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15 August 2007
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Cover Image
Cover Image
Tissue hypoxia is frequently observed in macroscopic tumors where it is indicative of poor clinical outcome. However, the hypoxic status of subclinical micrometastases is largely unknown. Li and colleagues determined the distribution of hypoxia in microscopic tumors by immunofluorescent visualization of the hypoxia marker pimonidazole in an animal model of disseminated peritoneal disease. In general, tumors of less than 1 mm in diameter were intensely hypoxic and possessed little vasculature. Larger tumors (1 to 4 mm in diameter) were not significantly hypoxic. The extent of hypoxia in microscopic tumors was reduced by carbogen breathing. If similar patterns of tumor hypoxia occur in human patients, the efficacy of systemic treatments for micrometastatic disease may be compromised by hypoxic resistance. The images on the cover show (top) the distributions of pimonidazole (green), perfusion marker Hoechst 33342 (blue), and the hypoxia-regulated protein carbonic anhydrase 9 (red) in small (<1 mm in diameter) and large peritoneal tumors. CD31 staining (bottom left) indicates that the small hypoxic tumors are avascular while larger tumors have extensive vasculature. The fraction of tumor area staining positive for pimonidazole (PPF) is shown (bottom right) as a function of tumor size. For details, see the article by Li and colleagues on page 7646 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Reviews
Meeting Report
Priority Reports
Molecular Biology, Pathobiology, and Genetics
Cell, Tumor, and Stem Cell Biology
Serial In vivo Spectroscopic Nuclear Magnetic Resonance Imaging of Lactate and Extracellular pH in Rat Gliomas Shows Redistribution of Protons Away from Sites of Glycolysis
Peggy Provent; Marina Benito; Bassem Hiba; Régine Farion; Pilar López-Larrubia; Paloma Ballesteros; Chantal Rémy; Christoph Segebarth; Sebastián Cerdán; Jonathan A. Coles; María Luisa García-Martín
Sequential Down-regulation of E-Cadherin with Squamous Cell Carcinoma Progression: Loss of E-Cadherin via a Prostaglandin E2-EP2–Dependent Posttranslational Mechanism
Sabine Brouxhon; Stephanos Kyrkanides; M. Kerry O'Banion; Renee Johnson; David A. Pearce; Gina M. Centola; Jen-nie H. Miller; Kieran H. McGrath; Brandon Erdle; Glynis Scott; Sandra Schneider; JoAnne VanBuskirk; Alice P. Pentland
Caveolin-1 Reduces Osteosarcoma Metastases by Inhibiting c-Src Activity and Met Signaling
Lara Cantiani; Maria Cristina Manara; Cinzia Zucchini; Paola De Sanctis; Monia Zuntini; Luisa Valvassori; Massimo Serra; Martina Olivero; Maria Flavia Di Renzo; Mario Paolo Colombo; Piero Picci; Katia Scotlandi
Tumor Suppressor Functions of ARLTS1 in Lung Cancers
Sai Yendamuri; Francesco Trapasso; Manuela Ferracin; Rossano Cesari; Cinzia Sevignani; Masayoshi Shimizu; Shashi Rattan; Tamotsu Kuroki; Kristoffel R. Dumon; Florencia Bullrich; Chang-gong Liu; Massimo Negrini; Noel N. Williams; Larry R. Kaiser; Carlo M. Croce; George A. Calin
Experimental Therapeutics, Molecular Targets, and Chemical Biology
Cisplatin-Induced Apoptosis Involves Membrane Fluidification via Inhibition of NHE1 in Human Colon Cancer Cells
Amélie Rebillard; Xavier Tekpli; Olivier Meurette; Odile Sergent; Gwenaëlle LeMoigne-Muller; Laurent Vernhet; Morgane Gorria; Martine Chevanne; Markus Christmann; Bernd Kaina; Laurent Counillon; Erich Gulbins; Dominique Lagadic-Gossmann; Marie-Thérèse Dimanche-Boitrel
Immunology
B7-H3 Ligand Expression by Prostate Cancer: A Novel Marker of Prognosis and Potential Target for Therapy
Timothy J. Roth; Yuri Sheinin; Christine M. Lohse; Susan M. Kuntz; Xavier Frigola; Brant A. Inman; Amy E. Krambeck; Maureen E. Mckenney; R. Jeffrey Karnes; Michael L. Blute; John C. Cheville; Thomas J. Sebo; Eugene D. Kwon
Clinical Research
Epidemiology and Prevention
Regulation of Genes of the Circadian Clock in Human Colon Cancer: Reduced Period-1 and Dihydropyrimidine Dehydrogenase Transcription Correlates in High-Grade Tumors
Walter Krugluger; Anita Brandstaetter; Enikö Kállay; Johann Schueller; Elisabeth Krexner; Stefan Kriwanek; Elisabeth Bonner; Heide S. Cross
Corrections
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