(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Advances in Brief

Ligand Responsiveness in Human Prostate Cancer: Structural Analysis of Mutant Androgen Receptors from LNCaP and CWR22 Tumors 1

Shawn McDonald; Lars Brive; David B. Agus; Howard I. Scher; Kathryn R. Ely

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Inducible Chemoresistance to 7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) in Colorectal Cancer Cells and a Xenograft Model Is Overcome by Inhibition of Nuclear Factor-κB Activation 1

James C. Cusack, Jr.; Rong Liu; Albert S. Baldwin, Jr.

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Nijmegen Breakage Syndrome Disease Protein and MRE11 at PML Nuclear Bodies and Meiotic Telomeres 1

David B. Lombard; Leonard Guarente

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Molecular Anatomy of BCL6 Translocations Revealed by Long-Distance Polymerase Chain Reaction-based Assays 1

Hiroshi Akasaka; Takashi Akasaka; Masayuki Kurata; Chiyoko Ueda; Akira Shimizu; Takashi Uchiyama; Hitoshi Ohno

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The Fhit Tumor Suppressor Protein Regulates the Intracellular Concentration of Diadenosine Triphosphate but not Diadenosine Tetraphosphate 1

Gillian A. Murphy; Deborah Halliday; Alexander G. McLennan

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Specific c-kit Mutations in Sinonasal Natural Killer/T-Cell Lymphoma in China and Japan 1

Tadashi Hongyo; Ting Li; Mukh Syaifudin; Rajamanickam Baskar; Hirokazu Ikeda; Yuzuru Kanakura; Katsuyuki Aozasa; Taisei Nomura

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Progesterone Receptor Gene Polymorphism Is Associated with Decreased Risk for Breast Cancer by Age 50 1

Shan Wang-Gohrke; Jenny Chang-Claude; Heiko Becher; Dirk G. Kieback; Ingo B. Runnebaum

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Kinetics of Plasma Epstein-Barr Virus DNA during Radiation Therapy for Nasopharyngeal Carcinoma 1

Y. M. Dennis Lo; Sing-Fai Leung; Lisa Y. S. Chan; Anthony T. C. Chan; Kwok-Wai Lo; Philip J. Johnson; Dolly P. Huang

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Identification of Differential Methylation of the WT1 Antisense Regulatory Region and Relaxation of Imprinting in Wilms’ Tumor 1

Karim Malik; Ashreena Salpekar; Anne Hancock; Kim Moorwood; Sally Jackson; Adrian Charles; Keith W. Brown

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The Ras-Mitogen-activated Protein Kinase Pathway Is Critical for the Activation of Matrix Metalloproteinase Secretion and the Invasiveness in v-crk-transformed 3Y1 1

Enbo Liu; Aye Aye Thant; Fumitaka Kikkawa; Hisashi Kurata; Shinya Tanaka; Akihiro Nawa; Shigehiko Mizutani; Satoru Matsuda; Hidesaburo Hanafusa; Michinari Hamaguchi

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Levels of E2F-1 Expression Are Higher in Lung Metastasis of Colon Cancer As Compared with Hepatic Metastasis and Correlate with Levels of Thymidylate Synthase 1

Debabrata Banerjee; Richard Gorlick; Anna Liefshitz; Kathy Danenberg; Peter C. Danenberg; Peter V. Danenberg; David Klimstra; Suresh Jhanwar; Carlos Cordon-Cardo; Yuman Fong; Nancy Kemeny; Joseph R. Bertino

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Inactivation of the DNA Repair Gene O⁶-Methylguanine-DNA Methyltransferase by Promoter Hypermethylation Is Associated with G to A Mutations in K-ras in Colorectal Tumorigenesis 1

Manel Esteller; Minoru Toyota; Montserrat Sanchez-Cespedes; Gabriel Capella; Miguel Angel Peinado; D. Neil Watkins; Jean-Pierre J. Issa; David Sidransky; Stephen B. Baylin; James G. Herman

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WRN or Telomerase Constructs Reverse 4-Nitroquinoline 1-Oxide Sensitivity in Transformed Werner Syndrome Fibroblasts 1

Fuki M. Hisama; Yao-Hui Chen; M. Stephen Meyn; Junko Oshima; Sherman M. Weissman

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Biochemistry and Biophysics

Nitric Oxide Inhibits Apoptosis via AP-1-dependent CD95L Transactivation 1

Gerry Melino; Francesca Bernassola; Maria Valeria Catani; Antonello Rossi; Marco Corazzari; Stefania Sabatini; Francis Vilbois; Douglas R. Green

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Tumor Necrosis Factor-related Apoptosis-inducing Ligand-mediated Apoptosis in Androgen-independent Prostate Cancer Cells 1

Rong Yu; Sandhya Mandlekar; Steve Ruben; Jian Ni; A-N. Tony Kong

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Carcinogenesis

Identification of the Messenger RNA for Human Cutaneous Fatty Acid-binding Protein as a Metastasis Inducer 1

Chun Jing; Carol Beesley; Christopher S. Foster; Philip S. Rudland; Hiroshi Fujii; Terno Ono; Haijuan Chen; Paul H. Smith; Youqiang Ke

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Ursolic Acid Inhibits Cyclooxygenase-2 Transcription in Human Mammary Epithelial Cells 1

Kotha Subbaramaiah; Pedro Michaluart; Michael B. Sporn; Andrew J. Dannenberg

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Endocrinology

Increased Gene Expression of Brown Fat Uncoupling Protein (UCP)1 and Skeletal Muscle UCP2 and UCP3 in MAC16-induced Cancer Cachexia 1

Chen Bing; Michael Brown; Peter King; Peter Collins; Michael J. Tisdale; Gareth Williams

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Epidemiology and Prevention

Functional Assay for BRCA1: Mutagenesis of the COOH-Terminal Region Reveals Critical Residues for Transcription Activation 1

Finbarr Hayes; Charmagne Cayanan; Daniela Barillà; Alvaro N. A. Monteiro

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Experimental Therapeutics

Flavopiridol Binds to Duplex DNA 1

Keith C. Bible; Roy H. Bible, Jr.; Timothy J. Kottke; Phyllis A. Svingen; Kun Xu; Yuan-Ping Pang; Elisabeth Hajdu; Scott H. Kaufmann

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Proteasome Inhibition Circumvents Solid Tumor Resistance to Topoisomerase II-directed Drugs 1

Yasunari Ogiso; Akihiro Tomida; Shuhong Lei; Satoshi Ōura; Takashi Tsuruo

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Immunology

Immunity to Murine Breast Cancer Cells Modified to Express MUC-1, a Human Breast Cancer Antigen, in Transgenic Mice Tolerant to Human MUC-1 1

Victoria Carr-Brendel; Dubravka Markovic; Karen Ferrer; Michael Smith; Joyce Taylor-Papadimitriou; Edward P. Cohen

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Combination Immunotherapy of Primary Prostate Cancer in a Transgenic Mouse Model Using CTLA-4 Blockade 1

Arthur A. Hurwitz; Barbara A. Foster; Eugene D. Kwon; Tan Truong; Eugene M. Choi; Norman M. Greenberg; Maurice B. Burg; James P. Allison

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Cytokine Gene Therapy of Gliomas: Induction of Reactive CD4⁺ T Cells by Interleukin-4-transfected 9L Gliosarcoma Is Essential for Protective Immunity 1

Katinka M. Giezeman-Smits; Hideho Okada; Cynthia S. Brissette-Storkus; Lorissa A. Villa; Jason Attanucci; Michael T. Lotze; Ian F. Pollack; Michael E. Bozik; William H. Chambers

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Molecular Biology and Genetics

Photorepair Prevents Ultraviolet-induced Apoptosis in Human Cells Expressing the Marsupial Photolyase Gene 1

Vanessa Chiganças; Eliane Namie Miyaji; Alysson Renato Muotri; Jacqueline de Fátima Jacysyn; Gustavo Pessini Amarante-Mendes; Akira Yasui; Carlos Frederico Martins Menck

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A Role for the p38 Mitogen-activated Protein Kinase Pathway in the Transcriptional Activation of p53 on Genotoxic Stress by Chemotherapeutic Agents 1

Ricardo Sanchez-Prieto; Jose M. Rojas; Yoichi Taya; J. Silvio Gutkind

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Progressive Increases in de Novo Methylation of CpG Islands in Bladder Cancer 1

Carol Salem; Gangning Liang; Yvonne C. Tsai; Jane Coulter; Margaret A. Knowles; An-Chen Feng; Susan Groshen; Peter W. Nichols; Peter A. Jones

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Allelic Loss at SMAD4 in Polyps from Juvenile Polyposis Patients and Use of Fluorescence in Situ Hybridization to Demonstrate Clonal Origin of the Epithelium

Kelly Woodford-Richens; Jill Williamson; Stephen Bevan; Joanne Young; Barbara Leggett; Ian Frayling; Yi Thway; Shirley Hodgson; Jin Cheon Kim; Takeo Iwama; Marco Novelli; Denise Sheer; Richard Poulsom; Nicholas Wright; Richard Houlston; Ian Tomlinson

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Genome-wide Screen for Allelic Imbalance in a Mouse Model for Neuroblastoma 1

William A. Weiss; Tony Godfrey; Carla Francisco; J. Michael Bishop

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Microsatellite Instability at Selected Tetranucleotide Repeats Is Associated with p53 Mutations in Non-Small Cell Lung Cancer 1

Steven A. Ahrendt; P. Anthony Decker; Kara Doffek; Benny Wang; Lihua Xu; Michael J. Demeure; Jin Jen; David Sidransky

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Genetic Instability and Hematologic Disease Risk in Werner Syndrome Patients and Heterozygotes 1

Michael J. Moser; William L. Bigbee; Stephen G. Grant; Mary J. Emond; Richard G. Langlois; Ronald H. Jensen; Junko Oshima; Raymond J. Monnat, Jr.

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Tumor Biology

Role of Extracellular Matrix Assembly in Interstitial Transport in Solid Tumors 1

Paolo A. Netti; David A. Berk; Melody A. Swartz; Alan J. Grodzinsky; Rakesh K. Jain

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A Critical Step in Metastasis: In Vivo Analysis of Intravasation at the Primary Tumor 1

Jeffrey B. Wyckoff; Joan G. Jones; John S. Condeelis; Jeffrey E. Segall

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A Spontaneous Murine Melanoma Lung Metastasis Comprised of Host × Tumor Hybrids 1

Ashok K. Chakraborty; Stefano Sodi; Michael Rachkovsky; Natalia Kolesnikova; James T. Platt; Jean L. Bolognia; John M. Pawelek

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Anti-angiogenic Cues from Vascular Basement Membrane Collagen 1

Pablo C. Colorado; Adriana Torre; George Kamphaus; Yohei Maeshima; Helmut Hopfer; Keiko Takahashi; Ruediger Volk; Eric D. Zamborsky; Seth Herman; Pradip K. Sarkar; Mark B. Ericksen; Mohanraj Dhanabal; Michael Simons; Mark Post; Donald W. Kufe; Ralph R. Weichselbaum; Vikas P. Sukhatme; Raghu Kalluri

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Human Myeloid and Lymphoid Malignancies in the Non-Obese Diabetic/Severe Combined Immunodeficiency Mouse Model: Frequency of Apoptotic Cells in Solid Tumors and Efficiency and Speed of Engraftment Correlate with Vascular Endothelial Growth Factor Production

Lisa Fusetti; Giancarlo Pruneri; Alberto Gobbi; Cristina Rabascio; Nadia Carboni; Fedro Peccatori; Giovanni Martinelli; Francesco Bertolini

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Establishment and Characterization of a Human Lung Cancer Cell Line NCI-H460-LNM35 with Consistent Lymphogenous Metastasis via Both Subcutaneous and Orthotopic Propagation 1

Ken-ichi Kozaki; Osamu Miyaishi; Tetsuya Tsukamoto; Yoshio Tatematsu; Toyoaki Hida; Toshitada Takahashi; Takashi Takahashi

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Temporal Progression of Metastasis in Lung: Cell Survival, Dormancy, and Location Dependence of Metastatic Inefficiency 1

M. Dianne Cameron; Eric E. Schmidt; Nancy Kerkvliet; Kishore V. Nadkarni; Vincent L. Morris; Alan C. Groom; Ann F. Chambers; Ian C. MacDonald

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Acquisition of Chemoresistant Phenotype by Overexpression of the Antiapoptotic Gene Testosterone-repressed Prostate Message-2 in Prostate Cancer Xenograft Models 1

Hideaki Miyake; Colleen Nelson; Paul S. Rennie; Martin E. Gleave

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Aspirin Inhibits Tumor Cell Invasiveness Induced by Epstein-Barr Virus Latent Membrane Protein 1 through Suppression of Matrix Metalloproteinase-9 Expression 1

Shigeyuki Murono; Tomokazu Yoshizaki; Hiroshi Sato; Hajime Takeshita; Mitsuru Furukawa; Joseph S. Pagano

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Concurrent and Independent Genetic Alterations in the Stromal and Epithelial Cells of Mammary Carcinoma: Implications for Tumorigenesis 1

Farid Moinfar; Yan Gao Man; Laurent Arnould; Gary L. Bratthauer; Manfred Ratschek; Fattaneh A. Tavassoli

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Advances in Brief

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