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Volume 63, Issue 17

1 September 2003

Cover Image

Cover Image

ISSN 0008-5472

EISSN 1538-7445

Issue Sections

Advances in Brief
Molecular Biology, Pathobiology, and Genetics
Cell and Tumor Biology
Experimental Therapeutics, Molecular Targets, and Chemical Biology
Immunology
Endocrinology
Clinical Research
Epidemiology and Prevention
Correction

Journal Archive

Cancer Research (1941-Present; volumes 1-current)

(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.

The American Journal of Cancer (1931-1940; volumes 15-40)

(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.

The Journal of Cancer Research (1916-1930); volumes 1-14)

(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Table of Contents

Advances in Brief

Loss of Tsc1 or Tsc2 Induces Vascular Endothelial Growth Factor Production through Mammalian Target of Rapamycin 1

Nisreen El-Hashemite; Victoria Walker; Hongbing Zhang; David J. Kwiatkowski

View articletitled, Loss of <strong><em>Tsc1</em></strong> or <strong><em>Tsc2</em></strong> Induces Vascular Endothelial Growth Factor Production through Mammalian Target of Rapamycin<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Alternative Splicing of the Human Proto-oncogene c-H-ras Renders a New Ras Family Protein That Trafficks to Cytoplasm and Nucleus 1^,2

Sònia Guil; Núria de La Iglesia; Juan Fernández-Larrea; Daniel Cifuentes; Juan C. Ferrer; Joan J. Guinovart; Montse Bach-Elias

View articletitled, Alternative Splicing of the Human Proto-oncogene c-H-<strong><em>ras</em></strong> Renders a New Ras Family Protein That Trafficks to Cytoplasm and Nucleus<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup><sup><a href="javascript:;" reveal-id="FN2" data-open="FN2" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">,2</a></sup>

Supplementary data

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Sparse Initial Entrapment of Systemically Injected Salmonella typhimurium Leads to Heterogeneous Accumulation within Tumors 1

Neil S. Forbes; Lance L. Munn; Dai Fukumura; Rakesh K. Jain

View articletitled, Sparse Initial Entrapment of Systemically Injected <strong><em>Salmonella typhimurium</em></strong> Leads to Heterogeneous Accumulation within Tumors<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Fluorescence Resonance Energy Transfer Reveals a Binding Site of a Photosensitizer for Photodynamic Therapy 1

Rachel L. Morris; Kashif Azizuddin; Minh Lam; Jeffrey Berlin; Anna-Liisa Nieminen; Malcolm E. Kenney; Anna C. S. Samia; Clemens Burda; Nancy L. Oleinick

View articletitled, Fluorescence Resonance Energy Transfer Reveals a Binding Site of a Photosensitizer for Photodynamic Therapy<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Suppression of BRAF^V599E in Human Melanoma Abrogates Transformation 1

Sunil R. Hingorani; Michael A. Jacobetz; Gavin P. Robertson; Meenhard Herlyn; David A. Tuveson

View articletitled, Suppression of BRAF<sup>V599E</sup> in Human Melanoma Abrogates Transformation<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Estrogen-mediated Down-Regulation of E-cadherin in Breast Cancer Cells 1

Steffi Oesterreich; Wanleng Deng; Shiming Jiang; Xiaojiang Cui; Margarita Ivanova; Rachel Schiff; Kaiyan Kang; Darryl L. Hadsell; Jürgen Behrens; Adrian V. Lee

View articletitled, Estrogen-mediated Down-Regulation of E-cadherin in Breast Cancer Cells<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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BRAF Mutations in Colon Cancer Are Not Likely Attributable to Defective DNA Mismatch Repair 1

Liang Wang; Julie M. Cunningham; Jennifer L. Winters; Jennifer C. Guenther; Amy J. French; Lisa A. Boardman; Lawrence J. Burgart; Shannon K. McDonnell; Daniel J. Schaid; Stephen N. Thibodeau

View articletitled, <strong><em>BRAF</em></strong> Mutations in Colon Cancer Are Not Likely Attributable to Defective DNA Mismatch Repair<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Selection of Chronic Lymphocytic Leukemia Binding Peptides 1

Satoshi Takahashi; Hoyin Mok; M. Brandon Parrott; Frank C. Marini, III; Michael Andreeff; Malcolm K. Brenner; Michael A. Barry

View articletitled, Selection of Chronic Lymphocytic Leukemia Binding Peptides<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Prostaglandin E₂ Stimulates the Growth of Colon Cancer Cells via Induction of Amphiregulin 1

Jinyi Shao; Sean B. Lee; Huiping Guo; B. Mark Evers; Hongmiao Sheng

View articletitled, Prostaglandin E<sub>2</sub> Stimulates the Growth of Colon Cancer Cells via Induction of Amphiregulin<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Matrix Metalloproteinases (MMP9 and MMP2) Induce the Release of Vascular Endothelial Growth Factor (VEGF) by Ovarian Carcinoma Cells: Implications for Ascites Formation 1

Dorina Belotti; Paola Paganoni; Luigi Manenti; Angela Garofalo; Sergio Marchini; Giulia Taraboletti; Raffaella Giavazzi

View articletitled, Matrix Metalloproteinases (MMP9 and MMP2) Induce the Release of Vascular Endothelial Growth Factor (VEGF) by Ovarian Carcinoma Cells<span class="subtitle-colon">: </span><span class="subtitle">Implications for Ascites Formation<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup></span>

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Competing Autocrine Pathways Involving Alternative Neuropilin-1 Ligands Regulate Chemotaxis of Carcinoma Cells 1

Robin E. Bachelder; Elizabeth A. Lipscomb; Xuena Lin; Melissa A. Wendt; Neil H. Chadborn; Britta J. Eickholt; Arthur M. Mercurio

View articletitled, Competing Autocrine Pathways Involving Alternative Neuropilin-1 Ligands Regulate Chemotaxis of Carcinoma Cells<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Phosphorylation of β-Catenin at S33, S37, or T41 Can Occur in the Absence of Phosphorylation at T45 in Colon Cancer Cells 1

Zhenghe Wang; Bert Vogelstein; Kenneth W. Kinzler

View articletitled, Phosphorylation of β-Catenin at S33, S37, or T41 Can Occur in the Absence of Phosphorylation at T45 in Colon Cancer Cells<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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A Functional Polymorphism in the Progesterone Receptor Gene Is Associated with an Increase in Breast Cancer Risk 1

Immaculata De Vivo; Susan E. Hankinson; Graham A. Colditz; David J. Hunter

View articletitled, A Functional Polymorphism in the Progesterone Receptor Gene Is Associated with an Increase in Breast Cancer Risk<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Inhibition of COX-2 in Colon Cancer Cell Lines by Celecoxib Increases the Nuclear Localization of Active p53 1

Malisetty V. Swamy; Christopher R. Herzog; Chinthalapally V. Rao

View articletitled, Inhibition of COX-2 in Colon Cancer Cell Lines by Celecoxib Increases the Nuclear Localization of Active p53<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Molecular Biology, Pathobiology, and Genetics

Diagnostic Markers That Distinguish Colon and Ovarian Adenocarcinomas: Identification by Genomic, Proteomic, and Tissue Array Profiling

Satoshi Nishizuka; Sing-Tsung Chen; Fuad G. Gwadry; Jes Alexander; Sylvia M. Major; Uwe Scherf; William C. Reinhold; Mark Waltham; Lu Charboneau; Lynn Young; Kimberly J. Bussey; Sohyoung Kim; Samir Lababidi; Jae K. Lee; Stefania Pittaluga; Dominic A. Scudiero; Edward A. Sausville; Peter J. Munson; Emmanuel F. Petricoin, III; Lance A. Liotta; Stephen M. Hewitt; Mark Raffeld; John N. Weinstein

View articletitled, Diagnostic Markers That Distinguish Colon and Ovarian Adenocarcinomas<span class="subtitle-colon">: </span><span class="subtitle">Identification by Genomic, Proteomic, and Tissue Array Profiling</span>

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Tumor Suppression by the Prohibitin Gene 3′Untranslated Region RNA in Human Breast Cancer 1

Sharmila Manjeshwar; Dannielle E. Branam; Megan R. Lerner; Daniel J. Brackett; Eldon R. Jupe

View articletitled, Tumor Suppression by the <strong><em>Prohibitin</em></strong> Gene 3′Untranslated Region RNA in Human Breast Cancer<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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A PMLRARA Transgene Results in a Retinoid-deficient Phenotype Associated with Enhanced Susceptibility to Skin Tumorigenesis 1

Laura A. Hansen; Diane Brown; Victoria Virador; Takemi Tanaka; Fausto Andreola; Kathryn Strain; Barbara Dancheck; Rebeccah Riley; Jeffrey M. Arbeit; Luigi M. De Luca; Scott Kogan; Stuart H. Yuspa

View articletitled, A <strong><em>PMLRARA</em></strong> Transgene Results in a Retinoid-deficient Phenotype Associated with Enhanced Susceptibility to Skin Tumorigenesis<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Genome-wide Array CGH Analysis of Murine Neuroblastoma Reveals Distinct Genomic Aberrations which Parallel those in Human Tumors 1^{, 2}

Christopher S. Hackett; J. Graeme Hodgson; Mark E. Law; Jane Fridlyand; Kazutoyo Osoegawa; Pieter J. de Jong; Norma J. Nowak; Daniel Pinkel; Donna G. Albertson; Ajay Jain; Robert Jenkins; Joe W. Gray; William A. Weiss

View articletitled, Genome-wide Array CGH Analysis of Murine Neuroblastoma Reveals Distinct Genomic Aberrations which Parallel those in Human Tumors<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup><sup><a href="javascript:;" reveal-id="FN2" data-open="FN2" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">, 2</a></sup>

Supplementary data

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Mutant Thyroid Hormone Receptor β Represses the Expression and Transcriptional Activity of Peroxisome Proliferator-activated Receptor γ during Thyroid Carcinogenesis

Hao Ying; Hideyo Suzuki; Li Zhao; Mark C. Willingham; Paul Meltzer; Sheue-Yann Cheng

View articletitled, Mutant Thyroid Hormone Receptor β Represses the Expression and Transcriptional Activity of Peroxisome Proliferator-activated Receptor γ during Thyroid Carcinogenesis

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Amplification of Plasmids Containing a Mammalian Replication Initiation Region Is Mediated by Controllable Conflict between Replication and Transcription 1

Noriaki Shimizu; Toshihiko Hashizume; Kenta Shingaki; June-ko Kawamoto

View articletitled, Amplification of Plasmids Containing a Mammalian Replication Initiation Region Is Mediated by Controllable Conflict between Replication and Transcription<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Expression of Mammalian Paralogues of HRAD9 and Mrad9 Checkpoint Control Genes in Normal and Cancerous Testicular Tissue 1

Kevin M. Hopkins; Xiaojian Wang; Ana Berlin; Haiying Hang; Harshwardhan M. Thaker; Howard B. Lieberman

View articletitled, Expression of Mammalian Paralogues of <strong><em>HRAD9</em></strong> and <strong><em>Mrad9</em></strong> Checkpoint Control Genes in Normal and Cancerous Testicular Tissue<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Stat1-dependent Induction of Tumor Necrosis Factor-related Apoptosis-inducing Ligand and the Cell-Surface Death Signaling Pathway by Interferon β in Human Cancer Cells 1

Eugene A. Choi; Hanqin Lei; David J. Maron; James M. Wilson; James Barsoum; Douglas L. Fraker; Wafik S. El-Deiry; Francis R. Spitz

View articletitled, Stat1-dependent Induction of Tumor Necrosis Factor-related Apoptosis-inducing Ligand and the Cell-Surface Death Signaling Pathway by Interferon β in Human Cancer Cells<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Molecular and Functional Analysis of PRKAR1A and its Locus (17q22–24) in Sporadic Adrenocortical Tumors: 17q Losses, Somatic Mutations, and Protein Kinase A Expression and Activity 1

Jerome Bertherat; Lionel Groussin; Fabiano Sandrini; Ludmila Matyakhina; Thalia Bei; Sotirios Stergiopoulos; Theocharis Papageorgiou; Isabelle Bourdeau; Lawrence S. Kirschner; Caroline Vincent-Dejean; Karine Perlemoine; Christine Gicquel; Xavier Bertagna; Constantine A. Stratakis

View articletitled, Molecular and Functional Analysis of <strong><em>PRKAR1A</em></strong> and its Locus (17q22–24) in Sporadic Adrenocortical Tumors<span class="subtitle-colon">: </span><span class="subtitle">17q Losses, Somatic Mutations, and Protein Kinase A Expression and Activity<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup></span>

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Hepatic Vascular Tumors, Angiectasis in Multiple Organs, and Impaired Spermatogenesis in Mice with Conditional Inactivation of the VHL Gene 1

Wenbin Ma; Lino Tessarollo; Seung-Beom Hong; Masaya Baba; Eileen Southon; Timothy C. Back; Sally Spence; Corrinne G. Lobe; Nirmala Sharma; Gregory W. Maher; Svetlana Pack; Alexander O. Vortmeyer; Chuanfa Guo; Berton Zbar; Laura S. Schmidt

View articletitled, Hepatic Vascular Tumors, Angiectasis in Multiple Organs, and Impaired Spermatogenesis in Mice with Conditional Inactivation of the <strong><em>VHL</em></strong> Gene<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

Supplementary data

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The Cardiac Homeobox Gene NKX2-5 Is Deregulated by Juxtaposition with BCL11B in Pediatric T-ALL Cell Lines via a Novel t(5;14)(q35.1;q32.2)1

Stefan Nagel; Maren Kaufmann; Hans G. Drexler; Roderick A. F. MacLeod

View articletitled, The Cardiac Homeobox Gene <strong><em>NKX2-5</em></strong> Is Deregulated by Juxtaposition with <strong><em>BCL11B</em></strong> in Pediatric T-ALL Cell Lines via a Novel t(5;14)(q35.1;q32.2)<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Atm-, p53-, and Gadd45a-Deficient Mice Show an Increased Frequency of Homologous Recombination at Different Stages during Development 1

Alexander J. R. Bishop; M. Christine Hollander; Bela Kosaras; Richard L. Sidman; Albert J. Fornace, Jr.; Robert H. Schiestl

View articletitled, Atm-, p53-, and Gadd45a-Deficient Mice Show an Increased Frequency of Homologous Recombination at Different Stages during Development<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Identification of Novel Gene Expression Targets for the Ras Association Domain Family 1 (RASSF1A) Tumor Suppressor Gene in Non-Small Cell Lung Cancer and Neuroblastoma 1

Angelo Agathanggelou; Ivan Bièche; Jalal Ahmed-Choudhury; Barbara Nicke; Reinhard Dammann; Shairaz Baksh; Boning Gao; John D. Minna; Julian Downward; Eamonn R. Maher; Farida Latif

View articletitled, Identification of Novel Gene Expression Targets for the Ras Association Domain Family 1 (<strong><em>RASSF1A</em></strong>) Tumor Suppressor Gene in Non-Small Cell Lung Cancer and Neuroblastoma<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Array Comparative Genome Hybridization for Tumor Classification and Gene Discovery in Mouse Models of Malignant Melanoma 1

Rónán C. O’Hagan; Cameron W. Brennan; Andrew Strahs; Xuegong Zhang; Karuppiah Kannan; Melissa Donovan; Craig Cauwels; Norman E. Sharpless; Wing Hung Wong; Lynda Chin

View articletitled, Array Comparative Genome Hybridization for Tumor Classification and Gene Discovery in Mouse Models of Malignant Melanoma<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Cell Growth Regulatory Role of Runx2 during Proliferative Expansion of Preosteoblasts 1

Jitesh Pratap; Mario Galindo; S. Kaleem Zaidi; Diana Vradii; Bheem M. Bhat; John A. Robinson; Je-Yong Choi; Toshisha Komori; Janet L. Stein; Jane B. Lian; Gary S. Stein; Andre J. van Wijnen

View articletitled, Cell Growth Regulatory Role of Runx2 during Proliferative Expansion of Preosteoblasts<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Cell and Tumor Biology

β1,6-branched Oligosaccharides and Coarse Vesicles: A Common, Pervasive Phenotype in Melanoma and Other Human Cancers 1

Tamara Handerson; John M. Pawelek

View articletitled, β1,6-branched Oligosaccharides and Coarse Vesicles<span class="subtitle-colon">: </span><span class="subtitle">A Common, Pervasive Phenotype in Melanoma and Other Human Cancers<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup></span>

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Transformation of Mammary Epithelial Cells by 3-Phosphoinositide- dependent Protein Kinase-1 Activates β-Catenin and c-Myc, and Down-Regulates Caveolin-1 1

Zhihui Xie; Xiao Zeng; Todd Waldman; Robert I. Glazer

View articletitled, Transformation of Mammary Epithelial Cells by 3-Phosphoinositide- dependent Protein Kinase-1 Activates β-Catenin and c-Myc, and Down-Regulates Caveolin-1<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Enhanced Expression of SPARC/Osteonectin in the Tumor-associated Stroma of Non-Small Cell Lung Cancer Is Correlated with Markers of Hypoxia/ Acidity and with Poor Prognosis of Patients 1

Michael I. Koukourakis; Alexandra Giatromanolaki; Rolf A. Brekken; Efthimios Sivridis; Kevin C. Gatter; Adrian L. Harris; E. Helene Sage

View articletitled, Enhanced Expression of SPARC/Osteonectin in the Tumor-associated Stroma of Non-Small Cell Lung Cancer Is Correlated with Markers of Hypoxia/ Acidity and with Poor Prognosis of Patients<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Differential Role of Tissue Factor Pathway Inhibitors 1 and 2 in Melanoma Vasculogenic Mimicry 1

Wolfram Ruf; Elisabeth A. Seftor; Ramona J. Petrovan; Robert M. Weiss; Lynn M. Gruman; Naira V. Margaryan; Richard E. B. Seftor; Yohei Miyagi; Mary J. C. Hendrix

View articletitled, Differential Role of Tissue Factor Pathway Inhibitors 1 and 2 in Melanoma Vasculogenic Mimicry<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Synergistic Interactions of Chemotherapeutic Drugs and Tumor Necrosis Factor-related Apoptosis-inducing Ligand/Apo-2 Ligand on Apoptosis and on Regression of Breast Carcinoma in Vivo1

Thiyam Ramsing Singh; Sharmila Shankar; Xufen Chen; Mohammed Asim; Rakesh K. Srivastava

View articletitled, Synergistic Interactions of Chemotherapeutic Drugs and Tumor Necrosis Factor-related Apoptosis-inducing Ligand/Apo-2 Ligand on Apoptosis and on Regression of Breast Carcinoma <strong><em>in Vivo</em></strong><sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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TR3/Nur77 in Colon Cancer Cell Apoptosis 1

Andrew J. Wilson; Diego Arango; John M. Mariadason; Barbara G. Heerdt; Leonard H. Augenlicht

View articletitled, TR3/Nur77 in Colon Cancer Cell Apoptosis<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Differential Effects of Vascular Endothelial Growth Factor A Isoforms in a Mouse Brain Metastasis Model of Human Melanoma 1

Benno Küsters; Robert M. W. de Waal; Pieter Wesseling; Kiek Verrijp; Cathy Maass; Arend Heerschap; Jelle O. Barentsz; Fred Sweep; Dirk J. Ruiter; William P. J. Leenders

View articletitled, Differential Effects of Vascular Endothelial Growth Factor A Isoforms in a Mouse Brain Metastasis Model of Human Melanoma<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Ionizing Radiation and Busulfan Induce Premature Senescence in Murine Bone Marrow Hematopoietic Cells 1

Aimin Meng; Yong Wang; Gary Van Zant; Daohong Zhou

View articletitled, Ionizing Radiation and Busulfan Induce Premature Senescence in Murine Bone Marrow Hematopoietic Cells<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Hemangiosarcomas, Medulloblastomas, and Other Tumors in Ink4c/p53-null Mice 1

Frederique Zindy; Lisa M. Nilsson; Luc Nguyen; Cecile Meunier; Richard J. Smeyne; Jerold E. Rehg; Charles Eberhart; Charles J. Sherr; Martine F. Roussel

View articletitled, Hemangiosarcomas, Medulloblastomas, and Other Tumors in <strong><em>Ink4c/p53</em></strong>-null Mice<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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A Molecular Fingerprint for Medulloblastoma 1

Youngsoo Lee; Heather L. Miller; Patricia Jensen; Roberto Hernan; Michele Connelly; Cynthia Wetmore; Frederique Zindy; Martine F. Roussel; Tom Curran; Richard J. Gilbertson; Peter J. McKinnon

View articletitled, A Molecular Fingerprint for Medulloblastoma<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

Supplementary data

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Receptor Activator of Nuclear Factor-κB Ligand Expression by Human Myeloma Cells Mediates Osteoclast Formation in Vitro and Correlates with Bone Destruction in Vivo1

Amanda N. Farrugia; Gerald J. Atkins; L. Bik To; Beiqing Pan; Noemi Horvath; Panagiota Kostakis; David M. Findlay; Peter Bardy; Andrew C. W. Zannettino

View articletitled, Receptor Activator of Nuclear Factor-κB Ligand Expression by Human Myeloma Cells Mediates Osteoclast Formation <strong><em>in Vitro</em></strong> and Correlates with Bone Destruction <strong><em>in Vivo</em></strong><sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Autotaxin Hydrolyzes Sphingosylphosphorylcholine to Produce the Regulator of Migration, Sphingosine-1-Phosphate

Timothy Clair; Junken Aoki; Eunjin Koh; Russell W. Bandle; Suk Woo Nam; Malgorzata M. Ptaszynska; Gordon B. Mills; Elliott Schiffmann; Lance A. Liotta; Mary L. Stracke

View articletitled, Autotaxin Hydrolyzes Sphingosylphosphorylcholine to Produce the Regulator of Migration, Sphingosine-1-Phosphate

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p38 Kinase Is a Key Signaling Molecule for H-Ras-induced Cell Motility and Invasive Phenotype in Human Breast Epithelial Cells 1

Mi-Sung Kim; Eun-Jung Lee; Hyeong-Reh Choi Kim; Aree Moon

View articletitled, p38 Kinase Is a Key Signaling Molecule for H-Ras-induced Cell Motility and Invasive Phenotype in Human Breast Epithelial Cells<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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A Novel Small Molecule Met Inhibitor Induces Apoptosis in Cells Transformed by the Oncogenic TPR-MET Tyrosine Kinase 1

Martin Sattler; Yuri B. Pride; Patrick Ma; Jessica L. Gramlich; Stephanie C. Chu; Laura A. Quinnan; Sheri Shirazian; Congxin Liang; Klaus Podar; James G. Christensen; Ravi Salgia

View articletitled, A Novel Small Molecule Met Inhibitor Induces Apoptosis in Cells Transformed by the Oncogenic TPR-MET Tyrosine Kinase<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Nitric-Oxide-induced Bax Integration into the Mitochondrial Membrane Commits MDA-MB-468 Cells to Apoptosis: Essential Role of Akt 1

Shehla Pervin; Rajan Singh; Gautam Chaudhuri

View articletitled, Nitric-Oxide-induced Bax Integration into the Mitochondrial Membrane Commits MDA-MB-468 Cells to Apoptosis<span class="subtitle-colon">: </span><span class="subtitle">Essential Role of Akt<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup></span>

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CD20-induced Lymphoma Cell Death Is Independent of Both Caspases and Its Redistribution into Triton X-100 Insoluble Membrane Rafts 1

H. T. Claude Chan; David Hughes; Ruth R. French; Alison L. Tutt; Claire A. Walshe; Jessica L. Teeling; Martin J. Glennie; Mark S. Cragg

View articletitled, CD20-induced Lymphoma Cell Death Is Independent of Both Caspases and Its Redistribution into Triton X-100 Insoluble Membrane Rafts<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Experimental Therapeutics, Molecular Targets, and Chemical Biology

Role of MutSα in the Recognition of Iododeoxyuridine in DNA 1

Suzanne E. Berry; Tamalette Loh; Tao Yan; Timothy J. Kinsella

View articletitled, Role of MutSα in the Recognition of Iododeoxyuridine in DNA<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Enhancing Targeted Radiotherapy by Copper(II)diacetyl- bis(N⁴-methylthiosemicarbazone) Using 2-Deoxy-d-Glucose 1

Rebecca L. Aft; Jason S. Lewis; Fanjie Zhang; Joonyoung Kim; Michael J. Welch

View articletitled, Enhancing Targeted Radiotherapy by Copper(II)diacetyl- bis(<strong><em>N</em></strong><sup>4</sup>-methylthiosemicarbazone) Using 2-Deoxy-<span class="small-caps">d</span>-Glucose<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Expression of Inflammatory Chemokines Combined with Local Tumor Destruction Enhances Tumor Regression and Long-term Immunity 1

Marka Crittenden; Michael Gough; Kevin Harrington; Ken Olivier; Jill Thompson; Richard G. Vile

View articletitled, Expression of Inflammatory Chemokines Combined with Local Tumor Destruction Enhances Tumor Regression and Long-term Immunity<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Dicumarol Inhibition of NADPH:Quinone Oxidoreductase Induces Growth Inhibition of Pancreatic Cancer via a Superoxide-mediated Mechanism 1

Joseph J. Cullen; Marilyn M. Hinkhouse; Matthew Grady; Andrew W. Gaut; Jingru Liu; Yu Ping Zhang; Christine J. Darby Weydert; Frederick E. Domann; Larry W. Oberley

View articletitled, Dicumarol Inhibition of NADPH:Quinone Oxidoreductase Induces Growth Inhibition of Pancreatic Cancer via a Superoxide-mediated Mechanism<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Selective Antimetastatic Activity of Cytosine Analog CS-682 in a Red Fluorescent Protein Orthotopic Model of Pancreatic Cancer 1

Matthew H. Katz; Michael Bouvet; Shinako Takimoto; Daniel Spivack; Abdool R. Moossa; Robert M. Hoffman

View articletitled, Selective Antimetastatic Activity of Cytosine Analog CS-682 in a Red Fluorescent Protein Orthotopic Model of Pancreatic Cancer<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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CD10 Is a Key Enzyme Involved in the Activation of Tumor-activated Peptide Prodrug CPI-0004Na and Novel Analogues: Implications for the Design of Novel Peptide Prodrugs for the Therapy of CD10⁺ Tumors

Chin Pan; Pina M. Cardarelli; Matthew H. Nieder; Lesley B. Pickford; Sanjeev Gangwar; David J. King; Geoffrey T. Yarranton; Dana Buckman; William Roscoe; Fengmin Zhou; Adam Salles; Tseng-Hui Chen; Killian Horgan; Yi-Hong Wang; Thi Nguyen; Christopher R. Bebbington

View articletitled, CD10 Is a Key Enzyme Involved in the Activation of Tumor-activated Peptide Prodrug CPI-0004Na and Novel Analogues: Implications for the Design of Novel Peptide Prodrugs for the Therapy of CD10<sup>+</sup> Tumors

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Generation of Escherichia Coli Nitroreductase Mutants Conferring Improved Cell Sensitization to the Prodrug CB1954 1

Jane I. Grove; Andrew L. Lovering; Christopher Guise; Paul R. Race; Christopher J. Wrighton; Scott A. White; Eva I. Hyde; Peter F. Searle

View articletitled, Generation of <strong><em>Escherichia Coli</em></strong> Nitroreductase Mutants Conferring Improved Cell Sensitization to the Prodrug CB1954<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Wild-Type Breast Cancer Resistance Protein (BCRP/ABCG2) is a Methotrexate Polyglutamate Transporter 1

Erin L. Volk; Erasmus Schneider

View articletitled, Wild-Type Breast Cancer Resistance Protein (BCRP/<strong><em>ABCG2</em></strong>) is a Methotrexate Polyglutamate Transporter<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Ras-dependent Oncolysis with an Adenovirus VAI Mutant

Manel Cascalló; Gabriel Capellà; Adela Mazo; Ramon Alemany

View articletitled, Ras-dependent Oncolysis with an Adenovirus VAI Mutant

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The Novel Triterpenoid CDDO and its Derivatives Induce Apoptosis by Disruption of Intracellular Redox Balance 1

Takashi Ikeda; Michael Sporn; Tadashi Honda; Gordon W. Gribble; Donald Kufe

View articletitled, The Novel Triterpenoid CDDO and its Derivatives Induce Apoptosis by Disruption of Intracellular Redox Balance<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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CEP-701 and CEP-751 Inhibit Constitutively Activated RET Tyrosine Kinase Activity and Block Medullary Thyroid Carcinoma Cell Growth 1

Christopher J. Strock; Jong-In Park; Mark Rosen; Craig Dionne; Bruce Ruggeri; Susan Jones-Bolin; Samuel R. Denmeade; Douglas W. Ball; Barry D. Nelkin

View articletitled, CEP-701 and CEP-751 Inhibit Constitutively Activated RET Tyrosine Kinase Activity and Block Medullary Thyroid Carcinoma Cell Growth<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Immunology

Tumor-specific Immunological Recognition of Frameshift-mutated Peptides in Colon Cancer with Microsatellite Instability 1

Toshiaki Ishikawa; Tomonobu Fujita; Yuriko Suzuki; Satoshi Okabe; Yasuhito Yuasa; Takehisa Iwai; Yutaka Kawakami

View articletitled, Tumor-specific Immunological Recognition of Frameshift-mutated Peptides in Colon Cancer with Microsatellite Instability<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Epithelial Ovarian Cancer Cells Secrete Functional Fas Ligand 1

Vikki M. Abrahams; Shawn L. Straszewski; Marijke Kamsteeg; Bozena Hanczaruk; Peter E. Schwartz; Thomas J. Rutherford; Gil Mor

View articletitled, Epithelial Ovarian Cancer Cells Secrete Functional Fas Ligand<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Bone Marrow Contains Melanoma-reactive CD8⁺ Effector T Cells and, Compared with Peripheral Blood, Enriched Numbers of Melanoma-reactive CD8⁺ Memory T Cells 1

Anne Letsch; Ulrich Keilholz; Geraldine Assfalg; Volker Mailänder; Eckhard Thiel; Carmen Scheibenbogen

View articletitled, Bone Marrow Contains Melanoma-reactive CD8<sup>+</sup> Effector T Cells and, Compared with Peripheral Blood, Enriched Numbers of Melanoma-reactive CD8<sup>+</sup> Memory T Cells<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Efficient Presentation of Known HLA Class II-restricted MAGE-A3 Epitopes by Dendritic Cells Electroporated with Messenger RNA Encoding an Invariant Chain with Genetic Exchange of Class II-associated Invariant Chain Peptide 1

Aude Bonehill; Carlo Heirman; Sandra Tuyaerts; Annelies Michiels; Yi Zhang; Pierre van der Bruggen; Kris Thielemans

View articletitled, Efficient Presentation of Known HLA Class II-restricted MAGE-A3 Epitopes by Dendritic Cells Electroporated with Messenger RNA Encoding an Invariant Chain with Genetic Exchange of Class II-associated Invariant Chain Peptide<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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CpG-A and B Oligodeoxynucleotides Enhance the Efficacy of Antibody Therapy by Activating Different Effector Cell Populations 1

Heidi H. van Ojik; Lisette Bevaart; Christopher E. Dahle; Annie Bakker; Marco J. H. Jansen; Martine J. van Vugt; Jan G. J. van de Winkel; George J. Weiner

View articletitled, CpG-A and B Oligodeoxynucleotides Enhance the Efficacy of Antibody Therapy by Activating Different Effector Cell Populations<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Tumor-reactive, SSX-2-specific CD8⁺ T Cells Are Selectively Expanded during Immune Responses to Antigen-expressing Tumors in Melanoma Patients 1

Maha Ayyoub; Donata Rimoldi; Philippe Guillaume; Pedro Romero; Jean-Charles Cerottini; Danila Valmori; Daniel Speiser

View articletitled, Tumor-reactive, SSX-2-specific CD8<sup>+</sup> T Cells Are Selectively Expanded during Immune Responses to Antigen-expressing Tumors in Melanoma Patients<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Regulation of Melanoma Epitope-specific Cytolytic T Lymphocyte Response by Immature and Activated Dendritic Cells, in Vitro1

Shikhar Mehrotra; Robert Stevens; Ryan Zengou; Nitya G. Chakraborty; Lisa H. Butterfield; James S. Economou; David I. Dorsky; Bijay Mukherji

View articletitled, Regulation of Melanoma Epitope-specific Cytolytic T Lymphocyte Response by Immature and Activated Dendritic Cells, <strong><em>in Vitro</em></strong><sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Endocrinology

Mutations in the SDHB Gene Are Associated with Extra-adrenal and/or Malignant Phaeochromocytomas 1

Anne-Paule Gimenez-Roqueplo; Judith Favier; Pierre Rustin; Claudine Rieubland; Malvina Crespin; Valérie Nau; Philippe Khau Van Kien; Pierre Corvol; Pierre-François Plouin; Xavier Jeunemaitre; for the COMETE (COrtical and MEdullary Tumour) Network

View articletitled, Mutations in the <strong><em>SDHB</em></strong> Gene Are Associated with Extra-adrenal and/or Malignant Phaeochromocytomas<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Enhanced Androgen Receptor Signaling Correlates with the Androgen-refractory Growth in a Newly Established MDA PCa 2b-hr Human Prostate Cancer Cell Subline

Takahito Hara; Kazuyo Nakamura; Hideo Araki; Masami Kusaka; Masuo Yamaoka

View articletitled, Enhanced Androgen Receptor Signaling Correlates with the Androgen-refractory Growth in a Newly Established MDA PCa 2b-hr Human Prostate Cancer Cell Subline

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Clinical Research

Epidermal Growth Factor Receptor-stimulated Activation of Phospholipase Cγ-1 Promotes Invasion of Head and Neck Squamous Cell Carcinoma 1

Sufi Mary Thomas; Francesca M. Coppelli; Alan Wells; William E. Gooding; John Song; Jareer Kassis; Stephanie D. Drenning; Jennifer Rubin Grandis

View articletitled, Epidermal Growth Factor Receptor-stimulated Activation of Phospholipase Cγ-1 Promotes Invasion of Head and Neck Squamous Cell Carcinoma<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Epidemiology and Prevention

NADPH Oxidase Activity Is Essential for Keap1/Nrf2-mediated Induction of GCLC in Response to 2-Indol-3-yl-methylenequinuclidin-3-ols 1

Konjeti R. Sekhar; Peter A. Crooks; Vijayakumar N. Sonar; David B. Friedman; Jeff Y. Chan; Michael J. Meredith; Joseph H. Starnes; Kathy R. Kelton; Samantha R. Summar; Soumya Sasi; Michael L. Freeman

View articletitled, NADPH Oxidase Activity Is Essential for Keap1/Nrf2-mediated Induction of <strong><em>GCLC</em></strong> in Response to 2-Indol-3-yl-methylenequinuclidin-3-ols<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>

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Correction

Correction

View articletitled, Correction

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