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15 October 2006
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Cover Image
Cover Image
Growing evidence links the Hedgehog signaling pathway to a wide range of human cancers, most of which arise sporadically. We report a novel somatic mouse cancer model and utilize this to survey Hedgehog-dependent sporadic tumors. By spontaneous and regulated recombination-mediated activation of an oncogenic form of Smoothened (SmoM2), we modulate tumor spectrum, frequency, and latency. Transcriptional profiling reveals a core expression signature in these diverse tumors. The cover image shows strong expression of PDGFRa in a medulloblastoma and rhabdomyosarcoma, two tumors resulting from SmoM2 activity. This model provides a robust tool for mechanistic dissection and treatment of Hedgehog-dependent tumors. More generally, the approach provides a genetic platform for identifying tumorigenic potential in either candidate oncogenes or tumor suppressors, as well as for the effective modeling of sporadic cancers. For details, see the article by Mao et al. on page 10171 of this issue.Close Modal - PDF Icon PDF LinkTable of Contents
ISSN 0008-5472
EISSN 1538-7445
Journal Archive
Cancer Research (1941-Present; volumes 1-current)
(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.The American Journal of Cancer (1931-1940; volumes 15-40)
(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.The Journal of Cancer Research (1916-1930); volumes 1-14)
(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.Table of Contents
Reviews
Commentary
Priority Report
Distal Colorectal Cancers with Microsatellite Instability (MSI) Display Distinct Gene Expression Profiles that Are Different from Proximal MSI Cancers
Toshiaki Watanabe; Takashi Kobunai; Etsuko Toda; Yoko Yamamoto; Takamitsu Kanazawa; Yoshihiro Kazama; Junichiro Tanaka; Toshiaki Tanaka; Tsuyosi Konishi; Yoshihiro Okayama; Yoshikazu Sugimoto; Toshinori Oka; Shin Sasaki; Tetsuichiro Muto; Hirokazu Nagawa
Molecular Biology, Pathobiology, and Genetics
High-risk Melanoma Susceptibility Genes and Pancreatic Cancer, Neural System Tumors, and Uveal Melanoma across GenoMEL
Alisa M. Goldstein; May Chan; Mark Harland; Elizabeth M. Gillanders; Nicholas K. Hayward; Marie-Francoise Avril; Esther Azizi; Giovanna Bianchi-Scarra; D. Timothy Bishop; Brigitte Bressac-de Paillerets; William Bruno; Donato Calista; Lisa A. Cannon Albright; Florence Demenais; David E. Elder; Paola Ghiorzo; Nelleke A. Gruis; Johan Hansson; David Hogg; Elizabeth A. Holland; Peter A. Kanetsky; Richard F. Kefford; Maria Teresa Landi; Julie Lang; Sancy A. Leachman; Rona M. MacKie; Veronica Magnusson; Graham J. Mann; Kristin Niendorf; Julia Newton Bishop; Jane M. Palmer; Susana Puig; Joan A. Puig-Butille; Femke A. de Snoo; Mitchell Stark; Hensin Tsao; Margaret A. Tucker; Linda Whitaker; Emanuel Yakobson; The Lund Melanoma Study Group; the Melanoma Genetics Consortium (GenoMEL)
Overexpression of Glycosylphosphatidylinositol (GPI) Transamidase Subunits Phosphatidylinositol Glycan Class T and/or GPI Anchor Attachment 1 Induces Tumorigenesis and Contributes to Invasion in Human Breast Cancer
Guojun Wu; Zhongmin Guo; Aditi Chatterjee; Xin Huang; Ethel Rubin; Feng Wu; Elizabeth Mambo; Xiaofei Chang; Motonobu Osada; Myoung Sook Kim; Chulso Moon; Joseph A. Califano; Edward A. Ratovitski; Susanne M. Gollin; Saraswati Sukumar; David Sidransky; Barry Trink
Transforming Growth Factor β Receptor Type II Inactivation Induces the Malignant Transformation of Intestinal Neoplasms Initiated by Apc Mutation
Nina M. Muñoz; Melissa Upton; Andres Rojas; M. Kay Washington; Li Lin; Anna Chytil; Elif G. Sozmen; Blair B. Madison; Ambra Pozzi; Randall T. Moon; Harold L. Moses; William M. Grady
A t(1;19)(q10;p10) Mediates the Combined Deletions of 1p and 19q and Predicts a Better Prognosis of Patients with Oligodendroglioma
Robert B. Jenkins; Hilary Blair; Karla V. Ballman; Caterina Giannini; Robert M. Arusell; Mark Law; Heather Flynn; Sandra Passe; Sara Felten; Paul D. Brown; Edward G. Shaw; Jan C. Buckner
Single-chain Antibodies to the EWS NH2 Terminus Structurally Discriminate between Intact and Chimeric EWS in Ewing's Sarcoma and Interfere with the Transcriptional Activity of EWS In vivo
Dave N.T. Aryee; Michael Kreppel; Radostina Bachmaier; Aykut Üren; Karin Muehlbacher; Stefan Wagner; Heimo Breiteneder; Jozef Ban; Jeffrey A. Toretsky; Heinrich Kovar
EBV Latent Membrane Protein 1 Up-regulates Hypoxia-Inducible Factor 1α through Siah1-Mediated Down-regulation of Prolyl Hydroxylases 1 and 3 in Nasopharyngeal Epithelial Cells
Satoru Kondo; So Young Seo; Tomokazu Yoshizaki; Naohiro Wakisaka; Mitsuru Furukawa; Irene Joab; Kyung Lib Jang; Joseph S. Pagano
Cell, Tumor, and Stem Cell Biology
ADAM28 Is Overexpressed in Human Breast Carcinomas: Implications for Carcinoma Cell Proliferation through Cleavage of Insulin-like Growth Factor Binding Protein-3
Yoko Mitsui; Satsuki Mochizuki; Takahide Kodama; Masayuki Shimoda; Takashi Ohtsuka; Takayuki Shiomi; Miyuki Chijiiwa; Tadashi Ikeda; Masaki Kitajima; Yasunori Okada
Signal Transducers and Activators of Transcription 5b Activation Enhances Hepatocellular Carcinoma Aggressiveness through Induction of Epithelial-Mesenchymal Transition
Terence K. Lee; Kwan Man; Ronnie T.P. Poon; Chung Mau Lo; Anthony P. Yuen; Irene O. Ng; Kevin T. Ng; Warren Leonard; Sheung Tat Fan
Low-Dose Etoposide Enhances Telomerase-Dependent Adenovirus-Mediated Cytosine Deaminase Gene Therapy through Augmentation of Adenoviral Infection and Transgene Expression in a Syngeneic Bladder Tumor Model
Gia-Shing Shieh; Ai-Li Shiau; Yi-Te Yo; Pey-Ru Lin; Chao-Ching Chang; Tzong-Shin Tzai; Chao-Liang Wu
Activation of EDTA-Resistant Gelatinases in Malignant Human Tumors
Donghai Chen; Alanna Kennedy; Jaw-Yuan Wang; Wei Zeng; Qiang Zhao; Michael Pearl; Mengzhen Zhang; Zhenhe Suo; Jahn M. Nesland; Yuhuan Qiao; Ah-Kau Ng; Naoko Hirashima; Tetsu Yamane; Yoshiyuki Mori; Masako Mitsumata; Giulio Ghersi; Wen-Tien Chen
Experimental Therapeutics, Molecular Targets, and Chemical Biology
Down-regulation of Androgen Receptor by 3,3′-Diindolylmethane Contributes to Inhibition of Cell Proliferation and Induction of Apoptosis in Both Hormone-Sensitive LNCaP and Insensitive C4-2B Prostate Cancer Cells
Mohammad M.R. Bhuiyan; Yiwei Li; Sanjeev Banerjee; Fakhara Ahmed; Zhiwei Wang; Shadan Ali; Fazlul H. Sarkar
Targeting Liposomal Chemotherapy via Both Tumor Cell–Specific and Tumor Vasculature–Specific Ligands Potentiates Therapeutic Efficacy
Fabio Pastorino; Chiara Brignole; Daniela Di Paolo; Bice Nico; Annalisa Pezzolo; Danilo Marimpietri; Gabriella Pagnan; Federica Piccardi; Michele Cilli; Renato Longhi; Domenico Ribatti; Angelo Corti; Theresa M. Allen; Mirco Ponzoni
Relationships of Human Papillomavirus Type, Qualitative Viral Load, and Age with Cytologic Abnormality
Melinda Butsch Kovacic; Philip E. Castle; Rolando Herrero; Mark Schiffman; Mark E. Sherman; Sholom Wacholder; Ana C. Rodriguez; Martha L. Hutchinson; M. Concepción Bratti; Allan Hildesheim; Jorge Morales; Mario Alfaro; Robert D. Burk
Immunology
Endocrinology
Regulation of Expression of BIK Proapoptotic Protein in Human Breast Cancer Cells: p53-Dependent Induction of BIK mRNA by Fulvestrant and Proteasomal Degradation of BIK Protein
Jingyung Hur; Daphne W. Bell; Kathleen L. Dean; Kathryn R. Coser; Pablo C. Hilario; Ross A. Okimoto; Erica M. Tobey; Shannon L. Smith; Kurt J. Isselbacher; Toshi Shioda
Estrogen Receptor-α Phosphorylated at Ser118 Is Present at the Promoters of Estrogen-Regulated Genes and Is Not Altered Due to HER-2 Overexpression
Gregory E. Weitsman; Lin Li; George P. Skliris; James R. Davie; Kanyarat Ung; Yulian Niu; Linda Curtis-Snell; Ladislav Tomes; Peter H. Watson; Leigh C. Murphy
RET Is Constitutively Activated by Novel Tandem Mutations that Alter the Active Site Resulting in Multiple Endocrine Neoplasia Type 2B
Aaron N. Cranston; Cristiana Carniti; Kim Oakhill; Elzbieta Radzio-Andzelm; Eric A. Stone; Andrew S. McCallion; Shirley Hodgson; Sue Clarke; Piera Mondellini; Jean Leyland; Marco A. Pierotti; Joanne Whittaker; Susan S. Taylor; Italia Bongarzone; Bruce A.J. Ponder
Clinical Research
Epidemiology and Prevention
Common Variants in RB1 Gene and Risk of Invasive Ovarian Cancer
Honglin Song; Susan J. Ramus; Danielle Shadforth; Lydia Quaye; Susanne Kruger Kjaer; Richard A. DiCioccio; Alison M. Dunning; Estrid Hogdall; Claus Hogdall; Alice S. Whittemore; Valerie McGuire; Fabienne Lesueur; Douglas F. Easton; Ian J. Jacobs; Bruce A.J. Ponder; Simon A. Gayther; Paul D.P. Pharoah
Correction
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