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Issues

Volume 65, Issue 6
15 March 2005
Issue Cover
All Issues
ISSN 0008-5472
EISSN 1538-7445

Cancer Research

Table of Contents


Review Article

ABL Oncogenes and Phosphoinositide 3-Kinase: Mechanism of Activation and Downstream Effectors
Michael G. Kharas; David A. Fruman
View articletitled, <em>ABL</em> Oncogenes and Phosphoinositide 3-Kinase: Mechanism of Activation and Downstream Effectors
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Priority Reports

Lower Induction of p53 and Decreased Apoptosis in NQO1-Null Mice Lead to Increased Sensitivity to Chemical-Induced Skin Carcinogenesis
Karim Iskander; Amos Gaikwad; Marilene Paquet; Delwin J. Long, II; Cory Brayton; Roberto Barrios; Anil K. Jaiswal
View articletitled, Lower Induction of p53 and Decreased Apoptosis in <em>NQO1</em>-Null Mice Lead to Increased Sensitivity to Chemical-Induced Skin Carcinogenesis
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The Antifolate Activity of Tea Catechins
Enma Navarro-Perán; Juan Cabezas-Herrera; Francisco García-Cánovas; Marcus C. Durrant; Roger N.F. Thorneley; José Neptuno Rodríguez-López
View articletitled, The Antifolate Activity of Tea Catechins
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Cell Type-Specific Tumor Suppression by Ink4a and Arf in Kras-Induced Mouse Gliomagenesis
Lene Uhrbom; Marianne Kastemar; Fredrik K. Johansson; Bengt Westermark; Eric C. Holland
View articletitled, Cell Type-Specific Tumor Suppression by <em>Ink4a</em> and <em>Arf</em> in Kras-Induced Mouse Gliomagenesis
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Genetic and Pharmacologic Identification of Akt as a Mediator of Brain-Derived Neurotrophic Factor/TrkB Rescue of Neuroblastoma Cells from Chemotherapy-Induced Cell Death
Zhijie Li; Jerry Jaboin; Phillip A. Dennis; Carol J. Thiele
View articletitled, Genetic and Pharmacologic Identification of Akt as a Mediator of Brain-Derived Neurotrophic Factor/TrkB Rescue of Neuroblastoma Cells from Chemotherapy-Induced Cell Death
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Glycogen Synthase Kinase-3β Participates in Nuclear Factor κB–Mediated Gene Transcription and Cell Survival in Pancreatic Cancer Cells
Andrei V. Ougolkov; Martin E. Fernandez-Zapico; Doris N. Savoy; Raul A. Urrutia; Daniel D. Billadeau
View articletitled, Glycogen Synthase Kinase-3β Participates in Nuclear Factor κB–Mediated Gene Transcription and Cell Survival in Pancreatic Cancer Cells
Supplementary data
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Androgen Causes Growth Suppression and Reversion of Androgen-Independent Prostate Cancer Xenografts to an Androgen-Stimulated Phenotype in Athymic Mice
Chih-pin Chuu; Richard A. Hiipakka; Junichi Fukuchi; John M. Kokontis; Shutsung Liao
View articletitled, Androgen Causes Growth Suppression and Reversion of Androgen-Independent Prostate Cancer Xenografts to an Androgen-Stimulated Phenotype in Athymic Mice
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Activated Ras Enhances Insulin-Like Growth Factor I Induction of Vascular Endothelial Growth Factor in Prostate Epithelial Cells
Mark Stearns; Jordan Tran; Mary Kay Francis; Hong Zhang; Christian Sell
View articletitled, Activated Ras Enhances Insulin-Like Growth Factor I Induction of Vascular Endothelial Growth Factor in Prostate Epithelial Cells
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Molecular Biology, Pathobiology, and Genetics

Extensive Chromosomal Instability in Rad51d-Deficient Mouse Cells
Phillip G. Smiraldo; Aaron M. Gruver; Joshua C. Osborn; Douglas L. Pittman
View articletitled, Extensive Chromosomal Instability in <em>Rad51d</em>-Deficient Mouse Cells
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C-Myc–Independent Restoration of Multiple Phenotypes by Two C-Myc Target Genes with Overlapping Functions
Krisiti Rothermund; Kenneth Rogulski; Elaine Fernandes; Amy Whiting; John Sedivy; Lixia Pu; Edward V. Prochownik
View articletitled, C-Myc–Independent Restoration of Multiple Phenotypes by Two C-Myc Target Genes with Overlapping Functions
Supplementary data
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Lack of Correlation between p53-Dependent Transcriptional Activity and the Ability to Induce Apoptosis among 179 Mutant p53s
Yuichi Kakudo; Hiroyuki Shibata; Kazunori Otsuka; Shunsuke Kato; Chikashi Ishioka
View articletitled, Lack of Correlation between p53-Dependent Transcriptional Activity and the Ability to Induce Apoptosis among 179 Mutant p53s
Supplementary data
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Discovery of Aberrant Expression of R-RAS by Cancer-Linked DNA Hypomethylation in Gastric Cancer Using Microarrays
Michiko Nishigaki; Kazuhiko Aoyagi; Inaho Danjoh; Masahide Fukaya; Kazuyoshi Yanagihara; Hiromi Sakamoto; Teruhiko Yoshida; Hiroki Sasaki
View articletitled, Discovery of Aberrant Expression of <em>R-RAS</em> by Cancer-Linked DNA Hypomethylation in Gastric Cancer Using Microarrays
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Apoptosis Factor EI24/PIG8 Is a Novel Endoplasmic Reticulum–Localized Bcl-2–Binding Protein which Is Associated with Suppression of Breast Cancer Invasiveness
Xiansi Zhao; Robert E. Ayer; Shannon L. Davis; Sarah J. Ames; Brian Florence; Cyrus Torchinsky; James S. Liou; Ling Shen; Remco A. Spanjaard
View articletitled, Apoptosis Factor EI24/PIG8 Is a Novel Endoplasmic Reticulum–Localized Bcl-2–Binding Protein which Is Associated with Suppression of Breast Cancer Invasiveness
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Functional Loss of the γ-Catenin Gene through Epigenetic and Genetic Pathways in Human Prostate Cancer
Hiroaki Shiina; Julia E. Breault; William W. Basset; Hideki Enokida; Shinji Urakami; Long-Cheng Li; Steven T. Okino; Masao Deguchi; Masanori Kaneuchi; Masaharu Terashima; Tatsuaki Yoneda; Kazushi Shigeno; Peter R. Carroll; Mikio Igawa; Rajvir Dahiya
View articletitled, Functional Loss of the <em>γ-Catenin</em> Gene through Epigenetic and Genetic Pathways in Human Prostate Cancer
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Loss of the Inactive X Chromosome and Replication of the Active X in BRCA1-Defective and Wild-type Breast Cancer Cells
Silvia M. Sirchia; Lisetta Ramoscelli; Francesca R. Grati; Floriana Barbera; Danila Coradini; Franca Rossella; Giovanni Porta; Elena Lesma; Anna Ruggeri; Paolo Radice; Giuseppe Simoni; Monica Miozzo
View articletitled, Loss of the Inactive X Chromosome and Replication of the Active X in <em>BRCA1</em>-Defective and Wild-type Breast Cancer Cells
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Molecular Staging of Cervical Lymph Nodes in Squamous Cell Carcinoma of the Head and Neck
Robert L. Ferris; Liqiang Xi; Siva Raja; Jennifer L. Hunt; Jun Wang; William E. Gooding; Lori Kelly; Jesus Ching; James D. Luketich; Tony E. Godfrey
View articletitled, Molecular Staging of Cervical Lymph Nodes in Squamous Cell Carcinoma of the Head and Neck
Supplementary data
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Cytoplasmic HuR Expression Is a Prognostic Factor in Invasive Ductal Breast Carcinoma
Mira Heinonen; Petri Bono; Kirsi Narko; Sung-Hee Chang; Johan Lundin; Heikki Joensuu; Henry Furneaux; Timothy Hla; Caj Haglund; Ari Ristimäki
View articletitled, Cytoplasmic HuR Expression Is a Prognostic Factor in Invasive Ductal Breast Carcinoma
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Human Epididymis Protein 4 (HE4) Is a Secreted Glycoprotein that Is Overexpressed by Serous and Endometrioid Ovarian Carcinomas
Ronny Drapkin; Hans Henning von Horsten; Yafang Lin; Samuel C. Mok; Christopher P. Crum; William R. Welch; Jonathan L. Hecht
View articletitled, Human Epididymis Protein 4 (HE4) Is a Secreted Glycoprotein that Is Overexpressed by Serous and Endometrioid Ovarian Carcinomas
Supplementary data
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Gene Expression Profiling Identifies Molecular Subtypes of Inflammatory Breast Cancer
François Bertucci; Pascal Finetti; Jacques Rougemont; Emmanuelle Charafe-Jauffret; Nathalie Cervera; Carole Tarpin; Catherine Nguyen; Luc Xerri; Rémi Houlgatte; Jocelyne Jacquemier; Patrice Viens; Daniel Birnbaum
View articletitled, Gene Expression Profiling Identifies Molecular Subtypes of Inflammatory Breast Cancer
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Immortalization of Primary Human Prostate Epithelial Cells by c-Myc
Jesús Gil; Preeti Kerai; Matilde Lleonart; David Bernard; Juan Cruz Cigudosa; Gordon Peters; Amancio Carnero; David Beach
View articletitled, Immortalization of Primary Human Prostate Epithelial Cells by c-Myc
Supplementary data
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p73β-Mediated Apoptosis Requires p57kip2 Induction and IEX-1 Inhibition
Susana Gonzalez; Manuel M. Perez-Perez; Eva Hernando; Manuel Serrano; Carlos Cordon-Cardo
View articletitled, p73β-Mediated Apoptosis Requires p57<sup>kip2</sup> Induction and IEX-1 Inhibition
Supplementary data
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Cell and Tumor Biology

Expression of the Carcinoembryonic Antigen Gene Is Inhibited by SOX9 in Human Colon Carcinoma Cells
Philippe Jay; Philippe Berta; Philippe Blache
View articletitled, Expression of the Carcinoembryonic Antigen Gene Is Inhibited by SOX9 in Human Colon Carcinoma Cells
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CDK4 and MDM2 Gene Alterations Mainly Occur in Highly Proliferative and Aggressive Mantle Cell Lymphomas with Wild-type INK4a/ARF Locus
Luis Hernández; Silvia Beà; Magda Pinyol; German Ott; Tiemo Katzenberger; Andreas Rosenwald; Francesc Bosch; Armando López-Guillermo; Jan Delabie; Dolors Colomer; Emili Montserrat; Elías Campo
View articletitled, <em>CDK4</em> and <em>MDM2</em> Gene Alterations Mainly Occur in Highly Proliferative and Aggressive Mantle Cell Lymphomas with Wild-type <em>INK4a/ARF</em> Locus
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Cancer/Testis Antigen Expression in Human Mesenchymal Stem Cells: Down-regulation of SSX Impairs Cell Migration and Matrix Metalloproteinase 2 Expression
Garth Cronwright; Katarina Le Blanc; Cecilia Götherström; Pádraig Darcy; Monika Ehnman; Bertha Brodin
View articletitled, Cancer/Testis Antigen Expression in Human Mesenchymal Stem Cells: Down-regulation of <em>SSX</em> Impairs Cell Migration and Matrix Metalloproteinase 2 Expression
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The E7 Protein of Cutaneous Human Papillomavirus Type 8 Causes Invasion of Human Keratinocytes into the Dermis in Organotypic Cultures of Skin
Baki Akgül; Ramón García-Escudero; Lucy Ghali; Herbert J. Pfister; Pawel G. Fuchs; Harshad Navsaria; Alan Storey
View articletitled, The E7 Protein of Cutaneous Human Papillomavirus Type 8 Causes Invasion of Human Keratinocytes into the Dermis in Organotypic Cultures of Skin
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Expression and Nuclear Location of the Transcriptional Repressor Kaiso Is Regulated by the Tumor Microenvironment
Adelheid Soubry; Jolanda van Hengel; Eef Parthoens; Cecile Colpaert; Eric Van Marck; David Waltregny; Albert B. Reynolds; Frans van Roy
View articletitled, Expression and Nuclear Location of the Transcriptional Repressor Kaiso Is Regulated by the Tumor Microenvironment
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Cyclooxygenase-2 Functions as a Downstream Mediator of Lysophosphatidic Acid to Promote Aggressive Behavior in Ovarian Carcinoma Cells
Jaime Symowicz; Brian P. Adley; Michelle M.M. Woo; Nelly Auersperg; Laurie G. Hudson; M. Sharon Stack
View articletitled, Cyclooxygenase-2 Functions as a Downstream Mediator of Lysophosphatidic Acid to Promote Aggressive Behavior in Ovarian Carcinoma Cells
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HYAL1 Hyaluronidase: A Molecular Determinant of Bladder Tumor Growth and Invasion
Vinata B. Lokeshwar; Wolfgang H. Cerwinka; Bal L. Lokeshwar
View articletitled, HYAL1 Hyaluronidase: A Molecular Determinant of Bladder Tumor Growth and Invasion
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Peroxisome Proliferator-Activated Receptor γ Inhibition Prevents Adhesion to the Extracellular Matrix and Induces Anoikis in Hepatocellular Carcinoma Cells
Katherine L. Schaefer; Koichiro Wada; Hirokazu Takahashi; Nobuyuki Matsuhashi; Shin Ohnishi; M. Michael Wolfe; Jerrold R. Turner; Atsushi Nakajima; Steven C. Borkan; Lawrence J. Saubermann
View articletitled, Peroxisome Proliferator-Activated Receptor γ Inhibition Prevents Adhesion to the Extracellular Matrix and Induces Anoikis in Hepatocellular Carcinoma Cells
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Tbx2 Is Overexpressed and Plays an Important Role in Maintaining Proliferation and Suppression of Senescence in Melanomas
Keith W. Vance; Suzanne Carreira; Gerald Brosch; Colin R. Goding
View articletitled, Tbx2 Is Overexpressed and Plays an Important Role in Maintaining Proliferation and Suppression of Senescence in Melanomas
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Dehydroepiandrosterone Can Inhibit the Proliferation of Myeloma Cells and the Interleukin-6 Production of Bone Marrow Mononuclear Cells from Patients with Myeloma
Shangqin Liu; Hideaki Ishikawa; Fu-Jun Li; Zi Ma; Ken-ichiro Otsuyama; Hideki Asaoku; Saeid Abroun; Xu Zheng; Naohiro Tsuyama; Masanori Obata; Michio M. Kawano
View articletitled, Dehydroepiandrosterone Can Inhibit the Proliferation of Myeloma Cells and the Interleukin-6 Production of Bone Marrow Mononuclear Cells from Patients with Myeloma
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Targeted Replacement of Hypoxia-Inducible Factor-1α by a Hypoxia-Inducible Factor-2α Knock-in Allele Promotes Tumor Growth
Kelly L. Covello; M. Celeste Simon; Brian Keith
View articletitled, Targeted Replacement of Hypoxia-Inducible Factor-1α by a Hypoxia-Inducible Factor-2α Knock-in Allele Promotes Tumor Growth
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Emodin Down-Regulates Androgen Receptor and Inhibits Prostate Cancer Cell Growth
Tai-Lung Cha; Lin Qiu; Chun-Te Chen; Yong Wen; Mien-Chie Hung
View articletitled, Emodin Down-Regulates Androgen Receptor and Inhibits Prostate Cancer Cell Growth
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Effect of Conditional Knockout of the Type II TGF-β Receptor Gene in Mammary Epithelia on Mammary Gland Development and Polyomavirus Middle T Antigen Induced Tumor Formation and Metastasis
Elizabeth Forrester; Anna Chytil; Brian Bierie; Mary Aakre; Agnieszka E. Gorska; Ali-Reza Sharif-Afshar; William J. Muller; Harold L. Moses
View articletitled, Effect of Conditional Knockout of the Type II <em>TGF-β</em> Receptor Gene in Mammary Epithelia on Mammary Gland Development and Polyomavirus Middle T Antigen Induced Tumor Formation and Metastasis
Supplementary data
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Human Osteocalcin and Bone Sialoprotein Mediating Osteomimicry of Prostate Cancer Cells: Role of cAMP-Dependent Protein Kinase A Signaling Pathway
Wen-Chin Huang; Zhihui Xie; Hiroyuki Konaka; Jaro Sodek; Haiyen E. Zhau; Leland W.K. Chung
View articletitled, Human Osteocalcin and Bone Sialoprotein Mediating Osteomimicry of Prostate Cancer Cells: Role of cAMP-Dependent Protein Kinase A Signaling Pathway
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IGFBP-3 Is a Direct Target of Transcriptional Regulation by ΔNp63α in Squamous Epithelium
Christopher E. Barbieri; Carmen A. Perez; Kimberly N. Johnson; Kim A. Ely; Dean Billheimer; Jennifer A. Pietenpol
View articletitled, IGFBP-3 Is a Direct Target of Transcriptional Regulation by ΔNp63α in Squamous Epithelium
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Reconstitution of Human Telomerase Reverse Transcriptase Expression Rescues Colorectal Carcinoma Cells from In vitro Senescence: Evidence against Immortality as a Constitutive Trait of Tumor Cells
Piero Dalerba; Cristiana Guiducci; Pietro Luigi Poliani; Ingrid Cifola; Mariella Parenza; Milo Frattini; Gianfrancesco Gallino; Ileana Carnevali; Ilvia Di Giulio; Salvatore Andreola; Claudia Lombardo; Licia Rivoltini; Tamás Schweighoffer; Filiberto Belli; Mario P. Colombo; Giorgio Parmiani; Chiara Castelli
View articletitled, Reconstitution of Human Telomerase Reverse Transcriptase Expression Rescues Colorectal Carcinoma Cells from <em>In vitro</em> Senescence: Evidence against Immortality as a Constitutive Trait of Tumor Cells
Supplementary data
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The Propeptide Mediates Formation of Stromal Stores of PROMIC-1: Role in Determining Prostate Cancer Outcome
Asne R. Bauskin; David A. Brown; Simon Junankar; Krishan K. Rasiah; Sarah Eggleton; Mark Hunter; Tao Liu; Dave Smith; Tamara Kuffner; Greg J. Pankhurst; Heiko Johnen; Pamela J. Russell; Wade Barret; Phillip D. Stricker; John J. Grygiel; James G. Kench; Susan M. Henshall; Robert L. Sutherland; Samuel N. Breit
View articletitled, The Propeptide Mediates Formation of Stromal Stores of PROMIC-1: Role in Determining Prostate Cancer Outcome
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Hair Follicle–Derived Blood Vessels Vascularize Tumors in Skin and Are Inhibited by Doxorubicin
Yasuyuki Amoh; Lingna Li; Meng Yang; Ping Jiang; Abdool R. Moossa; Kensei Katsuoka; Robert M. Hoffman
View articletitled, Hair Follicle–Derived Blood Vessels Vascularize Tumors in Skin and Are Inhibited by Doxorubicin
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Predominant Bcl-XL Knockdown Disables Antiapoptotic Mechanisms: Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Based Triple Chemotherapy Overcomes Chemoresistance in Pancreatic Cancer Cells In vitro
Jirong Bai; Jianhua Sui; Aram Demirjian; Charles M. Vollmer, Jr.; Wayne Marasco; Mark P. Callery
View articletitled, Predominant Bcl-XL Knockdown Disables Antiapoptotic Mechanisms: Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Based Triple Chemotherapy Overcomes Chemoresistance in Pancreatic Cancer Cells <em>In vitro</em>
Supplementary data
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Experimental Therapeutics, Molecular Targets, and Chemical Biology

Expression of Notch-1 and Its Ligands, Delta-Like-1 and Jagged-1, Is Critical for Glioma Cell Survival and Proliferation
Benjamin W. Purow; Raqeeb M. Haque; Martha W. Noel; Qin Su; Michael J. Burdick; Jeongwu Lee; Tilak Sundaresan; Sandra Pastorino; John K. Park; Irina Mikolaenko; Dragan Maric; Charles G. Eberhart; Howard A. Fine
View articletitled, Expression of Notch-1 and Its Ligands, Delta-Like-1 and Jagged-1, Is Critical for Glioma Cell Survival and Proliferation
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Modulation of Survival Signaling Pathways and Persistence of the Genotoxic Stress as a Basis for the Synergistic Interaction between the Atypical Retinoid ST1926 and the Epidermal Growth Factor Receptor Inhibitor ZD1839
Chiara Zanchi; Valentina Zuco; Cinzia Lanzi; Rosanna Supino; Franco Zunino
View articletitled, Modulation of Survival Signaling Pathways and Persistence of the Genotoxic Stress as a Basis for the Synergistic Interaction between the Atypical Retinoid ST1926 and the Epidermal Growth Factor Receptor Inhibitor ZD1839
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Selective Apoptotic Killing of Malignant Hemopoietic Cells by Antibody-Targeted Delivery of an Amphipathic Peptide
Alexandra J. Marks; Margaret S. Cooper; Robert J. Anderson; Kim H. Orchard; Geoffrey Hale; Janet M. North; Kanagasabai Ganeshaguru; Andrew J. Steele; Atul B. Mehta; Mark W. Lowdell; R. Gitendra Wickremasinghe
View articletitled, Selective Apoptotic Killing of Malignant Hemopoietic Cells by Antibody-Targeted Delivery of an Amphipathic Peptide
Supplementary data
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Increased Expression of Apoptosis Inhibitor Protein XIAP Contributes to Anoikis Resistance of Circulating Human Prostate Cancer Metastasis Precursor Cells
Olga Berezovskaya; Aaron D. Schimmer; Anna B. Glinskii; Clemencia Pinilla; Robert M. Hoffman; John C. Reed; Gennadi V. Glinsky
View articletitled, Increased Expression of Apoptosis Inhibitor Protein XIAP Contributes to Anoikis Resistance of Circulating Human Prostate Cancer Metastasis Precursor Cells
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The Tumor Bed Effect: Increased Metastatic Dissemination from Hypoxia-Induced Up-regulation of Metastasis-Promoting Gene Products
Einar K. Rofstad; Berit Mathiesen; Kristin Henriksen; Kristil Kindem; Kanthi Galappathi
View articletitled, The Tumor Bed Effect: Increased Metastatic Dissemination from Hypoxia-Induced Up-regulation of Metastasis-Promoting Gene Products
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The Seco-Taxane IDN5390 Is Able to Target Class III β-Tubulin and to Overcome Paclitaxel Resistance
Cristiano Ferlini; Giuseppina Raspaglio; Simona Mozzetti; Lucia Cicchillitti; Flavia Filippetti; Daniela Gallo; Caterina Fattorusso; Giuseppe Campiani; Giovanni Scambia
View articletitled, The Seco-Taxane IDN5390 Is Able to Target Class III β-Tubulin and to Overcome Paclitaxel Resistance
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Rapamycin Inhibits Ezrin-Mediated Metastatic Behavior in a Murine Model of Osteosarcoma
Xiaolin Wan; Arnulfo Mendoza; Chand Khanna; Lee J. Helman
View articletitled, Rapamycin Inhibits Ezrin-Mediated Metastatic Behavior in a Murine Model of Osteosarcoma
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Mutant V599EB-Raf Regulates Growth and Vascular Development of Malignant Melanoma Tumors
Arati Sharma; Nishit R. Trivedi; Melissa A. Zimmerman; David A. Tuveson; Charles D. Smith; Gavin P. Robertson
View articletitled, Mutant <sup>V599E</sup>B-Raf Regulates Growth and Vascular Development of Malignant Melanoma Tumors
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Coadministration of Histone Deacetylase Inhibitors and Perifosine Synergistically Induces Apoptosis in Human Leukemia Cells through Akt and ERK1/2 Inactivation and the Generation of Ceramide and Reactive Oxygen Species
Mohamed Rahmani; Erin Reese; Yun Dai; Cheryl Bauer; Shawn G. Payne; Paul Dent; Sarah Spiegel; Steven Grant
View articletitled, Coadministration of Histone Deacetylase Inhibitors and Perifosine Synergistically Induces Apoptosis in Human Leukemia Cells through Akt and ERK1/2 Inactivation and the Generation of Ceramide and Reactive Oxygen Species
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Antiangiogenic Concentrations of Paclitaxel Induce an Increase in Microtubule Dynamics in Endothelial Cells but Not in Cancer Cells
Eddy Pasquier; Stéphane Honore; Bertrand Pourroy; Mary Ann Jordan; Maxime Lehmann; Claudette Briand; Diane Braguer
View articletitled, Antiangiogenic Concentrations of Paclitaxel Induce an Increase in Microtubule Dynamics in Endothelial Cells but Not in Cancer Cells
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Mimicry of a Cellular Low Energy Status Blocks Tumor Cell Anabolism and Suppresses the Malignant Phenotype
Johannes V. Swinnen; Annelies Beckers; Koen Brusselmans; Sophie Organe; Joanna Segers; Leen Timmermans; Frank Vanderhoydonc; Ludo Deboel; Rita Derua; Etienne Waelkens; Ellen De Schrijver; Tine Van de Sande; Agnès Noël; Fabienne Foufelle; Guido Verhoeven
View articletitled, Mimicry of a Cellular Low Energy Status Blocks Tumor Cell Anabolism and Suppresses the Malignant Phenotype
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Immunology

Administration of IFN-α Enhances the Efficacy of a Granulocyte Macrophage Colony Stimulating Factor–Secreting Tumor Cell Vaccine
Rodney A. Prell; Betty Li; Jian Min Lin; Melinda VanRoey; Karin Jooss
View articletitled, Administration of IFN-α Enhances the Efficacy of a Granulocyte Macrophage Colony Stimulating Factor–Secreting Tumor Cell Vaccine
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Increased Populations of Regulatory T Cells in Peripheral Blood of Patients with Hepatocellular Carcinoma
Lars A. Ormandy; Tina Hillemann; Heiner Wedemeyer; Michael P. Manns; Tim F. Greten; Firouzeh Korangy
View articletitled, Increased Populations of Regulatory T Cells in Peripheral Blood of Patients with Hepatocellular Carcinoma
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Endocrinology

Conditional BRAFV600E Expression Induces DNA Synthesis, Apoptosis, Dedifferentiation, and Chromosomal Instability in Thyroid PCCL3 Cells
Norisato Mitsutake; Jeffrey A. Knauf; Shin Mitsutake; Cleo Mesa, Jr.; Lei Zhang; James A. Fagin
View articletitled, Conditional BRAF<sup>V600E</sup> Expression Induces DNA Synthesis, Apoptosis, Dedifferentiation, and Chromosomal Instability in Thyroid PCCL3 Cells
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Clinical Research

Estrogen Enhances whereas Tamoxifen Retards Development of Tsc Mouse Liver Hemangioma: A Tumor Related to Renal Angiomyolipoma and Pulmonary Lymphangioleiomyomatosis
Nisreen El-Hashemite; Victoria Walker; David J. Kwiatkowski
View articletitled, Estrogen Enhances whereas Tamoxifen Retards Development of Tsc Mouse Liver Hemangioma: A Tumor Related to Renal Angiomyolipoma and Pulmonary Lymphangioleiomyomatosis
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Epidemiology and Prevention

Methylenetetrahydrofolate Reductase Polymorphisms and Therapy Response in Pediatric Acute Lymphoblastic Leukemia
Richard Aplenc; Jennifer Thompson; Peggy Han; Mei La; Huaqing Zhao; Beverly Lange; Timothy Rebbeck
View articletitled, Methylenetetrahydrofolate Reductase Polymorphisms and Therapy Response in Pediatric Acute Lymphoblastic Leukemia
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19-Nor-1,25(OH)2D2 (a Novel, Noncalcemic Vitamin D Analogue), Combined with Arsenic Trioxide, Has Potent Antitumor Activity against Myeloid Leukemia
Takashi Kumagai; Lee-Yung Shih; Susan V. Hughes; Julian C. Desmond; James O'Kelly; Martin Hewison; H. Phillip Koeffler
View articletitled, 19-Nor-1,25(OH)<sub>2</sub>D<sub>2</sub> (a Novel, Noncalcemic Vitamin D Analogue), Combined with Arsenic Trioxide, Has Potent Antitumor Activity against Myeloid Leukemia
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Manganese Superoxide Dismutase Polymorphism, Prediagnostic Antioxidant Status, and Risk of Clinical Significant Prostate Cancer
Haojie Li; Philip W. Kantoff; Edward Giovannucci; Michael F. Leitzmann; J. Michael Gaziano; Meir J. Stampfer; Jing Ma
View articletitled, Manganese Superoxide Dismutase Polymorphism, Prediagnostic Antioxidant Status, and Risk of Clinical Significant Prostate Cancer
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Correction

STAT3, TFF3, VEGFR in Colon Cancer Cells
View articletitled, <em>STAT3</em>, <em>TFF3</em>, <em>VEGFR</em> in Colon Cancer Cells
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Journal Archive


Cancer Research

(1941-Present; volumes 1-current)

Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)

The American Journal of Cancer

(1931-1940; volumes 15-40)

Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)

The Journal of Cancer Research

(1916-1930); volumes 1-14)

Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)

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