(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Review

p53 Antibodies in the Sera of Patients with Various Types of Cancer: A Review 1

Thierry Soussi

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Advances in Brief

Acute Doxorubicin Cardiotoxicity Involves Cardiomyocyte Apoptosis 1

Olli J. Arola; Antti Saraste; Kari Pulkki; Markku Kallajoki; Martti Parvinen; Liisa-Maria Voipio-Pulkki

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Antitumor Activity of Endostatin against Carcinogen-induced Rat Primary Mammary Tumors 1

Gianpaolo Perletti; Paola Concari; Roberto Giardini; Emanuela Marras; Francesco Piccinini; Judah Folkman; Longchuan Chen

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Gene Transfer into Brain Parenchyma Elicits Antitumor Effects 1

Hassan M. Fathallah-Shaykh; Abdallah I. Kafrouni; Li-Juan Zhao; George M. Smith; James Forman

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Relative Reciprocity of NRAS and PTEN/MMAC1 Alterations in Cutaneous Melanoma Cell Lines 1

Hensin Tsao; Xue Zhang; Kianna Fowlkes; Frank G. Haluska

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Cyclooxygenase-2, a Colorectal Cancer Nonsteroidal Anti-inflammatory Drug Target, Is Regulated by c-MYB 1

Robert G. Ramsay; Annabel Friend; Yotta Vizantios; Ruth Freeman; Catherine Sicurella; Fleur Hammett; Jane Armes; Deon Venter

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Estrogen Receptor Protects p53 from Deactivation by Human Double Minute-21

Guozhen Liu; Janice A. Schwartz; Sam C. Brooks

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Antibody Response to the Tumor-associated Inhibitor of Apoptosis Protein Survivin in Cancer Patients 1

Jacques Rohayem; Petra Diestelkoetter; Bernd Weigle; Antje Oehmichen; Marc Schmitz; Juergen Mehlhorn; Karsten Conrad; Ernst Peter Rieber

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Inhibitor of Apoptosis Protein hILP Undergoes Caspase-mediated Cleavage during T Lymphocyte Apoptosis 1

Daniel E. Johnson; Brian R. Gastman; Eva Wieckowski; Gui-Qiang Wang; Andrew Amoscato; Scott M. Delach; Hannah Rabinowich

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Identification of B94 (TNFAIP2) as a Potential Retinoic Acid Target Gene in Acute Promyelocytic Leukemia 1

Michael E. Rusiniak; Min Yu; Douglas T. Ross; Erin C. Tolhurst; James L. Slack

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Oncogenic Base Substitution Mutations in Circulating Leukocytes of Normal Individuals 1

Vincent L. Wilson; Xiuqin Yin; Barbara Thompson; Kerry R. Wade; Jeremy P. Watkins; Qi Wei; William R. Lee

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Hypermethylation of Multiple Genes in Pancreatic Adenocarcinoma 1

Takashi Ueki; Minoru Toyota; Taylor Sohn; Charles J. Yeo; Jean-Pierre J. Issa; Ralph H. Hruban; Michael Goggins

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A Splice Variant of the Neuron-restrictive Silencer Factor Repressor Is Expressed in Small Cell Lung Cancer: A Potential Role in Derepression of Neuroendocrine Genes and a Useful Clinical Marker 1

Judy M. Coulson; Jodie L. Edgson; Penella J. Woll; John P. Quinn

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Nuclear Factor-κB Activation Is Involved in LMP1-mediated Transformation and Tumorigenesis of Rat-1 Fibroblasts 1

Zhimin He; Baozhong Xin; Xinhai Yang; Ching-ping Chan; Liang Cao

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Biochemistry and Biophysics

Unrepaired Fjord Region Polycyclic Aromatic Hydrocarbon-DNA Adducts in ras Codon 61 Mutational Hot Spots 1

Tonko Buterin; Martin T. Hess; Natalia Luneva; Nicholas E. Geacintov; Shantu Amin; Heiko Kroth; Albrecht Seidel; Hanspeter Naegeli

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Carcinogenesis

Spontaneous and Nitrosourea-induced Primary Tumors of the Central Nervous System in Fischer 344 Rats Exposed to Frequency-modulated Microwave Fields 1

W. Ross Adey; Craig V. Byus; Christopher D. Cain; Robert J. Higgins; Robert A. Jones; Charles J. Kean; Niels Kuster; Anne MacMurray; Robert B. Stagg; Grenith Zimmerman

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Chemopreventive Efficacy of Combined Piroxicam and Difluoromethylornithine Treatment of Apc Mutant Min Mouse Adenomas, and Selective Toxicity against Apc Mutant Embryos 1

Russell F. Jacoby; Carolyn E. Cole; Kendra Tutsch; Michael A. Newton; Gary Kelloff; Ernest T. Hawk; Ronald A. Lubet

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Clinical Investigations

A Phase I Trial of the Farnesyl Transferase Inhibitor SCH66336: Evidence for Biological and Clinical Activity 1

Alex A. Adjei; Charles Erlichman; Jenny N. Davis; David L. Cutler; Jeff A. Sloan; Randolph S. Marks; Lorelei J. Hanson; Phyllis A. Svingen; Pamela Atherton; W. Robert Bishop; Paul Kirschmeier; Scott H. Kaufmann

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Experimental Therapeutics

Antiangiogenic Scheduling of Chemotherapy Improves Efficacy against Experimental Drug-resistant Cancer 1

Timothy Browder; Catherine E. Butterfield; Birgit M. Kräling; Bin Shi; Blair Marshall; Michael S. O’Reilly; Judah Folkman

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Adenosine-mediated Killing of Cultured Epithelial Cancer Cells 1

Catherine P. Barry; Stuart E. Lind

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Antileukemic Activity of Flt3 Ligand in Murine Leukemia 1

Abing Wang; Stephen E. Braun; Guru Sonpavde; Kenneth Cornetta

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Immunology

Anthracyclines Trigger Apoptosis of Both G₀-G₁ and Cycling Peripheral Blood Lymphocytes and Induce Massive Deletion of Mature T and B Cells 1

Carole Ferraro; Laurence Quemeneur; Annie-France Prigent; Catherine Taverne; Jean-Pierre Revillard; Nathalie Bonnefoy-Berard

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Lysis of MYCN-amplified Neuroblastoma Cells by MYCN Peptide-specific Cytotoxic T Lymphocytes 1

Asis K. Sarkar; Jed G. Nuchtern

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Aberrant Expression of Photoreceptor-specific Calcium-binding Protein (Recoverin) in Cancer Cell Lines 1

Akiko Maeda; Hiroshi Ohguro; Tadao Maeda; Ikuo Wada; Noriyuki Sato; Yoshio Kuroki; Takashi Nakagawa

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The Human Antimouse Immunoglobulin Response and the Anti-idiotypic Network Have No Influence on Clinical Outcome in Patients with Minimal Residual Colorectal Cancer Treated with Monoclonal Antibody CO17–1A

Rudolf Gruber; Leonardus J. M. van Haarlem; Sven O. Warnaar; Elena Holz; Gert Riethmüller

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Resistance to Lysis by Cytotoxic T Cells: A Dominant Effect in Metastatic Mouse Prostate Cancer Cells 1

Hon-Man Lee; Terry L. Timme; Timothy C. Thompson

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Granulocyte Macrophage Colony-stimulating Factor and Interleukin 4 Enhance the Number and Antigen-presenting Activity of Circulating CD14⁺ and CD83⁺ Cells in Cancer Patients 1

Michael D. Roth; Barbara J. Gitlitz; Sylvia M. Kiertscher; Alice N. Park; Marcy Mendenhall; Nancy Moldawer; Robert A. Figlin

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Molecular Biology and Genetics

VHL Alterations in Human Clear Cell Renal Cell Carcinoma: Association with Advanced Tumor Stage and a Novel Hot Spot Mutation 1

Hiltrud Brauch; Gregor Weirich; Jürgen Brieger; Damjan Glavač; Heinz Rödl; Mariola Eichinger; Matthias Feurer; Eberhardt Weidt; Chutintorn Puranakanitstha; Christine Neuhaus; Sigmund Pomer; Walburgis Brenner; Peter Schirmacher; Stephan Störkel; Michael Rotter; Andrej Mašera; Nadja Gugeler; Hans-Joachim Decker

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High Resolution Chromosome 3p Allelotyping of Human Lung Cancer and Preneoplastic/Preinvasive Bronchial Epithelium Reveals Multiple, Discontinuous Sites of 3p Allele Loss and Three Regions of Frequent Breakpoints 1

Ignacio I. Wistuba; Carmen Behrens; Arvind K. Virmani; Gina Mele; Sara Milchgrub; Luc Girard; John W. Fondon, III; Harold R. Garner; Bruce McKay; Farida Latif; Michael I. Lerman; Stephen Lam; Adi F. Gazdar; John D. Minna

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LRP-DIT, a Putative Endocytic Receptor Gene, Is Frequently Inactivated in Non-Small Cell Lung Cancer Cell Lines 1

Chun-Xiang Liu; Simone Musco; Natalia M. Lisitsina; Eva Forgacs; John D. Minna; Nikolai A. Lisitsyn

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Gene Amplifications Characterize Acral Melanoma and Permit the Detection of Occult Tumor Cells in the Surrounding Skin 1

Boris C. Bastian; Mohammed Kashani-Sabet; Henning Hamm; Tony Godfrey; Dan H. Moore, II; Eva-B. Bröcker; Philip E. LeBoit; Dan Pinkel

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Mutations in the XPC Gene in Families with Xeroderma Pigmentosum and Consequences at the Cell, Protein, and Transcript Levels 1

Franz Chavanne; Bernard C. Broughton; Daniela Pietra; Tiziana Nardo; Alison Browitt; Alan R. Lehmann; Miria Stefanini

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Molecular Determinants of Apoptosis Induced by the Cytotoxic Ribonuclease Onconase: Evidence for Cytotoxic Mechanisms Different from Inhibition of Protein Synthesis 1

Mihail S. Iordanov; Olga P. Ryabinina; John Wong; Thanh-Hoai Dinh; Dianne L. Newton; Susanna M. Rybak; Bruce E. Magun

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Tumor Biology

Expression of Metallothionein II in Intestinal Metaplasia, Dysplasia, and Gastric Cancer 1

Matthias P. A. Ebert; Thomas Günther; Juliane Hoffmann; Jun Yu; Stephan Miehlke; Hans U. Schulz; Albert Roessner; Murray Korc; Peter Malfertheiner

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Loss of Expression of Dpc4 in Pancreatic Intraepithelial Neoplasia: Evidence That DPC4 Inactivation Occurs Late in Neoplastic Progression 1

Robb E. Wilentz; Christine A. Iacobuzio-Donahue; Pedram Argani; Denis M. McCarthy; Jennifer L. Parsons; Charles J. Yeo; Scott E. Kern; Ralph H. Hruban

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Insulin-like Growth Factor-I Protects Colon Cancer Cells from Death Factor-induced Apoptosis by Potentiating Tumor Necrosis Factor α-induced Mitogen-activated Protein Kinase and Nuclear Factor κB Signaling Pathways 1

Maryse M. Remacle-Bonnet; Françoise L. Garrouste; Sara Heller; Frédéric André; Jacques L. Marvaldi; Gilbert J. Pommier

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Detection of Hypoxia in Human Squamous Cell Carcinoma by EF5 Binding 1

Sydney M. Evans; Stephen Hahn; Deirdre R. Pook; W. Timothy Jenkins; Ara A. Chalian; Paul Zhang; Craig Stevens; Randall Weber; Gregory Weinstein; Ivor Benjamin; Natasha Mirza; Mark Morgan; Steven Rubin; W. Gillies McKenna; Edith M. Lord; Cameron J. Koch

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S-phase Arrest and Apoptosis Induced in Normal Mammary Epithelial Cells by a Novel Retinoid 1

Yuxiang Zhang; Arun K. Rishi; Marcia I. Dawson; Rainbow Tschang; Lulu Farhana; Madanamohan Boyanapalli; Uwe Reichert; Braham Shroot; Eric C. Van Buren; Joseph A. Fontana

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Fibrinogen Assembly, Secretion, and Deposition into Extracellular Matrix by MCF-7 Human Breast Carcinoma Cells 1

Brian J. Rybarczyk; Patricia J. Simpson-Haidaris

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1,25-Dihydroxyvitamin D₃ and All-trans-Retinoic Acid Sensitize Breast Cancer Cells to Chemotherapy-induced Cell Death 1

Qin Wang; Wen Yang; Myrna S. Uytingco; Sylvia Christakos; Robert Wieder

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BCR-ABL Tyrosine Kinase Activity Regulates the Expression of Multiple Genes Implicated in the Pathogenesis of Chronic Myeloid Leukemia 1

Michael W. N. Deininger; Sara Vieira; Rezzeline Mendiola; Beate Schultheis; John M. Goldman; Junia V. Melo

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Glucocorticoid Receptor Gene Mutations in Leukemic Cells Acquired in Vitro and in Vivo1

Andrew G. Hillmann; Jyoti Ramdas; Kirsi Multanen; Michael R. Norman; Jeffrey M. Harmon

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Erratum

J. Jongsma et al., Cancer Res., 60: 741–748,2000

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A self-propagating c-Met-SOX2 axis drives cancer-derived IgG signaling that promotes lung cancer cell stemness

Comprehensive DNA methylation analysis indicates that pancreatic intraepithelial neoplasia lesions are acinar-derived and epigenetically primed for carcinogenesis

PGC1α Degradation Suppresses Mitochondrial Biogenesis to Confer Radiation Resistance in Glioma

Extrachromosomal Amplification of Human Papillomavirus Episomes is a Mechanism of Cervical Carcinogenesis

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Review

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Experimental Therapeutics

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