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1 November 2006
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Tumor-reactive lymphadenopathy in sentinel lymph nodes has been observed for decades, but alterations of the lymphatic channels and vasculature in these nodes prior to the arrival of metastatic tumor cells remain unexplored. By inoculation of tumor cells into the left hind foot-pads of nude mice or immunocompetent mice, the authors show that tumor-reactive lymphadenopathy can be induced in the popliteal lymph node of the tumor-bearing limb, which is the sentinel lymph node in this model. The authors find that, during tumor-reactive lymphadenopathy, dilation of lymph sinuses as well as morphological and functional alterations of high endothelial venules within the sentinel lymph node can be induced by the primary tumor prior to the arrival of metastatic cancer cells. Moreover, the proliferation rate of the endothelial cells in the high endothelial venules is also increased before metastasis. For details, see the article by Qian et al. on page 10365 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Reviews
Priority Reports
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Neurospheres Enriched in Cancer Stem–Like Cells Are Highly Effective in Eliciting a Dendritic Cell–Mediated Immune Response against Malignant Gliomas
Serena Pellegatta; Pietro Luigi Poliani; Daniela Corno; Francesca Menghi; Francesco Ghielmetti; Blanca Suarez-Merino; Valentina Caldera; Sara Nava; Maria Ravanini; Fabio Facchetti; Maria Grazia Bruzzone; Gaetano Finocchiaro
Alterations of the Tumor Suppressor Gene ARLTS1 in Ovarian Cancer
Fabio Petrocca; Dimitrios Iliopoulos; Haiyan R. Qin; Milena S. Nicoloso; Say Yendamuri; Sylwia E. Wojcik; Masayoshi Shimizu; Gianpiero Di Leva; Andrea Vecchione; Francesco Trapasso; Andrew K. Godwin; Massimo Negrini; George A. Calin; Carlo M. Croce
Molecular Biology, Pathobiology, and Genetics
Genetic Reclassification of Histologic Grade Delineates New Clinical Subtypes of Breast Cancer
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Truncating Variants in p53AIP1 Disrupting DNA Damage–Induced Apoptosis Are Associated with Prostate Cancer Risk
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Chromosomal Breakpoints Affecting Immunoglobulin Loci Are Recurrent in Hodgkin and Reed-Sternberg Cells of Classical Hodgkin Lymphoma
José I. Martín-Subero; Wolfram Klapper; Anna Sotnikova; Evelyne Callet-Bauchu; Lana Harder; Christian Bastard; Roland Schmitz; Susanne Grohmann; Jorge Höppner; Jennifer Riemke; Thomas F.E. Barth; Françoise Berger; Heinz-Wolfram Bernd; Alexander Claviez; Stefan Gesk; Georgiy A. Frank; Irina B. Kaplanskaya; Peter Möller; Reza M. Parwaresch; Thomas Rüdiger; Harald Stein; Ralf Küppers; Martin L. Hansmann; Reiner Siebert; for the Deutsche Krebshilfe Network Project “Molecular Mechanisms in Malignant Lymphomas”
Norepinephrine Up-regulates the Expression of Vascular Endothelial Growth Factor, Matrix Metalloproteinase (MMP)-2, and MMP-9 in Nasopharyngeal Carcinoma Tumor Cells
Eric V. Yang; Anil K. Sood; Min Chen; Yang Li; Tim D. Eubank; Clay B. Marsh; Scott Jewell; Nicholas A. Flavahan; Carl Morrison; Peir-En Yeh; Stanley Lemeshow; Ronald Glaser
Preparing the “Soil”: The Primary Tumor Induces Vasculature Reorganization in the Sentinel Lymph Node before the Arrival of Metastatic Cancer Cells
Chao-Nan Qian; Bree Berghuis; Galia Tsarfaty; MaryBeth Bruch; Eric J. Kort; Jon Ditlev; Ilan Tsarfaty; Eric Hudson; David G. Jackson; David Petillo; Jindong Chen; James H. Resau; Bin Tean Teh
Mapping a Sex Hormone–Sensitive Gene Determining Female Resistance to Liver Carcinogenesis in a Congenic F344.BN-Hcs4 Rat
Maria R. De Miglio; Patrizia Virdis; Diego F. Calvisi; Maddalena Frau; Maria R. Muroni; Maria M. Simile; Lucia Daino; Giovanni M. Careddu; Eraldo Sanna-Passino; Rosa M. Pascale; Francesco Feo
Cell, Tumor, and Stem Cell Biology
Experimental Therapeutics, Molecular Targets, and Chemical Biology
The Urinary Metabolite Profile of the Dietary Carcinogen 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine Is Predictive of Colon DNA Adducts after a Low-Dose Exposure in Humans
Michael A. Malfatti; Karen H. Dingley; Susan Nowell-Kadlubar; Esther A. Ubick; Nisha Mulakken; David Nelson; Nicholas P. Lang; James S. Felton; Kenneth W. Turteltaub
Immunology
Characterization of GD2 Peptide Mimotope DNA Vaccines Effective against Spontaneous Neuroblastoma Metastases
Stefan Fest; Nicole Huebener; Silke Weixler; Matthias Bleeke; Yan Zeng; Anne Strandsby; Rudolf Volkmer-Engert; Christiane Landgraf; Gerhard Gaedicke; Angelika B. Riemer; Elke Michalsky; Ines S. Jaeger; Robert Preissner; Elisabeth Förster-Wald; Erika Jensen-Jarolim; Holger N. Lode
Endocrinology
Androgens Modulate Expression of Transcription Intermediary Factor 2, an Androgen Receptor Coactivator whose Expression Level Correlates with Early Biochemical Recurrence in Prostate Cancer
Irina U. Agoulnik; Ajula Vaid; Manjula Nakka; Misty Alvarado; William E. Bingman, III; Halime Erdem; Anna Frolov; Carolyn L. Smith; Gustavo E. Ayala; Michael M. Ittmann; Nancy L. Weigel
Epidemiology and Prevention
Correction
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