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Volume 62, Issue 22
15 November 2002
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ISSN 0008-5472
EISSN 1538-7445

Journal Archive

Cancer Research (1941-Present; volumes 1-current)

(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.

The American Journal of Cancer (1931-1940; volumes 15-40)

(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.

The Journal of Cancer Research (1916-1930); volumes 1-14)

(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Table of Contents

Advances in Brief

Regulation of BRCA1 Phosphorylation by Interaction with Protein Phosphatase 1α1
Ying Liu; David M. Virshup; Raymond L. White; Lih-Ching Hsu
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Elimination of Colon Cancer in Germ-free Transforming Growth Factor Beta 1-deficient Mice1
Sandra J. Engle; Ilona Ormsby; Sharon Pawlowski; Gregory P. Boivin; Joanne Croft; Edward Balish; Tom Doetschman
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Microadenomatous Lesions Involving Loss of Apc Heterozygosity in the Colon of Adult ApcMin/+ Mice1
Yasuhiro Yamada; Kazuya Hata; Yoshinobu Hirose; Akira Hara; Shigeyuki Sugie; Toshiya Kuno; Naoki Yoshimi; Takuji Tanaka; Hideki Mori
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High-Frequency Doppler Ultrasound Monitors the Effects of Antivascular Therapy on Tumor Blood Flow1
David E. Goertz; Joanne L. Yu; Robert S. Kerbel; Peter N. Burns; F. Stuart Foster
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The Retinoid X Receptor-Selective Retinoid, LGD1069, Prevents the Development of Estrogen Receptor-Negative Mammary Tumors in Transgenic Mice1
Kendall Wu; Yun Zhang; Xiao-Chun Xu; Jamal Hill; Joseph Celestino; Hee-Tae Kim; Syed K. Mohsin; Susan G. Hilsenbeck; William W. Lamph; Reid Bissonette; Powel H. Brown
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Growth Inhibition of Cervix Carcinoma Cells in Vivo by Endothelin A Receptor Blockade1
Anna Bagnato; Alessia Cirilli; Debora Salani; Paola Simeone; Antonio Muller; Maria Rita Nicotra; Pier Giorgio Natali; Aldo Venuti
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Induction of Medulloblastomas in Mice by Sonic Hedgehog, Independent of Gli11,2
Howard L. Weiner; Richard Bakst; Marc S. Hurlbert; Jason Ruggiero; Esther Ahn; Wing Shing Lee; Daniel Stephen; David Zagzag; Alexandra L. Joyner; Daniel H. Turnbull
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Gene Silencing of the Tyrosine Phosphatase SHP1 Gene by Aberrant Methylation in Leukemias/Lymphomas1
Takashi Oka; Mamoru Ouchida; Maho Koyama; Yoichiro Ogama; Shinichi Takada; Yoko Nakatani; Takehiro Tanaka; Tadashi Yoshino; Kazuhiko Hayashi; Nobuya Ohara; Eisaku Kondo; Kiyoshi Takahashi; Junjiro Tsuchiyama; Mitsune Tanimoto; Kenji Shimizu; Tadaatsu Akagi
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DNA Ligase IV Suppresses Medulloblastoma Formation1
Youngsoo Lee; Peter J. McKinnon
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Silencing Expression of the Catalytic Subunit of DNA-dependent Protein Kinase by Small Interfering RNA Sensitizes Human Cells for Radiation-induced Chromosome Damage, Cell Killing, and Mutation
Yuanlin Peng; Qinming Zhang; Hatsumi Nagasawa; Ryuichi Okayasu; Howard L. Liber; Joel S. Bedford
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Telomere Shortening Is an Early Somatic DNA Alteration in Human Prostate Tumorigenesis1
Alan K. Meeker; Jessica L. Hicks; Elizabeth A. Platz; Gerrun E. March; Christina J. Bennett; Michael J. Delannoy; Angelo M. De Marzo
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Elevated Hyaluronan Concentration without Hyaluronidase Activation in Malignant Epithelial Ovarian Tumors1
Essi L. J. Hiltunen; Maarit Anttila; Anne Kultti; Kirsi Ropponen; Jorma Penttinen; Merja Yliskoski; Arja T. Kuronen; Matti Juhola; Raija Tammi; Markku Tammi; Veli-Matti Kosma
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Cyclin B1 Overexpression and Resistance to Radiotherapy in Head and Neck Squamous Cell Carcinoma1
Khaled A. Hassan; K. Kian Ang; Adel K. El-Naggar; Michael D. Story; Janet I. Lee; Diane Liu; Waun K. Hong; Li Mao
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RhoGDI2 Is an Invasion and Metastasis Suppressor Gene in Human Cancer1
John J. Gildea; M. Jabed Seraj; Gary Oxford; Michael A. Harding; Garret M. Hampton; Christopher A. Moskaluk; Henry F. Frierson; Mark R. Conaway; Dan Theodorescu
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Carcinogenic Induction Directs the Selection of Allelic Losses in Mouse Lung Tumorigenesis1
Christopher R. Herzog; Theodora R. Devereux; Brian Pittman; Ming You
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Correlation between a Single Nucleotide Polymorphism in the Matrix Metalloproteinase-2 Promoter and Risk of Lung Cancer1
Chunyuan Yu; Kaifeng Pan; Deyin Xing; Gang Liang; Wen Tan; Lian Zhang; Dongxin Lin
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A Novel Folate Transport Activity in Human Mesothelioma Cell Lines with High Affinity and Specificity for the New-Generation Antifolate, Pemetrexed1
Yanhua Wang; Rongbao Zhao; Shrikanta Chattopadhyay; I. David Goldman
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Antigen-specific CD4+ T-Cell Help Is Required to Activate a Memory CD8+ T Cell to a Fully Functional Tumor Killer Cell1
Feng Guang Gao; Vithagna Khammanivong; Wen Jun Liu; Graham R. Leggatt; Ian H. Frazer; Germain J. P. Fernando
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Loss of Imprinting in Colorectal Cancer Linked to Hypomethylation of H19 and IGF21
Hengmi Cui; Patrick Onyango; Sheri Brandenburg; Yiqian Wu; Chih-Lin Hsieh; Andrew P. Feinberg
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3p14 and 9p21 Loss Is a Simple Tool for Predicting Second Oral Malignancy at Previously Treated Oral Cancer Sites1
Miriam P. Rosin; Wan L. Lam; Catherine Poh; Nhu D. Le; Robert Jinze Li; Tao Zeng; Robert Priddy; Lewei Zhang
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Similarity of the Phenotypic Patterns Associated with BRAF and KRAS Mutations in Colorectal Neoplasia1
Siu T. Yuen; Helen Davies; Tsun L. Chan; Judy W. Ho; Graham R. Bignell; Charles Cox; Philip Stephens; Sarah Edkins; Wendy W. Tsui; Annie S. Chan; P. Andrew Futreal; Michael R. Stratton; Richard Wooster; Suet Y. Leung
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Histone H3-Lysine 9 Methylation Is Associated with Aberrant Gene Silencing in Cancer Cells and Is Rapidly Reversed by 5-Aza-2′-deoxycytidine1
Carvell T. Nguyen; Daniel J. Weisenberger; Mihaela Velicescu; Felicidad A. Gonzales; Joy C. Y. Lin; Gangning Liang; Peter A. Jones
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Resistance to Chemotherapy Mediated by TrkB in Neuroblastomas1
Ruth Ho; Angelika Eggert; Tomoro Hishiki; Jane E. Minturn; Naohiko Ikegaki; Patricia Foster; Anna Marie Camoratto; Audrey E. Evans; Garrett M. Brodeur
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The Neurotransmitter γ-Aminobutyric Acid Is an Inhibitory Regulator for the Migration of SW 480 Colon Carcinoma Cells1
Jan Joseph; Bernd Niggemann; Kurt S. Zaenker; Frank Entschladen
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Extensive Somatic Mitochondrial Mutations in Primary Prostate Cancer Using Laser Capture Microdissection1
Junjian Z. Chen; Neriman Gokden; Graham F. Greene; Perkins Mukunyadzi; Fred F. Kadlubar
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14-3-3 Interacts with the Tumor Suppressor Tuberin at Akt Phosphorylation Site(s)1
Matt Y. Liu; Shengli Cai; Alexsandra Espejo; Mark T. Bedford; Cheryl Lyn Walker
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No Evidence for the Presence of an Imprinted Neuroblastoma Suppressor Gene within Chromosome Sub-Band 1p36.31
Michael D. Hogarty; Cynthia L. Winter; Xueyuan Liu; Chun Guo; Peter S. White; A. Thomas Look; Garrett M. Brodeur; John M. Maris
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Sequence Variants of α-Methylacyl-CoA Racemase Are Associated with Prostate Cancer Risk1
Siqun L. Zheng; Bao-li Chang; Dennis A. Faith; Jill R. Johnson; Sarah D. Isaacs; Gregory A. Hawkins; Aubrey Turner; Kathy E. Wiley; Eugene R. Bleecker; Patrick C. Walsh; Deborah A. Meyers; William B. Isaacs; Jianfeng Xu
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Biochemistry and Biophysics

β-Catenin Interacts with Low-Molecular-Weight Protein Tyrosine Phosphatase Leading to Cadherin-mediated Cell-Cell Adhesion Increase1
Maria Letizia Taddei; Paola Chiarugi; Paolo Cirri; Francesca Buricchi; Tania Fiaschi; Elisa Giannoni; Doriana Talini; Giacomo Cozzi; Lucia Formigli; Giovanni Raugei; Giampietro Ramponi
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Bile Acids Inhibit Mcl-1 Protein Turnover via an Epidermal Growth Factor Receptor/Raf-1-dependent Mechanism1
Jung-Hwan Yoon; Nathan W. Werneburg; Hajime Higuchi; Ali E. Canbay; Scott H. Kaufmann; Cahit Akgul; Steven W. Edwards; Gregory J. Gores
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Correlation between Electron-donating Ability of a Series of 3-Nitroflavones and Their Efficacy to Inhibit the Onset and Progression of Aberrant Crypt Foci in the Rat Colon1
Vernon E. Steele; Charles W. Boone; Daniel Dauzonne; Chinthalapally V. Rao; René V. Bensasson
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Clinical Investigations

Estrogen-related Receptor α and Estrogen-related Receptor γ Associate with Unfavorable and Favorable Biomarkers, Respectively, in Human Breast Cancer1
Eric A. Ariazi; Gary M. Clark; Janet E. Mertz
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Endocrinology

An Estrogen-responsive Element-targeted Histone Deacetylase Enzyme Has an Antiestrogen Activity That Differs from That of Hydroxytamoxifen1
Ediz Demirpence; Abdelhabib Semlali; Joan Oliva; Patrick Balaguer; Eric Badia; Marie-Josèphe Duchesne; Jean-Claude Nicolas; Michel Pons
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Reduced Expression of Insulin-like Growth Factor I Receptors in MCF-7 Breast Cancer Cells Leads to a More Metastatic Phenotype
Patricia A. Pennisi; Valarie Barr; Nomeli P. Nunez; Bethel Stannard; Derek Le Roith
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Experimental Therapeutics

Bisphosphonates Inhibit Angiogenesis in Vitro and Testosterone-stimulated Vascular Regrowth in the Ventral Prostate in Castrated Rats1
Pierrick Fournier; Sandrine Boissier; Stéphanie Filleur; Julien Guglielmi; Florence Cabon; Marc Colombel; Philippe Clézardin
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Herpes Simplex Virus (HSV) Amplicon-mediated Codelivery of Secondary Lymphoid Tissue Chemokine and CD40L Results in Augmented Antitumor Activity1
Khaled A. Tolba; William J. Bowers; Jacquelyn Muller; Vickie Housekneckt; Rita E. Giuliano; Howard J. Federoff; Joseph D. Rosenblatt
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Convection-enhanced Delivery of Boronated Epidermal Growth Factor for Molecular Targeting of EGF Receptor-positive Gliomas1
Weilian Yang; Rolf F. Barth; Dianne M. Adams; Michael J. Ciesielski; Robert A. Fenstermaker; Supriya Shukla; Werner Tjarks; Michael A. Caligiuri
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Acquisition of Resistance to Cisplatin Is Accompanied by Changes in the Cellular Pharmacology of Copper12
Kuniyuki Katano; Akira Kondo; Roohangiz Safaei; Alison Holzer; Goli Samimi; Misako Mishima; Yien-Ming Kuo; Myriam Rochdi; Stephen B. Howell
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Immunology

Viral Fusogenic Membrane Glycoproteins Kill Solid Tumor Cells by Nonapoptotic Mechanisms That Promote Cross Presentation of Tumor Antigens by Dendritic Cells1
Andrew R. Bateman; Kevin J. Harrington; Tim Kottke; Atique Ahmed; Alan A. Melcher; Michael J. Gough; Emmanouela Linardakis; David Riddle; Allan Dietz; Christine M. Lohse; Scott Strome; Tim Peterson; Robert Simari; Richard G. Vile
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Molecular Biology and Genetics

The ETS Transcription Factor MEF Is a Candidate Tumor Suppressor Gene on the X Chromosome1
Yoshiyuki Seki; Mary Ann Suico; Ayako Uto; Akinobu Hisatsune; Tsuyoshi Shuto; Yoichiro Isohama; Hirofumi Kai
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Unbiased Analysis of RB-mediated Transcriptional Repression Identifies Novel Targets and Distinctions from E2F Action1
Michael P. Markey; Steven P. Angus; Matthew W. Strobeck; Sarah L. Williams; Ranjaka W. Gunawardena; Bruce J. Aronow; Erik S. Knudsen
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Gene Expression Profiling of Favorable Histology Wilms Tumors and Its Correlation with Clinical Features
Masayuki Takahashi; Ximing J. Yang; Todd T. Lavery; Kyle A. Furge; Bart O. Williams; Maria Tretiakova; Anthony Montag; Nicholas J. Vogelzang; Gian G. Re; A. Julian Garvin; Stefan Söderhäll; Susumu Kagawa; Debra Hazel-Martin; Agneta Nordenskjold; Bin Tean Teh
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Characterization of a Novel Androgen Receptor Mutation in a Relapsed CWR22 Prostate Cancer Xenograft and Cell Line1
Clifford G. Tepper; David L. Boucher; Philip E. Ryan; Ai-Hong Ma; Liang Xia; Li-Fen Lee; Thomas G. Pretlow; Hsing-Jien Kung
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Genetic Interactions between the Wilms’ Tumor 1 Gene and the p53 Gene1
Aswin L. Menke; Alan R. Clarke; Andrea Leitch; Annemieke Ijpenberg; Kathy A. Williamson; Lee Spraggon; David J. Harrison; Nicholas D. Hastie
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Selective Inactivation of DNA-dependent Protein Kinase with Antisense Oligodeoxynucleotides: Consequences for the Rejoining of Radiation-induced DNA Double-Strand Breaks and Radiosensitivity of Human Cancer Cell Lines1
Ali Sak; Martin Stuschke; Reinhard Wurm; Gisela Schroeder; Brigitte Sinn; Gudrun Wolf; Volker Budach
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Characterization of a Tissue-specific CDP/Cux Isoform, p75, Activated in Breast Tumor Cells1
Brigitte Goulet; Peter Watson; Madeleine Poirier; Lam Leduy; Ginette Bérubé; Sarkis Meterissian; Paul Jolicoeur; Alain Nepveu
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Promoter Hypermethylation of the Death-associated Protein Kinase Gene in Breast Cancer Is Associated with the Invasive Lobular Subtype1
Ulrich Lehmann; Gülhan Celikkaya; Britta Hasemeier; Florian Länger; Hans Kreipe
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Methylthioadenosine Phosphorylase, a Gene Frequently Codeleted with p16cdkN2a/ARF, Acts as a Tumor Suppressor in a Breast Cancer Cell Line1
Scott A. Christopher; Paula Diegelman; Carl W. Porter; Warren D. Kruger
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Identification of Silencing of Nine Genes in Human Gastric Cancers12
Atsushi Kaneda; Michio Kaminishi; Kazuyoshi Yanagihara; Takashi Sugimura; Toshikazu Ushijima
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Supplementary data
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Evidence for a Hereditary Neuroblastoma Predisposition Locus at Chromosome 16p12–131
John M. Maris; Matthew J. Weiss; Yael Mosse; George Hii; Chun Guo; Peter S. White; Michael D. Hogarty; Tamar Mirensky; Garrett M. Brodeur; Timothy R. Rebbeck; Margrit Urbanek; Suzanne Shusterman
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Tumor Biology

Constitutive Activation of Stat3 in Human Prostate Tumors and Cell Lines: Direct Inhibition of Stat3 Signaling Induces Apoptosis of Prostate Cancer Cells1
Linda B. Mora; Ralf Buettner; John Seigne; Jose Diaz; Nazeel Ahmad; Roy Garcia; Tammy Bowman; Robert Falcone; Rita Fairclough; Alan Cantor; Carlos Muro-Cacho; Sandy Livingston; James Karras; Julio Pow-Sang; Richard Jove
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Active Signaling by HER-2/neu in a Subpopulation of HER-2/neu-overexpressing Ductal Carcinoma in Situ: Clinicopathological Correlates1
Michael P. DiGiovanna; Peiguo Chu; Tracey L. Davison; Christine L. Howe; Darryl Carter; Elizabeth B. Claus; David F. Stern
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The Bioenergetic Signature of Cancer: A Marker of Tumor Progression1
José M. Cuezva; Maryla Krajewska; Miguel López de Heredia; Stanislaw Krajewski; Gema Santamaría; Hoguen Kim; Juan M. Zapata; Hiroyuki Marusawa; Margarita Chamorro; John C. Reed
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Essential Roles of Tumor Necrosis Factor Receptor p55 in Liver Metastasis of Intrasplenic Administration of Colon 26 Cells
Hidekazu Kitakata; Yoko Nemoto-Sasaki; Yutaka Takahashi; Toshikazu Kondo; Masayoshi Mai; Naofumi Mukaida
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An Alternatively Spliced Cadherin-11 Enhances Human Breast Cancer Cell Invasion1
Carolyn M. Feltes; Akira Kudo; Orest Blaschuk; Stephen W. Byers
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Candidate Genes for Cross-Resistance against DNA-damaging Drugs12
Rainer Wittig; Michelle Nessling; Rainer D. Will; Jan Mollenhauer; Rüdiger Salowsky; Ewald Münstermann; Matthias Schick; Heike Helmbach; Brigitte Gschwendt; Bernhard Korn; Petra Kioschis; Peter Lichter; Dirk Schadendorf; Annemarie Poustka
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Direct Evidence for a Role of Cyclooxygenase 2-derived Prostaglandin E2 in Human Head and Neck Xenograft Tumors
Ben S. Zweifel; Thomas W. Davis; Richard L. Ornberg; Jaime L. Masferrer
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Systemic Gene Therapy in Human Xenograft Tumor Models by Liposomal Delivery of the E1A Gene1
Naoto T. Ueno; Chandra Bartholomeusz; Weiya Xia; Pervin Anklesaria; Elizabeth M. Bruckheimer; Elise Mebel; Ralph Paul; Song Li; George H. Yo; Leaf Huang; Mien-Chie Hung
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Mitogen-activated Protein Kinase Kinase 4 (MKK4) Acts as a Metastasis Suppressor Gene in Human Ovarian Carcinoma1
S. Diane Yamada; Jonathan A. Hickson; Yancey Hrobowski; Donald J. Vander Griend; David Benson; Anthony Montag; Theodore Karrison; Dezheng Huo; Joanne Rutgers; Sarah Adams; Carrie W. Rinker-Schaeffer
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Ink4a/Arf Deficiency Promotes Ultraviolet Radiation-induced Melanomagenesis1
Juan A. Recio; Frances P. Noonan; Hisashi Takayama; Miriam R. Anver; Paul Duray; Walter L. Rush; Gerd Lindner; Edward C. De Fabo; Ronald A. DePinho; Glenn Merlino
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Overexpression of Vascular Endothelial Growth Factor 165 Drives Peritumor Interstitial Convection and Induces Lymphatic Drain: Magnetic Resonance Imaging, Confocal Microscopy, and Histological Tracking of Triple-labeled Albumin1
Hagit Dafni; Tomer Israely; Zaver M. Bhujwalla; Laura E. Benjamin; Michal Neeman
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Proteomics of Human Breast Ductal Carcinoma in Situ1
Julia D. Wulfkuhle; Dennis C. Sgroi; Henry Krutzsch; Kelley McLean; Kelly McGarvey; Melodie Knowlton; She Chen; Hongjun Shu; Aysegul Sahin; Raffael Kurek; Diethelm Wallwiener; Maria J. Merino; Emanuel F. Petricoin, III; Yingming Zhao; Patricia S. Steeg
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Multiple Splice Variants of Lactate Dehydrogenase C Selectively Expressed in Human Cancer1,2
Michael Koslowski; Özlem Türeci; Carolin Bell; Patricia Krause; Hans-Anton Lehr; Joachim Brunner; Gerhard Seitz; Frank Oliver Nestle; Christoph Huber; Ugur Sahin
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Supplementary data
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Brain-derived Neurotrophic Factor Activation of TrkB Protects Neuroblastoma Cells from Chemotherapy-induced Apoptosis via Phosphatidylinositol 3′-Kinase Pathway
Jerry Jaboin; Chong Jai Kim; David R. Kaplan; Carol J. Thiele
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Mutant Epidermal Growth Factor Receptor Signaling Down-Regulates p27 through Activation of the Phosphatidylinositol 3-Kinase/Akt Pathway in Glioblastomas1
Yoshitaka Narita; Motoo Nagane; Kazuhiko Mishima; H-J. Su Huang; Frank B. Furnari; Webster K. Cavenee
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Protein Kinase CK2 Promotes Aberrant Activation of Nuclear Factor-κB, Transformed Phenotype, and Survival of Breast Cancer Cells1
Raphaëlle Romieu-Mourez; Esther Landesman-Bollag; David C. Seldin; Gail E. Sonenshein
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Meeting Reports

AACR Special Meeting in Cancer Research: Colon Cancer—Genetics to Prevention
Cameron N. Johnstone; Laura M. Chang; Matthias Ernst
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Epigenetic Mechanisms in Human Disease
Andrew P. Feinberg; Mitsuo Oshimura; J. Carl Barrett
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