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Issues

Volume 64, Issue 23
1 December 2004
Issue Cover
All Issues
ISSN 0008-5472
EISSN 1538-7445

Journal Archive

Cancer Research (1941-Present; volumes 1-current)

(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.

The American Journal of Cancer (1931-1940; volumes 15-40)

(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.

The Journal of Cancer Research (1916-1930); volumes 1-14)

(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Table of Contents

Review

Shark Cartilage, Cancer and the Growing Threat of Pseudoscience
Gary K. Ostrander; Keith C. Cheng; Jeffrey C. Wolf; Marilyn J. Wolfe
View articletitled, Shark Cartilage, Cancer and the Growing Threat of Pseudoscience
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Advances in Brief

Bone Marrow Contribution to Tumor-Associated Myofibroblasts and Fibroblasts
Natalie C. Direkze; Kairbaan Hodivala-Dilke; Rosemary Jeffery; Toby Hunt; Richard Poulsom; Dahmane Oukrif; Malcolm R. Alison; Nicholas A. Wright
View articletitled, Bone Marrow Contribution to Tumor-Associated Myofibroblasts and Fibroblasts
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Role of a BCL9-Related β-Catenin-Binding Protein, B9L, in Tumorigenesis Induced by Aberrant Activation of Wnt Signaling
Shungo Adachi; Takafumi Jigami; Toshio Yasui; Tetsuhiro Nakano; Susumu Ohwada; Yoshihiro Omori; Sumio Sugano; Bisei Ohkawara; Hiroshi Shibuya; Tsutomu Nakamura; Tetsu Akiyama
View articletitled, Role of a BCL9-Related β-Catenin-Binding Protein, B9L, in Tumorigenesis Induced by Aberrant Activation of Wnt Signaling
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TRAIL Inhibits Tumor Growth but Is Nontoxic to Human Hepatocytes in Chimeric Mice
Chunhai Hao; Jin H. Song; Belinda Hsi; Jamie Lewis; Doyoun K. Song; Kenneth C. Petruk; David L. J. Tyrrell; Norman M. Kneteman
View articletitled, TRAIL Inhibits Tumor Growth but Is Nontoxic to Human Hepatocytes in Chimeric Mice
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Identification of a Binding Partner for the Endothelial Cell Surface Proteins TEM7 and TEM7R
Akash Nanda; Phillip Buckhaults; Steven Seaman; Nishant Agrawal; Paula Boutin; Srinivas Shankara; Mariana Nacht; Beverly Teicher; Jason Stampfl; Sujay Singh; Bert Vogelstein; Kenneth W. Kinzler; Brad St. Croix
View articletitled, Identification of a Binding Partner for the Endothelial Cell Surface Proteins TEM7 and TEM7R
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2-(8-Hydroxy-6-methoxy-1-oxo-1Η-2-benzopyran-3-yl)propionic Acid, a Small Molecule Isocoumarin, Potentiates Dexamethasone-Induced Apoptosis of Human Multiple Myeloma Cells
Naoki Agata; Hiroko Nogi; Michael Milhollen; Surender Kharbanda; Donald Kufe
View articletitled, 2-(8-Hydroxy-6-methoxy-1-oxo-1Η-2-benzopyran-3-yl)propionic Acid, a Small Molecule Isocoumarin, Potentiates Dexamethasone-Induced Apoptosis of Human Multiple Myeloma Cells
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Analysis of Diepoxide-Specific Cyclic N-Terminal Globin Adducts in Mice and Rats after Inhalation Exposure to 1,3-Butadiene
Gunnar Boysen; Nadia I. Georgieva; Patricia B. Upton; Karupiah Jayaraj; Yutai Li; Vernon E. Walker; James A. Swenberg
View articletitled, Analysis of Diepoxide-Specific Cyclic <strong><em>N</em></strong>-Terminal Globin Adducts in Mice and Rats after Inhalation Exposure to 1,3-Butadiene
Supplementary data
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Spermine Oxidation Induced by Helicobacter pylori Results in Apoptosis and DNA Damage: Implications for Gastric Carcinogenesis
Hangxiu Xu; Rupesh Chaturvedi; Yulan Cheng; Francoise I. Bussiere; Mohammad Asim; Micheal D. Yao; Darryn Potosky; Stephen J. Meltzer; Juong G. Rhee; Sung S. Kim; Steven F. Moss; Amy Hacker; Yanlin Wang; Robert A. Casero, Jr.; Keith T. Wilson
View articletitled, Spermine Oxidation Induced by <strong><em>Helicobacter pylori</em></strong> Results in Apoptosis and DNA Damage<span class="subtitle-colon">: </span><span class="subtitle">Implications for Gastric Carcinogenesis</span>
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Molecular Biology, Pathobiology, and Genetics

Defective DNA Strand Break Repair after DNA Damage in Prostate Cancer Cells: Implications for Genetic Instability and Prostate Cancer Progression
Rong Fan; Tirukalikundram S. Kumaravel; Farid Jalali; Paula Marrano; Jeremy A. Squire; Robert G. Bristow
View articletitled, Defective DNA Strand Break Repair after DNA Damage in Prostate Cancer Cells<span class="subtitle-colon">: </span><span class="subtitle">Implications for Genetic Instability and Prostate Cancer Progression</span>
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Prognostic Relevance of Gene Amplifications and Coamplifications in Breast Cancer
Khawla Al-Kuraya; Peter Schraml; Joachim Torhorst; Coya Tapia; Boriana Zaharieva; Hedvika Novotny; Hanspeter Spichtin; Robert Maurer; Martina Mirlacher; Ossi Köchli; Markus Zuber; Holger Dieterich; Friedrich Mross; Kim Wilber; Ronald Simon; Guido Sauter
View articletitled, Prognostic Relevance of Gene Amplifications and Coamplifications in Breast Cancer
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Array Comparative Genomic Hybridization Analysis of Genomic Alterations in Breast Cancer Subtypes
Lenora W. M. Loo; Douglas I. Grove; Eleanor M. Williams; Cassandra L. Neal; Laura A. Cousens; Elizabeth L. Schubert; Ilona N. Holcomb; Hillary F. Massa; Jeri Glogovac; Christopher I. Li; Kathleen E. Malone; Janet R. Daling; Jeffrey J. Delrow; Barbara J. Trask; Li Hsu; Peggy L. Porter
View articletitled, Array Comparative Genomic Hybridization Analysis of Genomic Alterations in Breast Cancer Subtypes
Supplementary data
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Analysis of Gene Expression Patterns and Chromosomal Changes Associated with Aging
Jochen B. Geigl; Sabine Langer; Simone Barwisch; Katrin Pfleghaar; Gaby Lederer; Michael R. Speicher
View articletitled, Analysis of Gene Expression Patterns and Chromosomal Changes Associated with Aging
Supplementary data
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Gene Expression Profiling for Molecular Characterization of Inflammatory Breast Cancer and Prediction of Response to Chemotherapy
François Bertucci; Pascal Finetti; Jacques Rougemont; Emmanuelle Charafe-Jauffret; Valéry Nasser; Béatrice Loriod; Jacques Camerlo; Rebecca Tagett; Carole Tarpin; Gilles Houvenaeghel; Catherine Nguyen; Dominique Maraninchi; Jocelyne Jacquemier; Rémi Houlgatte; Daniel Birnbaum; Patrice Viens
View articletitled, Gene Expression Profiling for Molecular Characterization of Inflammatory Breast Cancer and Prediction of Response to Chemotherapy
Supplementary data
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Gene Expression in the Lung of p53 Mutant Mice Exposed to Cigarette Smoke
Alberto Izzotti; Cristina Cartiglia; Mariagrazia Longobardi; Maria Bagnasco; Andrea Merello; Ming You; Ronald A. Lubet; Silvio De Flora
View articletitled, Gene Expression in the Lung of <strong><em>p53</em></strong> Mutant Mice Exposed to Cigarette Smoke
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Cell and Tumor Biology

Overexpression of Activating Transcription Factor-2 Is Required for Tumor Growth and Progression in Mouse Skin Tumors
Paraskevi Papassava; Vassilis G. Gorgoulis; Dimitra Papaevangeliou; Spiros Vlahopoulos; Hans van Dam; Vassilis Zoumpourlis
View articletitled, Overexpression of Activating Transcription Factor-2 Is Required for Tumor Growth and Progression in Mouse Skin Tumors
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Identification and Testing of a Gene Expression Signature of Invasive Carcinoma Cells within Primary Mammary Tumors
Weigang Wang; Sumanta Goswami; Kyle Lapidus; Amber L. Wells; Jeffrey B. Wyckoff; Erik Sahai; Robert H. Singer; Jeffrey E. Segall; John S. Condeelis
View articletitled, Identification and Testing of a Gene Expression Signature of Invasive Carcinoma Cells within Primary Mammary Tumors
Supplementary data
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In vitro and In vivo Models Analyzing von Hippel-Lindau Disease-Specific Mutations
W. Kimryn Rathmell; Michele M. Hickey; Natalie A. Bezman; Christie A. Chmielecki; Natalie C. Carraway; M. Celeste Simon
View articletitled, <strong><em>In vitro</em></strong> and <strong><em>In vivo</em></strong> Models Analyzing von Hippel-Lindau Disease-Specific Mutations
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CXCR4 Regulates Growth of Both Primary and Metastatic Breast Cancer
Matthew C. P. Smith; Kathryn E. Luker; Joel R. Garbow; Julie L. Prior; Erin Jackson; David Piwnica-Worms; Gary D. Luker
View articletitled, CXCR4 Regulates Growth of Both Primary and Metastatic Breast Cancer
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Coagulation Facilitates Tumor Cell Spreading in the Pulmonary Vasculature during Early Metastatic Colony Formation
Jae Hong Im; Weili Fu; Hui Wang; Sujata K. Bhatia; Daniel A. Hammer; M. Anna Kowalska; Ruth J. Muschel
View articletitled, Coagulation Facilitates Tumor Cell Spreading in the Pulmonary Vasculature during Early Metastatic Colony Formation
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Increased Insulin-Like Growth Factor I Receptor Expression and Signaling Are Components of Androgen-Independent Progression in a Lineage-Derived Prostate Cancer Progression Model
Sandra L. Krueckl; Robert A. Sikes; N. Magnus Edlund; Robert H. Bell; Antonio Hurtado-Coll; Ladan Fazli; Martin E. Gleave; Michael E. Cox
View articletitled, Increased Insulin-Like Growth Factor I Receptor Expression and Signaling Are Components of Androgen-Independent Progression in a Lineage-Derived Prostate Cancer Progression Model
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Loss of Neural Cell Adhesion Molecule Induces Tumor Metastasis by Up-regulating Lymphangiogenesis
Ivana Crnic; Karin Strittmatter; Ugo Cavallaro; Lucie Kopfstein; Lotta Jussila; Kari Alitalo; Gerhard Christofori
View articletitled, Loss of Neural Cell Adhesion Molecule Induces Tumor Metastasis by Up-regulating Lymphangiogenesis
Supplementary data
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Phosphorylation of the Eukaryotic Translation Initiation Factor eIF4E Contributes to Its Transformation and mRNA Transport Activities
Ivan Topisirovic; Melisa Ruiz-Gutierrez; Katherine L. B. Borden
View articletitled, Phosphorylation of the Eukaryotic Translation Initiation Factor eIF4E Contributes to Its Transformation and mRNA Transport Activities
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Elevated Flk1 (Vascular Endothelial Growth Factor Receptor 2) Signaling Mediates Enhanced Angiogenesis in β3-Integrin–Deficient Mice
Andrew R. Reynolds; Louise E. Reynolds; Tobi E. Nagel; Julie C. Lively; Stephen D. Robinson; Daniel J. Hicklin; Sarah C. Bodary; Kairbaan M. Hodivala-Dilke
View articletitled, Elevated Flk1 (Vascular Endothelial Growth Factor Receptor 2) Signaling Mediates Enhanced Angiogenesis in β<sub>3</sub>-Integrin–Deficient Mice
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Transgenic Nude Mouse with Ubiquitous Green Fluorescent Protein Expression as a Host for Human Tumors
Meng Yang; Jose Reynoso; Ping Jiang; Lingna Li; Abdool R. Moossa; Robert M. Hoffman
View articletitled, Transgenic Nude Mouse with Ubiquitous Green Fluorescent Protein Expression as a Host for Human Tumors
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Matrix Metalloproteinase-26 Is Associated with Estrogen-Dependent Malignancies and Targets α1-Antitrypsin Serpin
Wei Li; Alexei Y. Savinov; Dmitri V. Rozanov; Vladislav S. Golubkov; Hirad Hedayat; Tatiana I. Postnova; Natalia V. Golubkova; Yu Linli; Stanislaw Krajewski; Alex Y. Strongin
View articletitled, Matrix Metalloproteinase-26 Is Associated with Estrogen-Dependent Malignancies and Targets α1-Antitrypsin Serpin
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Transcriptional Abnormality of the hsMAD2 Mitotic Checkpoint Gene Is a Potential Link to Hepatocellular Carcinogenesis
Sook-Jung Jeong; Hyun-Jin Shin; So-Jung Kim; Geun-Hyoung Ha; Bok-Im Cho; Kwan-Hyuck Baek; Chang-Min Kim; Chang-Woo Lee
View articletitled, Transcriptional Abnormality of the <strong><em>hsMAD2</em></strong> Mitotic Checkpoint Gene Is a Potential Link to Hepatocellular Carcinogenesis
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Integrin Fibronectin Receptors in Matrix Metalloproteinase-1–Dependent Invasion by Breast Cancer and Mammary Epithelial Cells
Yifeng Jia; Zhao-Zhu Zeng; Sonja M. Markwart; Korrene F. Rockwood; Kathleen M. Woods Ignatoski; Stephen P. Ethier; Donna L. Livant
View articletitled, Integrin Fibronectin Receptors in Matrix Metalloproteinase-1–Dependent Invasion by Breast Cancer and Mammary Epithelial Cells
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Membrane-Associated and Secreted Genes in Breast Cancer
Nathan O. Stitziel; Brenton G. Mar; Jie Liang; Carol A. Westbrook
View articletitled, Membrane-Associated and Secreted Genes in Breast Cancer
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RASSF4/AD037 Is a Potential Ras Effector/Tumor Suppressor of the RASSF Family
Kristin Eckfeld; Luke Hesson; Michele D. Vos; Ivan Bieche; Farida Latif; Geoffrey J. Clark
View articletitled, RASSF4/AD037 Is a Potential Ras Effector/Tumor Suppressor of the RASSF Family
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Functional Analysis of the Contribution of RhoA and RhoC GTPases to Invasive Breast Carcinoma
Kaylene J. Simpson; Aisling S. Dugan; Arthur M. Mercurio
View articletitled, Functional Analysis of the Contribution of RhoA and RhoC GTPases to Invasive Breast Carcinoma
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Loss of Heterozygosity of Chromosome 3p21 Is Associated with Mutant TP53 and Better Patient Survival in Non–Small-Cell Lung Cancer
Carmen J. Marsit; Masayuki Hasegawa; Tomoko Hirao; Duk-Hwan Kim; Kenneth Aldape; Philip W. Hinds; John K. Wiencke; Heather H. Nelson; Karl T. Kelsey
View articletitled, Loss of Heterozygosity of Chromosome 3p21 Is Associated with Mutant <strong><em>TP53</em></strong> and Better Patient Survival in Non–Small-Cell Lung Cancer
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Experimental Therapeutics, Molecular Targets, and Chemical Biology

Survivin Deregulation in β-Tubulin Mutant Ovarian Cancer Cells Underlies Their Compromised Mitotic Response to Taxol
Jun Zhou; Aurora O’Brate; Amelia Zelnak; Paraskevi Giannakakou
View articletitled, Survivin Deregulation in β-Tubulin Mutant Ovarian Cancer Cells Underlies Their Compromised Mitotic Response to Taxol
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Oral Consumption of Green Tea Polyphenols Inhibits Insulin-Like Growth Factor-I–Induced Signaling in an Autochthonous Mouse Model of Prostate Cancer
Vaqar Mustafa Adhami; Imtiaz Ahmad Siddiqui; Nihal Ahmad; Sanjay Gupta; Hasan Mukhtar
View articletitled, Oral Consumption of Green Tea Polyphenols Inhibits Insulin-Like Growth Factor-I–Induced Signaling in an Autochthonous Mouse Model of Prostate Cancer
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Inhibition of Akt/Protein Kinase B Signaling by Naltrindole in Small Cell Lung Cancer Cells
Yulong L. Chen; P. Y. Law; Horace H. Loh
View articletitled, Inhibition of Akt/Protein Kinase B Signaling by Naltrindole in Small Cell Lung Cancer Cells
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Mechanism of the Attenuation of Proteolysis-Inducing Factor Stimulated Protein Degradation in Muscle by β-Hydroxy-β-Methylbutyrate
Helen J. Smith; Stacey M. Wyke; Michael J. Tisdale
View articletitled, Mechanism of the Attenuation of Proteolysis-Inducing Factor Stimulated Protein Degradation in Muscle by β-Hydroxy-β-Methylbutyrate
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The Prosurvival Activity of p53 Protects Cells from UV-Induced Apoptosis by Inhibiting c-Jun NH2-terminal Kinase Activity and Mitochondrial Death Signaling
Pang-Kuo Lo; Sheng-Zhu Huang; Hsiang-Chin Chen; Fung-Fang Wang
View articletitled, The Prosurvival Activity of p53 Protects Cells from UV-Induced Apoptosis by Inhibiting c-Jun NH<sub>2</sub>-terminal Kinase Activity and Mitochondrial Death Signaling
Supplementary data
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Proteasomal Degradation of Topoisomerase I Is Preceded by c-Jun NH2-Terminal Kinase Activation, Fas Up-Regulation, and Poly(ADP-Ribose) Polymerase Cleavage in SN38-Mediated Cytotoxicity against Multiple Myeloma
Laurence Catley; Yu-Tzu Tai; Reshma Shringarpure; Renate Burger; Moni Thi Son; Klaus Podar; Pierfrancesco Tassone; Dharminder Chauhan; Teru Hideshima; Louis Denis; Paul Richardson; Nikhil C. Munshi; Kenneth C. Anderson
View articletitled, Proteasomal Degradation of Topoisomerase I Is Preceded by c-Jun NH<sub>2</sub>-Terminal Kinase Activation, Fas Up-Regulation, and Poly(ADP-Ribose) Polymerase Cleavage in SN38-Mediated Cytotoxicity against Multiple Myeloma
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Immunology

Liposome-Encapsulated CpG Oligodeoxynucleotides as a Potent Adjuvant for Inducing Type 1 Innate Immunity
Yoshinori Suzuki; Daiko Wakita; Kenji Chamoto; Yoshinori Narita; Takemasa Tsuji; Tsuguhide Takeshima; Hiroshi Gyobu; You Kawarada; Satoshi Kondo; Shizuo Akira; Hiroyuki Katoh; Hiroaki Ikeda; Takashi Nishimura
View articletitled, Liposome-Encapsulated CpG Oligodeoxynucleotides as a Potent Adjuvant for Inducing Type 1 Innate Immunity
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Spontaneous Regression of Grade 3 Vulvar Intraepithelial Neoplasia Associated with Human Papillomavirus-16–Specific CD4+ and CD8+ T-Cell Responses
Isabelle Bourgault Villada; Micheline Moyal Barracco; Marianne Ziol; Aude Chaboissier; Nathalie Barget; Sophie Berville; Bernard Paniel; Eric Jullian; Thierry Clerici; Bernard Maillère; Jean Gérard Guillet
View articletitled, Spontaneous Regression of Grade 3 Vulvar Intraepithelial Neoplasia Associated with Human Papillomavirus-16–Specific CD4<sup>+</sup> and CD8<sup>+</sup> T-Cell Responses
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Clinical Research

Automated Quantitative Analysis of HDM2 Expression in Malignant Melanoma Shows Association with Early-Stage Disease and Improved Outcome
Aaron J. Berger; Robert L. Camp; Kyle A. DiVito; Harriet M. Kluger; Ruth Halaban; David L. Rimm
View articletitled, Automated Quantitative Analysis of HDM2 Expression in Malignant Melanoma Shows Association with Early-Stage Disease and Improved Outcome
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Automated Quantitative Analysis of Tissue Microarrays Reveals an Association between High Bcl-2 Expression and Improved Outcome in Melanoma
Kyle A. DiVito; Aaron J. Berger; Robert L. Camp; Marisa Dolled-Filhart; David L. Rimm; Harriet M. Kluger
View articletitled, Automated Quantitative Analysis of Tissue Microarrays Reveals an Association between High Bcl-2 Expression and Improved Outcome in Melanoma
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Epidemiology and Prevention

The Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid Induces Apoptosis via Induction of 15-Lipoxygenase-1 in Colorectal Cancer Cells
Linda C. Hsi; Xiaopei Xi; Reuben Lotan; Imad Shureiqi; Scott M. Lippman
View articletitled, The Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid Induces Apoptosis via Induction of 15-Lipoxygenase-1 in Colorectal Cancer Cells
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Respective Roles of Serological Status and Blood Specific Antihuman Herpesvirus 8 Antibody Levels in Human Herpesvirus 8 Intrafamilial Transmission in a Highly Endemic Area
Sabine Plancoulaine; Laurent Abel; David Trégouët; Renan Duprez; Monique van Beveren; Patricia Tortevoye; Alain Froment; Antoine Gessain
View articletitled, Respective Roles of Serological Status and Blood Specific Antihuman Herpesvirus 8 Antibody Levels in Human Herpesvirus 8 Intrafamilial Transmission in a Highly Endemic Area
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Folate Is Associated with the Natural History of High-Risk Human Papillomaviruses
Chandrika J. Piyathilake; Olga L. Henao; Maurizio Macaluso; Phillip E. Cornwell; Sreelatha Meleth; Douglas C. Heimburger; Edward E. Partridge
View articletitled, Folate Is Associated with the Natural History of High-Risk Human Papillomaviruses
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Correction

Correction
View articletitled, Correction
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