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1 July 2007
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Cover Image
Cover Image
Inflammation and cancer are linked, particularly for tumors of the gastrointestinal tract. TIR8 (or SIGIRR) is a member of the IL-1/Toll-like receptor family with inhibitory activity on inflammatory reactions and high expression in intestinal mucosa. In this study, Garlanda and colleagues report that Tir8-deficient mice exhibited dramatic intestinal inflammation in response to dextran sulfate sodium salt (DSS) administration and showed increased susceptibility to carcinogenesis in response to azoxymethane and DSS, associated to increased permeability and local production of prostaglandin E2, proinflammatory cytokines, and chemokines. The cover image shows numerous high-grade adenomas and a single low-grade adenoma almost completely obliterating the rectal lumen in a Tir8-deficient mouse. These results are consistent with the hypothesis that TIR8, by negatively regulating intestinal inflammation, plays a nonredundant role in the control of the protumor activity of chronic inflammation in the gut. Further studies on polymorphisms at the TIR8 locus in human colon cancer and its value as a target for therapeutic intervention are warranted. For details, see the article by Garlanda and colleagues on page 6017 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Reviews
Priority Reports
Lineage-Specific Dependency of Lung Adenocarcinomas on the Lung Development Regulator TTF-1
Hisaaki Tanaka; Kiyoshi Yanagisawa; Keiko Shinjo; Ayumu Taguchi; Ken Maeno; Shuta Tomida; Yukako Shimada; Hirotaka Osada; Takayuki Kosaka; Hideo Matsubara; Tetsuya Mitsudomi; Yoshitaka Sekido; Mitsune Tanimoto; Yasushi Yatabe; Takashi Takahashi
Increased Susceptibility to Colitis-Associated Cancer of Mice Lacking TIR8, an Inhibitory Member of the Interleukin-1 Receptor Family
Cecilia Garlanda; Federica Riva; Tania Veliz; Nadia Polentarutti; Fabio Pasqualini; Enrico Radaelli; Marina Sironi; Manuela Nebuloni; Elisabetta Omodeo Zorini; Eugenio Scanziani; Alberto Mantovani
Androgen Withdrawal in Patients Reduces Prostate Cancer Hypoxia: Implications for Disease Progression and Radiation Response
Michael Milosevic; Peter Chung; Chris Parker; Robert Bristow; Ants Toi; Tony Panzarella; Padraig Warde; Charles Catton; Cynthia Menard; Andrew Bayley; Mary Gospodarowicz; Richard Hill
Molecular Biology, Pathobiology, and Genetics
The RON Receptor Tyrosine Kinase Mediates Oncogenic Phenotypes in Pancreatic Cancer Cells and Is Increasingly Expressed during Pancreatic Cancer Progression
Ryan M. Thomas; Kenya Toney; Cecilia Fenoglio-Preiser; Monica P. Revelo-Penafiel; Sunil R. Hingorani; David A. Tuveson; Susan E. Waltz; Andrew M. Lowy
Cyclin G1 Is a Target of miR-122a, a MicroRNA Frequently Down-regulated in Human Hepatocellular Carcinoma
Laura Gramantieri; Manuela Ferracin; Francesca Fornari; Angelo Veronese; Silvia Sabbioni; Chang-Gong Liu; George A. Calin; Catia Giovannini; Eros Ferrazzi; Gian Luca Grazi; Carlo M. Croce; Luigi Bolondi; Massimo Negrini
Alterations of the HBP1 Transcriptional Repressor Are Associated with Invasive Breast Cancer
K. Eric Paulson; Kimberly Rieger-Christ; Michael A. McDevitt; Charlotte Kuperwasser; Jiyoung Kim; Vincent E. Unanue; Xiaowei Zhang; Maowen Hu; Robin Ruthazer; Stephen P. Berasi; Chun-Yin Huang; Dilip Giri; Seth Kaufman; John M. Dugan; Joanne Blum; Georges Netto; David E. Wazer; Ian C. Summerhayes; Amy S. Yee
Cell, Tumor, and Stem Cell Biology
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Born to Be Exported: COOH-Terminal Nuclear Export Signals of Different Strength Ensure Cytoplasmic Accumulation of Nucleophosmin Leukemic Mutants
Niccolò Bolli; Ildo Nicoletti; M. Felicetta De Marco; Barbara Bigerna; Alessandra Pucciarini; Roberta Mannucci; Maria Paola Martelli; Arcangelo Liso; Cristina Mecucci; Francesco Fabbiano; Massimo F. Martelli; Beric R. Henderson; Brunangelo Falini
A Novel Epidermal Growth Factor Receptor Inhibitor Promotes Apoptosis in Non–Small Cell Lung Cancer Cells Resistant to Erlotinib
Thibault de La Motte Rouge; Lorenzo Galluzzi; Ken A. Olaussen; Yael Zermati; Ezgi Tasdemir; Thomas Robert; Hugues Ripoche; Vladimir Lazar; Philippe Dessen; Francis Harper; Gerard Pierron; Guillaume Pinna; Natalia Araujo; Annick Harel-Belan; Jean-Pierre Armand; Tai Wai Wong; Jean Charles Soria; Guido Kroemer
Experimental Therapeutics, Molecular Targets, and Chemical Biology
Tumor Suppressor 101F6 and Ascorbate Synergistically and Selectively Inhibit Non–Small Cell Lung Cancer Growth by Caspase-Independent Apoptosis and Autophagy
Shoichiro Ohtani; Arifumi Iwamaru; Wuguo Deng; Kentaro Ueda; Guanglin Wu; Gitanjali Jayachandran; Seiji Kondo; Edward N. Atkinson; John D. Minna; Jack A. Roth; Lin Ji
Antitumor Activity of PR-171, a Novel Irreversible Inhibitor of the Proteasome
Susan D. Demo; Christopher J. Kirk; Monette A. Aujay; Tonia J. Buchholz; Maya Dajee; Mark N. Ho; Jing Jiang; Guy J. Laidig; Evan R. Lewis; Francesco Parlati; Kevin D. Shenk; Mark S. Smyth; Congcong M. Sun; Marcy K. Vallone; Tina M. Woo; Christopher J. Molineaux; Mark K. Bennett
Immunology
Preferential Expression of Very Late Antigen-4 on Type 1 CTL Cells Plays a Critical Role in Trafficking into Central Nervous System Tumors
Kotaro Sasaki; Xinmei Zhu; Cecilia Vasquez; Fumihiko Nishimura; Jill E. Dusak; Jian Huang; Mitsugu Fujita; Amy Wesa; Douglas M. Potter; Paul R. Walker; Walter J. Storkus; Hideho Okada
Elevated Frequencies of Self-reactive CD8+ T Cells following Immunization with a Xenoantigen Are Due to the Presence of a Heteroclitic CD4+ T-Cell Helper Epitope
Korosh Kianizad; Laura A. Marshall; Natalie Grinshtein; Dannie Bernard; Renate Margl; Sheng Cheng; Friedrich Beermann; Yonghong Wan; Jonathan Bramson
Endocrinology
Epidemiology and Prevention
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Are Peroxisome Proliferator-Activated Receptors Involved in Skeletal Muscle Wasting during Experimental Cancer Cachexia? Role of β2-Adrenergic Agonists
Gemma Fuster; Sílvia Busquets; Elisabet Ametller; Mireia Olivan; Vanessa Almendro; Cibely Cristine Fontes de Oliveira; Maite Figueras; Francisco J. López-Soriano; Josep M. Argilés
Corrections
Editor’s Note
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