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Cancer Research (1941-Present; volumes 1-current)

(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.

The American Journal of Cancer (1931-1940; volumes 15-40)

(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.

The Journal of Cancer Research (1916-1930); volumes 1-14)

(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Advances in Brief

Constitutive Expression of ErbB-2 in Gallbladder Epithelium Results in Development of Adenocarcinoma 1

Kaoru Kiguchi; Steve Carbajal; Keith Chan; Linda Beltrán; Lynnsie Ruffino; Jianjun Shen; Takashi Matsumoto; Naoki Yoshimi; John DiGiovanni

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BARX2 Induces Cadherin 6 Expression and Is a Functional Suppressor of Ovarian Cancer Progression 1

Grant C. Sellar; Li Li; Karen P. Watt; Barry D. Nelkin; Genevieve J. Rabiasz; Euan A. Stronach; Eric P. Miller; David J. Porteous; John F. Smyth; Hani Gabra

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SKY1 Is Involved in Cisplatin-induced Cell Kill in Saccharomyces cerevisiae, and Inactivation of Its Human Homologue, SRPK1, Induces Cisplatin Resistance in a Human Ovarian Carcinoma Cell Line 1

Paul W. Schenk; Antonius W. M. Boersma; Jourica A. Brandsma; Hans den Dulk; Herman Burger; Gerrit Stoter; Jaap Brouwer; Kees Nooter

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Plasmids with a Mammalian Replication Origin and a Matrix Attachment Region Initiate the Event Similar to Gene Amplification 1

Noriaki Shimizu; Yuri Miura; Yu Sakamoto; Ken Tsutsui

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Age-related Hypermethylation of the 5′ Region of MLH1 in Normal Colonic Mucosa Is Associated with Microsatellite-unstable Colorectal Cancer Development 1

Hidewaki Nakagawa; Gerard J. Nuovo; Emmanuel E. Zervos; Edward W. Martin, Jr.; Reijo Salovaara; Lauri A. Aaltonen; Albert de la Chapelle

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Secreted and Cell Surface Genes Expressed in Benign and Malignant Colorectal Tumors 1

Phillip Buckhaults; Carlo Rago; Brad St. Croix; Katharine E. Romans; Saurabh Saha; Lin Zhang; Bert Vogelstein; Kenneth W. Kinzler

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Complete Inhibition of Vascular Endothelial Growth Factor (VEGF) Activities with a Bifunctional Diabody Directed against Both VEGF Kinase Receptors, fms-like Tyrosine Kinase Receptor and Kinase Insert Domain-containing Receptor

Dan Lu; Xenia Jimenez; Haifan Zhang; Yan Wu; Peter Bohlen; Larry Witte; Zhenping Zhu

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Adenovirus-mediated Transfection of Caspase-8 Augments Anoikis and Inhibits Peritoneal Dissemination of Human Gastric Carcinoma Cells 1

Susumu Nishimura; Masaaki Adachi; Tadao Ishida; Takahiro Matsunaga; Hiroaki Uchida; Hirofumi Hamada; Kohzoh Imai

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Identification of a Mononucleotide Repeat as a Major Target for Mitochondrial DNA Alterations in Human Tumors 1

Montserrat Sanchez-Cespedes; Paola Parrella; Shuji Nomoto; Daniel Cohen; Yan Xiao; Manel Esteller; Carmen Jeronimo; Richard C. K. Jordan; Theresa Nicol; Wayne M. Koch; Mark Schoenberg; Paola Mazzarelli; Vito M. Fazio; David Sidransky

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A Nonsense Mutation in MLH1 Causes Exon Skipping in Three Unrelated HNPCC Families 1

Alessandro Stella; Anja Wagner; Kazuhisa Shito; Steven M. Lipkin; Patrice Watson; Ginevra Guanti; Henry T. Lynch; Riccardo Fodde; Bo Liu

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Synergistic Activation of Functional Estrogen Receptor (ER)-α by DNA Methyltransferase and Histone Deacetylase Inhibition in Human ER-α-negative Breast Cancer Cells 1

Xiaowei Yang; Dawn L. Phillips; Anne T. Ferguson; William G. Nelson; James G. Herman; Nancy E. Davidson

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Substitutions That Compromise the Ionizing Radiation-induced Association of p53 with 14-3-3 Proteins Also Compromise the Ability of p53 to Induce Cell Cycle Arrest 1

Elena S. Stavridi; Nabil H. Chehab; Asra Malikzay; Thanos D. Halazonetis

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Frequent Epigenetic Inactivation of RASSF1A by Aberrant Promoter Hypermethylation in Human Gastric Adenocarcinoma 1

Do-Sun Byun; Min-Goo Lee; Kwon-Seok Chae; Byung-Gyu Ryu; Sung-Gil Chi

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Deletions of AXIN1, a Component of the WNT/wingless Pathway, in Sporadic Medulloblastomas 1

R. P. Dahmen; A. Koch; D. Denkhaus; J. C. Tonn; N. Sörensen; F. Berthold; J. Behrens; W. Birchmeier; O. D. Wiestler; T. Pietsch

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High Expression of S-Phase Kinase-interacting Protein 2, Human F-box Protein, Correlates with Poor Prognosis in Oral Squamous Cell Carcinomas 1

Yasusei Kudo; Shojiro Kitajima; Sunao Sato; Mutsumi Miyauchi; Ikuko Ogawa; Takashi Takata

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In Vivo Intracellular Signaling as a Marker of Antiangiogenic Activity 1

Carmen C. Solorzano; Young D. Jung; Corazon D. Bucana; David J. McConkey; Gary E. Gallick; Gerald McMahon; Lee M. Ellis

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Therapeutic Efficacy of E2F1 in Pancreatic Cancer Correlates with TP73 Induction 1

Florian Rödicker; Thorsten Stiewe; Sonja Zimmermann; Brigitte M. Pützer

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Brain Enriched Hyaluronan Binding (BEHAB)/Brevican Increases Aggressiveness of CNS-1 Gliomas in Lewis Rats 1

Catherine L. Nutt; Cynthia A. Zerillo; Gail M. Kelly; Susan Hockfield

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Suppression of Intestinal and Mammary Neoplasia by Lifetime Administration of Aspirin in Apc^Min/+ and Apc^Min/+, Msh2^−/− Mice 1

Owen J. Sansom; Lesley A. Stark; Malcolm G. Dunlop; Alan R. Clarke

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Biochemistry and Biophysics

Retinoic Acid Biosynthesis by Normal Human Breast Epithelium Is via Aldehyde Dehydrogenase 6, Absent in MCF-7 Cells 1

Brent N. Rexer; Wen Li Zheng; David E. Ong

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Redox-mediated Effects of Selenium on Apoptosis and Cell Cycle in the LNCaP Human Prostate Cancer Cell Line 1

Weixiong Zhong; Terry D. Oberley

Abstract

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Inhibition of Focal Adhesion Kinase Expression or Activity Disrupts Epidermal Growth Factor-stimulated Signaling Promoting the Migration of Invasive Human Carcinoma Cells 1

Christof R. Hauck; David J. Sieg; Datsun A. Hsia; Joseph C. Loftus; William A. Gaarde; Brett P. Monia; David D. Schlaepfer

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Carcinogenesis

Collagenase-3 Expression in Breast Myofibroblasts as a Molecular Marker of Transition of Ductal Carcinoma in Situ Lesions to Invasive Ductal Carcinomas 1

Boye Schnack Nielsen; Fritz Rank; José Manuel López; Milagros Balbin; Francisco Vizoso; Leif Røge Lund; Keld Danø; Carlos López-Otín

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Alterations of β- and γ-Catenin in N-Butyl-N-(-4-hydroxybutyl)nitrosamine-induced Murine Bladder Cancer 1

Hiroaki Shiina; Mikio Igawa; Shinji Urakami; Kazushi Shigeno; Tatsuaki Yoneda; Masaharu Terashima; Masao Deguchi; Leopoldo Ribeiro-Filho; Rajvir Dahiya

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Methylated CpG Dinucleotides Are the Preferential Targets for G-to-T Transversion Mutations Induced by Benzo[a]pyrene Diol Epoxide in Mammalian Cells: Similarities with the p53 Mutation Spectrum in Smoking-associated Lung Cancers 1

Jung-Hoon Yoon; Leslie E. Smith; Zaohui Feng; Moon-shong Tang; Chong-Soon Lee; Gerd P. Pfeifer

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Evidence for a Putative Senescence Gene Locus within the Chromosomal Region 10p14–p15 1

Manuela Poignée; Claudia Backsch; Katrin Beer; Lars Jansen; Nikola Wagenbach; Eric J. Stanbridge; Richard Kirchmayr; Achim Schneider; Matthias Dürst

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Endocrinology

Growth Inhibitory Effects of 1α, 25-Dihydroxyvitamin D₃ Are Mediated by Increased Levels of p21 in the Prostatic Carcinoma Cell Line ALVA-31 1

Kirsten A. Moffatt; Widya U. Johannes; Tammy E. Hedlund; Gary J. Miller

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Epidemiology and Prevention

Polymorphisms in Glutathione S-Transferases (GSTM1 and GSTT1) and Survival after Treatment for Breast Cancer 1

Christine B. Ambrosone; Carol Sweeney; Brian F. Coles; Patricia A. Thompson; Gail Y. McClure; Soheila Korourian; Manal Y. Fares; Angie Stone; Fred F. Kadlubar; Laura F. Hutchins

Abstract

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Dietary Folate Intake and Breast Cancer Risk: Results from the Shanghai Breast Cancer Study 1

Martha J. Shrubsole; Fan Jin; Qi Dai; Xiao-Ou Shu; John D. Potter; James R. Hebert; Yu-Tang Gao; Wei Zheng

Abstract

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Experimental Therapeutics

p202, an Interferon-inducible Protein, Mediates Multiple Antitumor Activities in Human Pancreatic Cancer Xenograft Models 1

Yong Wen; Duen-Hwa Yan; Bailiang Wang; Bill Spohn; Yi Ding; Ruping Shao; Yiyu Zou; Keping Xie; Mien-Chie Hung

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Induction of Apoptosis in 9-Nitrocamptothecin-treated DU145 Human Prostate Carcinoma Cells Correlates with de Novo Synthesis of CD95 and CD95 Ligand and Down-Regulation of c-FLIP_short 1

Devasis Chatterjee; Ingo Schmitz; Andreas Krueger; Kam Yeung; Sabine Kirchhoff; Peter H. Krammer; Marcus E. Peter; James H. Wyche; Panayotis Pantazis

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Pegylation of a Chlorin_e6 Polymer Conjugate Increases Tumor Targeting of Photosensitizer 1

Michael R. Hamblin; Jaimie L. Miller; Imran Rizvi; Bernhard Ortel; Edward V. Maytin; Tayyaba Hasan

Abstract

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Enhanced Uptake of a Thermally Responsive Polypeptide by Tumor Cells in Response to Its Hyperthermia-mediated Phase Transition 1

Drazen Raucher; Ashutosh Chilkoti

Abstract

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Antimitogenic and Proapoptotic Activities of Methylseleninic Acid in Vascular Endothelial Cells and Associated Effects on PI3K-AKT, ERK, JNK and p38 MAPK Signaling 1

Zaisen Wang; Cheng Jiang; Howard Ganther; Junxuan Lü

Abstract

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Differential Expression of Members of the Tumor Necrosis Factor α-related Apoptosis-inducing Ligand Pathway in Prostate Cancer Cells

Supriya Sridhar; Afshan A. Ali; Yayun Liang; M. Fathy El Etreby; Ronald W. Lewis; M. Vijay Kumar

Abstract

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The Tyrosine Kinase Inhibitor ZD1839 (“Iressa”) Inhibits HER2-driven Signaling and Suppresses the Growth of HER2-overexpressing Tumor Cells 1

Mark M. Moasser; Andrea Basso; Steven D. Averbuch; Neal Rosen

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Potent Antitumor Activity and Improved Pharmacological Profile of ST1481, a Novel 7-substituted Camptothecin 1

Michelandrea De Cesare; Graziella Pratesi; Paola Perego; Nives Carenini; Stella Tinelli; Lucio Merlini; Sergio Penco; Claudio Pisano; Federica Bucci; Loredana Vesci; Silvia Pace; Francesca Capocasa; Paolo Carminati; Franco Zunino

Abstract

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The Characterization of Novel, Dual ErbB-2/EGFR, Tyrosine Kinase Inhibitors: Potential Therapy for Cancer

Abstract

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Expression of CD26 and Its Associated Dipeptidyl Peptidase IV Enzyme Activity Enhances Sensitivity to Doxorubicin-induced Cell Cycle Arrest at the G₂/M Checkpoint 1

Ugur Aytac; Francois-Xavier Claret; Linus Ho; Kazuya Sato; Kei Ohnuma; Gordon B. Mills; Fernando Cabanillas; Chikao Morimoto; Nam H. Dang

Abstract

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Involvement of Cdc25A Phosphatase in Hep3B Hepatoma Cell Growth Inhibition Induced by Novel K Vitamin Analogs 1

Ziqiu Wang; Eileen C. Southwick; Meifang Wang; Siddhartha Kar; Kathryn S. Rosi; Craig S. Wilcox; John S. Lazo; Brian I. Carr

Abstract

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Mechanisms of Uptake and Resistance to Troxacitabine, a Novel Deoxycytidine Nucleoside Analogue, in Human Leukemic and Solid Tumor Cell Lines

Henriette Gourdeau; Marilyn L. Clarke; France Ouellet; Delores Mowles; Milada Selner; Annie Richard; Nola Lee; John R. Mackey; James D. Young; Jacques Jolivet; Ronald G. Lafrenière; Carol E. Cass

Abstract

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Transport of Methotrexate (MTX) and Folates by Multidrug Resistance Protein (MRP) 3 and MRP1: Effect of Polyglutamylation on MTX Transport 1

Hao Zeng; Zhe-Sheng Chen; Martin G. Belinsky; Philip A. Rea; Gary D. Kruh

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Immunology

Absence of the Wild-Type Allele Predicts Poor Prognosis in Adult de Novo Acute Myeloid Leukemia with Normal Cytogenetics and the Internal Tandem Duplication of FLT3: A Cancer and Leukemia Group B Study 1

Susan P. Whitman; Kellie J. Archer; Lan Feng; Claudia Baldus; Brian Becknell; Brian D. Carlson; Andrew J. Carroll; Krzysztof Mrózek; James W. Vardiman; Stephen L. George; Jonathan E. Kolitz; Richard A. Larson; Clara D. Bloomfield; Michael A. Caligiuri

Abstract

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Macrophages Orchestrate the Immune Response to Tumor Cell Death 1

Michael J. Gough; Alan A. Melcher; Atique Ahmed; Marka R. Crittenden; David S. Riddle; Emmanouela Linardakis; Anja N. Ruchatz; Lisa M. Emiliusen; Richard G. Vile

Abstract

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Molecular Biology and Genetics

Biochemical Genetic Analysis of Indanocine Resistance in Human Leukemia 1

Xuequn Helen Hua; Davide Genini; Rick Gussio; Rommel Tawatao; Hsien Shih; Thomas J. Kipps; Dennis A. Carson; Lorenzo M. Leoni

Abstract

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Par-4 Drives Trafficking and Activation of Fas and FasL to Induce Prostate Cancer Cell Apoptosis and Tumor Regression 1

Mala Chakraborty; Shirley Guofang Qiu; Krishna Murthi Vasudevan; Vivek M. Rangnekar

Abstract

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Second Primary or Recurrence? Comparative Patterns of p53 and K-ras Mutations Suggest that Serous Borderline Ovarian Tumors and Subsequent Serous Carcinomas Are Unrelated Tumors 1

B. Hannah Ortiz; Monica Ailawadi; Cristiano Colitti; Michael G. Muto; Michael Deavers; Elvio G. Silva; Ross S. Berkowitz; Samuel C. Mok; David M. Gershenson

Abstract

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Multipoint Imprinting Analysis Indicates a Common Precursor Cell for Gonadal and Nongonadal Pediatric Germ Cell Tumors 1

Dominik T. Schneider; Amy E. Schuster; Michael K. Fritsch; Jie Hu; Thomas Olson; Stephen Lauer; Ulrich Göbel; Elizabeth J. Perlman; the Pediatric Oncology Group; German Pediatric Germ Cell Tumor Study Group

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Epigenetic Inactivation of the RASSF1A 3p21.3 Tumor Suppressor Gene in Both Clear Cell and Papillary Renal Cell Carcinoma 1

Catherine Morrissey; Alonso Martinez; Malgorzata Zatyka; Angelo Agathanggelou; Sofia Honorio; Dewi Astuti; Neil V. Morgan; Holger Moch; Frances M. Richards; Takeshi Kishida; Masahiro Yao; Peter Schraml; Farida Latif; Eamonn R. Maher

Abstract

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Tumor Biology

Modulation of Angiogenesis and Tumorigenicity of Human Melanocytic Cells by Vascular Endothelial Growth Factor and Basic Fibroblast Growth Factor 1

Ullrich Graeven; Ulrich Rodeck; Sonja Karpinski; Monika Jost; Stathis Philippou; Wolff Schmiegel

Abstract

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Dynamics of Notch Expression during Murine Prostate Development and Tumorigenesis

Jianyong Shou; Sarajane Ross; Hartmut Koeppen; Frederic J. de Sauvage; Wei-Qiang Gao

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Generation of Multiple Angiogenesis Inhibitors by Human Pancreatic Cancer 1

Oliver Kisker; Shinya Onizuka; Jacqueline Banyard; Tomoko Komiyama; Christian M. Becker; Eike Gert Achilles; Carmen M. Barnes; Michael S. O’Reilly; Judah Folkman; Steven R. Pirie-Shepherd

Abstract

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Expression of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in Human Ovarian Tumors and Tumor-associated Macrophages 1

Alida H. Klimp; Harry Hollema; Claudia Kempinga; Ate G. J. van der Zee; Elisabeth G. E. de Vries; Toos Daemen

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Androgen Receptor Mediates the Reduced Tumor Growth, Enhanced Androgen Responsiveness, and Selected Target Gene Transactivation in a Human Prostate Cancer Cell Line 1

Bekir Cinar; Kenneth S. Koeneman; Magnus Edlund; Gail S. Prins; Haiyen E. Zhau; Leland W. K. Chung

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Insulin-like Growth Factor-1 Induces Survival and Growth of Biologically Early Melanoma Cells through Both the Mitogen-activated Protein Kinase and β-Catenin Pathways 1

Kapaettu Satyamoorthy; Gang Li; Bhavesh Vaidya; Dipa Patel; Meenhard Herlyn

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Cables Enhances Cdk2 Tyrosine 15 Phosphorylation by Wee1, Inhibits Cell Growth, and Is Lost in Many Human Colon and Squamous Cancers

Chin-Lee Wu; Sandra D. Kirley; Hua Xiao; Yenning Chuang; Daniel C. Chung; Lawrence R. Zukerberg

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Thioredoxin Expression in Primary T-Cell Acute Lymphoblastic Leukemia and Its Therapeutic Implication 1

Li-en Shao; Mitchell B. Diccianni; Tetsuya Tanaka; Ruby Gribi; Alice L. Yu; Jeanette D. Pullen; Bruce M. Camitta; John Yu

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Tumor Necrosis Factor-related Apoptosis-inducing Ligand-induced Apoptosis of Human Melanoma Is Regulated by Smac/DIABLO Release from Mitochondria 1

Xu Dong Zhang; Xi Yi Zhang; Christian P. Gray; Tam Nguyen; Peter Hersey

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Effects of ras and von Hippel-Lindau (VHL) Gene Mutations on Hypoxia-inducible Factor (HIF)-1α, HIF-2α, and Vascular Endothelial Growth Factor Expression and Their Regulation by the Phosphatidylinositol 3′-Kinase/Akt Signaling Pathway 1

Christine Blancher; John W. Moore; Naomi Robertson; Adrian L. Harris

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Expression of the Antiangiogenic Factor 16K hPRL in Human HCT116 Colon Cancer Cells Inhibits Tumor Growth in Rag1^−/− Mice 1

Frauke Bentzien; Ingrid Struman; Jean-François Martini; Joseph Martial; Richard Weiner

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Letters to the Editor

Correspondence re: Akasaka, H., et al., Molecular Anatomy of BCL6 Translocations Revealed by Long-Distance Polymerase Chain Reaction-based Assays. Cancer Res., 60: 2335–2341, 2000.

Izidore S. Lossos; Yakop Jacobs; Michael L. Cleary; Ronald Levy

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Issues

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Advances in Brief

Biochemistry and Biophysics

Carcinogenesis

Endocrinology

Epidemiology and Prevention

Experimental Therapeutics

Immunology

Molecular Biology and Genetics

Tumor Biology

Letters to the Editor

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