu Ishikawa; Yasuhisa Shinomura; Kohzoh Imai; Yusuke Nakamura; Hidewaki Nakagawa
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Epigenetic Regulation of the Human Retinoblastoma Tumor Suppressor Gene Promoter by CTCF
Inti A. De La Rosa-Velázquez; Héctor Rincón-Arano; Luis Benítez-Bribiesca; Félix Recillas-Targa
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G-Rich Proto-Oncogenes Are Targeted for Genomic Instability in B-Cell Lymphomas
Michelle L. Duquette; Michael D. Huber; Nancy Maizels
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15-Deoxy-Δ12,14-Prostaglandin J2 Inhibits Transcriptional Activity of Estrogen Receptor-α via Covalent Modification of DNA-Binding Domain
Han-Jong Kim; Joon-Young Kim; Zhaojing Meng; Li Hua Wang; Fa Liu; Thomas P. Conrads; Terrence R. Burke; Timothy D. Veenstra; William L. Farrar
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p53-Independent Abrogation of a Postmitotic Checkpoint Contributes to Human Papillomavirus E6-Induced Polyploidy
Yingwang Liu; Susan A. Heilman; Diego Illanes; Greenfield Sluder; Jason J. Chen
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Association of CYP1B1 Germ Line Mutations with Hepatocyte Nuclear Factor 1α–Mutated Hepatocellular Adenoma
Emmanuelle Jeannot; Karine Poussin; Laurence Chiche; Yannick Bacq; Nathalie Sturm; Jean-Yves Scoazec; Catherine Buffet; Jeanne Tran Van Nhieu; Christine Bellanné-Chantelot; Claudia de Toma; Pierre Laurent-Puig; Paulette Bioulac-Sage; Jessica Zucman-Rossi
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Large-Scale CpG Methylation Analysis Identifies Novel Candidate Genes and Reveals Methylation Hotspots in Acute Lymphoblastic Leukemia
Kristen H. Taylor; Keila E. Pena-Hernandez; J. Wade Davis; Gerald L. Arthur; Deiter J. Duff; Huidong Shi; Farah B. Rahmatpanah; Ozy Sjahputera; Charles W. Caldwell
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The Telomerase Reverse Transcriptase (hTERT) Gene Is a Direct Target of the Histone Methyltransferase SMYD3
Cheng Liu; Xiaolei Fang; Zheng Ge; Marit Jalink; Satoru Kyo; Magnus Björkholm; Astrid Gruber; Jan Sjöberg; Dawei Xu
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Genome-Wide Loss of Heterozygosity and Copy Number Analysis in Melanoma Using High-Density Single-Nucleotide Polymorphism Arrays
Mitchell Stark; Nicholas Hayward
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Oncogenic Activation of the RAS/RAF Signaling Pathway Impairs the Response of Metastatic Colorectal Cancers to Anti–Epidermal Growth Factor Receptor Antibody Therapies
Silvia Benvenuti; Andrea Sartore-Bianchi; Federica Di Nicolantonio; Carlo Zanon; Mauro Moroni; Silvio Veronese; Salvatore Siena; Alberto Bardelli
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Cell, Tumor, and Stem Cell Biology

Direct Visualization of Macrophage-Assisted Tumor Cell Intravasation in Mammary Tumors
Jeffrey B. Wyckoff; Yarong Wang; Elaine Y. Lin; Jiu-feng Li; Sumanta Goswami; E. Richard Stanley; Jeffrey E. Segall; Jeffrey W. Pollard; John Condeelis
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Molecular Cloning of hMena (ENAH) and Its Splice Variant hMena+11a: Epidermal Growth Factor Increases Their Expression and Stimulates hMena+11a Phosphorylation in Breast Cancer Cell Lines
Francesca Di Modugno; Lucia DeMonte; Michele Balsamo; Giovanna Bronzi; Maria Rita Nicotra; Massimo Alessio; Elke Jager; John S. Condeelis; Angela Santoni; Pier Giorgio Natali; Paola Nisticò
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Adrenomedullin Is Expressed in Pancreatic Cancer and Stimulates Cell Proliferation and Invasion in an Autocrine Manner via the Adrenomedullin Receptor, ADMR
Vijaya Ramachandran; Thiruvengadam Arumugam; Rosa F. Hwang; Joel K. Greenson; Diane M. Simeone; Craig D. Logsdon
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Genetic Alterations in Mouse Medulloblastomas and Generation of Tumors De novo from Primary Cerebellar Granule Neuron Precursors
Frederique Zindy; Tamar Uziel; Olivier Ayrault; Christopher Calabrese; Marc Valentine; Jerold E. Rehg; Richard J. Gilbertson; Charles J. Sherr; Martine F. Roussel
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Histone H2AX Is a Mediator of Gastrointestinal Stromal Tumor Cell Apoptosis following Treatment with Imatinib Mesylate
Ying Liu; Michelle Tseng; Sophie A. Perdreau; Ferdinand Rossi; Cristina Antonescu; Peter Besmer; Jonathan A. Fletcher; Stefan Duensing; Anette Duensing
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Integrin αvβ3 Controls Activity and Oncogenic Potential of Primed c-Src
Stephan Huveneers; Iman van den Bout; Petra Sonneveld; Ana Sancho; Arnoud Sonnenberg; Erik H.J. Danen
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Neuronal Differentiation and Synaptogenesis in Retinoblastoma
Dianna A. Johnson; Jiakun Zhang; Sharon Frase; Matthew Wilson; Carlos Rodriguez-Galindo; Michael A. Dyer
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Identification of a Fibroblast Growth Factor Receptor 1 Splice Variant That Inhibits Pancreatic Cancer Cell Growth
Zhanbing Liu; Nicola Neiss; Shaoxia Zhou; Doris Henne-Bruns; Murray Korc; Max Bachem; Marko Kornmann
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Warm Hepatic Ischemia-Reperfusion Promotes Growth of Colorectal Carcinoma Micrometastases in Mouse Liver via Matrix Metalloproteinase-9 Induction
Ian B. Nicoud; Christopher M. Jones; Janene M. Pierce; T. Mark Earl; Lynn M. Matrisian; Ravi S. Chari; D. Lee Gorden
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Effect of Vascular Normalization by Antiangiogenic Therapy on Interstitial Hypertension, Peritumor Edema, and Lymphatic Metastasis: Insights from a Mathematical Model
Rakesh K. Jain; Ricky T. Tong; Lance L. Munn
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Metallothionein Expression Is Suppressed in Primary Human Hepatocellular Carcinomas and Is Mediated through Inactivation of CCAAT/Enhancer Binding Protein α by Phosphatidylinositol 3-Kinase Signaling Cascade
Jharna Datta; Sarmila Majumder; Huban Kutay; Tasneem Motiwala; Wendy Frankel; Robert Costa; Hyuk C. Cha; Ormond A. MacDougald; Samson T. Jacob; Kalpana Ghoshal
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Mullerian-Inhibiting Substance Induces Gro-β Expression in Breast Cancer Cells through a Nuclear Factor-κB–Dependent and Smad1-Dependent Mechanism
Vandana Gupta; Giminna Yeo; Hirofumi Kawakubo; Vivek Rangnekar; Preethi Ramaswamy; Tetsu Hayashida; David T. MacLaughlin; Patricia K. Donahoe; Shyamala Maheswaran
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A Single Nucleotide Polymorphism in the MDM2 Gene Disrupts the Oscillation of p53 and MDM2 Levels in Cells
Wenwei Hu; Zhaohui Feng; Lan Ma; John Wagner; J. Jeremy Rice; Gustavo Stolovitzky; Arnold J. Levine
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Chemoresistance of Endothelial Cells Induced by Basic Fibroblast Growth Factor Depends on Raf-1–Mediated Inhibition of the Proapoptotic Kinase, ASK1
Alireza S. Alavi; Lisette Acevedo; Wang Min; David A. Cheresh
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Experimental Therapeutics, Molecular Targets, and Chemical Biology

Radionuclide Therapy of HER2-Positive Microxenografts Using a 177Lu-Labeled HER2-Specific Affibody Molecule
Vladimir Tolmachev; Anna Orlova; Rikard Pehrson; Joakim Galli; Barbro Baastrup; Karl Andersson; Mattias Sandström; Daniel Rosik; Jörgen Carlsson; Hans Lundqvist; Anders Wennborg; Fredrik Y. Nilsson
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The Proteasome Inhibitor Bortezomib Acts Independently of p53 and Induces Cell Death via Apoptosis and Mitotic Catastrophe in B-Cell Lymphoma Cell Lines
Sandra J. Strauss; Karen Higginbottom; Simone Jüliger; Lenushka Maharaj; Paul Allen; David Schenkein; T. Andrew Lister; Simon P. Joel
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A Target Cell–Specific Activatable Fluorescence Probe for In vivo Molecular Imaging of Cancer Based on a Self-Quenched Avidin-Rhodamine Conjugate
Yukihiro Hama; Yasuteru Urano; Yoshinori Koyama; Mako Kamiya; Marcelino Bernardo; Ronald S. Paik; In Soo Shin; Chang H. Paik; Peter L. Choyke; Hisataka Kobayashi
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Dasatinib Inhibits Migration and Invasion in Diverse Human Sarcoma Cell Lines and Induces Apoptosis in Bone Sarcoma Cells Dependent on Src Kinase for Survival
Audrey C. Shor; Elizabeth A. Keschman; Francis Y. Lee; Carlos Muro-Cacho; G. Douglas Letson; Jonathan C. Trent; W. Jack Pledger; Richard Jove
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Angiotensin-(1-7) Inhibits Growth of Human Lung Adenocarcinoma Xenografts in Nude Mice through a Reduction in Cyclooxygenase-2
Jyotsana Menon; David R. Soto-Pantoja; Michael F. Callahan; J. Mark Cline; Carlos M. Ferrario; E. Ann Tallant; Patricia E. Gallagher
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Betulinic Acid Inhibits Prostate Cancer Growth through Inhibition of Specificity Protein Transcription Factors
Sudhakar Chintharlapalli; Sabitha Papineni; Shashi K. Ramaiah; Stephen Safe
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Galectin-7 in Lymphoma: Elevated Expression in Human Lymphoid Malignancies and Decreased Lymphoma Dissemination by Antisense Strategies in Experimental Model
Mélanie Demers; Katherine Biron-Pain; Josée Hébert; Alain Lamarre; Thierry Magnaldo; Yves St-Pierre
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Functional Neoangiogenesis Imaging of Genetically Engineered Mouse Prostate Cancer Using Three-Dimensional Power Doppler Ultrasound
Jim W. Xuan; Michael Bygrave; Hongyi Jiang; Fatma Valiyeva; Joy Dunmore-Buyze; David W. Holdsworth; Jonathan I. Izawa; Glenn Bauman; Madeleine Moussa; Scott F. Winter; Norman M. Greenberg; Joseph L. Chin; Maria Drangova; Aaron Fenster; James C. Lacefield
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Oncolytic Immunovirotherapy for Melanoma Using Vesicular Stomatitis Virus
Rosa Maria Diaz; Feorillo Galivo; Timothy Kottke; Phonphimon Wongthida; Jian Qiao; Jill Thompson; Mikael Valdes; Glen Barber; Richard G. Vile
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Caveolin-1–Deficient Mice Have Increased Tumor Microvascular Permeability, Angiogenesis, and Growth
Michelle I. Lin; Jun Yu; Takahisa Murata; William C. Sessa
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Oncolytic Treatment and Cure of Neuroblastoma by a Novel Attenuated Poliovirus in a Novel Poliovirus-Susceptible Animal Model
Hidemi Toyoda; Jiang Yin; Steffen Mueller; Eckard Wimmer; Jeronimo Cello
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Sensitization of Mesothelioma Cells to Tumor Necrosis Factor–Related Apoptosis–Inducing Ligand–Induced Apoptosis by Heat Stress via the Inhibition of the 3-Phosphoinositide-Dependent Kinase 1/Akt Pathway
Melissa H. Pespeni; Maki Hodnett; Keith S. Abayasiriwardana; Jérémie Roux; Marybeth Howard; V. Courtney Broaddus; Jean-François Pittet
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Immunology

Combining Adoptive Cellular and Immunocytokine Therapies to Improve Treatment of B-Lineage Malignancy
Harjeet Singh; Lisa Marie Serrano; Timothy Pfeiffer; Simon Olivares; George McNamara; David D. Smith; Zaid Al-Kadhimi; Stephen J. Forman; Stephen D. Gillies; Michael C. Jensen; David Colcher; Andrew Raubitschek; Laurence J.N. Cooper
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Therapy of Established Tumors in a Novel Murine Model Transgenic for Human Carcinoembryonic Antigen and HLA-A2 with a Combination of Anti-idiotype Vaccine and CTL Peptides of Carcinoembryonic Antigen
Asim Saha; Sunil K. Chatterjee; Kenneth A. Foon; Esteban Celis; Malaya Bhattacharya-Chatterjee
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Clinical Research

Low-Level TOP2A Amplification in Prostate Cancer Is Associated with HER2 Duplication, Androgen Resistance, and Decreased Survival
Amanda J. Murphy; Caroline A. Hughes; Ciara Barrett; Hilary Magee; Barbara Loftus; John J. O'Leary; Orla Sheils
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Letters to the Editor

Picropodophyllotoxin or Podophyllotoxin Does Not Induce Cell Death via Insulin-like Growth Factor-I Receptor
Stig Linder; Maria C. Shoshan; Radhey S. Gupta
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Cyclolignans as Inhibitors of the Insulin-like Growth Factor-I Receptor
Olle Larsson; Magnus Axelson
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5-AZA-2′-Deoxycytidine in Cancer Immunotherapy: A Mouse to Man Story
Sandra Coral; Luca Sigalotti; Alessia Covre; Hugues J.M. Nicolay; Pier Giorgio Natali; Michele Maio
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5-AZA-2′-Deoxycytidine in Cancer Immunotherapy: A Mouse to Man Story
Z. Sheng Guo; Nicholas P. Restifo; David S. Schrump
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Defining Women at High Risk of Ovarian Cancer
Elizabeth M. Swisher; Mary-Claire King
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Defining Women at High Risk of Ovarian Cancer
Grover C. Bagby; Tanja Pejovic
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Correction

Breast Cancer and Gastrointestinal Bacteria
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Journal Archive


Cancer Research

(1941-Present; volumes 1-current)

Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)

The American Journal of Cancer

(1931-1940; volumes 15-40)

Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)

The Journal of Cancer Research

(1916-1930); volumes 1-14)

Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)

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