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Cancer Research (1941-Present; volumes 1-current)

(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.

The American Journal of Cancer (1931-1940; volumes 15-40)

(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.

The Journal of Cancer Research (1916-1930); volumes 1-14)

(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Reviews

Claudin Proteins in Human Cancer: Promising New Targets for Diagnosis and Therapy

Patrice J. Morin

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Hopping around the Tumor Genome: Transposons for Cancer Gene Discovery

Lara S. Collier; David A. Largaespada

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Priority Reports

Antiandrogen Bicalutamide Promotes Tumor Growth in a Novel Androgen-Dependent Prostate Cancer Xenograft Model Derived from a Bicalutamide-Treated Patient

Toru Yoshida; Hidefumi Kinoshita; Takehiko Segawa; Eijiro Nakamura; Takahiro Inoue; Yousuke Shimizu; Toshiyuki Kamoto; Osamu Ogawa

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Adenovirus-Mediated Overexpression of REIC/Dkk-3 Selectively Induces Apoptosis in Human Prostate Cancer Cells through Activation of c-Jun-NH₂-Kinase

Fernando Abarzua; Masakiyo Sakaguchi; Mikiro Takaishi; Yasutomo Nasu; Kyouhei Kurose; Shin Ebara; Masahiro Miyazaki; Masayoshi Namba; Hiromi Kumon; Nam-ho Huh

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Telomerase Expression in Noncancerous Bronchial Epithelia Is a Possible Marker of Early Development of Lung Cancer

Yuka Matsuoka Miyazu; Teruomi Miyazawa; Keiko Hiyama; Noriaki Kurimoto; Yasuo Iwamoto; Hiroo Matsuura; Koji Kanoh; Nobuoki Kohno; Masahiko Nishiyama; Eiso Hiyama

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A Polycistronic MicroRNA Cluster, miR-17-92, Is Overexpressed in Human Lung Cancers and Enhances Cell Proliferation

Yoji Hayashita; Hirotaka Osada; Yoshio Tatematsu; Hideki Yamada; Kiyoshi Yanagisawa; Shuta Tomida; Yasushi Yatabe; Katsunobu Kawahara; Yoshitaka Sekido; Takashi Takahashi

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An In vivo Tumor Model Exploiting Metabolic Response as a Biomarker for Targeted Drug Development

Carleen Cullinane; Donna S. Dorow; Maya Kansara; Nelly Conus; David Binns; Rodney J. Hicks; Leonie K. Ashman; Grant A. McArthur; David M. Thomas

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Fine Mapping Reveals Multiple Loci and a Possible Epistatic Interaction within the Mammary Carcinoma Susceptibility Quantitative Trait Locus, Mcs5

David J. Samuelson; Beth A. Aperavich; Jill D. Haag; Michael N. Gould

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Molecular Biology, Pathobiology, and Genetics

Constitutive Activation of Akt by Flt3 Internal Tandem Duplications Is Necessary for Increased Survival, Proliferation, and Myeloid Transformation

Christian H. Brandts; Bülent Sargin; Miriam Rode; Christoph Biermann; Beate Lindtner; Joachim Schwäble; Horst Buerger; Carsten Müller-Tidow; Chunaram Choudhary; Martin McMahon; Wolfgang E. Berdel; Hubert Serve

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Novel Pheochromocytoma Susceptibility Loci Identified by Integrative Genomics

Patricia L.M. Dahia; Ke Hao; John Rogus; Christian Colin; Miguel A.G. Pujana; Ken Ross; Danielle Magoffin; Neil Aronin; Alberto Cascon; César Y. Hayashida; Cheng Li; Sérgio P.A. Toledo; Charles D. Stiles; for the Familial Pheochromocytoma Consortium

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HIN-1, an Inhibitor of Cell Growth, Invasion, and AKT Activation

Ian Krop; Michele Taylor Parker; Noga Bloushtain-Qimron; Dale Porter; Rebecca Gelman; Hidefumi Sasaki; Matthew Maurer; Mary Beth Terry; Ramon Parsons; Kornelia Polyak

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Asbestos-Induced Lung Inflammation and Epithelial Cell Proliferation Are Altered in Myeloperoxidase-Null Mice

Astrid Haegens; Albert van der Vliet; Kelly J. Butnor; Nicholas Heintz; Douglas Taatjes; David Hemenway; Pamela Vacek; Bruce A. Freeman; Stanley L. Hazen; Marie Luise Brennan; Brooke T. Mossman

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Unexpected Roles for pRb in Mouse Skin Carcinogenesis

Sergio Ruiz; Mirentxu Santos; M. Fernanda Lara; Carmen Segrelles; Claudio Ballestín; Jesús M. Paramio

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Identification of an Aberrantly Spliced Form of HDMX in Human Tumors: A New Mechanism for HDM2 Stabilization

Simona Giglio; Francesca Mancini; Francesca Gentiletti; Giorgia Sparaco; Lara Felicioni; Fabio Barassi; Carla Martella; Andrea Prodosmo; Stefano Iacovelli; Fiamma Buttitta; Antonella Farsetti; Silvia Soddu; Antonio Marchetti; Ada Sacchi; Alfredo Pontecorvi; Fabiola Moretti

Abstract

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Copy Number Aberrations in Mouse Breast Tumors Reveal Loci and Genes Important in Tumorigenic Receptor Tyrosine Kinase Signaling

J. Graeme Hodgson; Tiffany Malek; Sophia Bornstein; Sujatmi Hariono; David G. Ginzinger; William J. Muller; Joe W. Gray

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Proteolysis of CCN1 by Plasmin: Functional Implications

Usha R. Pendurthi; Tien T. Tran; Marina Post; L. Vijaya Mohan Rao

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Loss of Heterozygosity and Somatic Mutations of the Glucocorticoid Receptor Gene Are Rarely Found at Relapse in Pediatric Acute Lymphoblastic Leukemia but May Occur in a Subpopulation Early in the Disease Course

Julie A.E. Irving; Lynne Minto; Simon Bailey; Andy G. Hall

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Mutations of C-RAF Are Rare in Human Cancer because C-RAF Has a Low Basal Kinase Activity Compared with B-RAF

Victoria Emuss; Mathew Garnett; Clive Mason; The Cancer Genome Project; Richard Marais

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Cell and Tumor Biology

Cyclin E Overexpression Obstructs Infiltrative Behavior in Breast Cancer: A Novel Role Reflected in the Growth Pattern of Medullary Breast Cancers

Pontus Berglund; Maria Stighall; Karin Jirström; Signe Borgquist; Anita Sjölander; Ingrid Hedenfalk; Göran Landberg

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Induction of Early Post-Transplant Graft-versus-Leukemia Effects Using Intentionally Mismatched Donor Lymphocytes and Elimination of Alloantigen-Primed Donor Lymphocytes for Prevention of Graft-versus-Host Disease

Iris Yung; Lola Weiss; Ali Abdul-Hai; Judith Kasir; Shoshana Reich; Shimon Slavin

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Pericytes and Endothelial Precursor Cells: Cellular Interactions and Contributions to Malignancy

Rebecca G. Bagley; William Weber; Cecile Rouleau; Beverly A. Teicher

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Maternal Embryonic Leucine Zipper Kinase/Murine Protein Serine-Threonine Kinase 38 Is a Promising Therapeutic Target for Multiple Cancers

Daniel Gray; Adrian M. Jubb; Deborah Hogue; Patrick Dowd; Noelyn Kljavin; Sothy Yi; Wei Bai; Gretchen Frantz; Zemin Zhang; Hartmut Koeppen; Frederic J. de Sauvage; David P. Davis

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Expression of Frzb/Secreted Frizzled-Related Protein 3, a Secreted Wnt Antagonist, in Human Androgen-Independent Prostate Cancer PC-3 Cells Suppresses Tumor Growth and Cellular Invasiveness

Xiaolin Zi; Yi Guo; Anne R. Simoneau; Christopher Hope; Jun Xie; Randall F. Holcombe; Bang H. Hoang

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Suberoylanilide Hydroxamic Acid Enhances Gap Junctional Intercellular Communication via Acetylation of Histone Containing Connexin 43 Gene Locus

Takahiko Ogawa; Tomonori Hayashi; Masahide Tokunou; Kei Nakachi; James E. Trosko; Chia-Cheng Chang; Noriaki Yorioka

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Progestins Initiate a Luminal to Myoepithelial Switch in Estrogen-Dependent Human Breast Tumors without Altering Growth

Carol A. Sartorius; Djuana M.E. Harvell; Tianjie Shen; Kathryn B. Horwitz

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Tumor-Secreted Vascular Endothelial Growth Factor-C Is Necessary for Prostate Cancer Lymphangiogenesis, but Lymphangiogenesis Is Unnecessary for Lymph Node Metastasis

Sunny Y. Wong; Herbert Haack; Denise Crowley; Marc Barry; Roderick T. Bronson; Richard O. Hynes

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A Role for Polymerase η in the Cellular Tolerance to Cisplatin-Induced Damage

Mark R. Albertella; Catherine M. Green; Alan R. Lehmann; Mark J. O'Connor

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Tocopherol-Associated Protein Suppresses Prostate Cancer Cell Growth by Inhibition of the Phosphoinositide 3-Kinase Pathway

Jing Ni; Xingqiao Wen; Jorge Yao; Hong-Chiang Chang; Yi Yin; Min Zhang; Shaozhen Xie; Ming Chen; Brenna Simons; Philip Chang; Anthony di Sant'Agnese; Edward M. Messing; Shuyuan Yeh

Abstract

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Addressing the “Fas Counterattack” Controversy: Blocking Fas Ligand Expression Suppresses Tumor Immune Evasion of Colon Cancer In vivo

Aideen E. Ryan; Fergus Shanahan; Joe O'Connell; Aileen M. Houston

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A Network of Genetic Events Sufficient to Convert Normal Human Cells to a Tumorigenic State

S. DiSean Kendall; Corinne M. Linardic; Stacey J. Adam; Christopher M. Counter

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High Correlation of Whole-Body Red Fluorescent Protein Imaging and Magnetic Resonance Imaging on an Orthotopic Model of Pancreatic Cancer

Michael Bouvet; Joseph Spernyak; Matthew H. Katz; Richard V. Mazurchuk; Shinako Takimoto; Ralph Bernacki; Youcef M. Rustum; Abdool R. Moossa; Robert M. Hoffman

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DNA Damage Disrupts the p14ARF-B23(Nucleophosmin) Interaction and Triggers a Transient Subnuclear Redistribution of p14ARF

Casey Lee; Brian A. Smith; Keya Bandyopadhyay; Ruth A. Gjerset

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Cerebrospinal Fluid Proteomic Analysis Reveals Dysregulation of Methionine Aminopeptidase-2 Expression in Human and Mouse Neurofibromatosis 1–Associated Glioma

Biplab Dasgupta; Yijun Yi; Balazs Hegedus; Jason D. Weber; David H. Gutmann

Abstract

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Focal Adhesion Kinase Promotes the Aggressive Melanoma Phenotype

Angela R. Hess; Lynne-Marie Postovit; Naira V. Margaryan; Elisabeth A. Seftor; Galen B. Schneider; Richard E.B. Seftor; Brian J. Nickoloff; Mary J.C. Hendrix

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The Intrinsic Mitochondrial Membrane Potential of Colonic Carcinoma Cells Is Linked to the Probability of Tumor Progression

Barbara G. Heerdt; Michele A. Houston; Leonard H. Augenlicht

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Proliferation of Human Neuroblastomas Mediated by the Epidermal Growth Factor Receptor

Ruth Ho; Jane E. Minturn; Tomoro Hishiki; Huaqing Zhao; Qun Wang; Avital Cnaan; John Maris; Audrey E. Evans; Garrett M. Brodeur

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Assessment of Low Linear Energy Transfer Radiation–Induced Bystander Mutagenesis in a Three-Dimensional Culture Model

Rudranath Persaud; Hongning Zhou; Sarah E. Baker; Tom K. Hei; Eric J. Hall

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Rac3-Mediated Transformation Requires Multiple Effector Pathways

Patricia J. Keller; Christyn M. Gable; Michele R. Wing; Adrienne D. Cox

Abstract

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Up-regulation of CXCR4 Expression in PC-3 Cells by Stromal-Derived Factor-1α (CXCL12) Increases Endothelial Adhesion and Transendothelial Migration: Role of MEK/ERK Signaling Pathway–Dependent NF-κB Activation

Promil Kukreja; Asim B. Abdel-Mageed; Debasis Mondal; Kai Liu; Krishna C. Agrawal

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Focal Adhesion Kinase Regulates Syndecan-2–Mediated Tumorigenic Activity of HT1080 Fibrosarcoma Cells

Haein Park; Innoc Han; Ho Jeong Kwon; Eok-Soo Oh

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The Role of DOC-2/DAB2 in Modulating Androgen Receptor–Mediated Cell Growth via the Nongenomic c-Src–Mediated Pathway in Normal Prostatic Epithelium and Cancer

Jian Zhoul; Gina Hernandez; Szu-Wei Tu; Chien-Ling Huang; Ching-Ping Tseng; Jer-Tsong Hsieh

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Induction of Hepatocyte Growth Factor/Scatter Factor by Fibroblast Clustering Directly Promotes Tumor Cell Invasiveness

Esko Kankuri; Dana Cholujova; Monika Comajova; Antti Vaheri; Jozef Bizik

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Retinol Inhibits the Growth of All-Trans-Retinoic Acid–Sensitive and All-Trans-Retinoic Acid–Resistant Colon Cancer Cells through a Retinoic Acid Receptor–Independent Mechanism

Eun Young Park; Alice Dillard; Elizabeth A. Williams; Erik T. Wilder; M. Reese Pepper; Michelle A. Lane

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Bombesin Regulates Cyclin D1 Expression through the Early Growth Response Protein Egr-1 in Prostate Cancer Cells

Dongmei Xiao; Dharmaraj Chinnappan; Richard Pestell; Christopher Albanese; Horst Christian Weber

Abstract

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Experimental Therapeutics, Molecular Targets, and Chemical Biology

Resveratrol Inhibits Myeloma Cell Growth, Prevents Osteoclast Formation, and Promotes Osteoblast Differentiation

Patrice Boissy; Thomas L. Andersen; Basem M. Abdallah; Moustapha Kassem; Torben Plesner; Jean-Marie Delaissé

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Mammalian Target of Rapamycin, a Molecular Target in Squamous Cell Carcinomas of the Head and Neck

Panomwat Amornphimoltham; Vyomesh Patel; Akrit Sodhi; Nikolaos G. Nikitakis; John J. Sauk; Edward A. Sausville; Alfredo A. Molinolo; J. Silvio Gutkind

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Development of a Conditional In vivo Model to Evaluate the Efficacy of Small Molecule Inhibitors for the Treatment of Raf-Transformed Hematopoietic Cells

Marina Konopleva; Yuexi Shi; Linda S. Steelman; John G. Shelton; Mark Munsell; Frank Marini; Teresa McQueen; Rooha Contractor; James A. McCubrey; Michael Andreeff

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Mitochondrially Targeted p53 Has Tumor Suppressor Activities In vivo

Flaminia Talos; Oleksi Petrenko; Patricio Mena; Ute M. Moll

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Myxoma Virus Is a Novel Oncolytic Virus with Significant Antitumor Activity against Experimental Human Gliomas

Xueqing Lun; Wenqing Yang; Tommy Alain; Zhong-Qiao Shi; Huong Muzik; John W. Barrett; Grant McFadden; John Bell; Mark G. Hamilton; Donna L. Senger; Peter A. Forsyth

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The Enhanced Tumor Selectivity of an Oncolytic Vaccinia Lacking the Host Range and Antiapoptosis Genes SPI-1 and SPI-2

Z. Sheng Guo; Arpana Naik; Mark E. O'Malley; Petar Popovic; Richard Demarco; Yun Hu; Xiaoyu Yin; Shuting Yang; Herbert J. Zeh; Bernard Moss; Michael T. Lotze; David L. Bartlett

Abstract

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Doxorubicin Induces Apoptosis in Germ Line Stem Cells in the Immature Rat Testis and Amifostine Cannot Protect against This Cytotoxicity

Mi Hou; Dionisios Chrysis; Mirja Nurmio; Martti Parvinen; Staffan Eksborg; Olle Söder; Kirsi Jahnukainen

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Formation of 17-Allylamino-Demethoxygeldanamycin (17-AAG) Hydroquinone by NAD(P)H:Quinone Oxidoreductase 1: Role of 17-AAG Hydroquinone in Heat Shock Protein 90 Inhibition

Wenchang Guo; Philip Reigan; David Siegel; Joseph Zirrolli; Daniel Gustafson; David Ross

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N-Benzyladriamycin-14-Valerate (AD198) Induces Apoptosis through Protein Kinase C-δ–Induced Phosphorylation of Phospholipid Scramblase 3

Yongwen He; Jihua Liu; David Durrant; Hung-Sheng Yang; Trevor Sweatman; Leonard Lothstein; Ray M. Lee

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Epigenetic Regulation of WTH3 in Primary and Cultured Drug-Resistant Breast Cancer Cells

Kegui Tian; Vladimir Jurukovski; Xue-Ping Wang; Mark H. Kaplan; Haopeng Xu

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Immunology

Renal Cancer Treatment with Low Levels of Mixed Chimerism Induced by Nonmyeloablative Regimen Using Cyclophosphamide in Mice

Masahiko Harano; Masatoshi Eto; Toshiro Iwai; Katsunori Tatsugami; Keijiro Kiyoshima; Yoriyuki Kamiryo; Masazumi Tsuneyoshi; Yasunobu Yoshikai; Seiji Naito

Abstract

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Protein Transduction of Dendritic Cells for NY-ESO-1-Based Immunotherapy of Myeloma

Ramesh B. Batchu; Amberly M. Moreno; Susann M. Szmania; Grant Bennett; Guilio C. Spagnoli; Selvarangan Ponnazhagan; Bart Barlogie; Guido Tricot; Frits van Rhee

Abstract

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Gene Expression Profiling Identifies BAX-δ as a Novel Tumor Antigen in Acute Lymphoblastic Leukemia

Sara Maia; W. Nicholas Haining; Sascha Ansén; Zhinan Xia; Scott A. Armstrong; Nilufer P. Seth; Paolo Ghia; Monique L. den Boer; Rob Pieters; Stephen E. Sallan; Lee M. Nadler; Angelo A. Cardoso

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Tumor Cell Loaded Type-1 Polarized Dendritic Cells Induce Th1-Mediated Tumor Immunity

David A. Hokey; Adriana T. Larregina; Geza Erdos; Simon C. Watkins; Louis D. Falo, Jr.

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A Novel Strategy for the Discovery of MHC Class II–Restricted Tumor Antigens: Identification of a Melanotransferrin Helper T-Cell Epitope

Till A. Röhn; Annette Reitz; Annette Paschen; Xuan D. Nguyen; Dirk Schadendorf; Anne B. Vogt; Harald Kropshofer

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High Frequencies of Functional Tumor-Reactive T Cells in Bone Marrow and Blood of Pancreatic Cancer Patients

Friedrich H. Schmitz-Winnenthal; Christine Volk; Kaspar Z'graggen; Luis Galindo; Daniel Nummer; Yvonne Ziouta; Marianna Bucur; Jürgen Weitz; Volker Schirrmacher; Markus W. Büchler; Philipp Beckhove

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Genetic Ablation of Protein Tyrosine Phosphatase 1B Accelerates Lymphomagenesis of p53-Null Mice through the Regulation of B-Cell Development

Nadia Dubé; Annie Bourdeau; Krista M. Heinonen; Alan Cheng; Ailsa Lee Loy; Michel L. Tremblay

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Clinical Research

Application of Embryonic Lethal or Other Obvious Phenotypes to Characterize the Clinical Significance of Genetic Variants Found in Trans with Known Deleterious Mutations

Thaddeus Judkins; Brant C. Hendrickson; Amie M. Deffenbaugh; Kristilyn Eliason; Benoît Leclair; Michael J. Norton; Brian E. Ward; Dmitri Pruss; Thomas Scholl

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Quantification of Cellular Proliferation in Tumor and Normal Tissues of Patients with Breast Cancer by [¹⁸F]Fluorothymidine-Positron Emission Tomography Imaging: Evaluation of Analytical Methods

Laura M. Kenny; David M. Vigushin; Adil Al-Nahhas; Safiye Osman; Sajinder K. Luthra; Sami Shousha; R. Charles Coombes; Eric O. Aboagye

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Epidemiology and Prevention

HER2/neu-Induced Mammary Tumorigenesis and Angiogenesis Are Reduced in Cyclooxygenase-2 Knockout Mice

Louise R. Howe; Sung-Hee Chang; Kelly C. Tolle; Rachelle Dillon; Lawrence J.T. Young; Robert D. Cardiff; Robert A. Newman; Peiying Yang; Howard T. Thaler; William J. Muller; Clifford Hudis; Anthony M.C. Brown; Timothy Hla; Kotha Subbaramaiah; Andrew J. Dannenberg

Abstract

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Letter to the Editor

SV40 Detection in Human Tumor Specimens

Michele Carbone; Monica A. Rdzanek; Jennifer J. Rudzinski; Melissa A. De Marco; Maurizio Bocchetta; Maria Ramos Niño; Brooke Mossman; Harvey I. Pass

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