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1 March 2007
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Early diagnosis and therapy of prostate cancer continue to be challenging. By means of advanced computational genome data-mining and modeling methods, Pospisil et al. have identified prostatic acid phosphatase (PAP) as a candidate for Enzyme-Mediated Cancer Imaging and Therapy (EMCIT), an enzyme-dependent, tumor-specific approach that aims to precipitate water-soluble radioactive prodrugs within the extracellular space of solid tumors. The authors show that the prodrug 2-(2′-phosphoryloxyphenyl)-6-[125I/127I]iodo-4-(3H)-quinazolinone ([125IQ2-P/127IQ2-P]) favorably docks in silico into the X-raystructure of PAP. In vitro studies show that incubation of the iodinated,nonfluorescent, water-soluble prodrug with PAP leads to rapid hydrolysis and formation of the iodinated, fluorescent, water-insoluble drug 2-(2′-hydroxyphenyl)-6-[125I/127I]iodo-4-(3H)-quinazolinone ([125IQ2-OH/127IQ2-OH]).Similarly, the incubation of 127IQ2-P with human LNCaP, PC-3, and 22Rv1 prostate tumor cells results in formation of large fluorescent 127IQ2-OH crystals, whereas no hydrolysis is seen in the presence of normal human cells. Autoradiography of tumor cells that had been incubated with 125IQ2-P demonstrates accumulation of radioactive grains (125IQ2-OH) around the cells. When the prodrug is labeled with a suitable radioiodine isotope, the EMCIT approach has potential for detection (123I-SPECT, 124I-PET) and treatment (131I) of solid prostate tumors. For details, see the article by Pospisil et al. on page 2197 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Reviews
Priority Reports
Genetic Variation at the CYP19A1 Locus Predicts Circulating Estrogen Levels but not Breast Cancer Risk in Postmenopausal Women
Christopher A. Haiman; Laure Dossus; V. Wendy Setiawan; Daniel O. Stram; Alison M. Dunning; Gilles Thomas; Michael J. Thun; Demetrius Albanes; David Altshuler; Eva Ardanaz; Heiner Boeing; Julie Buring; Noël Burtt; Eugenia E. Calle; Stephen Chanock; Françoise Clavel-Chapelon; Graham A. Colditz; David G. Cox; Heather Spencer Feigelson; Susan E. Hankinson; Richard B. Hayes; Brian E. Henderson; Joel N. Hirschhorn; Robert Hoover; David J. Hunter; Rudolf Kaaks; Laurence N. Kolonel; Loïc Le Marchand; Per Lenner; Eiliv Lund; Salvatore Panico; Petra H. Peeters; Malcolm C. Pike; Elio Riboli; Anne Tjonneland; Ruth Travis; Dimitrios Trichopoulos; Sholom Wacholder; Regina G. Ziegler
Molecular Biology, Pathobiology, and Genetics
Elevated Expression of the Oncogene c-fms and Its Ligand, the Macrophage Colony-Stimulating Factor-1, in Cervical Cancer and the Role of Transforming Growth Factor-β1 in Inducing c-fms Expression
Nameer Kirma; Luciano S. Hammes; Ya-Guang Liu; Hareesh B. Nair; Philip T. Valente; Shantha Kumar; Lisa C. Flowers; Rajeshwar Rao Tekmal
Cell, Tumor, and Stem Cell Biology
Differential Constitutive Activation of the Epidermal Growth Factor Receptor in Non–Small Cell Lung Cancer Cells Bearing EGFR Gene Mutation and Amplification
Takafumi Okabe; Isamu Okamoto; Kenji Tamura; Masaaki Terashima; Takeshi Yoshida; Taroh Satoh; Minoru Takada; Masahiro Fukuoka; Kazuhiko Nakagawa
Experimental Therapeutics, Molecular Targets, and Chemical Biology
Down-regulation of Apurinic/Apyrimidinic Endonuclease 1/Redox Factor-1 Expression by Soy Isoflavones Enhances Prostate Cancer Radiotherapy In vitro and In vivo
Julian J. Raffoul; Sanjeev Banerjee; Vinita Singh-Gupta; Zvi E. Knoll; Alemu Fite; Hao Zhang; Judith Abrams; Fazlul H. Sarkar; Gilda G. Hillman
Blockade of Hedgehog Signaling Inhibits Pancreatic Cancer Invasion and Metastases: A New Paradigm for Combination Therapy in Solid Cancers
Georg Feldmann; Surajit Dhara; Volker Fendrich; Djahida Bedja; Robert Beaty; Michael Mullendore; Collins Karikari; Hector Alvarez; Christine Iacobuzio-Donahue; Antonio Jimeno; Kathleen L. Gabrielson; William Matsui; Anirban Maitra
In vitro Biological Characterization of a Novel, Synthetic Diaryl Pyrazole Resorcinol Class of Heat Shock Protein 90 Inhibitors
Swee Y. Sharp; Kathy Boxall; Martin Rowlands; Chrisostomos Prodromou; S. Mark Roe; Alison Maloney; Marissa Powers; Paul A. Clarke; Gary Box; Sharon Sanderson; Lisa Patterson; Thomas P. Matthews; Kwai-Ming J. Cheung; Karen Ball; Angela Hayes; Florence Raynaud; Richard Marais; Laurence Pearl; Sue Eccles; Wynne Aherne; Edward McDonald; Paul Workman
Immunology
Fractalkine (CX3CL1)– and Interleukin-2–Enriched Neuroblastoma Microenvironment Induces Eradication of Metastases Mediated by T Cells and Natural Killer Cells
Yan Zeng; Nicole Huebener; Stefan Fest; Silke Weixler; Ulrike Schroeder; Gerhard Gaedicke; Rong Xiang; Alexander Schramm; Angelika Eggert; Ralph A. Reisfeld; Holger N. Lode
Clinical Research
A Novel Small-Molecule Inhibitor of Transforming Growth Factor β Type I Receptor Kinase (SM16) Inhibits Murine Mesothelioma Tumor Growth In vivo and Prevents Tumor Recurrence after Surgical Resection
Eiji Suzuki; Samuel Kim; H.-Kam Cheung; Michael J. Corbley; Xiamei Zhang; Lihong Sun; Feng Shan; Juswinder Singh; Wen-Cherng Lee; Steven M. Albelda; Leona E. Ling
Epidemiology and Prevention
Corrections
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