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15 June 2007
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Cover Image
Cover Image
The relationship between stem cells and cancer remains poorly understood. Because mouse prostate stem cells preferentially locate in the proximal region of the prostatic ducts, Zhou et al. performed a stage-by-stage evaluation of prostate carcinogenesis associated with p53 and Rb deficiency. Their study demonstrates that all highly aggressive carcinomas originate from the stem/progenitor cell compartment and that neoplastic progression of initiated cells is affected by the prostate microenvironment. These results provide important evidence that p53 and Rb play an essential role in regulation of the prostate stem cell compartment, in which transformation may lead to particularly aggressive cancers. The images on the cover show coexpression (yellow) of cytokeratin 8 (CK8, green) and synaptophysin (red) in putative stem/progenitor cells of the normal prostate (top) and cells of the earliest dysplastic lesion in the proximal region of prostatic ducts in mice with prostate-specific conditional inactivation of p53 and Rb (middle). Cells of dysplastic lesions in the distal region of prostatic ducts express CK8 (green) but not synaptophysin (red; bottom). For details, see the article by Zhou et al. on page 5683 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Reviews
Priority Reports
Inhibition of Epidermal Growth Factor Receptor Signaling Elevates 15-Hydroxyprostaglandin Dehydrogenase in Non–Small-Cell Lung Cancer
Li Yang; Joseph M. Amann; Takefumi Kikuchi; Rut Porta; Marta Guix; Adriana Gonzalez; Kyung-Ho Park; Dean Billheimer; Carlos L. Arteaga; Hsin-Hsiung Tai; Raymond DuBois; David P. Carbone; David H. Johnson
Membrane-Bound Interleukin (IL)-15 on Renal Tumor Cells Rescues Natural Killer Cells from IL-2 Starvation-Induced Apoptosis
Sebastian Wittnebel; Sylvie Da Rocha; Julien Giron-Michel; Abdelali Jalil; Paule Opolon; Bernard Escudier; Pierre Validire; Krystel Khawam; Salem Chouaib; Bruno Azzarone; Anne Caignard
The Tumor Suppressor Gene hCDC4 Is Frequently Mutated in Human T-Cell Acute Lymphoblastic Leukemia with Functional Consequences for Notch Signaling
Alena Malyukova; Takeaki Dohda; Natalie von der Lehr; Shahab Akhondi; Martin Corcoran; Mats Heyman; Charles Spruck; Dan Grandér; Urban Lendahl; Olle Sangfelt
Molecular Biology, Pathobiology, and Genetics
Identification of Differentially Regulated Splice Variants and Novel Exons in Glial Brain Tumors Using Exon Expression Arrays
Pim J. French; Justine Peeters; Sebastiaan Horsman; Elza Duijm; Ivar Siccama; Martin J. van den Bent; Theo M. Luider; Johan M. Kros; Peter van der Spek; Peter A. Sillevis Smitt
Patterns of EGFR, HER2, TP53, and KRAS Mutations of p14arf Expression in Non–Small Cell Lung Cancers in Relation to Smoking History
Mounia Mounawar; Anush Mukeria; Florence Le Calvez; Rayjean J. Hung; Helene Renard; Alexis Cortot; Claire Bollart; David Zaridze; Paul Brennan; Paolo Boffetta; Elisabeth Brambilla; Pierre Hainaut
Cell, Tumor, and Stem Cell Biology
Effects of Tetramethoxystilbene on Hormone-Resistant Breast Cancer Cells: Biological and Biochemical Mechanisms of Action
Hoyong Park; Sarah E. Aiyar; Ping Fan; Jiping Wang; Wei Yue; Tatiana Okouneva; Corey Cox; Mary Ann Jordan; Laurence Demers; Hyungjun Cho; Sanghee Kim; Robert X.-D. Song; Richard J. Santen
Experimental Therapeutics, Molecular Targets, and Chemical Biology
Acquired Resistance to Erlotinib in A-431 Epidermoid Cancer Cells Requires Down-regulation of MMAC1/PTEN and Up-regulation of Phosphorylated Akt
Fumiyuki Yamasaki; Mary J. Johansen; Dongwei Zhang; Savitri Krishnamurthy; Edward Felix; Chandra Bartholomeusz; Richard J. Aguilar; Kaoru Kurisu; Gordon B. Mills; Gabriel N. Hortobagyi; Naoto T. Ueno
Monoclonal Antibodies to Six-Transmembrane Epithelial Antigen of the Prostate-1 Inhibit Intercellular Communication In vitro and Growth of Human Tumor Xenografts In vivo
Pia M. Challita-Eid; Kendall Morrison; Soudabeh Etessami; Zili An; Karen J. Morrison; Juan J. Perez-Villar; Arthur B. Raitano; Xiao-Chi Jia; Jean M. Gudas; Steven B. Kanner; Aya Jakobovits
Pharmacologic Characterization of a Potent Inhibitor of Class I Phosphatidylinositide 3-Kinases
Florence I. Raynaud; Suzanne Eccles; Paul A. Clarke; Angela Hayes; Bernard Nutley; Sonia Alix; Alan Henley; Francesca Di-Stefano; Zahida Ahmad; Sandrine Guillard; Lynn M. Bjerke; Lloyd Kelland; Melanie Valenti; Lisa Patterson; Sharon Gowan; Alexis de Haven Brandon; Masahiko Hayakawa; Hiroyuki Kaizawa; Tomonubu Koizumi; Takahide Ohishi; Sonal Patel; Nahid Saghir; Peter Parker; Mike Waterfield; Paul Workman
Intratumoral Delivery and Suppression of Prostate Tumor Growth by Attenuated Salmonella enterica serovar typhimurium Carrying Plasmid-Based Small Interfering RNAs
Ling Zhang; Lifang Gao; Lijuan Zhao; Baofeng Guo; Kun Ji; Yong Tian; Jinguo Wang; Hao Yu; Jiadi Hu; Dhananjaya V. Kalvakolanu; Dennis J. Kopecko; Xuejian Zhao; De-Qi Xu
MPC-6827: A Small-Molecule Inhibitor of Microtubule Formation That Is Not a Substrate for Multidrug Resistance Pumps
Shailaja Kasibhatla; Vijay Baichwal; Sui Xiong Cai; Bruce Roth; Ira Skvortsova; Sergej Skvortsov; Peter Lukas; Nicole M. English; Nilantha Sirisoma; John Drewe; Azra Pervin; Ben Tseng; Robert O. Carlson; Christopher M. Pleiman
Tunicamycin Sensitizes Human Melanoma Cells to Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Induced Apoptosis by Up-regulation of TRAIL-R2 via the Unfolded Protein Response
Chen Chen Jiang; Li Hua Chen; Susan Gillespie; Kelly A. Kiejda; Nizar Mhaidat; Yu Fang Wang; Rick Thorne; Xu Dong Zhang; Peter Hersey
Immunology
Combination of Tumor Site–Located CTL-Associated Antigen-4 Blockade and Systemic Regulatory T-Cell Depletion Induces Tumor-Destructive Immune Responses
Sebastian Tuve; Bing-Mae Chen; Ying Liu; Tian-Lu Cheng; Papa Touré; Papa Salif Sow; Qinghua Feng; Nancy Kiviat; Robert Strauss; Shaoheng Ni; Zong-Yi Li; Steve R. Roffler; André Lieber
Regression of Experimental Medulloblastoma following Transfer of HER2-Specific T Cells
Nabil Ahmed; Maheshika Ratnayake; Barbara Savoldo; Laszlo Perlaky; Gianpietro Dotti; Winfried S. Wels; Meenakshi B. Bhattacharjee; Richard J. Gilbertson; H. David Shine; Heidi L. Weiss; Cliona M. Rooney; Helen E. Heslop; Stephen Gottschalk
Endocrinology
Epidemiology and Prevention
Hawaii Cohort Study of Serum Micronutrient Concentrations and Clearance of Incident Oncogenic Human Papillomavirus Infection of the Cervix
Marc T. Goodman; Yurii B. Shvetsov; Katharine McDuffie; Lynne R. Wilkens; Xuemei Zhu; Adrian A. Franke; Cathy Cramer Bertram; Bruce Kessel; Marge Bernice; Christian Sunoo; Lily Ning; David Easa; Jeffrey Killeen; Lori Kamemoto; Brenda Y. Hernandez
Letters to the Editor
Corrections
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