Issues
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Cover Image
Cover Image
Doubrovin and colleagues report on a retroviral vector encoding the human norepinephrine transporter (hNET) that, when transduced into EBV-antigen specific T cells, permits quantitative in vivo imaging of the accumulation of adoptively transferred T cells in EBV+ tumors by PET or SPECT based on their selective uptake of radiolabeled metaiodobenzylguanidine (MIBG). Differential uptake of [123I]MIBG by transduced hNET-CD4+ T cells and [124I]FIAU by transduced HSV-TK-CD8+ T cells also permits independent, contemporaneous tracking of each T-cell population in the same animal by SPECT and PET, respectively. This human reporter system should not be immunogenic and may prove useful for clinical imaging of transduced cells following adoptive transfer or transplantation. For details, see the article by Doubrovin and colleagues on page 11959 of this issue. - PDF Icon PDF LinkTable of Contents
Cancer Research
Table of Contents
Reviews
Priority Reports
A Smac Mimetic Rescue Screen Reveals Roles for Inhibitor of Apoptosis Proteins in Tumor Necrosis Factor-α Signaling
Molecular Biology, Pathobiology, and Genetics
Concordant Epigenetic Silencing of Transforming Growth Factor-β Signaling Pathway Genes Occurs Early in Breast Carcinogenesis
Integrated Profiling of Basal and Luminal Breast Cancers
Cancer-Testis Antigen Lymphocyte Antigen 6 Complex Locus K Is a Serologic Biomarker and a Therapeutic Target for Lung and Esophageal Carcinomas
Cell, Tumor, and Stem Cell Biology
BCL-2 and Mutant NRAS Interact Physically and Functionally in a Mouse Model of Progressive Myelodysplasia
Experimental Therapeutics, Molecular Targets, and Chemical Biology
Biological Role and Potential Therapeutic Targeting of the Chemokine Receptor CXCR4 in Undifferentiated Thyroid Cancer
Betulinic Acid, a Catalytic Inhibitor of Topoisomerase I, Inhibits Reactive Oxygen Species–Mediated Apoptotic Topoisomerase I–DNA Cleavable Complex Formation in Prostate Cancer Cells but Does Not Affect the Process of Cell Death
Vitamin E Analogues Inhibit Angiogenesis by Selective Induction of Apoptosis in Proliferating Endothelial Cells: The Role of Oxidative Stress
PF00299804, an Irreversible Pan-ERBB Inhibitor, Is Effective in Lung Cancer Models with EGFR and ERBB2 Mutations that Are Resistant to Gefitinib
Immunology
Induction of hsp70-Mediated Th17 Autoimmunity Can Be Exploited as Immunotherapy for Metastatic Prostate Cancer
Elements Related to Heterogeneity of Antibody-Dependent Cell Cytotoxicity in Patients Under Trastuzumab Therapy for Primary Operable Breast Cancer Overexpressing Her2
Identification of 14-3-3𝛉 as an Antigen that Induces a Humoral Response in Lung Cancer
Prevention
Corrections
Acknowledgment to Reviewers
Journal Archive
Cancer Research
(1941-Present; volumes 1-current)Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)
The American Journal of Cancer
(1931-1940; volumes 15-40)Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)
The Journal of Cancer Research
(1916-1930); volumes 1-14)Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)
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