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1 April 2006
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Cover Image
This study presents selective oral treatment-mechanism of human breast cancer implanted in mice by a nontoxic antimicrotubule drug, EM015. EM015 selectively treats cancer cells by exploiting their compromised checkpoint mechanisms owing to various mutations, allowing multiple rounds of DNA synthesis without cell division, thus leading to the accumulation of genotoxic DNA amounts and apoptosis. EM015 was synthesized from a naturally occurring alkaloid, noscapine, itself a nontoxic anticough medicine with desirable pharmacokinetic/pharmacodynamic profiles in humans. For details, see the article by Aneja et al. on page 3782 of this issue.
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ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Reviews
Priority Reports
Prediction of Sensitivity of Rectal Cancer Cells in Response to Preoperative Radiotherapy by DNA Microarray Analysis of Gene Expression Profiles
Toshiaki Watanabe; Yasuhiro Komuro; Tomomichi Kiyomatsu; Takamitsu Kanazawa; Yoshihiro Kazama; Junichiro Tanaka; Toshiaki Tanaka; Yoko Yamamoto; Masatoshi Shirane; Tetsuichiro Muto; Hirokazu Nagawa
Tumor B7-H1 Is Associated with Poor Prognosis in Renal Cell Carcinoma Patients with Long-term Follow-up
R. Houston Thompson; Susan M. Kuntz; Bradley C. Leibovich; Haidong Dong; Christine M. Lohse; W. Scott Webster; Shomik Sengupta; Igor Frank; Alexander S. Parker; Horst Zincke; Michael L. Blute; Thomas J. Sebo; John C. Cheville; Eugene D. Kwon
Molecular Biology, Pathobiology, and Genetics
Two Transforming C-RAF Germ-Line Mutations Identified in Patients with Therapy-Related Acute Myeloid Leukemia
Armin Zebisch; Philipp B. Staber; Ali Delavar; Claudia Bodner; Karin Hiden; Katja Fischereder; Manickam Janakiraman; Werner Linkesch; Holger W. Auner; Werner Emberger; Christian Windpassinger; Michael G. Schimek; Gerald Hoefler; Jakob Troppmair; Heinz Sill
N-Methyl-d-Aspartate Receptor Type 2B Is Epigenetically Inactivated and Exhibits Tumor-Suppressive Activity in Human Esophageal Cancer
Myoung Sook Kim; Keishi Yamashita; Jin Hyen Baek; Hannah Lui Park; Andre Lopes Carvalho; Motonobu Osada; Mohammad Obaidul Hoque; Sunil Upadhyay; Masaki Mori; Chulso Moon; David Sidransky
Frequent Met Oncogene Amplification in a Brca1/Trp53 Mouse Model of Mammary Tumorigenesis
Gromoslaw A. Smolen; Beth Muir; Gayatry Mohapatra; Anne Barmettler; Woo J. Kim; Miguel N. Rivera; Sara M. Haserlat; Ross A. Okimoto; Eunice Kwak; Sonika Dahiya; Judy E. Garber; Daphne W. Bell; Dennis C. Sgroi; Lynda Chin; Chu-Xia Deng; Daniel A. Haber
Combined Array-Comparative Genomic Hybridization and Single-Nucleotide Polymorphism-Loss of Heterozygosity Analysis Reveals Complex Changes and Multiple Forms of Chromosomal Instability in Colorectal Cancers
Michelle Gaasenbeek; Kimberley Howarth; Andrew J. Rowan; Patricia A. Gorman; Angela Jones; Tracy Chaplin; Ying Liu; David Bicknell; Eleanor J. Davison; Heike Fiegler; Nigel P. Carter; Rebecca R. Roylance; Ian P.M. Tomlinson
Cell, Tumor, and Stem Cell Biology
hTERT-Immortalized Prostate Epithelial and Stromal-Derived Cells: an Authentic In vitro Model for Differentiation and Carcinogenesis
Ira Kogan; Naomi Goldfinger; Michael Milyavsky; Merav Cohen; Igor Shats; Gabriele Dobler; Helmut Klocker; Bohdan Wasylyk; Maureen Voller; Tilly Aalders; Jack A. Schalken; Moshe Oren; Varda Rotter
Telomerase- and Alternative Telomere Lengthening–Independent Telomere Stabilization in a Metastasis-Derived Human Non–Small Cell Lung Cancer Cell Line: Effect of Ectopic hTERT
Andreas Brachner; Soleman Sasgary; Christine Pirker; Chantal Rodgarkia; Mario Mikula; Wolfgang Mikulits; Helga Bergmeister; Ulrike Setinek; Matthias Wieser; Suet-Feung Chin; Carlos Caldas; Michael Micksche; Christa Cerni; Walter Berger
Antibodies Neutralizing Hepsin Protease Activity Do Not Impact Cell Growth but Inhibit Invasion of Prostate and Ovarian Tumor Cells in Culture
Jian-Ai Xuan; Doug Schneider; Pam Toy; Rick Lin; Alicia Newton; Ying Zhu; Silke Finster; David Vogel; Bob Mintzer; Harald Dinter; David Light; Renate Parry; Mark Polokoff; Marc Whitlow; Qingyu Wu; Gordon Parry
Targeted Anti–Vascular Endothelial Growth Factor Receptor-2 Therapy Leads to Short-term and Long-term Impairment of Vascular Function and Increase in Tumor Hypoxia
Marcela Franco; Shan Man; Limor Chen; Urban Emmenegger; Yuval Shaked; Alison M. Cheung; Allison S. Brown; Daniel J. Hicklin; F. Stuart Foster; Robert S. Kerbel
ERBB2-Mediated Transcriptional Up-regulation of the α5β1 Integrin Fibronectin Receptor Promotes Tumor Cell Survival Under Adverse Conditions
Christian Spangenberg; Ekkehart U. Lausch; Tatjana M. Trost; Dirk Prawitt; Andreas May; Romy Keppler; Stephan A. Fees; Dirk Reutzel; Carolin Bell; Steffen Schmitt; Ilka B. Schiffer; Achim Weber; Walburgis Brenner; Matthias Hermes; Ugur Sahin; Özlem Türeci; Heinz Koelbl; Jan G. Hengstler; Bernhard U. Zabel
Experimental Therapeutics, Molecular Targets, and Chemical Biology
Simultaneous Inhibition of PDK1/AKT and Fms-Like Tyrosine Kinase 3 Signaling by a Small-Molecule KP372-1 Induces Mitochondrial Dysfunction and Apoptosis in Acute Myelogenous Leukemia
Zhihong Zeng; Ismael J. Samudio; Weiguo Zhang; Zeev Estrov; Hélène Pelicano; David Harris; Olga Frolova; Numsen Hail, Jr.; Wenjing Chen; Steven M. Kornblau; Peng Huang; Yiling Lu; Gordon B. Mills; Michael Andreeff; Marina Konopleva
Improvement of the Tumor-Suppressive Effect of Boron Neutron Capture Therapy for Amelanotic Melanoma by Intratumoral Injection of the Tyrosinase Gene
Norimasa Morita; Junichi Hiratsuka; Hirohumi Kondoh; Masako Uno; Tomoyuki Asano; Yoko Niki; Yoshinori Sakurai; Koji Ono; Tamotsu Harada; Yoshinari Imajo
Aggresome Disruption: A Novel Strategy to Enhance Bortezomib-Induced Apoptosis in Pancreatic Cancer Cells
Steffan T. Nawrocki; Jennifer S. Carew; Maria S. Pino; Ralph A. Highshaw; Robert H.I. Andtbacka; Kenneth Dunner, Jr.; Ashutosh Pal; William G. Bornmann; Paul J. Chiao; Peng Huang; Henry Xiong; James L. Abbruzzese; David J. McConkey
Transforming Growth Factor α Expression Drives Constitutive Epidermal Growth Factor Receptor Pathway Activation and Sensitivity to Gefitinib (Iressa) in Human Pancreatic Cancer Cell Lines
Maria S. Pino; Marissa Shrader; Cheryl H. Baker; Francesco Cognetti; Henry Q. Xiong; James L. Abbruzzese; David J. McConkey
Targeting PIM Kinases Impairs Survival of Hematopoietic Cells Transformed by Kinase Inhibitor–Sensitive and Kinase Inhibitor–Resistant Forms of Fms-Like Tyrosine Kinase 3 and BCR/ABL
Myriam Adam; Vanda Pogacic; Marina Bendit; Richard Chappuis; Martijn C. Nawijn; Justus Duyster; Casey J. Fox; Craig B. Thompson; Jan Cools; Juerg Schwaller
Immunology
CD1d-Restricted Natural Killer T Cells Can Down-regulate Tumor Immunosurveillance Independent of Interleukin-4 Receptor-Signal Transducer and Activator of Transcription 6 or Transforming Growth Factor-β
Masaki Terabe; Chand Khanna; Seuli Bose; Fraia Melchionda; Arnulfo Mendoza; Crystal L. Mackall; Lee J. Helman; Jay A. Berzofsky
Endocrinology
Clinical Research
Transcription Analysis of Human Equilibrative Nucleoside Transporter-1 Predicts Survival in Pancreas Cancer Patients Treated with Gemcitabine
Elisa Giovannetti; Mario Del Tacca; Valentina Mey; Niccola Funel; Sara Nannizzi; Sergio Ricci; Cinzia Orlandini; Ugo Boggi; Daniela Campani; Marco Del Chiaro; Mauro Iannopollo; Generoso Bevilacqua; Franco Mosca; Romano Danesi
Epidemiology and Prevention
Letters to the Editor
Correction
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