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Cancer Research (1941-Present; volumes 1-current)

(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.

The American Journal of Cancer (1931-1940; volumes 15-40)

(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.

The Journal of Cancer Research (1916-1930); volumes 1-14)

(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Reviews

Bisphosphonates and Cancer-Induced Bone Disease: Beyond Their Antiresorptive Activity

Philippe Clézardin; Frank H. Ebetino; Pierrick G.J. Fournier

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Targeting Medulloblastoma: Small-Molecule Inhibitors of the Sonic Hedgehog Pathway as Potential Cancer Therapeutics

Justyna Romer; Tom Curran

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Priority Reports

[^99mTcOAADT]-(CH₂)₂-NEt₂: A Potential Small-Molecule Single-Photon Emission Computed Tomography Probe for Imaging Metastatic Melanoma

Zhen Cheng; Ashfaq Mahmood; Huazhi Li; Alan Davison; Alun G. Jones

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DNA-Dependent Protein Kinase Is a Molecular Target for the Development of Noncytotoxic Radiation–Sensitizing Drugs

Eric T. Shinohara; Ling Geng; Jiahui Tan; Heidi Chen; Yu Shir; Eric Edwards; James Halbrook; Edward A. Kesicki; Adam Kashishian; Dennis E. Hallahan

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Global Gene Expression Profiling of Circulating Tumor Cells

Denis A. Smirnov; Daniel R. Zweitzig; Bradley W. Foulk; M. Craig Miller; Gerald V. Doyle; Kenneth J. Pienta; Neal J. Meropol; Louis M. Weiner; Steven J. Cohen; Jose G. Moreno; Mark C. Connelly; Leon W.M.M. Terstappen; S. Mark O'Hara

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Element Array by Scanning X-ray Fluorescence Microscopy after Cis-Diamminedichloro-Platinum(II) Treatment

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Systemic Gene-Directed Enzyme Prodrug Therapy of Hepatocellular Carcinoma Using a Targeted Adenovirus Armed with Carboxypeptidase G2

Silke Schepelmann; Paul Hallenbeck; Lesley M. Ogilvie; Douglas Hedley; Frank Friedlos; Janet Martin; Ian Scanlon; Carl Hay; Lynda K. Hawkins; Richard Marais; Caroline J. Springer

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Toll-Like Receptors on Tumor Cells Facilitate Evasion of Immune Surveillance

Bo Huang; Jie Zhao; Hongxing Li; Kai-Li He; Yibang Chen; Lloyd Mayer; Jay C. Unkeless; Huabao Xiong

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Association of Genetic Polymorphisms in the VEGF Gene with Breast Cancer Survival

Hua Lu; Xiao-Ou Shu; Yong Cui; Nobuhiko Kataoka; Wanqing Wen; Qiuyin Cai; Zhi-Xian Ruan; Yu-Tang Gao; Wei Zheng

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Plasmacytoid Dendritic Cells Induce CD8⁺ Regulatory T Cells In Human Ovarian Carcinoma

Shuang Wei; Ilona Kryczek; Linhua Zou; Ben Daniel; Pui Cheng; Peter Mottram; Tyler Curiel; Andrzej Lange; Weiping Zou

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Immunostimulatory Effects of Low-Dose Cyclophosphamide Are Controlled by Inducible Nitric Oxide Synthase

Markus Loeffler; Jörg A. Krüger; Ralph A. Reisfeld

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Molecular Biology, Pathobiology, and Genetics

Gene Expression Profiling of Microsatellite Unstable and Microsatellite Stable Endometrial Cancers Indicates Distinct Pathways of Aberrant Signaling

John I. Risinger; G. Larry Maxwell; Gadisetti V.R. Chandramouli; Olga Aprelikova; Tracy Litzi; Asad Umar; Andrew Berchuck; J. Carl Barrett

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Coexpression of Cyclooxygenases (COX-1, COX-2) and Vascular Endothelial Growth Factors (VEGF-A, VEGF-C) in Esophageal Adenocarcinoma

Burkhard H.A. von Rahden; Hubert J. Stein; Franziska Pühringer; Ina Koch; Rupert Langer; Guido Piontek; J. Rüdiger Siewert; Heinz Höfler; Mario Sarbia

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In vitro Modeling of Human Pancreatic Duct Epithelial Cell Transformation Defines Gene Expression Changes Induced by K-ras Oncogenic Activation in Pancreatic Carcinogenesis

Jiaying Qian; Jiangong Niu; Ming Li; Paul J. Chiao; Ming-Sound Tsao

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Identification of a Genetic Signature of Activated Signal Transducer and Activator of Transcription 3 in Human Tumors

James V. Alvarez; Phillip G. Febbo; Sridhar Ramaswamy; Massimo Loda; Andrea Richardson; David A. Frank

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Bcl-2 Acts in a Proangiogenic Signaling Pathway through Nuclear Factor-κB and CXC Chemokines

Elisabeta Karl; Kristy Warner; Benjamin Zeitlin; Tomoatsu Kaneko; Lindsey Wurtzel; Taocong Jin; Jia Chang; Shaomeng Wang; Cun-Yu Wang; Robert M. Strieter; Gabriel Nunez; Peter J. Polverini; Jacques E. Nör

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Meningioma Transcript Profiles Reveal Deregulated Notch Signaling Pathway

Ileana C. Cuevas; Alison L. Slocum; Peter Jun; Joseph F. Costello; Andrew W. Bollen; Gregory J. Riggins; Michael W. McDermott; Anita Lal

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TP53 and KRAS Mutation Load and Types in Lung Cancers in Relation to Tobacco Smoke: Distinct Patterns in Never, Former, and Current Smokers

Florence Le Calvez; Anush Mukeria; Jay D. Hunt; Olaf Kelm; Rayjean J. Hung; Philippe Tanière; Paul Brennan; Paolo Boffetta; David G. Zaridze; Pierre Hainaut

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Novel Cellular Genes Essential for Transformation of Endothelial Cells by Kaposi's Sarcoma–Associated Herpesvirus

Camilo Raggo; Rebecca Ruhl; Shane McAllister; Henry Koon; Bruce J. Dezube; Klaus Früh; Ashlee V. Moses

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A Genomic Map of p53 Binding Sites Identifies Novel p53 Targets Involved in an Apoptotic Network

Chaouki Miled; Marco Pontoglio; Serge Garbay; Moshe Yaniv; Jonathan B. Weitzman

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Characterization of Common CYP1B1 Variants with Different Capacity for Benzo[a]pyrene-7,8-Dihydrodiol Epoxide Formation from Benzo[a]pyrene

Eleni Aklillu; Steinar Øvrebø; Ingrid V. Botnen; Charlotta Otter; Magnus Ingelman-Sundberg

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Cell and Tumor Biology

Heightened Expression of CTCF in Breast Cancer Cells Is Associated with Resistance to Apoptosis

France Docquier; Dawn Farrar; Vivien D'Arcy; Igor Chernukhin; Abigail F. Robinson; Dmitry Loukinov; Sergei Vatolin; Svetlana Pack; Alan Mackay; Robert A. Harris; Heather Dorricott; Michael J. O'Hare; Victor Lobanenkov; Elena Klenova

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Secreted Protein Acidic and Rich in Cysteine Produced by Human Melanoma Cells Modulates Polymorphonuclear Leukocyte Recruitment and Antitumor Cytotoxic Capacity

Mariano J. Alvarez; Federico Prada; Edgardo Salvatierra; Alicia I. Bravo; Viviana P. Lutzky; Cecilia Carbone; Fernando J. Pitossi; H. Eduardo Chuluyan; Osvaldo L. Podhajcer

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Early Growth Response 1 Acts as a Tumor Suppressor In vivo and In vitro via Regulation of p53

Anja Krones-Herzig; Shalu Mittal; Kelly Yule; Hongyan Liang; Chris English; Rafael Urcis; Tarun Soni; Eileen D. Adamson; Dan Mercola

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Two Functional Epitopes of Pigment Epithelial–Derived Factor Block Angiogenesis and Induce Differentiation in Prostate Cancer

Stephanie Filleur; Karl Volz; Thomas Nelius; Yelena Mirochnik; Hanhua Huang; Tetiana A. Zaichuk; Maria S. Aymerich; Sofia P. Becerra; Ronald Yap; Dorina Veliceasa; Emelyn H. Shroff; Olga V. Volpert

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Up-Regulation of TWIST in Prostate Cancer and Its Implication as a Therapeutic Target

Wai Kei Kwok; Ming-Tat Ling; Tak-Wing Lee; Tracy C.M. Lau; Chun Zhou; Xiaomeng Zhang; Chee Wai Chua; Kwok W. Chan; Franky L. Chan; Carlotta Glackin; Yong-Chuan Wong; Xianghong Wang

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Spatial Heterogeneity and Oxygen Dependence of Glucose Consumption in R3230Ac and Fibrosarcomas of the Fischer 344 Rat

Thies Schroeder; Hong Yuan; Benjamin L. Viglianti; Cathryn Peltz; Shubha Asopa; Zeljko Vujaskovic; Mark W. Dewhirst

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Somatic Induction of Pten Loss in a Preclinical Astrocytoma Model Reveals Major Roles in Disease Progression and Avenues for Target Discovery and Validation

Andrew Xiao; Chaoying Yin; Chunyu Yang; Antonio Di Cristofano; Pier Paolo Pandolfi; Terry Van Dyke

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Loss of the Forkhead Transcription Factor FoxM1 Causes Centrosome Amplification and Mitotic Catastrophe

Diane R. Wonsey; Maximillian T. Follettie

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Cathepsin D Is a Potential Serum Marker for Poor Prognosis in Glioma Patients

Mieko E. Fukuda; Yasuo Iwadate; Toshio Machida; Takaki Hiwasa; Yoshinori Nimura; Yuichiro Nagai; Masaki Takiguchi; Hideki Tanzawa; Akira Yamaura; Naohiko Seki

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Tumor-Associated NH₂-Terminal Fragments Are the Most Stable Part of the Adenomatous Polyposis Coli Protein and Can Be Regulated by Interactions with COOH-Terminal Domains

Zhuoyu Li; Inke S. Näthke

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A Novel Function for Galectin-7: Promoting Tumorigenesis by Up-regulating MMP-9 Gene Expression

Mélanie Demers; Thierry Magnaldo; Yves St-Pierre

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Tumor Cyclooxygenase-2/Prostaglandin E₂–Dependent Promotion of FOXP3 Expression and CD4⁺CD25⁺ T Regulatory Cell Activities in Lung Cancer

Sherven Sharma; Seok-Chul Yang; Li Zhu; Karen Reckamp; Brian Gardner; Felicita Baratelli; Min Huang; Raj K. Batra; Steven M. Dubinett

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Silencing of Epidermal Growth Factor Receptor Suppresses Hypoxia-Inducible Factor-2–Driven VHL^−/− Renal Cancer

Karlene Smith; Lakshman Gunaratnam; Melissa Morley; Aleksandra Franovic; Karim Mekhail; Stephen Lee

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Three-dimensional High-Frequency Ultrasound Imaging for Longitudinal Evaluation of Liver Metastases in Preclinical Models

Kevin C. Graham; Lauren A. Wirtzfeld; Lisa T. MacKenzie; Carl O. Postenka; Alan C. Groom; Ian C. MacDonald; Aaron Fenster; James C. Lacefield; Ann F. Chambers

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Heat Shock Protein 70 Surface-Positive Tumor Exosomes Stimulate Migratory and Cytolytic Activity of Natural Killer Cells

Robert Gastpar; Mathias Gehrmann; Maria A. Bausero; Alexzander Asea; Catharina Gross; Josef A. Schroeder; Gabriele Multhoff

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Sensitization of Glioma Cells to Fas-Dependent Apoptosis by Chemotherapy-Induced Oxidative Stress

Shuli Xia; Eliot M. Rosen; John Laterra

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SV40-Dependent AKT Activity Drives Mesothelial Cell Transformation after Asbestos Exposure

Paola Cacciotti; Dario Barbone; Camillo Porta; Deborah A. Altomare; Joseph R. Testa; Luciano Mutti; Giovanni Gaudino

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A Human- and Male-Specific Protocadherin that Acts through the Wnt Signaling Pathway to Induce Neuroendocrine Transdifferentiation of Prostate Cancer Cells

Xuezhen Yang; Min-Wei Chen; Stephane Terry; Francis Vacherot; Dominique K. Chopin; Debra L. Bemis; Jan Kitajewski; Mitchell C. Benson; Yinglu Guo; Ralph Buttyan

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4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone from Cigarette Smoke Stimulates Colon Cancer Growth via β-Adrenoceptors

William K.K. Wu; Helen P.S. Wong; Shi W. Luo; Kevin Chan; Fung Y. Huang; Marco K.C. Hui; Emily K.Y. Lam; Vivian Y. Shin; Yi N. Ye; Ying H. Yang; Chi H. Cho

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Experimental Therapeutics, Molecular Targets, and Chemical Biology

Macrophages Promote the Invasion of Breast Carcinoma Cells via a Colony-Stimulating Factor-1/Epidermal Growth Factor Paracrine Loop

Sumanta Goswami; Erik Sahai; Jeffrey B. Wyckoff; Michael Cammer; Dianne Cox; Fiona J. Pixley; E. Richard Stanley; Jeffrey E. Segall; John S. Condeelis

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Survivin-Responsive Conditionally Replicating Adenovirus Exhibits Cancer-Specific and Efficient Viral Replication

Junichi Kamizono; Satoshi Nagano; Yoshiteru Murofushi; Setsuro Komiya; Hisayoshi Fujiwara; Toyojiro Matsuishi; Ken-ichiro Kosai

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Targeted Measles Virus Vector Displaying Echistatin Infects Endothelial Cells via αvβ3 and Leads to Tumor Regression

Louay K. Hallak; Jaime R. Merchan; Chris M. Storgard; Joseph C. Loftus; Stephen J. Russell

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Expression of Siva-1 Protein or Its Putative Amphipathic Helical Region Enhances Cisplatin-Induced Apoptosis in Breast Cancer Cells: Effect of Elevated Levels of BCL-2

Fei Chu; John Barkinge; Sarah Hawkins; Radhika Gudi; Ravi Salgia; Prasad V.S. Kanteti

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Inhibition of DNA Repair by a Herpes Simplex Virus Vector Enhances the Radiosensitivity of Human Glioblastoma Cells

Costas G. Hadjipanayis; Neal A. DeLuca

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Nanoparticle Targeting of Anticancer Drug Improves Therapeutic Response in Animal Model of Human Epithelial Cancer

Jolanta F. Kukowska-Latallo; Kimberly A. Candido; Zhengyi Cao; Shraddha S. Nigavekar; Istvan J. Majoros; Thommey P. Thomas; Lajos P. Balogh; Mohamed K. Khan; James R. Baker, Jr.

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Antitumor Activity of Rapamycin in a Transgenic Mouse Model of ErbB2-Dependent Human Breast Cancer

Mei Liu; Amy Howes; Jacqueline Lesperance; William B. Stallcup; Craig A. Hauser; Kuniko Kadoya; Robert G. Oshima; Robert T. Abraham

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DNA-Protein Cross-links and Replication-Dependent Histone H2AX Phosphorylation Induced by Aminoflavone (NSC 686288), a Novel Anticancer Agent Active against Human Breast Cancer Cells

Ling-hua Meng; Glenda Kohlhagen; Zhi-yong Liao; Smitha Antony; Edward Sausville; Yves Pommier

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The Antitumor Enediyne C-1027 Alters Cell Cycle Progression and Induces Chromosomal Aberrations and Telomere Dysfunction

Mary M. McHugh; Loretta S. Gawron; Sei-Ichi Matsui; Terry A. Beerman

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Nestin-Linked Green Fluorescent Protein Transgenic Nude Mouse for Imaging Human Tumor Angiogenesis

Yasuyuki Amoh; Meng Yang; Lingna Li; Jose Reynoso; Michael Bouvet; Abdool R. Moossa; Kensei Katsuoka; Robert M. Hoffman

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SKI-606, a Src/Abl Inhibitor with In vivo Activity in Colon Tumor Xenograft Models

Jennifer M. Golas; Judy Lucas; Carlo Etienne; Jonathan Golas; Carolyn Discafani; Latha Sridharan; Erwin Boghaert; Kim Arndt; Fei Ye; Diane H. Boschelli; Fangbiao Li; Craig Titsch; Christine Huselton; Inder Chaudhary; Frank Boschelli

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In vitro Procoagulant Activity Induced in Endothelial Cells by Chemotherapy and Antiangiogenic Drug Combinations: Modulation by Lower-Dose Chemotherapy

Li Ma; Giulio Francia; Alicia Viloria-Petit; Daniel J. Hicklin; Jeanne du Manoir; Janusz Rak; Robert S. Kerbel

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Enhanced Susceptibility of Irradiated Tumor Vessels to Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibition

Daniel Zips; Wolfgang Eicheler; Peter Geyer; Franziska Hessel; Annegret Dörfler; Howard D. Thames; Martin Haberey; Michael Baumann

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Activation of Mitogen-Activated Protein Kinase in Xenografts and Cells during Prolonged Treatment with Aromatase Inhibitor Letrozole

Danijela Jelovac; Gauri Sabnis; Brian J. Long; Luciana Macedo; Olga G. Goloubeva; Angela M.H. Brodie

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Potent Modulation of Intestinal Tumorigenesis in Apc^min/+ Mice by the Polyamine Catabolic Enzyme Spermidine/Spermine N¹-acetyltransferase

Jody M. Tucker; John T. Murphy; Nicholas Kisiel; Paula Diegelman; Karen W. Barbour; Celestia Davis; Moussumi Medda; Leena Alhonen; Juhani Jänne; Debora L. Kramer; Carl W. Porter; Franklin G. Berger

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Seliciclib (CYC202, R-Roscovitine) Induces Cell Death in Multiple Myeloma Cells by Inhibition of RNA Polymerase II–Dependent Transcription and Down-regulation of Mcl-1

David E. MacCallum; Jean Melville; Sheelagh Frame; Kathryn Watt; Sian Anderson; Athos Gianella-Borradori; David P. Lane; Simon R. Green

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Calcium/Calmodulin-Dependent Kinase I and Calcium/Calmodulin-Dependent Kinase Kinase Participate in the Control of Cell Cycle Progression in MCF-7 Human Breast Cancer Cells

Oswaldo G. Rodriguez-Mora; Michelle M. LaHair; James A. McCubrey; Richard A. Franklin

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Immunology

Artificial Antigen-Presenting Cells Transduced with Telomerase Efficiently Expand Epitope-Specific, Human Leukocyte Antigen–Restricted Cytotoxic T Cells

Jakob Dupont; Jean-Baptiste Latouche; Chia Ma; Michel Sadelain

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Glioblastomas Induce T-Lymphocyte Death by Two Distinct Pathways Involving Gangliosides and CD70

Ali Chahlavi; Patricia Rayman; Amy L. Richmond; Kaushik Biswas; Renliang Zhang; Michael Vogelbaum; Charles Tannenbaum; Gene Barnett; James H. Finke

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Endocrinology

Additive Antitumor Effect of Aromatase Inhibitor Letrozole and Antiestrogen Fulvestrant in a Postmenopausal Breast Cancer Model

Danijela Jelovac; Luciana Macedo; Olga G. Goloubeva; Venkatesh Handratta; Angela M.H. Brodie

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The Androgen Derivative 5α-Androstane-3β,17β-Diol Inhibits Prostate Cancer Cell Migration Through Activation of the Estrogen Receptor β Subtype

Vittoria Guerini; Daniela Sau; Eugenia Scaccianoce; Paola Rusmini; Paolo Ciana; Adriana Maggi; Paolo G.V. Martini; Benita S. Katzenellenbogen; Luciano Martini; Marcella Motta; Angelo Poletti

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Clinical Research

Inactivation of Myc in Murine Two-Hit B lymphomas Causes Dormancy with Elevated Levels of Interleukin 10 Receptor and CD20: Implications for Adjuvant Therapies

Duonan Yu; Michael Dews; Andrea Park; John W. Tobias; Andrei Thomas-Tikhonenko

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Epidemiology

Individual Variation of Somatic Gene Mutability in Relation to Cancer Susceptibility: Prospective Study on Erythrocyte Glycophorin A Gene Mutations of Atomic Bomb Survivors

Seishi Kyoizumi; Yoichiro Kusunoki; Tomonori Hayashi; Masayuki Hakoda; John B. Cologne; Kei Nakachi

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Sun Exposure, Vitamin D Receptor Gene Polymorphisms, and Risk of Advanced Prostate Cancer

Esther M. John; Gary G. Schwartz; Jocelyn Koo; David Van Den Berg; Sue A. Ingles

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Corrections

E2F Regulates Topoisomerase IIβ

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RASSF1 Tumor Suppressor Gene

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Retraction

Retraction: Article on Estrogen Receptor β in Ovarian Carcinogenesis

Gwendal Lazennec

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