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Volume 61, Issue 1

1 January 2001

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Cover Image

Cover Image

ISSN 0008-5472

EISSN 1538-7445

Issue Sections

Editorial
Advances in Brief
Carcinogenesis
Clinical Investigations
Epidemiology & Prevention
Experimental Therapeutics
Immunology
Tumor Biology

Journal Archive

Cancer Research (1941-Present; volumes 1-current)

(ISSN 0008-5472) Published twice monthly since 1987. From 1941-1986, published monthly.

The American Journal of Cancer (1931-1940; volumes 15-40)

(ISSN 0099-7374) Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.

The Journal of Cancer Research (1916-1930); volumes 1-14)

(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Editorial

Message from the Editor-in-Chief

Frank J. Rauscher, III

Extract

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Advances in Brief

Histone Deacetylase-targeted Treatment Restores Retinoic Acid Signaling and Differentiation in Acute Myeloid Leukemia 1

Fabiana F. Ferrara; Francesco Fazi; Andrea Bianchini; Fabrizio Padula; Vania Gelmetti; Saverio Minucci; Marco Mancini; Pier Giuseppe Pelicci; Francesco Lo Coco; Clara Nervi

Abstract

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Evidence for the Development of p53 Mutations after Cytotoxic Therapy in a Neuroblastoma Cell Line 1

Deborah A. Tweddle; Archie J. Malcolm; Nick Bown; Andrew D. J. Pearson; John Lunec

Abstract

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Usefulness of Repeated Direct Intratumoral Gene Transfer Using Hemagglutinating Virus of Japan-Liposome Method for Cytosine Deaminase Suicide Gene Therapy

Hiroki Kanyama; Naohiro Tomita; Tomoki Yamano; Tomohiko Aihara; Yasuo Miyoshi; Masayuki Ohue; Mitsugu Sekimoto; Isao Sakita; Yasuhiro Tamaki; Yasufumi Kaneda; Peter D. Senter; Morito Monden

Abstract

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More Frequent β-Catenin Exon 3 Mutations in Gallbladder Adenomas Than in Carcinomas Indicate Different Lineages 1

Nobuyuki Yanagisawa; Tetuo Mikami; Makoto Saegusa; Isao Okayasu

Abstract

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Alterations of the Double-Strand Break Repair Gene MRE11 in Cancer 1

Toshikatu Fukuda; Tatsuaki Sumiyoshi; Mamoru Takahashi; Tsuyoshi Kataoka; Toshimasa Asahara; Hiroki Inui; Masahiro Watatani; Masayuki Yasutomi; Nanao Kamada; Kiyoshi Miyagawa

Abstract

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Lack of Telomerase RNA Gene hTERC Expression in Alternative Lengthening of Telomeres Cells Is Associated with Methylation of the hTERC Promoter 1

Stacey F. Hoare; Lisa A. Bryce; G. Bea A. Wisman; Sharon Burns; James J. Going; Ate G. J. van der Zee; W. Nicol Keith

Abstract

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Specific p53 Mutations Detected in Plasma and Tumors of Hepatocellular Carcinoma Patients by Electrospray Ionization Mass Spectrometry 1

Peta E. Jackson; Geng-Sun Qian; Marlin D. Friesen; Yuan-Rong Zhu; Peixin Lu; Jin-Bing Wang; Yiqian Wu; Thomas W. Kensler; Bert Vogelstein; John D. Groopman

Abstract

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Frameshift Mutations at Coding Mononucleotide Repeats of the hRAD50 Gene in Gastrointestinal Carcinomas with Microsatellite Instability 1

Nam-Gyun Kim; Yon Rak Choi; Myung Jin Baek; Yun Hee Kim; Haeyoun Kang; Nam Kyu Kim; Jin Sik Min; Hoguen Kim

Abstract

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Vascular Endothelial Growth Factor Receptor-2-blocking Antibody Potentiates Radiation-induced Long-Term Control of Human Tumor Xenografts 1

Sergey V. Kozin; Yves Boucher; Daniel J. Hicklin; Peter Bohlen; Rakesh K. Jain; Herman D. Suit

Abstract

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Tumor Progression Is Associated with a Significant Decrease in the Expression of the Endostatin Precursor Collagen XVIII in Human Hepatocellular Carcinomas 1

Orlando Musso; Marko Rehn; Nathalie Théret; Bruno Turlin; Paulette Bioulac-Sage; Dominique Lotrian; Jean-Pierre Campion; Taina Pihlajaniemi; Bruno Clément

Abstract

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Highly Elevated Ultraviolet-induced Mutation Frequency in Isolated Chinese Hamster Cell Lines Defective in Nucleotide Excision Repair and Mismatch Repair Proteins 1

Ken-ichiro Nara; Fumio Nagashima; Akira Yasui

Abstract

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Topoisomerase I-mediated Cytotoxicity of N-Methyl-N′-nitro-N-nitrosoguanidine: Trapping of Topoisomerase I by the O⁶-Methylguanine 1

Philippe Pourquier; Jessica L. Waltman; Yoshimasa Urasaki; Natalia A. Loktionova; Anthony E. Pegg; John L. Nitiss; Yves Pommier

Abstract

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The Partial Nontandem Duplication of the MLL (ALL1) Gene Is a Novel Rearrangement That Generates Three Distinct Fusion Transcripts in B-Cell Acute Lymphoblastic Leukemia 1

Susan P. Whitman; Matthew P. Strout; Guido Marcucci; Aharon G. Freud; Lucia L. Culley; Nancy J. Zeleznik-Le; Krzysztof Mrózek; Karl S. Theil; Ursula R. Kees; Clara D. Bloomfield; Michael A. Caligiuri

Abstract

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Human Homologue of Yeast Rad23 Protein A Interacts with p300/Cyclic AMP-responsive Element Binding (CREB)-binding Protein to Down-Regulate Transcriptional Activity of p53 1

Qianzheng Zhu; Gulzar Wani; Manzoor A. Wani; Altaf A. Wani

Abstract

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Intact Nitric Oxide Synthase II Gene Is Required for Interferon-β-mediated Suppression of Growth and Metastasis of Pancreatic Adenocarcinoma 1

Bailiang Wang; Qinghua Xiong; Qian Shi; Xiangdong Le; James L. Abbruzzese; Keping Xie

Abstract

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Proteomic Analysis Reveals that 14-3-3σ Is Down-Regulated in Human Breast Cancer Cells 1

Anne-Sophie Vercoutter-Edouart; Jérôme Lemoine; Xuefen Le Bourhis; Hornez Louis; Bénoni Boilly; Victor Nurcombe; Françoise Révillion; Jean-Philippe Peyrat; Hubert Hondermarck

Abstract

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A Three-Dimensional and Temporo-Spatial Model to Study Invasiveness of Cancer Cells by Heregulin and Prostaglandin E₂ 1

Liana Adam; Abhijit Mazumdar; Tushar Sharma; Terence R. Jones; Rakesh Kumar

Abstract

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Carcinogenesis

p53 Modulates Base Excision Repair Activity in a Cell Cycle-specific Manner after Genotoxic Stress 1

Hagai Offer; Irit Zurer; Gaspar Banfalvi; Marian Reha’k; Ayellet Falcovitz; Michael Milyavsky; Naomi Goldfinger; Varda Rotter

Abstract

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Progesterone Receptor B Gene Inactivation and CpG Hypermethylation in Human Uterine Endometrial Cancer

Masahiro Sasaki; Abhipsa Dharia; Bong R. Oh; Yuichiro Tanaka; Sei-ichiro Fujimoto; Rajvir Dahiya

Abstract

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Protection against 2-Hydroxyamino-1-methyl-6-phenylimidazo[4,5-b]pyridine Cytotoxicity and DNA Adduct Formation in Human Prostate by Glutathione S-Transferase P1 1

Chad P. Nelson; La Creis R. Kidd; Jurga Sauvageot; William B. Isaacs; Angelo M. De Marzo; John D. Groopman; William G. Nelson; Thomas W. Kensler

Abstract

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Clinical Investigations

Synthesis and Evaluation of ¹⁸F-labeled Choline as an Oncologic Tracer for Positron Emission Tomography: Initial Findings in Prostate Cancer

Timothy R. DeGrado; R. Edward Coleman; Shuyan Wang; Steven W. Baldwin; Matthew D. Orr; Cary N. Robertson; Thomas J. Polascik; David T. Price

Abstract

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Epidemiology & Prevention

(+)-Catechin Inhibits Intestinal Tumor Formation and Suppresses Focal Adhesion Kinase Activation in the Min/+ Mouse 1

Michael J. Weyant; Adelaide M. Carothers; Andrew J. Dannenberg; Monica M. Bertagnolli

Abstract

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Estrogens Reduce and Withdrawal of Estrogens Increase Risk of Microsatellite Instability-positive Colon Cancer 1

Martha L. Slattery; John D. Potter; Karen Curtin; Sandra Edwards; Khe-Ni Ma; Kristin Anderson; Donna Schaffer; Wade S. Samowitz

Abstract

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Experimental Therapeutics

Characterization of the Antitumor Effects of the Selective Farnesyl Protein Transferase Inhibitor R115777 in Vivo and in Vitro

David W. End; Gerda Smets; Alison V. Todd; Tanya L. Applegate; Caroline J. Fuery; Patrick Angibaud; Marc Venet; Gerard Sanz; Herve Poignet; Stacy Skrzat; Ann Devine; Walter Wouters; Charles Bowden

Abstract

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Expression of a Truncated First Exon BCR Sequence in Chronic Myelogenous Leukemia Cells Blocks Cell Growth and Induces Cell Death 1

Yan Wang; Jiaxin Liu; Yun Wu; Weiping Luo; Sue-Hwa Lin; Hui Lin; Natalyn Hawk; Tong Sun; Jie Qiang Guo; Zeev Estrov; Moshe Talpaz; Richard Champlin; Ralph B. Arlinghaus

Abstract

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Mitochondrial Dysfunction after Aerobic Exposure to the Hypoxic Cytotoxin Tirapazamine 1

Bradly G. Wouters; Yvette M. Delahoussaye; James W. Evans; Geoffrey W. Birrell; Mary Jo Dorie; Jingli Wang; Dhara MacDermed; Roland K. Chiu; J. Martin Brown

Abstract

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In Situ Expression of Soluble B7-1 in the Context of Oncolytic Herpes Simplex Virus Induces Potent Antitumor Immunity 1

Tomoki Todo; Robert L. Martuza; Margaret J. Dallman; Samuel D. Rabkin

Abstract

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Tumor Cell Vaccine Elicits Potent Antitumor Immunity after Allogeneic T-Cell-depleted Bone Marrow Transplantation 1

Takanori Teshima; Nicolas Mach; Geoffrey R. Hill; Luying Pan; Silke Gillessen; Glenn Dranoff; James L. M. Ferrara

Abstract

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Simultaneous Treatment with 1-β-d-Arabinofuranosylcytosine and Daunorubicin Induces Cross-Resistance to Both Drugs due to a Combination-specific Mechanism in HL60 Cells 1

Haruyuki Takemura; Yoshimasa Urasaki; Akira Yoshida; Toshihiro Fukushima; Takanori Ueda

Abstract

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Induction of Differentiation of Acute Promyelocytic Leukemia Cells by a Cytidine Deaminase-resistant Analogue of 1-β-d-Arabinofuranosylcytosine, 1-(2-Deoxy-2-methylene-β-d-erythro-pentofuranosyl)cytidine 1

Nozomi Niitsu; Yuki Ishii; Akira Matsuda; Yoshio Honma

Abstract

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Adenovirus-mediated Bax Overexpression for the Induction of Therapeutic Apoptosis in Prostate Cancer 1

Xiaoying Li; Michela Marani; Jiang Yu; Bicheng Nan; Jack A. Roth; Shunsuke Kagawa; Bingliang Fang; Larry Denner; Marco Marcelli

Abstract

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Immunology

Immunological and Viral Factors Associated with the Response of Vulval Intraepithelial Neoplasia to Photodynamic Therapy 1

El-Said Abdel-Hady; Pierre Martin-Hirsch; Maggie Duggan-Keen; Peter L. Stern; James V. Moore; Gerald Corbitt; Henry C. Kitchener; Ian N. Hampson

Abstract

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A Retrogen Strategy for Presentation of an Intracellular Tumor Antigen as an Exogenous Antigen by Dendritic Cells Induces Potent Antitumor T Helper and CTL Responses 1

Zhaoyang You; Jenny Hester; Lisa Rollins; Giulio C. Spagnoli; Pierre van der Bruggen; Si-Yi Chen

Abstract

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Granulocyte/Macrophage-Colony Stimulating Factor Produced by Recombinant Avian Poxviruses Enriches the Regional Lymph Nodes with Antigen-presenting Cells and Acts as an Immunoadjuvant

Erik Kass; Dennis L. Panicali; Gail Mazzara; Jeffrey Schlom; John W. Greiner

Abstract

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Persistence of Immunogenic Pulmonary Metastases in the Presence of Protective Anti-melanoma Immunity 1

Cherrie K. Donawho; Michael W. Pride; Margaret L. Kripke

Abstract

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Human Heat Shock Protein 70 Peptide Complexes Specifically Activate Antimelanoma T Cells 1

Chiara Castelli; Anne-Marie T. Ciupitu; Francesca Rini; Licia Rivoltini; Arabella Mazzocchi; Rolf Kiessling; Giorgio Parmiani

Abstract

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Local Administration of Dendritic Cells Inhibits Established Breast Tumor Growth: Implications for Apoptosis-inducing Agents 1

Kimberly A. Candido; Koichi Shimizu; Julie C. McLaughlin; Robin Kunkel; Jennifer A. Fuller; Bruce G. Redman; Elaine K. Thomas; Brian J. Nickoloff; James J. Mulé

Abstract

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A Novel Role of Metalloproteinase in Cancer-mediated Immunosuppression 1

Bor-Ching Sheu; Su-Ming Hsu; Hong-Nerng Ho; Huang-Chun Lien; Su-Cheng Huang; Rong-Hwa Lin

Abstract

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The Chemotherapeutic Drug 5-Fluorouracil Induces Apoptosis in Mouse Thymocytes in Vivo via Activation of the CD95(APO-1/Fas) System

Sören T. Eichhorst; Susanne Müerköster; Markus A. Weigand; Peter H. Krammer

Abstract

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Aberrant Promoter Methylation of Multiple Genes in Non-Small Cell Lung Cancers 1

Sabine Zöchbauer-Müller; Kwun M. Fong; Arvind K. Virmani; Joseph Geradts; Adi F. Gazdar; John D. Minna

Abstract

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Transforming Growth Factor-β-induced Growth Inhibition in a Smad4 Mutant Colon Adenoma Cell Line 1

Stephen P. Fink; Sandra E. Swinler; James D. Lutterbaugh; Joan Massagué; Sam Thiagalingam; Kenneth W. Kinzler; Bert Vogelstein; James K. V. Willson; Sanford Markowitz

Abstract

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A Role for CCAAT/Enhancer Binding Protein β-Liver-enriched Inhibitory Protein in Mammary Epithelial Cell Proliferation 1

Cynthia A. Zahnow; Robert D. Cardiff; Rodolfo Laucirica; Daniel Medina; Jeffrey M. Rosen

Abstract

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Nonhomologous End-Joining of Ionizing Radiation-induced DNA Double-Stranded Breaks in Human Tumor Cells Deficient in BRCA1 or BRCA2 1

Huichen Wang; Zhao-Chong Zeng; Tu-Anh Bui; Steven J. DiBiase; Wei Qin; Fen Xia; Simon N. Powell; George Iliakis

Abstract

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Mutant E-cadherin Breast Cancer Cells Do Not Display Constitutive Wnt Signaling 1

Marc van de Wetering; Nick Barker; I. Clara Harkes; Marcel van der Heyden; Nicolette J. Dijk; Antoinette Hollestelle; Jan G. M. Klijn; Hans Clevers; Mieke Schutte

Abstract

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High Resolution Allelotype of Nonfunctional Pancreatic Endocrine Tumors: Identification of Two Molecular Subgroups with Clinical Implications 1

Gildas Rigaud; Edoardo Missiaglia; Patrick S. Moore; Giuseppe Zamboni; Massimo Falconi; Giorgio Talamini; Anna Pesci; Antonella Baron; Daniele Lissandrini; Guido Rindi; Piergiovanni Grigolato; Paolo Pederzoli; Aldo Scarpa

Abstract

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Tumor Biology

Five Novel Hormone-responsive Cell Lines Derived from Murine Mammary Ductal Carcinomas: In Vivo and in Vitro Effects of Estrogens and Progestins 1

Claudia Lanari; Isabel Lüthy; Caroline A. Lamb; Victoria Fabris; Eleonora Pagano; Luisa A. Helguero; Norberto Sanjuan; Susana Merani; Alfredo A. Molinolo

Abstract

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Expression of Cyclooxygenase 2 in Human Malignant Melanoma

Carsten Denkert; Martin Köbel; Stefan Berger; Antje Siegert; Anja Leclere; Uwe Trefzer; Steffen Hauptmann

Abstract

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Modulation of Tumor Angiogenesis by Conditional Expression of Fibroblast Growth Factor-2 Affects Early but not Established Tumors 1

Raffaella Giavazzi; Roberta Giuliani; Daniela Coltrini; Maria Rosa Bani; Cristina Ferri; Barbara Sennino; Maria Pia Molinari Tosatti; Antonella Stoppacciaro; Marco Presta

Abstract

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Antiapoptotic Role of Endogenous Nitric Oxide in Human Melanoma Cells 1

Ombretta Salvucci; Marilisa Carsana; Ilaria Bersani; Gabrina Tragni; Andrea Anichini

Abstract

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p53 Induction and Apoptosis in Response to Radio- and Chemotherapy in Vivo Is Tumor-Type-dependent 1

Christopher J. Kemp; Shaoli Sun; Kay E. Gurley

Abstract

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Apoptosis: An Early Event in Metastatic Inefficiency 1

Christopher W. Wong; Andrea Lee; Lisa Shientag; Jong Yu; Yao Dong; Gary Kao; Abu B. Al-Mehdi; Eric J. Bernhard; Ruth J. Muschel

Abstract

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Laminin Isoforms 8 and 10 Are Primary Components of the Subendothelial Basement Membrane Promoting Interaction with Neoplastic Lymphocytes 1

Paola Spessotto; Zhinan Yin; Gaetano Magro; Rainer Deutzmann; Arlene Chiu; Alfonso Colombatti; Roberto Perris

Abstract

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Reconstitution of Caspase 3 Sensitizes MCF-7 Breast Cancer Cells to Doxorubicin- and Etoposide-induced Apoptosis 1

Xiao-He Yang; Todd L. Sladek; Xuesong Liu; Bryn R. Butler; Christopher J. Froelich; Ann D. Thor

Abstract

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Cytogenetic Analysis of Multifocal Bladder Cancer Supports a Monoclonal Origin and Intraepithelial Spread of Tumor Cells 1

Ronald Simon; Elke Eltze; Karl-Ludwig Schäfer; Horst Bürger; Axel Semjonow; Lothar Hertle; Barbara Dockhorn-Dworniczak; Hans-Joachim Terpe; Werner Böcker

Abstract

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Neuroblastoma-derived Gangliosides Inhibit Dendritic Cell Generation and Function 1

Galina V. Shurin; Michael R. Shurin; Svetlana Bykovskaia; Jeffrey Shogan; Michael T. Lotze; Edward M. Barksdale, Jr.

Abstract

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Specifically Targeted Killing of Carcinoembryonic Antigen (CEA)-expressing Cells by a Retroviral Vector Displaying Single-Chain Variable Fragmented Antibody to CEA and Carrying the Gene for Inducible Nitric Oxide Synthase 1

Pranay D. Khare; Liao Shao-Xi; Motomu Kuroki; Yumiko Hirose; Fumiko Arakawa; Ken Nakamura; Yoshihiro Tomita; Masahide Kuroki

Abstract

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Matrix Metalloproteinase 2 in Tumor Cell-induced Platelet Aggregation: Regulation by Nitric Oxide 1

Paul Jurasz; Grzegorz Sawicki; Marek Duszyk; Jolanta Sawicka; Carlos Miranda; Irvin Mayers; Marek W. Radomski

Abstract

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Interleukin 6 Inhibits Proliferation and, in Cooperation with an Epidermal Growth Factor Receptor Autocrine Loop, Increases Migration of T47D Breast Cancer Cells 1

Ali Badache; Nancy E. Hynes

Abstract

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D-24851, a Novel Synthetic Microtubule Inhibitor, Exerts Curative Antitumoral Activity in Vivo, Shows Efficacy toward Multidrug-resistant Tumor Cells, and Lacks Neurotoxicity 1

Gerald Bacher; Bernd Nickel; Peter Emig; Udo Vanhoefer; Siegfried Seeber; Alexei Shandra; Thomas Klenner; Thomas Beckers

Abstract

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Heregulin Regulation of Urokinase Plasminogen Activator and its Receptor: Human Breast Epithelial Cell Invasion 1

Abhijit Mazumdar; Liana Adam; Douglas Boyd; Rakesh Kumar

Abstract

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