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Cancer Research (1941-Present; volumes 1-current)

(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.

The American Journal of Cancer (1931-1940; volumes 15-40)

(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.

The Journal of Cancer Research (1916-1930); volumes 1-14)

(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Perspectives in Cancer Research

Tumor Hypoxia, the Physiological Link between Trousseau’s Syndrome (Carcinoma-induced Coagulopathy) and Metastasis

Nicholas C. Denko; Amato J. Giaccia

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Review

Selected Cell and Selective Microenvironment in Neoplastic Development

Harry Rubin

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Advances in Brief

Protein Kinase C-ε Transgenic Mice: A Unique Model for Metastatic Squamous Cell Carcinoma 1

Aaron P. Jansen; Eric G. Verwiebe; Nancy E. Dreckschmidt; Deric L. Wheeler; Terry D. Oberley; Ajit K. Verma

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Efficient Oncolysis by a Replicating Adenovirus (Ad) in Vivo Is Critically Dependent on Tumor Expression of Primary Ad Receptors 1

Joanne T. Douglas; Myunghee Kim; Lucretia A. Sumerel; Delicia E. Carey; David T. Curiel

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Evidence That Genetic Instability Occurs at an Early Stage of Colorectal Tumorigenesis 1

Ie-Ming Shih; Wei Zhou; Steven N. Goodman; Christoph Lengauer; Kenneth W. Kinzler; Bert Vogelstein

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PAX3 Is Expressed in Human Melanomas and Contributes to Tumor Cell Survival 1

Florence A. Scholl; Jivko Kamarashev; Omar V. Murmann; Ralf Geertsen; Reinhard Dummer; Beat W. Schäfer

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Methylation of O–6-Methylguanine DNA Methyltransferase Characterizes a Subset of Colorectal Cancer with Low-level DNA Microsatellite Instability 1

Vicki L. J. Whitehall; Michael D. Walsh; Joanne Young; Barbara A. Leggett; Jeremy R. Jass

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Simultaneous Detection of Multiple Genetic Aberrations in Single Cells by Spectral Fluorescence in Situ Hybridization 1

Marilyn L. Slovak; Lucene Tcheurekdjian; Feiyu F. Zhang; Joyce L. Murata-Collins

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Loss of Fhit Expression Is a Predictor of Poor Outcome in Tongue Cancer 1

Janet I. Lee; Jean-Charles Soria; Khaled Hassan; Diane Liu; Ximing Tang; Adel El-Naggar; Waun Ki Hong; Li Mao

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Vaccination of Malignant Glioma Patients with Peptide-pulsed Dendritic Cells Elicits Systemic Cytotoxicity and Intracranial T-cell Infiltration 1

John S. Yu; Christopher J. Wheeler; Paul M. Zeltzer; Han Ying; Divina N. Finger; Paul K. Lee; William H. Yong; Francesca Incardona; Reid C. Thompson; Mary S. Riedinger; Wenxuan Zhang; Robert M. Prins; Keith L. Black

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Risk of Endometrial Cancer and Estrogen Replacement Therapy History by CYP17 Genotype 1

Roberta McKean-Cowdin; Heather Spencer Feigelson; Malcolm C. Pike; Gerhard A. Coetzee; Laurence N. Kolonel; Brian E. Henderson

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Inhibition of Epidermal Growth Factor-induced Cell Transformation and Activator Protein 1 Activation by [6]-Gingerol 1

Ann M. Bode; Wei-Ya Ma; Young-Joon Surh; Zigang Dong

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A Mammalian Two-Hybrid System for Adenomatous Polyposis Coli-Mutated Colon Cancer Therapeutics 1

Kenichi Wakita; Osamu Tetsu; Frank McCormick

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Therapeutic Tumor Immunity Induced by Polyimmunization with Melanoma Antigens gp100 and TRP-2

Sanjeev Kumar Mendiratta; Gerald Thai; Nima K. Eslahi; Nikolyn M. Thull; Majed Matar; Vincenzo Bronte; Federica Pericle

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Intraneoplastic Polymer-based Delivery of Cyclophosphamide for Intratumoral Bioconversion by a Replicating Oncolytic Viral Vector 1

Tomotsugu Ichikawa; William P. Petros; Susan M. Ludeman; Jim Fangmeier; Fred H. Hochberg; O. Michael Colvin; E. Antonio Chiocca

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Identification of a Cytotoxic T Lymphocyte Response to the Apoptosis Inhibitor Protein Survivin in Cancer Patients 1

Mads Hald Andersen; Lars Østergaard Pedersen; Jürgen C. Becker; Per thor Straten

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Cytotoxic T Lymphocytes from HLA-A2.1 Transgenic Mice Define a Potential Human Epitope from Simian Virus 40 Large T Antigen 1

Todd D. Schell; John D. Lippolis; Satvir S. Tevethia

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The Collaboration of Both Humoral and Cellular HER-2/neu-targeted Immune Responses Is Required for the Complete Eradication of HER-2/neu-expressing Tumors 1

R. Todd Reilly; Jean-Pascal H. Machiels; Leisha A. Emens; Anne M. Ercolini; Francesca I. Okoye; Rachel Y. Lei; Diane Weintraub; Elizabeth M. Jaffee

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Interleukin-18 (IL-18) Synergizes with IL-2 to Enhance Cytotoxicity, Interferon-γ Production, and Expansion of Natural Killer Cells 1

Young-Ik Son; Ramsey M. Dallal; Robbie B. Mailliard; Shinichi Egawa; Zdenka L. Jonak; Michael T. Lotze

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Differential Gene Expression Profiles of Scirrhous Gastric Cancer Cells with High Metastatic Potential to Peritoneum or Lymph Nodes 1

Yoshitaka Hippo; Masakazu Yashiro; Masami Ishii; Hirokazu Taniguchi; Shuichi Tsutsumi; Kosei Hirakawa; Tatsuhiko Kodama; Hiroyuki Aburatani

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Microsatellite Instability and Mismatch-Repair Protein Expression in Hereditary and Sporadic Colorectal Carcinogenesis 1

Monica Pedroni; Elisa Sala; Alessandra Scarselli; Francesca Borghi; Mirco Menigatti; Piero Benatti; Antonio Percesepe; Giuseppina Rossi; Moira Foroni; Lorena Losi; Carmela Di Gregorio; Anto De Pol; Riccardo Nascimbeni; Ernesto Di Betta; Bruno Salerni; Maurizio Ponz de Leon; Luca Roncucci

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Detection of Aberrantly Methylated hMLH1 Promoter DNA in the Serum of Patients with Microsatellite Unstable Colon Cancer 1

William M. Grady; Ashwani Rajput; James D. Lutterbaugh; Sanford D. Markowitz

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Overexpression of the Steroid Receptor Coactivator AIB1 in Breast Cancer Correlates with the Absence of Estrogen and Progesterone Receptors and Positivity for p53 and HER2/neu1

Toula Bouras; Melissa C. Southey; Deon J. Venter

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The Androgen Receptor and Genetic Susceptibility to Ovarian Cancer: Results from a Case Series 1

Douglas A. Levine; Jeff Boyd

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Telomere Length Abnormalities in Mammalian Radiosensitive Cells 1

Joanne McIlrath; Simon D. Bouffler; Enrique Samper; Andrew Cuthbert; Andrzej Wojcik; Irena Szumiel; Peter E. Bryant; Andrew C. Riches; Alastair Thompson; Maria A. Blasco; Robert F. Newbold; Predrag Slijepcevic

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Differential Binding of the Menin Tumor Suppressor Protein to JunD Isoforms

Oya Yazgan; Curt M. Pfarr

Abstract

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Wilms’ Tumor Suppressor Gene (WT1) Is Expressed in Primary Breast Tumors Despite Tumor-specific Promoter Methylation 1

David M. Loeb; Ella Evron; Chirag B. Patel; Prem Mohini Sharma; Birunthi Niranjan; Lakjaya Buluwela; Sigmund A. Weitzman; Dorian Korz; Saraswati Sukumar

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Versican Accumulation in Human Prostatic Fibroblast Cultures Is Enhanced by Prostate Cancer Cell-derived Transforming Growth Factor β1 1

Andrew J. Sakko; Carmela Ricciardelli; Keiko Mayne; Wayne D. Tilley; Richard G. LeBaron; David J. Horsfall

Abstract

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MS-275, A Histone Deacetylase Inhibitor, Selectively Induces Transforming Growth Factor β Type II Receptor Expression in Human Breast Cancer Cells

Byoung Ick Lee; Seok Hee Park; Jin Woo Kim; Edward A. Sausville; Heung Tae Kim; Osamu Nakanishi; Jane B. Trepel; Seong-Jin Kim

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p73α Overexpression Is Associated with Resistance to Treatment with DNA-damaging Agents in a Human Ovarian Cancer Cell Line 1

Faina Vikhanskaya; Sergio Marchini; Mirko Marabese; Emanuela Galliera; Massimo Broggini

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Promoter Hypermethylation Patterns of p16, O⁶-Methylguanine-DNA-methyltransferase, and Death-associated Protein Kinase in Tumors and Saliva of Head and Neck Cancer Patients 1

Siane Lopes Bittencourt Rosas; Wayne Koch; Maria da Gloria da Costa Carvalho; Li Wu; Joseph Califano; William Westra; Jin Jen; David Sidransky

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Biochemistry and Biophysics

Phorbol Esters Modulate the Ras Exchange Factor RasGRP3

Patricia S. Lorenzo; Justin W. Kung; Drell A. Bottorff; Susan H. Garfield; James C. Stone; Peter M. Blumberg

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High Density O-Glycosylation of the MUC2 Tandem Repeat Unit by N-Acetylgalactosaminyltransferase-3 in Colonic Adenocarcinoma Extracts 1

Mizue Inoue; Shuji Takahashi; Ikuo Yamashina; Masaki Kaibori; Tadayoshi Okumura; Yasuo Kamiyama; Sophie Vichier-Guerre; Danièle Cantacuzène; Hiroshi Nakada

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Identification of Precursor Forms of Free Prostate-specific Antigen in Serum of Prostate Cancer Patients by Immunosorption and Mass Spectrometry

Jochen Peter; Carlo Unverzagt; Thomas N. Krogh; Ole Vorm; Wolfgang Hoesel

Abstract

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Kinase Suppressor of Ras Is Necessary for Tumor Necrosis Factor α Activation of Extracellular Signal-regulated Kinase/Mitogen-activated Protein Kinase in Intestinal Epithelial Cells 1

Fang Yan; D. Brent Polk

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Carcinogeniesis

Overexpression of Plasminogen Activator Inhibitor Type 2 in Basal Keratinocytes Enhances Papilloma Formation in Transgenic Mice 1

Hong-Ming Zhou; Isabelle Bolon; Anthony Nichols; Annelise Wohlwend; Jean-Dominique Vassalli

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Early p53-positive Foci as Indicators of Tumor Risk in Ultraviolet-exposed Hairless Mice: Kinetics of Induction, Effects of DNA Repair Deficiency, and p53 Heterozygosity 1

Heggert Rebel; Laurent O. Mosnier; Rob J. W. Berg; Anja Westerman-de Vries; Harry van Steeg; Henk J. van Kranen; Frank R. de Gruijl

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Overexpression of Membrane-type Matrix Metalloproteinase-1 Gene Induces Mammary Gland Abnormalities and Adenocarcinoma in Transgenic Mice 1

Hye-Yeong Ha; Hyung-Bae Moon; Myoung-Soo Nam; Jeong-Woong Lee; Zae-Yoong Ryoo; Tae-Hoon Lee; Kyung-Kwang Lee; Byung-Jan So; Hiroshi Sato; Motoharu Seiki; Dae-Yeul Yu

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Clinical Investigations

Protoporphyrin IX Occurs Naturally in Colorectal Cancers and Their Metastases 1

K. Thomas Moesta; Bernd Ebert; Tim Handke; Dirk Nolte; Christian Nowak; Wolfgang E. Haensch; Ravindra K. Pandey; Thomas J. Dougherty; Herbert Rinneberg; Peter M. Schlag

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Epidemiology and Prevention

A Molecular Variant of the APC Gene at Codon 1822: Its Association with Diet, Lifestyle, and Risk of Colon Cancer 1

Martha L. Slattery; Wade Samowitz; Linda Ballard; Donna Schaffer; Mark Leppert; John D. Potter

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Experimental Therapeutics

Electroporation-mediated Interleukin-12 Gene Therapy for Hepatocellular Carcinoma in the Mice Model

Yo-ichi Yamashita; Mitsuo Shimada; Hirofumi Hasegawa; Ryosuke Minagawa; Tatsuya Rikimaru; Takayuki Hamatsu; Shinji Tanaka; Ken Shirabe; Jun-ichi Miyazaki; Keizo Sugimachi

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In Vitro and In Vivo Anticancer Activities of Synthetic Macrocyclic Ketone Analogues of Halichondrin B 1

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Metastatin: A Hyaluronan-binding Complex from Cartilage That Inhibits Tumor Growth 1

Ningfei Liu; Randall K. Lapcevich; Charles B. Underhill; Zeqiu Han; Feng Gao; Glenn Swartz; Stacy M. Plum; Lurong Zhang; Shawn J. Green

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Dual Antitumor Effects of 5-Fluorouracil on the Cell Cycle in Colorectal Carcinoma Cells: A Novel Target Mechanism Concept for Pharmacokinetic Modulating Chemotherapy

Reigetsu Yoshikawa; Masato Kusunoki; Hidenori Yanagi; Masafumi Noda; Jun-ichi Furuyama; Takehira Yamamura; Tomoko Hashimoto-Tamaoki

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Anticancer Drugs Induce Increased Mitochondrial Cytochrome c Expression That Precedes Cell Death 1

José A. Sánchez-Alcázar; Alexey Khodjakov; Erasmus Schneider

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Tumor Necrosis Factor α Sensitizes Low Epidermal Growth Factor Receptor (EGFR)-expressing Carcinomas for Anti-EGFR Therapy 1

Markus Hambek; Christine Solbach; Hans-Georg Schnuerch; Marc Roller; Manfred Stegmueller; Anja Sterner-Kock; Jan Kiefer; Rainald Knecht

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Triggering of Antitumor Activity Through Melanoma-specific Transduction of a Constitutively Active Tumor Necrosis Factor (TNF) R1 Chimeric Receptor in the Absence of TNF-α 1

Flavia Bazzoni; Elisabetta Regalia

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Characterization of Metabolites of the Chemopreventive Agent Curcumin in Human and Rat Hepatocytes and in the Rat in Vivo, and Evaluation of Their Ability to Inhibit Phorbol Ester-induced Prostaglandin E₂ Production 1

Christopher Ireson; Samantha Orr; Don J. L. Jones; Richard Verschoyle; Chang-Kee Lim; Jin-Li Luo; Lynne Howells; Simon Plummer; Rebekah Jukes; Marion Williams; William P. Steward; Andreas Gescher

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S-Phase Arrest by Nucleoside Analogues and Abrogation of Survival without Cell Cycle Progression by 7-Hydroxystaurosporine 1

Zheng Shi; Atsushi Azuma; Deepa Sampath; Ye-Xiong Li; Peng Huang; William Plunkett

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Inhibition of N-myc Expression and Induction of Apoptosis by Iron Chelation in Human Neuroblastoma Cells 1

Liju Fan; Jaya Iyer; Shaoxian Zhu; Kevin K. Frick; Randall K. Wada; Allen E. Eskenazi; Patricia E. Berg; Naohiko Ikegaki; Roger H. Kennett; Christopher N. Frantz

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Immunology

Enhancement of DNA Vaccine Potency by Linkage of Antigen Gene to a Gene Encoding the Extracellular Domain of Fms-like Tyrosine Kinase 3-Ligand 1

Chien-Fu Hung; Keng-Fu Hsu; Wen-Fang Cheng; Chee-Yin Chai; Liangmei He; Morris Ling; T-C. Wu

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Use of an in Vitro Immunoselected Tumor Line to Identify Shared Melanoma Antigens Recognized by HLA-A*0201-restricted T Cells

Mamoru Harada; Yong F. Li; Mona El-Gamil; Steven A. Rosenberg; Paul F. Robbins

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Characterization of the Major Histocompatibility Complex Class I Deficiencies in B16 Melanoma Cells 1

Barbara Seliger; Ursula Wollscheid; Frank Momburg; Thomas Blankenstein; Christoph Huber

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Macrophage Arginase Promotes Tumor Cell Growth and Suppresses Nitric Oxide-mediated Tumor Cytotoxicity 1

Chiung-I Chang; James C. Liao; Lih Kuo

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Optimal Induction of Effector but not Memory Antitumor Cytotoxic T Lymphocytes Involves Direct Antigen Presentation by the Tumor Cells 1

Yannik Guilloux; Xue-feng Bai; Xingluo Liu; Pan Zheng; Yang Liu

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Molecular Biology and Genetics

Heat-activated Transgene Expression from Adenovirus Vectors Infected into Human Prostate Cancer Cells 1

Michael J. Borrelli; Diane M. Schoenherr; Alden Wong; Laura J. Bernock; Peter M. Corry

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Analysis of Complex Relationships between Age, p53, Epidermal Growth Factor Receptor, and Survival in Glioblastoma Patients 1

Martha L. Simmons; Kathleen R. Lamborn; Michelle Takahashi; Pengchin Chen; Mark A. Israel; Mitchel S. Berger; Tony Godfrey; Janice Nigro; Michael Prados; Susan Chang; Fred G. Barker, II; Ken Aldape

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Different Mechanisms of Radiation-induced Loss of Heterozygosity in Two Human Lymphoid Cell Lines from a Single Donor 1

Claudia Wiese; Stacey S. Gauny; Wei-Chung Liu; Corinne L. Cherbonnel-Lasserre; Amy Kronenberg

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Signaling Events Triggered by Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL): Caspase-8 Is Required for TRAIL-induced Apoptosis 1

Dai-Wu Seol; Jianrong Li; Mi-Hyang Seol; Sang-Youel Park; Robert V. Talanian; Timothy R. Billiar

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Identification of a Novel Member of the Snail/Gfi-1 Repressor Family, mlt 1, Which Is Methylated and Silenced in Liver Tumors of SV40 T Antigen Transgenic Mice 1

Minako Tateno; Yoshifumi Fukunishi; Sei Komatsu; Yasushi Okazaki; Jun Kawai; Kazuhiro Shibata; Masayoshi Itoh; Masami Muramatsu; William A. Held; Yoshihide Hayashizaki

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Evidence for Three Tumor Suppressor Loci on Chromosome 9p Involved in Melanoma Development

Pamela M. Pollock; John Welch; Nicholas K. Hayward

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Induction and Intracellular Regulation of Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) Mediated Apotosis in Human Malignant Glioma Cells 1

Chunhai Hao; Francesco Beguinot; Gerolama Condorelli; Alessandra Trencia; Erwin G. Van Meir; V. Wee Yong; Ian F. Parney; Wilson H. Roa; Kenneth C. Petruk

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Loss of Heterozygosity Mapping at Chromosome Arm 16q in 712 Breast Tumors Reveals Factors that Influence Delineation of Candidate Regions 1

Anne-Marie Cleton-Jansen; David F. Callen; Ram Seshadri; Sandra Goldup; Brett McCallum; Joanna Crawford; Jason A. Powell; Chatri Settasatian; Hetty van Beerendonk; Elna W. Moerland; Vincent T. B. H. M. Smit; William H. Harris; Rosemary Millis; Neil V. Morgan; Diana Barnes; Christopher G. Mathew; Cees J. Cornelisse

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A Modest Reduction in c-Myc Expression Has Minimal Effects on Cell Growth and Apoptosis But Dramatically Reduces Susceptibility to Ras and Raf Transformation 1

Alex V. Bazarov; Susumu Adachi; Sheng-Feng Li; Maria K. Mateyak; Shan Wei; John M. Sedivy

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Involvement of the Oct-1 Regulatory Element of the gadd45 Promoter in the p53-independent Response to Ultraviolet Irradiation 1

Senye Takahashi; Shoichi Saito; Naoko Ohtani; Toshiyuki Sakai

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Tumor Biology

Expression of Adrenomedullin and Peptide Amidation Activity in Human Prostate Cancer and in Human Prostate Cancer Cell Lines 1

Palma Rocchi; Françoise Boudouresque; Alfredo J. Zamora; Xavier Muracciole; Eric Lechevallier; Pierre-Marie Martin; L’Houcine Ouafik

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Involvement of Flt-1 Tyrosine Kinase (Vascular Endothelial Growth Factor Receptor-1) in Pathological Angiogenesis 1

Sachie Hiratsuka; Yoshiro Maru; Akiko Okada; Motoharu Seiki; Tetsuo Noda; Masabumi Shibuya

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Chromosomal Rearrangements and Oncogene Amplification Precede Aneuploidization in the Genetic Evolution of Breast Cancer 1

Karin Rennstam; Bo Baldetorp; Soili Kytölä; Minna Tanner; Jorma Isola

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Intranuclear Compartmentalization of Cyclin E during the Cell Cycle: Disruption of the Nucleoplasm-Nucleolar Shuttling of Cyclin E in Bladder Cancer 1

Gloria Juan; Carlos Cordon-Cardo

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Loss of Caspase-1 and Caspase-3 Protein Expression in Human Prostate Cancer 1

Rachel N. Winter; Andrew Kramer; Andrew Borkowski; Natasha Kyprianou

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Induction of Apoptotic Cell Death and Prevention of Tumor Growth by Ceramide Analogues in Metastatic Human Colon Cancer 1

Markus Selzner; Alicja Bielawska; Michael A. Morse; Hannes A. Rüdiger; David Sindram; Yusuf A. Hannun; Pierre-Alain Clavien

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Journal Archive

Table of Contents

Perspectives in Cancer Research

Review

Advances in Brief

Biochemistry and Biophysics

Carcinogeniesis

Clinical Investigations

Epidemiology and Prevention

Experimental Therapeutics

Immunology

Molecular Biology and Genetics

Tumor Biology

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