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1 December 2006
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Cover Image
The development of a tumor vasculature, termed the angiogenic switch, is a crucial step for the survival and metastasis of malignant tumors. However, the biological regulation of the process is largely unknown. Using genetic approaches to alter the infiltration and function of macrophages in a transgene-induced mouse model of mammary tumorigenesis, the authors show that tumor-associated macrophages play an important role in promoting this process (top panels). The authors find that the onset of the angiogenic switch, identified as the formation of a high-density vessel network, is restricted to the sites of malignant transformation in the heterogeneous tumor (top left). This angiogenic switch occurs subsequent to an increase in macrophage infiltration (bottom panels). Inhibition of this infiltration delays the angiogenic switch and the transition to malignancy (top right), while restoration of the macrophage population rescues these phenotypes. Furthermore, premature induction of macrophage infiltration into premalignant lesions promotes an early onset of the angiogenic switch independent of tumor progression. These findings indicate that macrophages play a key regulatory role in tumor angiogenesis. Identification of the mechanism(s) macrophages employ to promote the angiogenic switch therefore will be very important for the development of novel and effective therapeutic strategies against tumors. For details, see the article by Lin et al. on page 11238 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Reviews
Meeting Report
Priority Reports
Demonstration of a Genetic Therapeutic Index for Tumors Expressing Oncogenic BRAF by the Kinase Inhibitor SB-590885
Alastair J. King; Denis R. Patrick; Roberta S. Batorsky; Maureen L. Ho; Hieu T. Do; Shu Yun Zhang; Rakesh Kumar; David W. Rusnak; Andrew K. Takle; David M. Wilson; Erin Hugger; Lifu Wang; Florian Karreth; Julie C. Lougheed; Jae Lee; David Chau; Thomas J. Stout; Earl W. May; Cynthia M. Rominger; Michael D. Schaber; Lusong Luo; Ami S. Lakdawala; Jerry L. Adams; Rooja G. Contractor; Keiran S.M. Smalley; Meenhard Herlyn; Michael M. Morrissey; David A. Tuveson; Pearl S. Huang
Molecular Biology, Pathobiology, and Genetics
Blastemal Expression of Type I Insulin-Like Growth Factor Receptor in Wilms' Tumors Is Driven by Increased Copy Number and Correlates with Relapse
Rachael Natrajan; Jorge S. Reis-Filho; Suzanne E. Little; Boo Messahel; Marie-Anne Brundler; Jeffrey S. Dome; Paul E. Grundy; Gordan M. Vujanic; Kathy Pritchard-Jones; Chris Jones
Isolation of Germ Cells from Leukemia and Lymphoma Cells in a Human In vitro Model: Potential Clinical Application for Restoring Human Fertility after Anticancer Therapy
Kazutoshi Fujita; Akira Tsujimura; Yasushi Miyagawa; Hiroshi Kiuchi; Yasuhiro Matsuoka; Tetsuya Takao; Shingo Takada; Norio Nonomura; Akihiko Okuyama
Genome-Wide Allelic Imbalance Analysis of Pediatric Gliomas by Single Nucleotide Polymorphic Allele Array
Kwong-Kwok Wong; Yvonne T.M. Tsang; Yi-Mieng Chang; Jack Su; Angela M. Di Francesco; Daniela Meco; Riccardo Riccardi; Laszlo Perlaky; Robert C. Dauser; Adekunle Adesina; Meenakshi Bhattacharjee; Murali Chintagumpala; Ching C. Lau
Cell, Tumor, and Stem Cell Biology
Experimental Therapeutics, Molecular Targets, and Chemical Biology
In vitro and In vivo Activity of SKI-606, a Novel Src-Abl Inhibitor, against Imatinib-Resistant Bcr-Abl+ Neoplastic Cells
Miriam Puttini; Addolorata Maria Luce Coluccia; Frank Boschelli; Loredana Cleris; Edoardo Marchesi; Arianna Donella-Deana; Shaheen Ahmed; Sara Redaelli; Rocco Piazza; Vera Magistroni; Federica Andreoni; Leonardo Scapozza; Franca Formelli; Carlo Gambacorti-Passerini
The PTEN/Akt Pathway Dictates the Direct αVβ3-Dependent Growth-Inhibitory Action of an Active Fragment of Tumstatin in Glioma Cells In vitro and In vivo
Tomohiro Kawaguchi; Yoji Yamashita; Masayuki Kanamori; Raelene Endersby; Krystof S. Bankiewicz; Suzanne J. Baker; Gabriele Bergers; Russell O. Pieper
Androgen Receptor Coactivators Lysine-Specific Histone Demethylase 1 and Four and a Half LIM Domain Protein 2 Predict Risk of Prostate Cancer Recurrence
Philip Kahl; Lucia Gullotti; Lukas Carl Heukamp; Susanne Wolf; Nicolaus Friedrichs; Roland Vorreuther; Gerold Solleder; Patrick J. Bastian; Jörg Ellinger; Eric Metzger; Roland Schüle; Reinhard Buettner
A Novel BH3 Mimetic Reveals a Mitogen-Activated Protein Kinase–Dependent Mechanism of Melanoma Cell Death Controlled by p53 and Reactive Oxygen Species
Monique Verhaegen; Joshua A. Bauer; Cristina Martín de la Vega; Guoping Wang; Keith G. Wolter; J. Chadwick Brenner; Zaneta Nikolovska-Coleska; Audrey Bengtson; Rajan Nair; James T. Elder; Matt Van Brocklin; Thomas E. Carey; Carol R. Bradford; Shaomeng Wang; María S. Soengas
Transcriptional Profiling Identifies Cyclin D1 as a Critical Downstream Effector of Mutant Epidermal Growth Factor Receptor Signaling
Susumu Kobayashi; Takeshi Shimamura; Stefano Monti; Ulrich Steidl; Christopher J. Hetherington; April M. Lowell; Todd Golub; Matthew Meyerson; Daniel G. Tenen; Geoffrey I. Shapiro; Balázs Halmos
Immunology
Superior Antitumor In vitro Responses of Allogeneic Matched Sibling Compared with Autologous Patient CD8+ T Cells
Sandra Kausche; Thomas Wehler; Elke Schnürer; Volker Lennerz; Walburgis Brenner; Sebastian Melchior; Mark Gröne; Marion Nonn; Susanne Strand; Ralf Meyer; Elena Ranieri; Christoph Huber; Christine S. Falk; Wolfgang Herr
Endocrinology
Clinical Research
Epidemiology and Prevention
Marked Genomic Differences Characterize Primary and Secondary Glioblastoma Subtypes and Identify Two Distinct Molecular and Clinical Secondary Glioblastoma Entities
Elizabeth A. Maher; Cameron Brennan; Patrick Y. Wen; Laura Durso; Keith L. Ligon; Aaron Richardson; Deepak Khatry; Bin Feng; Raktim Sinha; David N. Louis; John Quackenbush; Peter McL. Black; Lynda Chin; Ronald A. DePinho
Obituaries
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