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Volume 61, Issue 22

15 November 2001

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Cover Image

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ISSN 0008-5472

EISSN 1538-7445

Issue Sections

Advances in Brief
Carcinogenesis
Experimental Therapeutics
Immunology
Molecular Biology and Genetics
Tumor Biology
Letters to the Editor

Journal Archive

Cancer Research (1941-Present; volumes 1-current)

(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.

The American Journal of Cancer (1931-1940; volumes 15-40)

(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.

The Journal of Cancer Research (1916-1930); volumes 1-14)

(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Advances in Brief

Hydrogen Peroxide Mediates Activation of Nuclear Factor of Activated T Cells (NFAT) by Nickel Subsulfide

Chuanshu Huang; Jingxia Li; Max Costa; Zhuo Zhang; Stephen S. Leonard; Vincent Castranova; Val Vallyathan; Gong Ju; Xianglin Shi

Abstract

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In Situ Expression of Interleukin-4 (IL-4) Receptors in Human Brain Tumors and Cytotoxicity of a Recombinant IL-4 Cytotoxin in Primary Glioblastoma Cell Cultures 1

Bharat H. Joshi; Pamela Leland; Anthony Asher; Richard A. Prayson; Frederick Varricchio; Raj K. Puri

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Destabilization of CHK2 by a Missense Mutation Associated with Li-Fraumeni Syndrome 1

Sean Bong Lee; Sang Hyon Kim; Daphne W. Bell; Doke C. R. Wahrer; Taryn A. Schiripo; Melissa M. Jorczak; Dennis C. Sgroi; Judy E. Garber; Frederick P. Li; Kim E. Nichols; Jenny M. Varley; Andrew K. Godwin; Kristen M. Shannon; Ed Harlow; Daniel A. Haber

Abstract

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WWOX, the FRA16D Gene, Behaves as a Suppressor of Tumor Growth 1

Andrzej K. Bednarek; Catherine L. Keck-Waggoner; Rachael L. Daniel; Kendra J. Laflin; P. Leif Bergsagel; Kaoru Kiguchi; Andrew J. Brenner; C. Marcelo Aldaz

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Cytoplasmic Localization of the Oncogenic Protein Ski in Human Cutaneous Melanomas in Vivo: Functional Implications for Transforming Growth Factor β Signaling 1

Jon A. Reed; Elise Bales; Weidong Xu; Nihal A. Okan; Debdutta Bandyopadhyay; Estela E. Medrano

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LYVE-1 Is Not Restricted to the Lymph Vessels: Expression in Normal Liver Blood Sinusoids and Down-Regulation in Human Liver Cancer and Cirrhosis 1

Carla Mouta Carreira; Selim M. Nasser; Emmanuelle di Tomaso; Timothy P. Padera; Yves Boucher; Stanislav I. Tomarev; Rakesh K. Jain

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β-Catenin Expression Is Altered in Human Colonic Aberrant Crypt Foci 1

Xing Pei Hao; Thomas G. Pretlow; J. Sunil Rao; Theresa P. Pretlow

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Expression of the Invasion Factor Laminin γ2 in Colorectal Carcinomas Is Regulated by β-Catenin 1

Falk Hlubek; Andreas Jung; Nicole Kotzor; Thomas Kirchner; Thomas Brabletz

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Hypermethylation in Human Cancers of the RIZ1 Tumor Suppressor Gene, a Member of a Histone/Protein Methyltransferase Superfamily 1

Yong Du; Tobias Carling; Wei Fang; Zhe Piao; Jin-Chuan Sheu; Shi Huang

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Mining the Melanosome for Tumor Vaccine Targets: P.polypeptide Is a Novel Tumor-associated Antigen

Christopher E. Touloukian; Wolfgang W. Leitner; Paul F. Robbins; Steven A. Rosenberg; Nicholas P. Restifo

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Comparative Analysis of Necrotic and Apoptotic Tumor Cells As a Source of Antigen(s) in Dendritic Cell-based Immunization 1

Yoshihito Kotera; Koichi Shimizu; James J. Mulé

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Modulation of the Immune Response by Systemic Targeting of Antigens to Lymph Nodes 1

Martin Trepel; Wadih Arap; Renata Pasqualini

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O⁶-Methylguanine-DNA Methyltransferase Promoter Hypermethylation Shifts the p53 Mutational Spectrum in Non-Small Cell Lung Cancer 1

Patrick Wolf; Ying Chuan Hu; Kara Doffek; David Sidransky; Steven A. Ahrendt

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KIT Activation Is a Ubiquitous Feature of Gastrointestinal Stromal Tumors

Brian P. Rubin; Samuel Singer; Connie Tsao; Anette Duensing; Marcia L. Lux; Robert Ruiz; Michele K. Hibbard; Chang-Jie Chen; Sheng Xiao; David A. Tuveson; George D. Demetri; Christopher D. M. Fletcher; Jonathan A. Fletcher

Abstract

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T-Cell Receptor γ Chain Alternate Reading Frame Protein (TARP) Expression in Prostate Cancer Cells Leads to an Increased Growth Rate and Induction of Caveolins and Amphiregulin

Curt D. Wolfgang; Magnus Essand; Byungkook Lee; Ira Pastan

Abstract

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Carcinogenesis

Induction of Antitumor Immunity via Intratumoral Tetra-Costimulator Protein Transfer 1

Guoxing Zheng; Aoshuang Chen; Raymond E. Sterner; Paul J. Zhang; Tao Pan; Nadya Kiyatkin; Mark L. Tykocinski

Abstract

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Malignant Transformation in a Nontumorigenic Human Prostatic Epithelial Cell Line 1

Simon W. Hayward; Yuzhuo Wang; Mei Cao; Yun Kit Hom; Baohui Zhang; Gary D. Grossfeld; Daniel Sudilovsky; Gerald R. Cunha

Abstract

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The Consequences of Chromosomal Aneuploidy on Gene Expression Profiles in a Cell Line Model for Prostate Carcinogenesis

John L. Phillips; Simon W. Hayward; Yuzhuo Wang; James Vasselli; Christian Pavlovich; Hesed Padilla-Nash; John R. Pezullo; B. Michael Ghadimi; Gary D. Grossfeld; Alexandra Rivera; W. Marston Linehan; Gerald R. Cunha; Thomas Ried

Abstract

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Induction of Melanoma in Murine Macrophage Inflammatory Protein 2 Transgenic Mice Heterozygous for Inhibitor of Kinase/Alternate Reading Frame 1

Jinming Yang; Jing Luan; Yingchun Yu; Cunxi Li; Ronald A. DePinho; Lynda Chin; Ann Richmond

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UV-induced DNA Damage and Mutations in Hupki (Human p53 Knock-in) Mice Recapitulate p53 Hotspot Alterations in Sun-exposed Human Skin 1

Jun-Li Luo; Wei-Min Tong; Jung-Hoon Yoon; Manfred Hergenhahn; Riita Koomagi; Qin Yang; Dominique Galendo; Gerd P. Pfeifer; Zhao-Qi Wang; Monica Hollstein

Abstract

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A New Selective and Potent Inhibitor of Human Cytochrome P450 1B1 and Its Application to Antimutagenesis 1

Young-Jin Chun; Sanghee Kim; Donghak Kim; Sang-Kwang Lee; F. Peter Guengerich

Abstract

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Experimental Therapeutics

Inhibition of Angiogenesis-driven Kaposi’s Sarcoma Tumor Growth in Nude Mice by Oral N-Acetylcysteine 1

Adriana Albini; Monica Morini; Francesco D’Agostini; Nicoletta Ferrari; Francesco Campelli; Giuseppe Arena; Douglas M. Noonan; Carlo Pesce; Silvio De Flora

Abstract

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Quantitative Imaging and Microlocalization of Boron-10 in Brain Tumors and Infiltrating Tumor Cells by SIMS Ion Microscopy: Relevance to Neutron Capture Therapy 1

Duane R. Smith; Subhash Chandra; Rolf F. Barth; Weilian Yang; Darrel D. Joel; Jeffrey A. Coderre

Abstract

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A Genetically Engineered Influenza A Virus with ras-Dependent Oncolytic Properties 1

Michael Bergmann; Ingrid Romirer; Monika Sachet; Reinhard Fleischhacker; Adolfo García-Sastre; Peter Palese; Klaus Wolff; Hubert Pehamberger; Raimund Jakesz; Thomas Muster

Abstract

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Molecular Basis for the Synergistic Interaction of Adriamycin with the Formaldehyde-releasing Prodrug Pivaloyloxymethyl Butyrate (AN-9)1

Suzanne M. Cutts; Ada Rephaeli; Abraham Nudelman; Inesa Hmelnitsky; Don R. Phillips

Abstract

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The Phosphatidylinositide 3′-Kinase/Akt Survival Pathway Is a Target for the Anticancer and Radiosensitizing Agent PKC412, an Inhibitor of Protein Kinase C 1

Angela Tenzer; Daniel Zingg; Sonia Rocha; Brian Hemmings; Doriano Fabbro; Christoph Glanzmann; P. August Schubiger; Stephan Bodis; Martin Pruschy

Abstract

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Radiosensitization of p53 Mutant Cells by PD0166285, a Novel G₂ Checkpoint Abrogator

Yuli Wang; Jun Li; Robert N. Booher; Alan Kraker; Theodore Lawrence; Wilbur R. Leopold; Yi Sun

Abstract

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Immunology

Phases of Apoptosis of Melanoma Cells, but not of Normal Melanocytes, Differently Affect Maturation of Myeloid Dendritic Cells 1

Gabriella Pietra; Roberta Mortarini; Giorgio Parmiani; Andrea Anichini

Abstract

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Immunization with Wild-Type p53 Gene Sequences Coadministered with Flt3 Ligand Induces an Antigen-specific Type 1 T-Cell Response

Prahlad Parajuli; Vladimir Pisarev; Jennifer Sublet; Amy Steffel; Michelle Varney; Rakesh Singh; Drake LaFace; James E. Talmadge

Abstract

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Molecular Biology and Genetics

New Amplified and Highly Expressed Genes Discovered in the ERBB2 Amplicon in Breast Cancer by cDNA Microarrays 1

Päivikki Kauraniemi; Maarit Bärlund; Outi Monni; Anne Kallioniemi

Abstract

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Identification of Cytogenetic Subgroups and Karyotypic Pathways in Transitional Cell Carcinoma 1

Mattias Höglund; Torbjörn Säll; Sverre Heim; Felix Mitelman; Nils Mandahl; Imad Fadl-Elmula

Abstract

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Diverse Mechanisms of β-Catenin Deregulation in Ovarian Endometrioid Adenocarcinomas

Rong Wu; Yali Zhai; Eric R. Fearon; Kathleen R. Cho

Abstract

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p53R2-dependent Pathway for DNA Synthesis in a p53-regulated Cell Cycle Checkpoint 1

Tatsuya Yamaguchi; Koichi Matsuda; Yoji Sagiya; Manabu Iwadate; Masayuki A. Fujino; Yusuke Nakamura; Hirofumi Arakawa

Abstract

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Independent Amplification of Two Gene Clusters on Chromosome 4 in Rat Endometrial Cancer: Identification and Molecular Characterization 1

Anna Walentinsson; Khalil Helou; Ville Wallenius; Hans J. Hedrich; Claude Szpirer; Göran Levan

Abstract

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Intrachromosomal Genomic Instability in Human Sporadic Colorectal Cancer Measured by Genome-Wide Allelotyping and Inter-(Simple Sequence Repeat) PCR 1

Garth R. Anderson; Bruce M. Brenner; Helen Swede; Neng Chen; W. Michael Henry; Jeffrey M. Conroy; Matthew J. Karpenko; Jean-Pierre Issa; Jeremy D. Bartos; Joslyn K. Brunelle; Gerald P. Jahreis; Morton S. Kahlenberg; Mark Basik; Sheila Sait; Miguel A. Rodriguez-Bigas; Norma J. Nowak; Nicholas J. Petrelli; Thomas B. Shows; Daniel L. Stoler

Abstract

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p16^INK4a Lesions Are Common, Early Abnormalities that Undergo Clonal Expansion in Barrett’s Metaplastic Epithelium 1

David J. Wong; Thomas G. Paulson; Laura J. Prevo; Patricia C. Galipeau; Gary Longton; Patricia L. Blount; Brian J. Reid

Abstract

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Loss of DNA Mismatch Repair Imparts Defective cdc2 Signaling and G₂ Arrest Responses without Altering Survival after Ionizing Radiation 1

Tao Yan; Jane E. Schupp; Hwa-shin Hwang; Mark W. Wagner; Suzanne E. Berry; Sue Strickfaden; Martina L. Veigl; W. David Sedwick; David A. Boothman; Timothy J. Kinsella

Abstract

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Tumor Biology

Transgenic Polyoma Middle-T Mice Model Premalignant Mammary Disease 1

Jeannie E. Maglione; Drew Moghanaki; Lawrence J. T. Young; Cathyryne K. Manner; Lesley G. Ellies; Sasha O. Joseph; Benjamin Nicholson; Robert D. Cardiff; Carol L. MacLeod

Abstract

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Transforming Growth Factor-β1 Increases Survival of Human Melanoma through Stroma Remodeling 1

Carola Berking; Richelle Takemoto; Helmut Schaider; Louise Showe; Kapaettu Satyamoorthy; Paul Robbins; Meenhard Herlyn

Abstract

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Increased p53 Mutation Frequency during Tumor Progression—Results from a Breast Cancer Cohort 1

Torbjörn Norberg; Sigrid Klaar; Gunilla Kärf; Hans Nordgren; Lars Holmberg; Jonas Bergh

Abstract

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Induction of Glucose-regulated Protein 78 by Chronic Hypoxia in Human Gastric Tumor Cells through a Protein Kinase C-ε/ERK/AP-1 Signaling Cascade 1

Min Sup Song; Yong Keun Park; Je-Ho Lee; Kyoungsook Park

Abstract

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Heterogeneous Transforming Growth Factor (TGF)-β Unresponsiveness and Loss of TGF-β Receptor Type II Expression Caused by Histone Deacetylation in Lung Cancer Cell Lines 1

Hirotaka Osada; Yoshio Tatematsu; Akira Masuda; Toshiko Saito; Miyabi Sugiyama; Kiyoshi Yanagisawa; Takashi Takahashi

Abstract

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Endothelin-1 Induces Tumor Proteinase Activation and Invasiveness of Ovarian Carcinoma Cells 1

Laura Rosanò; Marco Varmi; Debora Salani; Valeriana Di Castro; Francesca Spinella; Pier Giorgio Natali; Anna Bagnato

Abstract

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Letters to the Editor

Correspondence re: J. W. Baish and R. K. Jain, Fractals and Cancer. Cancer Res., 60: 3683–3688, 2000.

Hsiao-Wen Chung; Hsiao-Jen Chung

Extract

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TβR-I(6A) Polymorphism Is not a Tumor Susceptibility Allele in Macedonian Colorectal Cancer Patients 1 Correspondence re: B. Pasche et al. Type I TβR-I(6A) Is a Candidate Tumor Susceptibility Allele. Cancer Res., 58: 2727–2732, 1998.

Ana-Marija Stefanovska; Georgi D. Efremov; Aleksandar J. Dimovski; Djingis Jasar; Gjorgi Zografski; Toni Josifovski; Milco Panovski; Renata Jankova; Mirko Spiroski

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Issues

Cover Image

Journal Archive

Table of Contents

Advances in Brief

Carcinogenesis

Experimental Therapeutics

Immunology

Molecular Biology and Genetics

Tumor Biology

Letters to the Editor

TβR-I(6A) Polymorphism Is not a Tumor Susceptibility Allele in Macedonian Colorectal Cancer Patients1 Correspondence re: B. Pasche et al. Type I TβR-I(6A) Is a Candidate Tumor Susceptibility Allele. Cancer Res., 58: 2727–2732, 1998.

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TβR-I(6A) Polymorphism Is not a Tumor Susceptibility Allele in Macedonian Colorectal Cancer Patients 1 Correspondence re: B. Pasche et al. Type I TβR-I(6A) Is a Candidate Tumor Susceptibility Allele. Cancer Res., 58: 2727–2732, 1998.