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Recently, microarray and other gene expression profile studies have been performed, showing that at the gene expression level, Barrett’s esophagus has strong similarities with normal squamous esophagus and gastric cardia. Nevertheless, the signal transduction events that occur in Barrett’s esophagus are poorly understood. Therefore, peptide arrays, exhibiting 1176 specific consensus sequences for protein kinases, were used to produce a global analysis of cellular kinase activity in biopsies of Barrett’s esophagus. The results were compared with the neighboring gastric cardia and normal squamous epithelia. Provisional signal transduction schemes showing the differences in cellular signaling were constructed. The results indicate that the activity of the MAPK signaling cascade was significantly decreased. Additionally, an enhanced glycolytic activity was found in Barrett’s esophagus. Furthermore, the EGF receptor was significantly more activated in normal squamous esophagus compared to Barrett’s esophagus. These data confirm that Barrett’s esophagus does not represent a true transdifferentiation, but is indeed an incompletely differentiated type of epithelium that has strong similarities with the two different surrounding types of tissue. Manipulations of several of these cellular events may possibly lead to a more effective treatment of Barrett’s esophagus. For details, see the article by van Baal et al. on page 11605 of this issue. - PDF Icon PDF LinkTable of Contents
Cancer Research
Table of Contents
Reviews
Special Workshop Report
Meeting Report
Priority Reports
Ataxia Telangiectasia Mutated Down-regulates Phospho-Extracellular Signal-Regulated Kinase 1/2 via Activation of MKP-1 in Response to Radiation
Adrenal Hyperplasia and Adenomas Are Associated with Inhibition of Phosphodiesterase 11A in Carriers of PDE11A Sequence Variants That Are Frequent in the Population
Tcl1 Expression in Chronic Lymphocytic Leukemia Is Regulated by miR-29 and miR-181
Molecular Biology, Pathobiology, and Genetics
Up-regulation of GPR48 Induced by Down-regulation of p27Kip1 Enhances Carcinoma Cell Invasiveness and Metastasis
Cell, Tumor, and Stem Cell Biology
Cross-talk between G Protein–Coupled Receptor and Epidermal Growth Factor Receptor Signaling Pathways Contributes to Growth and Invasion of Head and Neck Squamous Cell Carcinoma
Experimental Therapeutics, Molecular Targets, and Chemical Biology
Retargeted Oncolytic Measles Strains Entering via the EGFRvIII Receptor Maintain Significant Antitumor Activity against Gliomas with Increased Tumor Specificity
Dendrimer-Encapsulated Camptothecins: Increased Solubility, Cellular Uptake, and Cellular Retention Affords Enhanced Anticancer Activity In vitro
A Novel Pathway Involving Melanoma Differentiation Associated Gene-7/Interleukin-24 Mediates Nonsteroidal Anti-inflammatory Drug–Induced Apoptosis and Growth Arrest of Cancer Cells
Immunology
Endocrinology
Diverse Gene Expression and DNA Methylation Profiles Correlate with Differential Adaptation of Breast Cancer Cells to the Antiestrogens Tamoxifen and Fulvestrant
Clinical Research
The Tumor Metastasis Suppressor Gene Drg-1 Down-regulates the Expression of Activating Transcription Factor 3 in Prostate Cancer
Antitumor Effect of 2-Methoxyestradiol in a Rat Orthotopic Brain Tumor Model
Epidemiology and Prevention
A Systematic Assessment of Common Genetic Variation in CYP11A and Risk of Breast Cancer
Obituaries
Correction
Journal Archive
Cancer Research
(1941-Present; volumes 1-current)Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)
The American Journal of Cancer
(1931-1940; volumes 15-40)Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)
The Journal of Cancer Research
(1916-1930); volumes 1-14)Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)
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