Issues
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Cover Image
Cover Image
Human papillomavirus type 16 (HPV-16) E7 protein has previously been shown to alter the AKT signaling pathway. Here we show that HPV-16 E7-positive high-grade intraepithelial cervical lesions (HSIL, bottom panel exhibited elevated active AKT (green) when compared to normal cervical tissue. Loss of the retinoblastoma protein (Rb,red), induced by E7, correlates with elevated AKT activity (green) in HSIL tissue (bottom panel) in contrast to normal cervical epithleium (top panel). Together these data demonstrate that HPV-16 E7 can up-regulate AKT activity in cervical precancer lesions through inhibition of Rb. Mechanistically understanding how Rb regulates the PI3K-AKT pathway is of future interest and may provide new downstream effectors of Rb loss that contribute to tumor formation and cancer. For details, see the article by Menges et al. on page 5555 of this issue.
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Cancer Research
Table of Contents
Reviews
Position Paper
Priority Reports
Targeted Deletion of MKK4 in Cancer Cells: A Detrimental Phenotype Manifests as Decreased Experimental Metastasis and Suggests a Counterweight to the Evolution of Tumor-Suppressor Loss
Molecular Biology, Pathobiology, and Genetics
Mnt-Deficient Mammary Glands Exhibit Impaired Involution and Tumors with Characteristics of Myc Overexpression
Dominant-Negative Histone H3 Lysine 27 Mutant Derepresses Silenced Tumor Suppressor Genes and Reverses the Drug-Resistant Phenotype in Cancer Cells
Cell, Tumor, and Stem Cell Biology
Epidermal Growth Factor Receptor Signaling Is Up-regulated in Human Colonic Aberrant Crypt Foci
Experimental Therapeutics, Molecular Targets, and Chemical Biology
Inhibition of Poly(ADP-Ribose) Polymerase Modulates Tumor-Related Gene Expression, Including Hypoxia-Inducible Factor-1 Activation, during Skin Carcinogenesis
The Structure of Dasatinib (BMS-354825) Bound to Activated ABL Kinase Domain Elucidates Its Inhibitory Activity against Imatinib-Resistant ABL Mutants
Connective Tissue Growth Factor–Specific Monoclonal Antibody Therapy Inhibits Pancreatic Tumor Growth and Metastasis
Immunology
Immunologic and Clinical Responses after Vaccinations with Peptide-Pulsed Dendritic Cells in Metastatic Renal Cancer Patients
Endocrinology
Mechanism of Apoptosis Induced by the Inhibition of Fatty Acid Synthase in Breast Cancer Cells
Epidemiology and Prevention
Corrections
Journal Archive
Cancer Research
(1941-Present; volumes 1-current)Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)
The American Journal of Cancer
(1931-1940; volumes 15-40)Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)
The Journal of Cancer Research
(1916-1930); volumes 1-14)Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)
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