Issues
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Cover Image
Cover Image
Epidemiological data demonstrate a positive correlation between obesity and cancer risk. We examined carcinogenesis in a "fatless" mouse that has profound type 2 diabetes and chronic inflammation. These "fatless" mice developed both chemically induced papillomas and genetically induced breast tumors (cover image) earlier than wild-type controls and these tumors are more numerous and bigger. These data indicate that diabetes and inflammation promote tumor development in the absence of adipose tissue. Thus, the observed epidemiological correlation between obesity and cancer may not necessarily be due to excessive adipose tissue or its secreted adipokines, but rather to indirect consequences of obesity, i.e., insulin resistance/diabetes and/or inflammation. For details, see the article by Nunez et al. on page 5469 of this issue.
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Cancer Research
Table of Contents
Reviews
Priority Reports
Evidence of Linkage to Chromosome 9q22.33 in Colorectal Cancer Kindreds from the United Kingdom
Novel 5′ Untranslated Region Variants of BCRP mRNA Are Differentially Expressed in Drug-Selected Cancer Cells and in Normal Human Tissues: Implications for Drug Resistance, Tissue-Specific Expression, and Alternative Promoter Usage
Molecular Biology, Pathobiology, and Genetics
Cell, Tumor, and Stem Cell Biology
Membrane-Type 4 Matrix Metalloproteinase Promotes Breast Cancer Growth and Metastases
Earlier Onset of Tumoral Angiogenesis in Matrix Metalloproteinase-19–Deficient Mice
Tumor Cell–Derived and Macrophage-Derived Cathepsin B Promotes Progression and Lung Metastasis of Mammary Cancer
Progression-Specific Genes Identified by Expression Profiling of Matched Ductal Carcinomas In situ and Invasive Breast Tumors, Combining Laser Capture Microdissection and Oligonucleotide Microarray Analysis
Experimental Therapeutics, Molecular Targets, and Chemical Biology
Cyclooxygenase-2–Dependent Regulation of E-Cadherin: Prostaglandin E2 Induces Transcriptional Repressors ZEB1 and Snail in Non–Small Cell Lung Cancer
KRASD13 Promotes Apoptosis of Human Colorectal Tumor Cells by ReovirusT3D and Oxaliplatin but not by Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand
Immunology
Endocrinology
Clinical Research
DNA Methylation Changes after 5-Aza-2′-Deoxycytidine Therapy in Patients with Leukemia
Epidemiology and Prevention
Corrections
Journal Archive
Cancer Research
(1941-Present; volumes 1-current)Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)
The American Journal of Cancer
(1931-1940; volumes 15-40)Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)
The Journal of Cancer Research
(1916-1930); volumes 1-14)Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)
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