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Issues

Volume 66, Issue 2
15 January 2006
Issue Cover
All Issues
ISSN 0008-5472
EISSN 1538-7445

Journal Archive

Cancer Research (1941-Present; volumes 1-current)

(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.

The American Journal of Cancer (1931-1940; volumes 15-40)

(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.

The Journal of Cancer Research (1916-1930); volumes 1-14)

(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Table of Contents

Reviews

Cranking the Immunologic Engine with Chemotherapy: Using Context to Drive Tumor Antigen Cross-Presentation towards Useful Antitumor Immunity
Robbert G. van der Most; Andrew Currie; Bruce W.S. Robinson; Richard A. Lake
View articletitled, Cranking the Immunologic Engine with Chemotherapy: Using Context to Drive Tumor Antigen Cross-Presentation towards Useful Antitumor Immunity
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Distinct Role of Macrophages in Different Tumor Microenvironments
Claire E. Lewis; Jeffrey W. Pollard
View articletitled, Distinct Role of Macrophages in Different Tumor Microenvironments
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Priority Reports

Combined Inhibitory Effects of Curcumin and Phenethyl Isothiocyanate on the Growth of Human PC-3 Prostate Xenografts in Immunodeficient Mice
Tin Oo Khor; Young-Sam Keum; Wen Lin; Jung-Hwan Kim; Rong Hu; Guoxiang Shen; Changjiang Xu; Avanthika Gopalakrishnan; Bandaru Reddy; Xi Zheng; Allan H. Conney; Ah-Ng Tony Kong
View articletitled, Combined Inhibitory Effects of Curcumin and Phenethyl Isothiocyanate on the Growth of Human PC-3 Prostate Xenografts in Immunodeficient Mice
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Significance of Murine Retroviral Mutagenesis for Identification of Disease Genes in Human Acute Myeloid Leukemia
Stefan J. Erkeland; Roel G.W. Verhaak; Peter J.M. Valk; Ruud Delwel; Bob Löwenberg; Ivo P. Touw
View articletitled, Significance of Murine Retroviral Mutagenesis for Identification of Disease Genes in Human Acute Myeloid Leukemia
Supplementary data
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HIV-1 Vpr Induces DNA Double-Strand Breaks
Hiroaki Tachiwana; Mari Shimura; Chikako Nakai-Murakami; Kenzo Tokunaga; Yoshimasa Takizawa; Tetsutaro Sata; Hitoshi Kurumizaka; Yukihito Ishizaka
View articletitled, HIV-1 Vpr Induces DNA Double-Strand Breaks
Supplementary data
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Comparison of Metabolic Pathways between Cancer Cells and Stromal Cells in Colorectal Carcinomas: a Metabolic Survival Role for Tumor-Associated Stroma
Michael I. Koukourakis; Alexandra Giatromanolaki; Adrian L. Harris; Efthimios Sivridis
View articletitled, Comparison of Metabolic Pathways between Cancer Cells and Stromal Cells in Colorectal Carcinomas: a Metabolic Survival Role for Tumor-Associated Stroma
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Ductal Access for Prevention and Therapy of Mammary Tumors
Satoshi Murata; Scott L. Kominsky; Mustafa Vali; Zhe Zhang; Elizabeth Garrett-Mayer; Dorian Korz; David Huso; Sharyn D. Baker; James Barber; Elizabeth Jaffee; R. Todd Reilly; Saraswati Sukumar
View articletitled, Ductal Access for Prevention and Therapy of Mammary Tumors
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The Single Nucleotide Polymorphism IVS1+309 in Mouse Double Minute 2 Does Not Affect Risk of Familial Breast Cancer
Stefan Wilkening; Justo Lorenzo Bermejo; Barbara Burwinkel; Rüdiger Klaes; Claus R. Bartram; Alfons Meindl; Peter Bugert; Rita K. Schmutzler; Barbara Wappenschmidt; Michael Untch; Kari Hemminki; Asta Försti
View articletitled, The Single Nucleotide Polymorphism IVS1+309 in <em>Mouse Double Minute 2</em> Does Not Affect Risk of Familial Breast Cancer
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Tumor Cell Lines Expressing the Proteasome Subunit Isoform LMP7E1 Exhibit Immunoproteasome Deficiency
Sylvia Heink; Benjamin Fricke; Daniela Ludwig; Peter-M. Kloetzel; Elke Krüger
View articletitled, Tumor Cell Lines Expressing the Proteasome Subunit Isoform LMP7E1 Exhibit Immunoproteasome Deficiency
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CpG Island Methylation and Expression of the Secreted Frizzled-Related Protein Gene Family in Chronic Lymphocytic Leukemia
Te-Hui Liu; Aparna Raval; Shih-Shih Chen; Jennifer J. Matkovic; John C. Byrd; Christoph Plass
View articletitled, CpG Island Methylation and Expression of the Secreted Frizzled-Related Protein Gene Family in Chronic Lymphocytic Leukemia
Supplementary data
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Gene Conversion Is a Frequent Mechanism of Inactivation of the Wild-Type Allele in Cancers from MLH1/MSH2 Deletion Carriers
Jian Zhang; Annette Lindroos; Saara Ollila; Anna Russell; Giancarlo Marra; Hansjakob Mueller; Paivi Peltomaki; Martina Plasilova; Karl Heinimann
View articletitled, Gene Conversion Is a Frequent Mechanism of Inactivation of the Wild-Type Allele in Cancers from <em>MLH1/MSH2</em> Deletion Carriers
Supplementary data
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Molecular Biology, Pathobiology, and Genetics

PEG10 Is a c-MYC Target Gene in Cancer Cells
Chi-Ming Li; Adam A. Margolin; Martha Salas; Lorenzo Memeo; Mahesh Mansukhani; Hanina Hibshoosh; Matthias Szabolcs; Apostolos Klinakis; Benjamin Tycko
View articletitled, <em>PEG10</em> Is a c-MYC Target Gene in Cancer Cells
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c-Myc Overexpression Causes Anaplasia in Medulloblastoma
Duncan Stearns; Aneeka Chaudhry; Ty W. Abel; Peter C. Burger; Chi V. Dang; Charles G. Eberhart
View articletitled, c-Myc Overexpression Causes Anaplasia in Medulloblastoma
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De novo CpG Island Methylation in Human Cancer Cells
Kam-Wing Jair; Kurtis E. Bachman; Hiromu Suzuki; Angela H. Ting; Ina Rhee; Ray-Whay Chiu Yen; Stephen B. Baylin; Kornel E. Schuebel
View articletitled, <em>De novo</em> CpG Island Methylation in Human Cancer Cells
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A Functional Variant in the Transcriptional Regulatory Region of Gene LOC344967 Cosegregates with Disease Phenotype in Familial Nasopharyngeal Carcinoma
Ri-Cheng Jiang; Hai-De Qin; Mu-Sheng Zeng; Wei Huang; Bing-Jian Feng; Feng Zhang; Han-Kui Chen; Wei-Hua Jia; Li-Zhen Chen; Qi-Sheng Feng; Ru-Hua Zhang; Xing-Juan Yu; Mei-Zhen Zheng; Yi-Xin Zeng
View articletitled, A Functional Variant in the Transcriptional Regulatory Region of Gene <em>LOC344967</em> Cosegregates with Disease Phenotype in Familial Nasopharyngeal Carcinoma
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Thymosin β4 Is a Determinant of the Transformed Phenotype and Invasiveness of S-Adenosylmethionine Decarboxylase–Transfected Fibroblasts
Pirjo Nummela; Miao Yin; Mari Kielosto; Virna Leaner; Michael J. Birrer; Erkki Hölttä
View articletitled, Thymosin β4 Is a Determinant of the Transformed Phenotype and Invasiveness of <em>S</em>-Adenosylmethionine Decarboxylase–Transfected Fibroblasts
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Protein Kinase C δ Overexpressing Transgenic Mice Are Resistant to Chemically but not to UV Radiation–Induced Development of Squamous Cell Carcinomas: A Possible Link to Specific Cytokines and Cyclooxygenase-2
Moammir H. Aziz; Deric L. Wheeler; Bhushan Bhamb; Ajit K. Verma
View articletitled, Protein Kinase C δ Overexpressing Transgenic Mice Are Resistant to Chemically but not to UV Radiation–Induced Development of Squamous Cell Carcinomas: A Possible Link to Specific Cytokines and Cyclooxygenase-2
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TC1 (C8orf4) Enhances the Wnt/β-Catenin Pathway by Relieving Antagonistic Activity of Chibby
Yusun Jung; Seunghyun Bang; Kyungho Choi; Eunsoon Kim; Youngmi Kim; Jungtae Kim; Juhee Park; Hyunlyoung Koo; Randall T. Moon; Kyuyoung Song; Inchul Lee
View articletitled, TC1 (C8orf4) Enhances the Wnt/β-Catenin Pathway by Relieving Antagonistic Activity of Chibby
Supplementary data
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Differential Requirement for DNA Methyltransferase 1 in Maintaining Human Cancer Cell Gene Promoter Hypermethylation
Angela H. Ting; Kam-wing Jair; Kornel E. Schuebel; Stephen B. Baylin
View articletitled, Differential Requirement for DNA Methyltransferase 1 in Maintaining Human Cancer Cell Gene Promoter Hypermethylation
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PTEN Autoregulates Its Expression by Stabilization of p53 in a Phosphatase-Independent Manner
Yufang Tang; Charis Eng
View articletitled, PTEN Autoregulates Its Expression by Stabilization of p53 in a Phosphatase-Independent Manner
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Profiling Genetic Variation along the Androgen Biosynthesis and Metabolism Pathways Implicates Several Single Nucleotide Polymorphisms and Their Combinations as Prostate Cancer Risk Factors
Nina Mononen; Eija H. Seppälä; Priya Duggal; Ville Autio; Tarja Ikonen; Pekka Ellonen; Juha Saharinen; Janna Saarela; Mauno Vihinen; Teuvo L.J. Tammela; Olli Kallioniemi; Joan E. Bailey-Wilson; Johanna Schleutker
View articletitled, Profiling Genetic Variation along the Androgen Biosynthesis and Metabolism Pathways Implicates Several Single Nucleotide Polymorphisms and Their Combinations as Prostate Cancer Risk Factors
Supplementary data
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Critical Roles for Polymerase ζ in Cellular Tolerance to Nitric Oxide–Induced DNA Damage
Xiaohua Wu; Katsuya Takenaka; Eiichiro Sonoda; Helfrid Hochegger; Shosuke Kawanishi; Takuo Kawamoto; Shunichi Takeda; Mitsuyoshi Yamazoe
View articletitled, Critical Roles for Polymerase ζ in Cellular Tolerance to Nitric Oxide–Induced DNA Damage
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In utero Exposure of Mice to Dibenzo[a,l]Pyrene Produces Lymphoma in the Offspring: Role of the Aryl Hydrocarbon Receptor
Zhen Yu; Christiane V. Loehr; Kay A. Fischer; Mandy A. Louderback; Sharon K. Krueger; Roderick H. Dashwood; Nancy I. Kerkvliet; Clifford B. Pereira; Jamie E. Jennings-Gee; Stephanie T. Dance; Mark Steven Miller; George S. Bailey; David E. Williams
View articletitled, <em>In utero</em> Exposure of Mice to Dibenzo[<em>a,l</em>]Pyrene Produces Lymphoma in the Offspring: Role of the Aryl Hydrocarbon Receptor
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Altered Expression and Localization of Creatine Kinase B, Heterogeneous Nuclear Ribonucleoprotein F, and High Mobility Group Box 1 Protein in the Nuclear Matrix Associated with Colon Cancer
Manimalha Balasubramani; Billy W. Day; Robert E. Schoen; Robert H. Getzenberg
View articletitled, Altered Expression and Localization of Creatine Kinase B, Heterogeneous Nuclear Ribonucleoprotein F, and High Mobility Group Box 1 Protein in the Nuclear Matrix Associated with Colon Cancer
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Cell, Tumor, and Stem Cell Biology

Nitric Oxide Is a Factor in the Stabilization of Hypoxia-Inducible Factor-1α in Cancer: Role of Free Radical Formation
Marisol Quintero; Peter A. Brennan; Gareth J. Thomas; Salvador Moncada
View articletitled, Nitric Oxide Is a Factor in the Stabilization of Hypoxia-Inducible Factor-1α in Cancer: Role of Free Radical Formation
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Angiopoietin 2 Induces Glioma Cell Invasion by Stimulating Matrix Metalloprotease 2 Expression through the αvβ1 Integrin and Focal Adhesion Kinase Signaling Pathway
Bo Hu; Michael J. Jarzynka; Ping Guo; Yorihisha Imanishi; David D. Schlaepfer; Shi-Yuan Cheng
View articletitled, Angiopoietin 2 Induces Glioma Cell Invasion by Stimulating Matrix Metalloprotease 2 Expression through the α<sub>v</sub>β<sub>1</sub> Integrin and Focal Adhesion Kinase Signaling Pathway
Supplementary data
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Phospholipase D Prevents Etoposide-Induced Apoptosis by Inhibiting the Expression of Early Growth Response-1 and Phosphatase and Tensin Homologue Deleted on Chromosome 10
Joommo Kim; Young Han Lee; Taeg Kyu Kwon; Jong-Soo Chang; Kwang Chul Chung; Do Sik Min
View articletitled, Phospholipase D Prevents Etoposide-Induced Apoptosis by Inhibiting the Expression of Early Growth Response-1 and Phosphatase and Tensin Homologue Deleted on Chromosome 10
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The Gene Expression Program of Prostate Fibroblast Senescence Modulates Neoplastic Epithelial Cell Proliferation through Paracrine Mechanisms
Claes Bavik; Ilsa Coleman; James P. Dean; Beatrice Knudsen; Steven Plymate; Peter S. Nelson
View articletitled, The Gene Expression Program of Prostate Fibroblast Senescence Modulates Neoplastic Epithelial Cell Proliferation through Paracrine Mechanisms
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The Possible Role of EWS-Fli1 in Evasion of Senescence in Ewing Family Tumors
Tomoya Matsunobu; Kazuhiro Tanaka; Tomoyuki Nakamura; Fumihiko Nakatani; Riku Sakimura; Masuo Hanada; Xu Li; Takamitsu Okada; Yoshinao Oda; Masazumi Tsuneyoshi; Yukihide Iwamoto
View articletitled, The Possible Role of EWS-Fli1 in Evasion of Senescence in Ewing Family Tumors
Supplementary data
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Overexpression of c-Maf Contributes to T-Cell Lymphoma in Both Mice and Human
Naoki Morito; Keigyou Yoh; Yuki Fujioka; Takako Nakano; Homare Shimohata; Yuko Hashimoto; Akiko Yamada; Atsuko Maeda; Fumihiko Matsuno; Hiroyuki Hata; Atsushi Suzuki; Shigehiko Imagawa; Hiroaki Mitsuya; Hiroyasu Esumi; Akio Koyama; Masayuki Yamamoto; Naoyoshi Mori; Satoru Takahashi
View articletitled, Overexpression of c-Maf Contributes to T-Cell Lymphoma in Both Mice and Human
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Down-Regulation of Stem Cell Genes, Including Those in a 200-kb Gene Cluster at 12p13.31, Is Associated with In vivo Differentiation of Human Male Germ Cell Tumors
James E. Korkola; Jane Houldsworth; Rajendrakumar S.V. Chadalavada; Adam B. Olshen; Debbie Dobrzynski; Victor E. Reuter; George J. Bosl; R.S.K. Chaganti
View articletitled, Down-Regulation of Stem Cell Genes, Including Those in a 200-kb Gene Cluster at 12p13.31, Is Associated with <em>In vivo</em> Differentiation of Human Male Germ Cell Tumors
Supplementary data
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Helicobacter Infection Is Required for Inflammation and Colon Cancer in Smad3-Deficient Mice
Lillian Maggio-Price; Piper Treuting; Weiping Zeng; Mark Tsang; Helle Bielefeldt-Ohmann; Brian M. Iritani
View articletitled, <em>Helicobacter</em> Infection Is Required for Inflammation and Colon Cancer in Smad3-Deficient Mice
Supplementary data
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Protein Kinase C-δ and Mitogen-Activated Protein/Extracellular Signal–Regulated Kinase-1 Control GLI Activation in Hedgehog Signaling
Natalia A. Riobo; Gwendolyn M. Haines; Charles P. Emerson, Jr.
View articletitled, Protein Kinase C-δ and Mitogen-Activated Protein/Extracellular Signal–Regulated Kinase-1 Control GLI Activation in Hedgehog Signaling
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Roles of Myofibroblasts in Prostaglandin E2–Stimulated Intestinal Epithelial Proliferation and Angiogenesis
Jinyi Shao; George G. Sheng; Randy C. Mifflin; Don W. Powell; Hongmiao Sheng
View articletitled, Roles of Myofibroblasts in Prostaglandin E<sub>2</sub>–Stimulated Intestinal Epithelial Proliferation and Angiogenesis
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MSF-A Interacts with Hypoxia-Inducible Factor-1α and Augments Hypoxia-Inducible Factor Transcriptional Activation to Affect Tumorigenicity and Angiogenesis
Sharon Amir; Ruoxiang Wang; Haim Matzkin; Jonathan W. Simons; Nicola J. Mabjeesh
View articletitled, MSF-A Interacts with Hypoxia-Inducible Factor-1α and Augments Hypoxia-Inducible Factor Transcriptional Activation to Affect Tumorigenicity and Angiogenesis
Supplementary data
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Differential Gene Expression Analysis Reveals Generation of an Autocrine Loop by a Mutant Epidermal Growth Factor Receptor in Glioma Cells
Deepti B. Ramnarain; Seongmi Park; Diana Y. Lee; Kimmo J. Hatanpaa; Shane O. Scoggin; Hasan Otu; Towia A. Libermann; Jack M. Raisanen; Raheela Ashfaq; Eric T. Wong; Julian Wu; Robert Elliott; Amyn A. Habib
View articletitled, Differential Gene Expression Analysis Reveals Generation of an Autocrine Loop by a Mutant Epidermal Growth Factor Receptor in Glioma Cells
Supplementary data
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Angiostatin Is Directly Cytotoxic to Tumor Cells at Low Extracellular pH: A Mechanism Dependent on Cell Surface–Associated ATP Synthase
Sulene L. Chi; Salvatore V. Pizzo
View articletitled, Angiostatin Is Directly Cytotoxic to Tumor Cells at Low Extracellular pH: A Mechanism Dependent on Cell Surface–Associated ATP Synthase
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Increased Expression of Osteopontin Contributes to the Progression of Prostate Cancer
Ani C. Khodavirdi; Zhigang Song; Shangxin Yang; Chen Zhong; Shunyou Wang; Hong Wu; Colin Pritchard; Peter S. Nelson; Pradip Roy-Burman
View articletitled, Increased Expression of Osteopontin Contributes to the Progression of Prostate Cancer
Supplementary data
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Deregulation of the HOXA10 Homeobox Gene in Endometrial Carcinoma: Role in Epithelial-Mesenchymal Transition
Hiroyuki Yoshida; Russell Broaddus; Wenjun Cheng; SuSu Xie; Honami Naora
View articletitled, Deregulation of the <em>HOXA10</em> Homeobox Gene in Endometrial Carcinoma: Role in Epithelial-Mesenchymal Transition
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Identification of a Putative Tumor Suppressor Gene Rap1GAP in Pancreatic Cancer
Lizhi Zhang; Li Chenwei; Redah Mahmood; Kenneth van Golen; Joel Greenson; Gangyong Li; Nisha J. D'Silva; Xiangquan Li; Charles F. Burant; Craig D. Logsdon; Diane M. Simeone
View articletitled, Identification of a Putative Tumor Suppressor Gene <em>Rap1GAP</em> in Pancreatic Cancer
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The P2X7 Receptor Sustains the Growth of Human Neuroblastoma Cells through a Substance P–Dependent Mechanism
Lizzia Raffaghello; Paola Chiozzi; Simonetta Falzoni; Francesco Di Virgilio; Vito Pistoia
View articletitled, The P2X<sub>7</sub> Receptor Sustains the Growth of Human Neuroblastoma Cells through a Substance P–Dependent Mechanism
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Effect of Rapamycin on Mouse Chronic Lymphocytic Leukemia and the Development of Nonhematopoietic Malignancies in Eμ-TCL1 Transgenic Mice
Nicola Zanesi; Rami Aqeilan; Alessandra Drusco; Mohamed Kaou; Cinzia Sevignani; Stefan Costinean; Laura Bortesi; Gaspare La Rocca; Pavel Koldovsky; Stefano Volinia; Rita Mancini; George Calin; Charles P. Scott; Yuri Pekarsky; Carlo M. Croce
View articletitled, Effect of Rapamycin on Mouse Chronic Lymphocytic Leukemia and the Development of Nonhematopoietic Malignancies in <em>Eμ-TCL1</em> Transgenic Mice
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Elevated Expression of ISG15 in Tumor Cells Interferes with the Ubiquitin/26S Proteasome Pathway
Shyamal D. Desai; Arthur L. Haas; Laurence M. Wood; Yu-Chen Tsai; Sidney Pestka; Eric H. Rubin; Ahamed Saleem; Alam Nur-E-Kamal; Leroy F. Liu
View articletitled, Elevated Expression of ISG15 in Tumor Cells Interferes with the Ubiquitin/26S Proteasome Pathway
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Cisplatin Mimics ARF Tumor Suppressor Regulation of RelA (p65) Nuclear Factor-κB Transactivation
Kirsteen J. Campbell; James M. Witty; Sonia Rocha; Neil D. Perkins
View articletitled, Cisplatin Mimics ARF Tumor Suppressor Regulation of RelA (p65) Nuclear Factor-κB Transactivation
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Experimental Therapeutics, Molecular Targets, and Chemical Biology

Efficient Inhibition of Intra-Peritoneal Tumor Growth and Dissemination of Human Ovarian Carcinoma Cells in Nude Mice by Anti-L1-Cell Adhesion Molecule Monoclonal Antibody Treatment
Matthias J.E. Arlt; Ilse Novak-Hofer; Daniela Gast; Verena Gschwend; Gerhard Moldenhauer; Jürgen Grünberg; Michael Honer; P. August Schubiger; Peter Altevogt; Achim Krüger
View articletitled, Efficient Inhibition of Intra-Peritoneal Tumor Growth and Dissemination of Human Ovarian Carcinoma Cells in Nude Mice by Anti-L1-Cell Adhesion Molecule Monoclonal Antibody Treatment
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Restoring E-Cadherin Expression Increases Sensitivity to Epidermal Growth Factor Receptor Inhibitors in Lung Cancer Cell Lines
Samir E. Witta; Robert M. Gemmill; Fred R. Hirsch; Christopher D. Coldren; Karla Hedman; Larisa Ravdel; Barbara Helfrich; Rafal Dziadziuszko; Daniel C. Chan; Michio Sugita; Zeng Chan; Anna Baron; Wilbur Franklin; Harry A. Drabkin; Luc Girard; Adi F. Gazdar; John D. Minna; Paul A. Bunn, Jr.
View articletitled, Restoring E-Cadherin Expression Increases Sensitivity to Epidermal Growth Factor Receptor Inhibitors in Lung Cancer Cell Lines
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The Synthetic Compound CC-5079 Is a Potent Inhibitor of Tubulin Polymerization and Tumor Necrosis Factor-α Production with Antitumor Activity
Ling-Hua Zhang; Lei Wu; Heather K. Raymon; Roger S. Chen; Laura Corral; Michael A. Shirley; Rama Krishna Narla; Jim Gamez; George W. Muller; David I. Stirling; J. Blake Bartlett; Peter H. Schafer; Faribourz Payvandi
View articletitled, The Synthetic Compound CC-5079 Is a Potent Inhibitor of Tubulin Polymerization and Tumor Necrosis Factor-α Production with Antitumor Activity
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Effect of Adenovirus-Mediated Heat Shock Protein Expression and Oncolysis in Combination with Low-Dose Cyclophosphamide Treatment on Antitumor Immune Responses
Nelson C. Di Paolo; Sebastian Tuve; Shaoheng Ni; Karl Erik Hellström; Ingegerd Hellström; André Lieber
View articletitled, Effect of Adenovirus-Mediated Heat Shock Protein Expression and Oncolysis in Combination with Low-Dose Cyclophosphamide Treatment on Antitumor Immune Responses
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Targeting Cell-Impermeable Prodrug Activation to Tumor Microenvironment Eradicates Multiple Drug-Resistant Neoplasms
Wenyuan Wu; Yunping Luo; Chengzao Sun; Yuan Liu; Paul Kuo; Janos Varga; Rong Xiang; Ralph Reisfeld; Kim D. Janda; Thomas S. Edgington; Cheng Liu
View articletitled, Targeting Cell-Impermeable Prodrug Activation to Tumor Microenvironment Eradicates Multiple Drug-Resistant Neoplasms
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Synergistic Effects of Gemcitabine and Gefitinib in the Treatment of Head and Neck Carcinoma
Patrick Y. Chun; Felix Y. Feng; Ashley M. Scheurer; Mary A. Davis; Theodore S. Lawrence; Mukesh K. Nyati
View articletitled, Synergistic Effects of Gemcitabine and Gefitinib in the Treatment of Head and Neck Carcinoma
Supplementary data
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Activity of the Adenoviral E1A Deletion Mutant dl922-947 in Ovarian Cancer: Comparison with E1A Wild-type Viruses, Bioluminescence Monitoring, and Intraperitoneal Delivery in Icodextrin
Michelle Lockley; Mario Fernandez; Yaohe Wang; N. Fiona Li; Susan Conroy; Nicholas Lemoine; Iain McNeish
View articletitled, Activity of the Adenoviral E1A Deletion Mutant <em>dl</em>922-947 in Ovarian Cancer: Comparison with E1A Wild-type Viruses, Bioluminescence Monitoring, and Intraperitoneal Delivery in Icodextrin
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Oncogenic BRAF Is Required for Tumor Growth and Maintenance in Melanoma Models
Klaus P. Hoeflich; Daniel C. Gray; Michael T. Eby; Janet Y. Tien; Leo Wong; Janeko Bower; Alvin Gogineni; Jiping Zha; Mary J. Cole; Howard M. Stern; Lesley J. Murray; David P. Davis; Somasekar Seshagiri
View articletitled, Oncogenic BRAF Is Required for Tumor Growth and Maintenance in Melanoma Models
Supplementary data
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Structure of the Kinase Domain of an Imatinib-Resistant Abl Mutant in Complex with the Aurora Kinase Inhibitor VX-680
Matthew A. Young; Neil P. Shah; Luke H. Chao; Markus Seeliger; Zdravko V. Milanov; William H. Biggs, III; Daniel K. Treiber; Hitesh K. Patel; Patrick P. Zarrinkar; David J. Lockhart; Charles L. Sawyers; John Kuriyan
View articletitled, Structure of the Kinase Domain of an Imatinib-Resistant Abl Mutant in Complex with the Aurora Kinase Inhibitor VX-680
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OSI-930: A Novel Selective Inhibitor of Kit and Kinase Insert Domain Receptor Tyrosine Kinases with Antitumor Activity in Mouse Xenograft Models
Andrew J. Garton; Andrew P.A. Crew; Maryland Franklin; Andrew R. Cooke; Graham M. Wynne; Linda Castaldo; Jennifer Kahler; Shannon L. Winski; April Franks; Eric N. Brown; Mark A. Bittner; John F. Keily; Paul Briner; Chris Hidden; Mary C. Srebernak; Carrie Pirrit; Matthew O'Connor; Anna Chan; Bojana Vulevic; Dwight Henninger; Karen Hart; Regina Sennello; An-Hu Li; Tao Zhang; Frank Richardson; David L. Emerson; Arlindo L. Castelhano; Lee D. Arnold; Neil W. Gibson
View articletitled, OSI-930: A Novel Selective Inhibitor of Kit and Kinase Insert Domain Receptor Tyrosine Kinases with Antitumor Activity in Mouse Xenograft Models
Supplementary data
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Antitumor Activity of Epidermal Growth Factor Receptor–Related Protein Is Mediated by Inactivation of ErbB Receptors and Nuclear Factor-κB in Pancreatic Cancer
Yuxiang Zhang; Sanjeev Banerjee; Zhiwei Wang; Hu Xu; Liyue Zhang; Ramzi Mohammad; Amro Aboukameel; Nazmi V. Adsay; Mingxin Che; James L. Abbruzzese; Adhip P.N. Majumdar; Fazlul H. Sarkar
View articletitled, Antitumor Activity of Epidermal Growth Factor Receptor–Related Protein Is Mediated by Inactivation of ErbB Receptors and Nuclear Factor-κB in Pancreatic Cancer
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The Penetration of Anticancer Drugs through Tumor Tissue as a Function of Cellular Adhesion and Packing Density of Tumor Cells
Rama Grantab; Shankar Sivananthan; Ian F. Tannock
View articletitled, The Penetration of Anticancer Drugs through Tumor Tissue as a Function of Cellular Adhesion and Packing Density of Tumor Cells
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Farnesyl and Geranylgeranyl Transferase Inhibitors Induce G1 Arrest by Targeting the Proteasome
Ekem T. Efuet; Khandan Keyomarsi
View articletitled, Farnesyl and Geranylgeranyl Transferase Inhibitors Induce G<sub>1</sub> Arrest by Targeting the Proteasome
Supplementary data
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Radiation-Induced Changes in Gene Expression Involve Recruitment of Existing Messenger RNAs to and away from Polysomes
Xing Lü; Lorena de la Peña; Christopher Barker; Kevin Camphausen; Philip J. Tofilon
View articletitled, Radiation-Induced Changes in Gene Expression Involve Recruitment of Existing Messenger RNAs to and away from Polysomes
Supplementary data
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RNA Interference–Mediated Depletion of Phosphoinositide 3-Kinase Activates Forkhead Box Class O Transcription Factors and Induces Cell Cycle Arrest and Apoptosis in Breast Carcinoma Cells
Shannon Reagan-Shaw; Nihal Ahmad
View articletitled, RNA Interference–Mediated Depletion of Phosphoinositide 3-Kinase Activates Forkhead Box Class O Transcription Factors and Induces Cell Cycle Arrest and Apoptosis in Breast Carcinoma Cells
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Rapamycin Disrupts Cyclin/Cyclin-Dependent Kinase/p21/Proliferating Cell Nuclear Antigen Complexes and Cyclin D1 Reverses Rapamycin Action by Stabilizing These Complexes
Mary Law; Elizabeth Forrester; Anna Chytil; Patrick Corsino; Gail Green; Bradley Davis; Thomas Rowe; Brian Law
View articletitled, Rapamycin Disrupts Cyclin/Cyclin-Dependent Kinase/p21/Proliferating Cell Nuclear Antigen Complexes and Cyclin D1 Reverses Rapamycin Action by Stabilizing These Complexes
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Intracellular Signaling Pathways Involved in the Cell Growth Inhibition of Glioma Cells by Melatonin
Vanesa Martín; Federico Herrera; Pilar Carrera-Gonzalez; Guillermo García-Santos; Isaac Antolín; Jezabel Rodriguez-Blanco; Carmen Rodriguez
View articletitled, Intracellular Signaling Pathways Involved in the Cell Growth Inhibition of Glioma Cells by Melatonin
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17-Allylamino-17-Demethoxygeldanamycin Synergistically Potentiates Tumor Necrosis Factor–Induced Lung Cancer Cell Death by Blocking the Nuclear Factor-κB Pathway
Xia Wang; Wei Ju; Jordan Renouard; James Aden; Steven A. Belinsky; Yong Lin
View articletitled, 17-Allylamino-17-Demethoxygeldanamycin Synergistically Potentiates Tumor Necrosis Factor–Induced Lung Cancer Cell Death by Blocking the Nuclear Factor-κB Pathway
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Immunology

Selective Targeting of Antitumor Immune Responses with Engineered Live-Attenuated Listeria monocytogenes
Kiyoshi Yoshimura; Ajay Jain; Heather E. Allen; Lindsay S. Laird; Christina Y. Chia; Sowmya Ravi; Dirk G. Brockstedt; Martin A. Giedlin; Keith S. Bahjat; Meredith L. Leong; Jill E. Slansky; David N. Cook; Thomas W. Dubensky; Drew M. Pardoll; Richard D. Schulick
View articletitled, Selective Targeting of Antitumor Immune Responses with Engineered Live-Attenuated <em>Listeria monocytogenes</em>
Supplementary data
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De novo Induction of a Cancer/Testis Antigen by 5-Aza-2′-Deoxycytidine Augments Adoptive Immunotherapy in a Murine Tumor Model
Z. Sheng Guo; Julie A. Hong; Kari R. Irvine; G. Aaron Chen; Paul J. Spiess; Yang Liu; Gang Zeng; John R. Wunderlich; Dao M. Nguyen; Nicholas P. Restifo; David S. Schrump
View articletitled, <em>De novo</em> Induction of a Cancer/Testis Antigen by 5-Aza-2′-Deoxycytidine Augments Adoptive Immunotherapy in a Murine Tumor Model
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Prostaglandin E2 Impairs CD4+ T Cell Activation by Inhibition of lck: Implications in Hodgkin's Lymphoma
Jens M. Chemnitz; Julia Driesen; Sabine Classen; James L. Riley; Svenja Debey; Marc Beyer; Alexey Popov; Thomas Zander; Joachim L. Schultze
View articletitled, Prostaglandin E<sub>2</sub> Impairs CD4<sup>+</sup> T Cell Activation by Inhibition of lck: Implications in Hodgkin's Lymphoma
Supplementary data
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Gr-1+CD115+ Immature Myeloid Suppressor Cells Mediate the Development of Tumor-Induced T Regulatory Cells and T-Cell Anergy in Tumor-Bearing Host
Bo Huang; Ping-Ying Pan; Qingsheng Li; Alice I. Sato; David E. Levy; Jonathan Bromberg; Celia M. Divino; Shu-Hsia Chen
View articletitled, Gr-1<sup>+</sup>CD115<sup>+</sup> Immature Myeloid Suppressor Cells Mediate the Development of Tumor-Induced T Regulatory Cells and T-Cell Anergy in Tumor-Bearing Host
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The In vivo Expansion Rate of Properly Stimulated Transferred CD8+ T Cells Exceeds That of an Aggressively Growing Mouse Tumor
Leroy N. Hwang; Zhiya Yu; Douglas C. Palmer; Nicholas P. Restifo
View articletitled, The <em>In vivo</em> Expansion Rate of Properly Stimulated Transferred CD8<sup>+</sup> T Cells Exceeds That of an Aggressively Growing Mouse Tumor
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Radiofrequency Thermal Ablation of Hepatocellular Carcinoma Liver Nodules Can Activate and Enhance Tumor-Specific T-Cell Responses
Alessandro Zerbini; Massimo Pilli; Amalia Penna; Guido Pelosi; Claudia Schianchi; Atim Molinari; Simona Schivazappa; Carlo Zibera; Francesco F. Fagnoni; Carlo Ferrari; Gabriele Missale
View articletitled, Radiofrequency Thermal Ablation of Hepatocellular Carcinoma Liver Nodules Can Activate and Enhance Tumor-Specific T-Cell Responses
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Tumor Cells Transduced with the MHC Class II Transactivator and CD80 Activate Tumor-Specific CD4+ T Cells Whether or Not They Are Silenced for Invariant Chain
James A. Thompson; Samudra K. Dissanayake; Bruce R. Ksander; Keith L. Knutson; Mary L. Disis; Suzanne Ostrand-Rosenberg
View articletitled, Tumor Cells Transduced with the MHC Class II Transactivator and CD80 Activate Tumor-Specific CD4<sup>+</sup> T Cells Whether or Not They Are Silenced for Invariant Chain
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Efficient Induction of Tumor Antigen–Specific CD8+ Memory T Cells by Recombinant Lentivectors
Laurence Chapatte; Sara Colombetti; Jean-Charles Cerottini; Frédéric Lévy
View articletitled, Efficient Induction of Tumor Antigen–Specific CD8<sup>+</sup> Memory T Cells by Recombinant Lentivectors
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Chaperoning Function of Stress Protein grp170, a Member of the hsp70 Superfamily, Is Responsible for its Immunoadjuvant Activity
Jun-Eui Park; John Facciponte; Xing Chen; Ian MacDonald; Elizabeth A. Repasky; Masoud H. Manjili; Xiang-Yang Wang; John R. Subjeck
View articletitled, Chaperoning Function of Stress Protein grp170, a Member of the hsp70 Superfamily, Is Responsible for its Immunoadjuvant Activity
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Vaccine with β-Defensin 2–Transduced Leukemic Cells Activates Innate and Adaptive Immunity to Elicit Potent Antileukemia Responses
Xiao-Tong Ma; Bin Xu; Li-Li An; Cheng-Ya Dong; Yong-Min Lin; Yang Shi; Ke-Fu Wu
View articletitled, Vaccine with β-Defensin 2–Transduced Leukemic Cells Activates Innate and Adaptive Immunity to Elicit Potent Antileukemia Responses
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Endocrinology

Polymorphisms in RET and Its Coreceptors and Ligands as Genetic Modifiers of Multiple Endocrine Neoplasia Type 2A
Fabienne Lesueur; Arancha Cebrian; Mercedes Robledo; Patricia Niccoli-Sire; Karl-Axel Svensson; Stephane Pinson; Jean Leyland; Joanne Whittaker; Paul D. Pharoah; Bruce A.J. Ponder
View articletitled, Polymorphisms in <em>RET</em> and Its Coreceptors and Ligands as Genetic Modifiers of Multiple Endocrine Neoplasia Type 2A
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Clinical Research

Diagnostic Markers of Ovarian Cancer by High-Throughput Antigen Cloning and Detection on Arrays
Madhumita Chatterjee; Saroj Mohapatra; Alexei Ionan; Gagandeep Bawa; Rouba Ali-Fehmi; Xiaoju Wang; James Nowak; Bin Ye; Fatimah A. Nahhas; Karen Lu; Steven S. Witkin; David Fishman; Adnan Munkarah; Robert Morris; Nancy K. Levin; Natalie N. Shirley; Gerard Tromp; Judith Abrams; Sorin Draghici; Michael A. Tainsky
View articletitled, Diagnostic Markers of Ovarian Cancer by High-Throughput Antigen Cloning and Detection on Arrays
Supplementary data
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Expression of a Fibroblast Growth Factor–Binding Protein during the Development of Adenocarcinoma of the Pancreas and Colon
Elena Tassi; Ralf T. Henke; Emma T. Bowden; Matthew R. Swift; David P. Kodack; Angera H. Kuo; Anirban Maitra; Anton Wellstein
View articletitled, Expression of a Fibroblast Growth Factor–Binding Protein during the Development of Adenocarcinoma of the Pancreas and Colon
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Induction of Metastasis by S100P in a Rat Mammary Model and Its Association with Poor Survival of Breast Cancer Patients
Guozheng Wang; Angela Platt-Higgins; Joe Carroll; Suzete de Silva Rudland; John Winstanley; Roger Barraclough; Philip S. Rudland
View articletitled, Induction of Metastasis by S100P in a Rat Mammary Model and Its Association with Poor Survival of Breast Cancer Patients
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DNA Methylation Alterations in the Pancreatic Juice of Patients with Suspected Pancreatic Disease
Hiroyuki Matsubayashi; Marcia Canto; Norihiro Sato; Alison Klein; Tadayoshi Abe; Keishi Yamashita; Charles J. Yeo; Anthony Kalloo; Ralph Hruban; Michael Goggins
View articletitled, DNA Methylation Alterations in the Pancreatic Juice of Patients with Suspected Pancreatic Disease
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Epidemiology and Prevention

Age-Related Changes of the Cervix Influence Human Papillomavirus Type Distribution
Philip E. Castle; Jose Jeronimo; Mark Schiffman; Rolando Herrero; Ana C. Rodríguez; M. Concepción Bratti; Allan Hildesheim; Sholom Wacholder; L. Rodney Long; Leif Neve; Ruth Pfeiffer; Robert D. Burk
View articletitled, Age-Related Changes of the Cervix Influence Human Papillomavirus Type Distribution
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Tagging Single-Nucleotide Polymorphisms in Antioxidant Defense Enzymes and Susceptibility to Breast Cancer
Arancha Cebrian; Paul D. Pharoah; Shahana Ahmed; Paula L. Smith; Craig Luccarini; Robert Luben; Karen Redman; Hannah Munday; Douglas F. Easton; Alison M. Dunning; Bruce A.J. Ponder
View articletitled, Tagging Single-Nucleotide Polymorphisms in Antioxidant Defense Enzymes and Susceptibility to Breast Cancer
Supplementary data
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Chemoprevention of Human Prostate Cancer by Oral Administration of Green Tea Catechins in Volunteers with High-Grade Prostate Intraepithelial Neoplasia: A Preliminary Report from a One-Year Proof-of-Principle Study
Saverio Bettuzzi; Maurizio Brausi; Federica Rizzi; Giovanni Castagnetti; Giancarlo Peracchia; Arnaldo Corti
View articletitled, Chemoprevention of Human Prostate Cancer by Oral Administration of Green Tea Catechins in Volunteers with High-Grade Prostate Intraepithelial Neoplasia: A Preliminary Report from a One-Year Proof-of-Principle Study
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Dietary Soy Isoflavones Inhibit Estrogen Effects in the Postmenopausal Breast
Charles E. Wood; Thomas C. Register; Adrian A. Franke; Mary S. Anthony; J. Mark Cline
View articletitled, Dietary Soy Isoflavones Inhibit Estrogen Effects in the Postmenopausal Breast
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Correction

Promotion of Invasion and Metastatic Potential by Bcl-2
View articletitled, Promotion of Invasion and Metastatic Potential by Bcl-2
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  • Print ISSN 0008-5472

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