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Issues

Volume 65, Issue 24
15 December 2005
Issue Cover
All Issues
ISSN 0008-5472
EISSN 1538-7445

Journal Archive

Cancer Research (1941-Present; volumes 1-current)

(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.

The American Journal of Cancer (1931-1940; volumes 15-40)

(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.

The Journal of Cancer Research (1916-1930); volumes 1-14)

(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Table of Contents

Editorial

It Is Time for a Human Epigenome Project
Frank J. Rauscher, III
View articletitled, It Is Time for a Human Epigenome Project
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Reviews

Anoikis and Survival Connections in the Tumor Microenvironment: Is There a Role in Prostate Cancer Metastasis?
Gabriela Rennebeck; Matthew Martelli; Natasha Kyprianou
View articletitled, Anoikis and Survival Connections in the Tumor Microenvironment: Is There a Role in Prostate Cancer Metastasis?
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Loss of Imprinting of IGF2: A Common Epigenetic Modifier of Intestinal Tumor Risk
Atsushi Kaneda; Andrew P. Feinberg
View articletitled, Loss of Imprinting of <em>IGF2</em>: A Common Epigenetic Modifier of Intestinal Tumor Risk
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Special Workshop

A Blueprint for a Human Epigenome Project: The AACR Human Epigenome Workshop
Peter A. Jones; Robert Martienssen
View articletitled, A Blueprint for a Human Epigenome Project: The AACR Human Epigenome Workshop
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Meeting Reports

Modeling Human Cancer: Report on the Eighth Beatson International Cancer Conference
Michael F. Olson
View articletitled, Modeling Human Cancer: Report on the Eighth Beatson International Cancer Conference
Supplementary data
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Seventeenth Annual Pezcoller Symposium: Molecular Understanding of Solid Tumors
Enrico Mihich; William R. Sellers
View articletitled, Seventeenth Annual Pezcoller Symposium: Molecular Understanding of Solid Tumors
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Priority Reports

Cyclophosphamide Allows for In vivo Dose Reduction of a Potent Oncolytic Virus
Hirokazu Kambara; Yoshinaga Saeki; E. Antonio Chiocca
View articletitled, Cyclophosphamide Allows for <em>In vivo</em> Dose Reduction of a Potent Oncolytic Virus
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Identification of GATA3 as a Breast Cancer Prognostic Marker by Global Gene Expression Meta-analysis
Rohit Mehra; Sooryanarayana Varambally; Lei Ding; Ronglai Shen; Michael S. Sabel; Debashis Ghosh; Arul M. Chinnaiyan; Celina G. Kleer
View articletitled, Identification of GATA3 as a Breast Cancer Prognostic Marker by Global Gene Expression Meta-analysis
Supplementary data
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TRAIL Receptor-Selective Mutants Signal to Apoptosis via TRAIL-R1 in Primary Lymphoid Malignancies
Marion MacFarlane; Susan L. Kohlhaas; Michael J. Sutcliffe; Martin J.S. Dyer; Gerald M. Cohen
View articletitled, TRAIL Receptor-Selective Mutants Signal to Apoptosis via TRAIL-R1 in Primary Lymphoid Malignancies
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Organ-Specific Increase in Mutation Accumulation and Apoptosis Rate in CuZn-Superoxide Dismutase–Deficient Mice
Rita A. Busuttil; Ana Maria Garcia; Carlos Cabrera; Armando Rodriguez; Yousin Suh; Woo Ho Kim; Ting-Ting Huang; Jan Vijg
View articletitled, Organ-Specific Increase in Mutation Accumulation and Apoptosis Rate in CuZn-Superoxide Dismutase–Deficient Mice
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Loss of Phosphatase and Tensin Homologue Increases Transforming Growth Factor β–Mediated Invasion with Enhanced SMAD3 Transcriptional Activity
Anita B. Hjelmeland; Mark D. Hjelmeland; Qing Shi; Janet L. Hart; Darell D. Bigner; Xiao-Fan Wang; Christopher D. Kontos; Jeremy N. Rich
View articletitled, Loss of Phosphatase and Tensin Homologue Increases Transforming Growth Factor β–Mediated Invasion with Enhanced SMAD3 Transcriptional Activity
Supplementary data
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Akt Phosphorylates and Regulates Pdcd4 Tumor Suppressor Protein
Alexey Palamarchuk; Alexey Efanov; Vadim Maximov; Rami I. Aqeilan; Carlo M. Croce; Yuri Pekarsky
View articletitled, Akt Phosphorylates and Regulates Pdcd4 Tumor Suppressor Protein
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Aromatase Inhibitors in Human Lung Cancer Therapy
Olga K. Weinberg; Diana C. Marquez-Garban; Michael C. Fishbein; Lee Goodglick; Hermes J. Garban; Steven M. Dubinett; Richard J. Pietras
View articletitled, Aromatase Inhibitors in Human Lung Cancer Therapy
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Checkpoint Abrogation in G2 Compromises Repair of Chromosomal Breaks in Ataxia Telangiectasia Cells
Georgia I. Terzoudi; Kaliopi N. Manola; Gabriel E. Pantelias; George Iliakis
View articletitled, Checkpoint Abrogation in G<sub>2</sub> Compromises Repair of Chromosomal Breaks in Ataxia Telangiectasia Cells
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Molecular Biology, Pathobiology, and Genetics

Mutation of Lkb1 and p53 Genes Exert a Cooperative Effect on Tumorigenesis
Chongjuan Wei; Christopher I. Amos; L. Clifton Stephens; Imelda Campos; Jian Min Deng; Richard R. Behringer; Asif Rashid; Marsha L. Frazier
View articletitled, Mutation of <em>Lkb1</em> and <em>p53</em> Genes Exert a Cooperative Effect on Tumorigenesis
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FBXO31 Is the Chromosome 16q24.3 Senescence Gene, a Candidate Breast Tumor Suppressor, and a Component of an SCF Complex
Raman Kumar; Paul M. Neilsen; Joanne Crawford; Ross McKirdy; Jaclyn Lee; Jason A. Powell; Zarqa Saif; Julie M. Martin; Marc Lombaerts; Cees J. Cornelisse; Anne-Marie Cleton-Jansen; David F. Callen
View articletitled, <em>FBXO31</em> Is the Chromosome 16q24.3 Senescence Gene, a Candidate Breast Tumor Suppressor, and a Component of an SCF Complex
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ANLN Plays a Critical Role in Human Lung Carcinogenesis through the Activation of RHOA and by Involvement in the Phosphoinositide 3-Kinase/AKT Pathway
Chie Suzuki; Yataro Daigo; Nobuhisa Ishikawa; Tatsuya Kato; Satoshi Hayama; Tomoo Ito; Eiju Tsuchiya; Yusuke Nakamura
View articletitled, ANLN Plays a Critical Role in Human Lung Carcinogenesis through the Activation of RHOA and by Involvement in the Phosphoinositide 3-Kinase/AKT Pathway
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A Putative Role for Psoriasin in Breast Tumor Progression
Ian Krop; Annette März; Hanna Carlsson; Xiaochun Li; Noga Bloushtain-Qimron; Min Hu; Rebecca Gelman; Michael S. Sabel; Stuart Schnitt; Sridhar Ramaswamy; Celina G. Kleer; Charlotta Enerbäck; Kornelia Polyak
View articletitled, A Putative Role for Psoriasin in Breast Tumor Progression
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Gene Expression Profiles Associated with Treatment Response in Oligodendrogliomas
Pim J. French; Sigrid M.A. Swagemakers; Jord H.A. Nagel; Mathilde C.M. Kouwenhoven; Eric Brouwer; Peter van der Spek; Theo M. Luider; Johan M. Kros; Martin J. van den Bent; Peter A. Sillevis Smitt
View articletitled, Gene Expression Profiles Associated with Treatment Response in Oligodendrogliomas
Supplementary data
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Mutually Exclusive Cyclin-Dependent Kinase 4/Cyclin D1 and Cyclin-Dependent Kinase 6/Cyclin D2 Pairing Inactivates Retinoblastoma Protein and Promotes Cell Cycle Dysregulation in Multiple Myeloma
Scott Ely; Maurizio Di Liberto; Ruben Niesvizky; Linda B. Baughn; Hearn J. Cho; Eunice N. Hatada; Daniel M. Knowles; Joseph Lane; Selina Chen-Kiang
View articletitled, Mutually Exclusive Cyclin-Dependent Kinase 4/Cyclin D1 and Cyclin-Dependent Kinase 6/Cyclin D2 Pairing Inactivates Retinoblastoma Protein and Promotes Cell Cycle Dysregulation in Multiple Myeloma
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Negative Regulation of TSC1-TSC2 by Mammalian D-Type Cyclins
Sima J. Zacharek; Yue Xiong; Stuart D. Shumway
View articletitled, Negative Regulation of TSC1-TSC2 by Mammalian D-Type Cyclins
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CDC4 Mutations Occur in a Subset of Colorectal Cancers but Are Not Predicted to Cause Loss of Function and Are Not Associated with Chromosomal Instability
Zoe Kemp; Andrew Rowan; William Chambers; Noel Wortham; Sarah Halford; Oliver Sieber; Neil Mortensen; Axel von Herbay; Thomas Gunther; Mohammad Ilyas; Ian Tomlinson
View articletitled, <em>CDC4</em> Mutations Occur in a Subset of Colorectal Cancers but Are Not Predicted to Cause Loss of Function and Are Not Associated with Chromosomal Instability
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Leukemogenic MLL Fusion Proteins Bind across a Broad Region of the Hox a9 Locus, Promoting Transcription and Multiple Histone Modifications
Thomas A. Milne; Mary Ellen Martin; Hugh W. Brock; Robert K. Slany; Jay L. Hess
View articletitled, Leukemogenic MLL Fusion Proteins Bind across a Broad Region of the <em>Hox a9</em> Locus, Promoting Transcription and Multiple Histone Modifications
Supplementary data
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Inducible IκB Kinase/IκB Kinase ε Expression Is Induced by CK2 and Promotes Aberrant Nuclear Factor-κB Activation in Breast Cancer Cells
Sean F. Eddy; Shangqin Guo; Elizabeth G. Demicco; Raphaëlle Romieu-Mourez; Esther Landesman-Bollag; David C. Seldin; Gail E. Sonenshein
View articletitled, Inducible IκB Kinase/IκB Kinase ε Expression Is Induced by CK2 and Promotes Aberrant Nuclear Factor-κB Activation in Breast Cancer Cells
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BRCA1 Regulates RAD51 Function in Response to DNA Damage and Suppresses Spontaneous Sister Chromatid Replication Slippage: Implications for Sister Chromatid Cohesion, Genome Stability, and Carcinogenesis
Isabelle Cousineau; Christine Abaji; Abdellah Belmaaza
View articletitled, BRCA1 Regulates RAD51 Function in Response to DNA Damage and Suppresses Spontaneous Sister Chromatid Replication Slippage: Implications for Sister Chromatid Cohesion, Genome Stability, and Carcinogenesis
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Cell and Tumor Biology

Widespread CXCR4 Activation in Astrocytomas Revealed by Phospho-CXCR4-Specific Antibodies
B. Mark Woerner; Nicole M. Warrington; Andrew L. Kung; Arie Perry; Joshua B. Rubin
View articletitled, Widespread CXCR4 Activation in Astrocytomas Revealed by Phospho-CXCR4-Specific Antibodies
Supplementary data
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Methyl CpG–Binding Domain Protein 3 Mediates Cancer-Selective Cytotoxicity by Histone Deacetylase Inhibitors via Differential Transcriptional Reprogramming in Lung Cancer Cells
Eun Joo Noh; Eun Ryoung Jang; Gajin Jeong; You Mie Lee; Churl Ki Min; Jong-Soo Lee
View articletitled, Methyl CpG–Binding Domain Protein 3 Mediates Cancer-Selective Cytotoxicity by Histone Deacetylase Inhibitors via Differential Transcriptional Reprogramming in Lung Cancer Cells
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Stepwise Neoplastic Transformation of a Telomerase Immortalized Fibroblast Cell Line
Samantha Zongaro; Elisa de Stanchina; Tina Colombo; Maurizio D'Incalci; Elena Giulotto; Chiara Mondello
View articletitled, Stepwise Neoplastic Transformation of a Telomerase Immortalized Fibroblast Cell Line
Supplementary data
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ABCC Drug Efflux Pumps and Organic Anion Uptake Transporters in Human Gliomas and the Blood-Tumor Barrier
Holger Bronger; Jörg König; Kathrin Kopplow; Hans-Herbert Steiner; Rezvan Ahmadi; Christel Herold-Mende; Dietrich Keppler; Anne T. Nies
View articletitled, ABCC Drug Efflux Pumps and Organic Anion Uptake Transporters in Human Gliomas and the Blood-Tumor Barrier
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Lysyl Oxidase Regulates Breast Cancer Cell Migration and Adhesion through a Hydrogen Peroxide–Mediated Mechanism
Stacey L. Payne; Ben Fogelgren; Angela R. Hess; Elisabeth A. Seftor; Elizabeth L. Wiley; Sheri F.T. Fong; Katalin Csiszar; Mary J.C. Hendrix; Dawn A. Kirschmann
View articletitled, Lysyl Oxidase Regulates Breast Cancer Cell Migration and Adhesion through a Hydrogen Peroxide–Mediated Mechanism
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γ-Aminobutyric Acid Inhibits Cholangiocarcinoma Growth by Cyclic AMP–Dependent Regulation of the Protein Kinase A/Extracellular Signal-Regulated Kinase 1/2 Pathway
Giammarco Fava; Luca Marucci; Shannon Glaser; Heather Francis; Sharon De Morrow; Antonio Benedetti; Domenico Alvaro; Julie Venter; Cynthia Meininger; Tushar Patel; Silvia Taffetani; Marco Marzioni; Ryun Summers; Ramona Reichenbach; Gianfranco Alpini
View articletitled, γ-Aminobutyric Acid Inhibits Cholangiocarcinoma Growth by Cyclic AMP–Dependent Regulation of the Protein Kinase A/Extracellular Signal-Regulated Kinase 1/2 Pathway
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Cyclooxygenase-2 Inhibition Sensitizes Human Colon Carcinoma Cells to TRAIL-Induced Apoptosis through Clustering of DR5 and Concentrating Death-Inducing Signaling Complex Components into Ceramide-Enriched Caveolae
Sophie Martin; Darren C. Phillips; Kinga Szekely-Szucs; Lynda Elghazi; Fabienne Desmots; Janet A. Houghton
View articletitled, Cyclooxygenase-2 Inhibition Sensitizes Human Colon Carcinoma Cells to TRAIL-Induced Apoptosis through Clustering of DR5 and Concentrating Death-Inducing Signaling Complex Components into Ceramide-Enriched Caveolae
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Development of Ewing's Sarcoma from Primary Bone Marrow–Derived Mesenchymal Progenitor Cells
Nicolò Riggi; Luisa Cironi; Paolo Provero; Mario-Luca Suvà; Konstantinos Kaloulis; Carlos Garcia-Echeverria; Francesco Hoffmann; Andreas Trumpp; Ivan Stamenkovic
View articletitled, Development of Ewing's Sarcoma from Primary Bone Marrow–Derived Mesenchymal Progenitor Cells
Supplementary data
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Inhibition of DNA Methylation Sensitizes Glioblastoma for Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Mediated Destruction
Adriana Eramo; Roberto Pallini; Fiorenza Lotti; Giovanni Sette; Mariella Patti; Monica Bartucci; Lucia Ricci-Vitiani; Michele Signore; Giorgio Stassi; Luigi M. Larocca; Lucio Crinò; Cesare Peschle; Ruggero De Maria
View articletitled, Inhibition of DNA Methylation Sensitizes Glioblastoma for Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand–Mediated Destruction
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High Expression of ErbB Family Members and Their Ligands in Lung Adenocarcinomas That Are Sensitive to Inhibition of Epidermal Growth Factor Receptor
Nobukazu Fujimoto; Marie Wislez; Jie Zhang; Kentaro Iwanaga; Jennifer Dackor; Amy E. Hanna; Shailaja Kalyankrishna; Dianna D. Cody; Roger E. Price; Mitsuo Sato; Jerry W. Shay; John D. Minna; Michael Peyton; Ximing Tang; Erminia Massarelli; Roy Herbst; David W. Threadgill; Ignacio I. Wistuba; Jonathan M. Kurie
View articletitled, High Expression of ErbB Family Members and Their Ligands in Lung Adenocarcinomas That Are Sensitive to Inhibition of Epidermal Growth Factor Receptor
Supplementary data
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The Critical Role of 15-Lipoxygenase-1 in Colorectal Epithelial Cell Terminal Differentiation and Tumorigenesis
Imad Shureiqi; Yuanqing Wu; Dongning Chen; Xiu L. Yang; Baoxiang Guan; Jeffrey S. Morris; Peiying Yang; Robert A. Newman; Russell Broaddus; Stanley R. Hamilton; Patrick Lynch; Bernard Levin; Susan M. Fischer; Scott M. Lippman
View articletitled, The Critical Role of 15-Lipoxygenase-1 in Colorectal Epithelial Cell Terminal Differentiation and Tumorigenesis
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Expression of Endogenous Oncogenic V600EB-raf Induces Proliferation and Developmental Defects in Mice and Transformation of Primary Fibroblasts
Kathryn Mercer; Susan Giblett; Stuart Green; David Lloyd; Silvy DaRocha Dias; Mark Plumb; Richard Marais; Catrin Pritchard
View articletitled, Expression of Endogenous Oncogenic <em><sup>V600E</sup>B-raf</em> Induces Proliferation and Developmental Defects in Mice and Transformation of Primary Fibroblasts
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Headpin: A Serpin with Endogenous and Exogenous Suppression of Angiogenesis
Thomas D. Shellenberger; Abhijit Mazumdar; Ying Henderson; Katrina Briggs; Mary Wang; Chandrani Chattopadhyay; Arumugam Jayakumar; Mitchell Frederick; Gary L. Clayman
View articletitled, Headpin: A Serpin with Endogenous and Exogenous Suppression of Angiogenesis
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Bortezomib Inhibits PKR-Like Endoplasmic Reticulum (ER) Kinase and Induces Apoptosis via ER Stress in Human Pancreatic Cancer Cells
Steffan T. Nawrocki; Jennifer S. Carew; Kenneth Dunner, Jr.; Lawrence H. Boise; Paul J. Chiao; Peng Huang; James L. Abbruzzese; David J. McConkey
View articletitled, Bortezomib Inhibits PKR-Like Endoplasmic Reticulum (ER) Kinase and Induces Apoptosis via ER Stress in Human Pancreatic Cancer Cells
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Tumor Cell Plasticity in Ewing Sarcoma, an Alternative Circulatory System Stimulated by Hypoxia
Daisy W.J. van der Schaft; Femke Hillen; Patrick Pauwels; Dawn A. Kirschmann; Karolien Castermans; Mirjam G.A. oude Egbrink; Maxine G.B. Tran; Rafael Sciot; Esther Hauben; Pancras C.W. Hogendoorn; Olivier Delattre; Patrick H. Maxwell; Mary J.C. Hendrix; Arjan W. Griffioen
View articletitled, Tumor Cell Plasticity in Ewing Sarcoma, an Alternative Circulatory System Stimulated by Hypoxia
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Apoptotic Cells Initiate Endothelial Cell Sprouting via Electrostatic Signaling
Zhang Weihua; Rachel Tsan; Alan J. Schroit; Isaiah J. Fidler
View articletitled, Apoptotic Cells Initiate Endothelial Cell Sprouting via Electrostatic Signaling
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The G691S RET Polymorphism Increases Glial Cell Line–Derived Neurotrophic Factor–Induced Pancreatic Cancer Cell Invasion by Amplifying Mitogen-Activated Protein Kinase Signaling
Hirozumi Sawai; Yuji Okada; Kevork Kazanjian; Joseph Kim; Sascha Hasan; Oscar J. Hines; Howard A. Reber; Dave S.B. Hoon; Guido Eibl
View articletitled, The G691S RET Polymorphism Increases Glial Cell Line–Derived Neurotrophic Factor–Induced Pancreatic Cancer Cell Invasion by Amplifying Mitogen-Activated Protein Kinase Signaling
Supplementary data
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Dentin Matrix Protein 1 Enhances Invasion Potential of Colon Cancer Cells by Bridging Matrix Metalloproteinase-9 to Integrins and CD44
Abdullah Karadag; Neal S. Fedarko; Larry W. Fisher
View articletitled, Dentin Matrix Protein 1 Enhances Invasion Potential of Colon Cancer Cells by Bridging Matrix Metalloproteinase-9 to Integrins and CD44
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Gold(III) Porphyrin 1a Induced Apoptosis by Mitochondrial Death Pathways Related to Reactive Oxygen Species
Ying Wang; Qing-Yu He; Raymond Wai-Yin Sun; Chi-Ming Che; Jen-Fu Chiu
View articletitled, Gold(III) Porphyrin 1a Induced Apoptosis by Mitochondrial Death Pathways Related to Reactive Oxygen Species
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Context-Dependent Hormone-Refractory Progression Revealed through Characterization of a Novel Murine Prostate Cancer Cell Line
Philip A. Watson; Katharine Ellwood-Yen; Jennifer C. King; John Wongvipat; Michelle M. LeBeau; Charles L. Sawyers
View articletitled, Context-Dependent Hormone-Refractory Progression Revealed through Characterization of a Novel Murine Prostate Cancer Cell Line
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Novel Role for PDEF in Epithelial Cell Migration and Invasion
Ruwanthi N. Gunawardane; Dennis C. Sgroi; Carolyn N. Wrobel; Eugene Koh; George Q. Daley; Joan S. Brugge
View articletitled, Novel Role for PDEF in Epithelial Cell Migration and Invasion
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Prognostic and Functional Significance of Thromboxane Synthase Gene Overexpression in Invasive Bladder Cancer
Omar Moussa; John S. Yordy; Hassan Abol-Enein; Debajyoti Sinha; Nabil K. Bissada; Perry V. Halushka; Mohamed A. Ghoneim; Dennis K. Watson
View articletitled, Prognostic and Functional Significance of Thromboxane Synthase Gene Overexpression in Invasive Bladder Cancer
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Differentiation of Androgen-Independent Prostate Cancer PC-3 Cells Is Associated with Increased Nuclear Factor-κB Activity
Daniel Floryk; Eliezer Huberman
View articletitled, Differentiation of Androgen-Independent Prostate Cancer PC-3 Cells Is Associated with Increased Nuclear Factor-κB Activity
Supplementary data
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Hypoxia-Induced Down-regulation of BRCA1 Expression by E2Fs
Ranjit S. Bindra; Shannon L. Gibson; Alice Meng; Ulrica Westermark; Maria Jasin; Andrew J. Pierce; Robert G. Bristow; Marie K. Classon; Peter M. Glazer
View articletitled, Hypoxia-Induced Down-regulation of <em>BRCA1</em> Expression by E2Fs
Supplementary data
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The Shed Ectodomain of Nr-CAM Stimulates Cell Proliferation and Motility, and Confers Cell Transformation
Maralice Conacci-Sorrell; Anna Kaplan; Shani Raveh; Nancy Gavert; Takeshi Sakurai; Avri Ben-Ze'ev
View articletitled, The Shed Ectodomain of Nr-CAM Stimulates Cell Proliferation and Motility, and Confers Cell Transformation
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Papillomavirus E2 Protein Induces Expression of the Matrix Metalloproteinase-9 via the Extracellular Signal-Regulated Kinase/Activator Protein-1 Signaling Pathway
Andreas Behren; Christian Simon; Roxana Michaela Schwab; Ekaterina Loetzsch; Stephan Brodbeck; Evamaria Huber; Frank Stubenrauch; Hans Peter Zenner; Thomas Iftner
View articletitled, Papillomavirus E2 Protein Induces Expression of the Matrix Metalloproteinase-9 via the Extracellular Signal-Regulated Kinase/Activator Protein-1 Signaling Pathway
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Experimental Therapeutics, Molecular Targets, and Chemical Biology

Hypoxia-Regulated Expression of Attenuated Diphtheria Toxin A Fused with Hypoxia-Inducible Factor-1α Oxygen-Dependent Degradation Domain Preferentially Induces Apoptosis of Hypoxic Cells in Solid Tumor
Nobuko Koshikawa; Keizo Takenaga
View articletitled, Hypoxia-Regulated Expression of Attenuated Diphtheria Toxin A Fused with Hypoxia-Inducible Factor-1α Oxygen-Dependent Degradation Domain Preferentially Induces Apoptosis of Hypoxic Cells in Solid Tumor
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Epidermal Growth Factor Receptor–Targeted Immunoliposomes Significantly Enhance the Efficacy of Multiple Anticancer Drugs In vivo
Christoph Mamot; Daryl C. Drummond; Charles O. Noble; Verena Kallab; Zexiong Guo; Keelung Hong; Dmitri B. Kirpotin; John W. Park
View articletitled, Epidermal Growth Factor Receptor–Targeted Immunoliposomes Significantly Enhance the Efficacy of Multiple Anticancer Drugs <em>In vivo</em>
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Cancer Cells Regulate Lymphocyte Recruitment and Leukocyte-Endothelium Interactions in the Tumor-Draining Lymph Node
Virginie Carrière; Renaud Colisson; Carine Jiguet-Jiglaire; Elisabeth Bellard; Gérard Bouche; Talal Al Saati; François Amalric; Jean-Philippe Girard; Christine M'Rini
View articletitled, Cancer Cells Regulate Lymphocyte Recruitment and Leukocyte-Endothelium Interactions in the Tumor-Draining Lymph Node
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Endothelin-1 Promotes Epithelial-to-Mesenchymal Transition in Human Ovarian Cancer Cells
Laura Rosanò; Francesca Spinella; Valeriana Di Castro; Maria Rita Nicotra; Shoukat Dedhar; Antonio Garcia de Herreros; Pier Giorgio Natali; Anna Bagnato
View articletitled, Endothelin-1 Promotes Epithelial-to-Mesenchymal Transition in Human Ovarian Cancer Cells
Supplementary data
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Bortezomib Sensitizes Pancreatic Cancer Cells to Endoplasmic Reticulum Stress-Mediated Apoptosis
Steffan T. Nawrocki; Jennifer S. Carew; Maria S. Pino; Ralph A. Highshaw; Kenneth Dunner, Jr.; Peng Huang; James L. Abbruzzese; David J. McConkey
View articletitled, Bortezomib Sensitizes Pancreatic Cancer Cells to Endoplasmic Reticulum Stress-Mediated Apoptosis
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Sphingosine Kinase-1 as a Chemotherapy Sensor in Prostate Adenocarcinoma Cell and Mouse Models
Dimitri Pchejetski; Muriel Golzio; Elisabeth Bonhoure; Cyril Calvet; Nicolas Doumerc; Virginie Garcia; Catherine Mazerolles; Pascal Rischmann; Justin Teissié; Bernard Malavaud; Olivier Cuvillier
View articletitled, Sphingosine Kinase-1 as a Chemotherapy Sensor in Prostate Adenocarcinoma Cell and Mouse Models
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Motexafin Gadolinium and Zinc Induce Oxidative Stress Responses and Apoptosis in B-Cell Lymphoma Lines
Philip S. Lecane; Mazen W. Karaman; Mint Sirisawad; Louie Naumovski; Richard A. Miller; Joseph G. Hacia; Darren Magda
View articletitled, Motexafin Gadolinium and Zinc Induce Oxidative Stress Responses and Apoptosis in B-Cell Lymphoma Lines
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Bcl-2/Adenovirus E1B 19 kDa Interacting Protein-3 Knockdown Enables Growth of Breast Cancer Metastases in the Lung, Liver, and Bone
David Manka; Zachary Spicer; David E. Millhorn
View articletitled, <em>Bcl-2</em>/Adenovirus E1B 19 kDa Interacting Protein-3 Knockdown Enables Growth of Breast Cancer Metastases in the Lung, Liver, and Bone
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Aberrant Transcription from an Unrelated Promoter Can Result in MDR-1 Expression following Drug Selection In vitro and in Relapsed Lymphoma Samples
Lyn Mickley Huff; Zheng Wang; Angel Iglesias; Tito Fojo; Jong-Seok Lee
View articletitled, Aberrant Transcription from an Unrelated Promoter Can Result in <em>MDR-1</em> Expression following Drug Selection <em>In vitro</em> and in Relapsed Lymphoma Samples
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Multiple Repair Pathways Mediate Tolerance to Chemotherapeutic Cross-linking Agents in Vertebrate Cells
Kuniharu Nojima; Helfrid Hochegger; Alihossein Saberi; Toru Fukushima; Koji Kikuchi; Michio Yoshimura; Brian J. Orelli; Douglas K. Bishop; Seiki Hirano; Mioko Ohzeki; Masamichi Ishiai; Kazuhiko Yamamoto; Minoru Takata; Hiroshi Arakawa; Jean-Marie Buerstedde; Mitsuyoshi Yamazoe; Takuo Kawamoto; Kasumi Araki; Jun A. Takahashi; Nobuo Hashimoto; Shunichi Takeda; Eiichiro Sonoda
View articletitled, Multiple Repair Pathways Mediate Tolerance to Chemotherapeutic Cross-linking Agents in Vertebrate Cells
Supplementary data
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Immunomodulatory Drug Lenalidomide (CC-5013, IMiD3) Augments Anti-CD40 SGN-40–Induced Cytotoxicity in Human Multiple Myeloma: Clinical Implications
Yu-Tzu Tai; Xian-Feng Li; Laurence Catley; Rory Coffey; Iris Breitkreutz; Jooeun Bae; Weihua Song; Klaus Podar; Teru Hideshima; Dharminder Chauhan; Robert Schlossman; Paul Richardson; Steven P. Treon; Iqbal S. Grewal; Nikhil C. Munshi; Kenneth C. Anderson
View articletitled, Immunomodulatory Drug Lenalidomide (CC-5013, IMiD3) Augments Anti-CD40 SGN-40–Induced Cytotoxicity in Human Multiple Myeloma: Clinical Implications
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BGC 945, a Novel Tumor-Selective Thymidylate Synthase Inhibitor Targeted to α-Folate Receptor–Overexpressing Tumors
David D. Gibbs; Davinder S. Theti; Nadya Wood; Matthew Green; Florence Raynaud; Melanie Valenti; Martin D. Forster; Fraser Mitchell; Vassilios Bavetsias; Elisa Henderson; Ann L. Jackman
View articletitled, BGC 945, a Novel Tumor-Selective Thymidylate Synthase Inhibitor Targeted to α-Folate Receptor–Overexpressing Tumors
Supplementary data
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Para to Ortho Repositioning of the Arsenical Moiety of the Angiogenesis Inhibitor 4-(N-(S-Glutathionylacetyl)Amino)Phenylarsenoxide Results in a Markedly Increased Cellular Accumulation and Antiproliferative Activity
Pierre J. Dilda; Stephanie Decollogne; Michael Rossiter-Thornton; Philip J. Hogg
View articletitled, <em>Para</em> to <em>Ortho</em> Repositioning of the Arsenical Moiety of the Angiogenesis Inhibitor 4-(<em>N</em>-(<em>S</em>-Glutathionylacetyl)Amino)Phenylarsenoxide Results in a Markedly Increased Cellular Accumulation and Antiproliferative Activity
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Glutathione-Related Systems and Modulation of Extracellular Signal–Regulated Kinases Are Involved in the Resistance of AGS Adenocarcinoma Gastric Cells to Diallyl Disulfide–Induced Apoptosis
Giuseppe Filomeni; Katia Aquilano; Giuseppe Rotilio; Maria R. Ciriolo
View articletitled, Glutathione-Related Systems and Modulation of Extracellular Signal–Regulated Kinases Are Involved in the Resistance of AGS Adenocarcinoma Gastric Cells to Diallyl Disulfide–Induced Apoptosis
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Immunology

Interleukin-13–regulated M2 Macrophages in Combination with Myeloid Suppressor Cells Block Immune Surveillance against Metastasis
Pratima Sinha; Virginia K. Clements; Suzanne Ostrand-Rosenberg
View articletitled, Interleukin-13–regulated M2 Macrophages in Combination with Myeloid Suppressor Cells Block Immune Surveillance against Metastasis
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Activation of Tumor-Associated Macrophages by the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid Induces an Effective CD8+ T-Cell–Mediated Antitumor Immune Response in Murine Models of Lung Cancer and Mesothelioma
Arminder S. Jassar; Eiji Suzuki; Veena Kapoor; Jing Sun; Michael B. Silverberg; Lumei Cheung; Marie D. Burdick; Robert M. Strieter; Lai-Ming Ching; Larry R. Kaiser; Steven M. Albelda
View articletitled, Activation of Tumor-Associated Macrophages by the Vascular Disrupting Agent 5,6-Dimethylxanthenone-4-Acetic Acid Induces an Effective CD8<sup>+</sup> T-Cell–Mediated Antitumor Immune Response in Murine Models of Lung Cancer and Mesothelioma
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Endocrinology

Coactivation of Liver Receptor Homologue-1 by Peroxisome Proliferator-Activated Receptor γ Coactivator-1α on Aromatase Promoter II and Its Inhibition by Activated Retinoid X Receptor Suggest a Novel Target for Breast-Specific Antiestrogen Therapy
Rachid Safi; Agnes Kovacic; Stéphanie Gaillard; Yoko Murata; Evan R. Simpson; Donald P. McDonnell; Colin D. Clyne
View articletitled, Coactivation of Liver Receptor Homologue-1 by Peroxisome Proliferator-Activated Receptor γ Coactivator-1α on Aromatase Promoter II and Its Inhibition by Activated Retinoid X Receptor Suggest a Novel Target for Breast-Specific Antiestrogen Therapy
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Epidemiology and Prevention

Sequence Variants of Toll-Like Receptor 4 and Susceptibility to Prostate Cancer
Yen-Ching Chen; Edward Giovannucci; Ross Lazarus; Peter Kraft; Shamika Ketkar; David J. Hunter
View articletitled, Sequence Variants of Toll-Like Receptor 4 and Susceptibility to Prostate Cancer
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A Prospective Study of Meat and Meat Mutagens and Prostate Cancer Risk
Amanda J. Cross; Ulrike Peters; Victoria A. Kirsh; Gerald L. Andriole; Douglas Reding; Richard B. Hayes; Rashmi Sinha
View articletitled, A Prospective Study of Meat and Meat Mutagens and Prostate Cancer Risk
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Correction

Targeting LPAAT-β in Gynecologic Cancer
View articletitled, Targeting LPAAT-β in Gynecologic Cancer
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  • Online ISSN 1538-7445
  • Print ISSN 0008-5472

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