(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Advances in Brief

Chemotherapeutic DNA-damaging Drugs Activate Interferon Regulatory Factor-7 by the Mitogen-activated Protein Kinase Kinase-4-c-Jun NH₂-Terminal Kinase Pathway 1

Tae Kook Kim; Taeil Kim; Tae Young Kim; Woo Ghil Lee; Jeongbin Yim

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Antitumor Effect of Adenovirus-mediated Bax Gene Transfer on p53-sensitive and p53-resistant Cancer Lines 1

Shunsuke Kagawa; Jian Gu; Stephen G. Swisher; Lin Ji; Jack A. Roth; Dejian Lai; L. Clifton Stephens; Bingliang Fang

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Association of the Bloom Syndrome Protein with Topoisomerase IIIα in Somatic and Meiotic Cells 1

F. Brad Johnson; David B. Lombard; Norma F. Neff; Mary-Ann Mastrangelo; William Dewolf; Nathan A. Ellis; Robert A. Marciniak; Yizhong Yin; Rudolf Jaenisch; Leonard Guarente

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Interleukin-13 Receptor α Chain: A Novel Tumor-associated Transmembrane Protein in Primary Explants of Human Malignant Gliomas

Bharat H. Joshi; Gregory E. Plautz; Raj K. Puri

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Carbonyl Reductase: A Novel Metastasis-modulating Function 1

Endom Ismail; Fahd Al-Mulla; Shigeki Tsuchida; Kohji Suto; Paul Motley; Paul R. Harrison; George D. Birnie

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Altered Expression of Fhit in Carcinoma and Precarcinomatous Lesions of the Esophagus 1

Masaki Mori; Koshi Mimori; Takeshi Shiraishi; Hansjuerg Alder; Hiroshi Inoue; Yoichi Tanaka; Keizo Sugimachi; Kay Huebner; Carlo M. Croce

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Transforming Growth Factor β₂ Promotes Glucose Carbon Incorporation into Nucleic Acid Ribose through the Nonoxidative Pentose Cycle in Lung Epithelial Carcinoma Cells 1

Laszlo G. Boros; John S. Torday; Shu Lim; Sara Bassilian; Marta Cascante; Wai-Nang Paul Lee

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Further Evidence That the Radioprotective Aminothiol, WR-1065, Catalytically Inactivates Mammalian Topoisomerase II 1

Ronald D. Snyder; David J. Grdina

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Characterization of CPT-11 Hydrolysis by Human Liver Carboxylesterase Isoforms hCE-1 and hCE-2 1

Rod Humerickhouse; Karen Lohrbach; Lin Li; William F. Bosron; M. Eileen Dolan

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In Vivo Antitumor Activity of ONYX-015 Is Influenced by p53 Status and Is Augmented by Radiotherapy 1

Kenneth R. Rogulski; Svend O. Freytag; Kang Zhang; Jeff D. Gilbert; Dell L. Paielli; Jae Ho Kim; Carla C. Heise; David H. Kirn

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A New Temperature-sensitive Liposome for Use with Mild Hyperthermia: Characterization and Testing in a Human Tumor Xenograft Model 1

David Needham; Gopal Anyarambhatla; Garheng Kong; Mark W. Dewhirst

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Nuclear Factor-κB/Rel Is Apoptogenic in Cytokine Withdrawal-induced Programmed Cell Death 1

U. Shivraj Sohur; Chih-Li Chen; Donna J. Hicks; Fiona E. Yull; Lawrence D. Kerr

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Major Improvement in the Efficacy of BRCA1 Mutation Screening Using Morphoclinical Features of Breast Cancer 1

Rosette Lidereau; François Eisinger; Marie-Hélène Champème; Catherine Noguès; Ivan Bièche; Daniel Birnbaum; Claude Pallud; Jocelyne Jacquemier; Hagay Sobol

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Loss of pRb Expression in Pituitary Adenomas Is Associated with Methylation of the RB1 CpG Island 1

David J. Simpson; Nigel A. Hibberts; Anne Marie McNicol; Richard N. Clayton; William E. Farrell

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CD95 (Fas/APO-1) and p53 Signal Apoptosis Independently in Diverse Cell Types 1

Liam O’Connor; Alan W. Harris; Andreas Strasser

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Fibroblast Growth Factor Receptor-1 α-Exon Exclusion and Polypyrimidine Tract-binding Protein in Glioblastoma Multiforme Tumors 1

Wei Jin; Ian E. McCutcheon; Gregory N. Fuller; Eileen S-C. Huang; Gilbert J. Cote

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Inhibition of Constitutively Activated Stat3 Signaling Pathway Suppresses Growth of Prostate Cancer Cells 1

Zuyao Ni; Wei Lou; Eddy S. Leman; Allen C. Gao

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Biochemistry and Biophysics

Tetrocarcin A Inhibits Mitochondrial Functions of Bcl-2 and Suppresses Its Anti-apoptotic Activity

Takayuki Nakashima; Masayuki Miura; Mitsunobu Hara

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The Tumor Growth-inhibiting Cell Adhesion Molecule CEACAM1 (C-CAM) Is Differently Expressed in Proliferating and Quiescent Epithelial Cells and Regulates Cell Proliferation 1

Bernhard B. Singer; Inka Scheffrahn; Björn Öbrink

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DNA-dependent Protein Kinase Stimulates an Independently Active, Nonhomologous, End-Joining Apparatus 1

Steven J. DiBiase; Zhao-Chong Zeng; Richard Chen; Terry Hyslop; Walter J. Curran, Jr.; George Iliakis

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Carcinogenesis

Irradiated Mammary Gland Stroma Promotes the Expression of Tumorigenic Potential by Unirradiated Epithelial Cells 1

Mary Helen Barcellos-Hoff; Shraddha A. Ravani

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Overexpression of Human Aspartyl (Asparaginyl) β-Hydroxylase Is Associated with Malignant Transformation 1

Nedim Ince; Suzanne M. de la Monte; Jack R. Wands

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Sensitivity of the Cervical Transformation Zone to Estrogen-induced Squamous Carcinogenesis 1

David A. Elson; Rebeccah R. Riley; Ama Lacey; Gudmundur Thordarson; Frank J. Talamantes; Jeffrey M. Arbeit

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Detection of DNA Alkylphosphotriesters by ³²P Postlabeling: Evidence for the Nonrandom Manifestation of Phosphotriester Lesions in Vivo1

Yves Guichard; George D. D. Jones; Peter B. Farmer

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The Food-derived Carcinogen 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine Activates S-Phase Checkpoint and Apoptosis, and Induces Gene Mutation in Human Lymphoblastoid TK6 Cells 1

Huijun Zhu; Alan R. Boobis; Nigel J Gooderham

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Factors Underlying the Cell Growth-related Bystander Responses to α Particles 1

Rashi Iyer; Bruce E. Lehnert

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Clinical Investigations

Increased Urinary Excretion of 2-Hydroxyestrone but not 16α-Hydroxyestrone in Premenopausal Women during a Soya Diet Containing Isoflavones 1

Lee-Jane W. Lu; Melanie Cree; Shylaja Josyula; Manubai Nagamani; James J. Grady; Karl E. Anderson

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Experimental Therapeutics

Antiangiogenic and Antitumor Activities of Cyclooxygenase-2 Inhibitors

Jaime L. Masferrer; Kathleen M. Leahy; Alane T. Koki; Ben S. Zweifel; Steven L. Settle; B. Mark Woerner; Dorothy A. Edwards; Amy G. Flickinger; Rosalyn J. Moore; Karen Seibert

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Copper-transporting P-Type Adenosine Triphosphatase (ATP7B) Is Associated with Cisplatin Resistance 1

Masaharu Komatsu; Tomoyuki Sumizawa; Masato Mutoh; Zhe-Sheng Chen; Kunihiko Terada; Tatsuhiko Furukawa; Xiao-Li Yang; Hui Gao; Naoyuki Miura; Toshihiro Sugiyama; Shin-ichi Akiyama

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Cdc25 Inhibition and Cell Cycle Arrest by a Synthetic Thioalkyl Vitamin K Analogue 1

Kenji Tamura; Eileen C. Southwick; Jeffrey Kerns; Katherine Rosi; Brian I. Carr; Craig Wilcox; John S. Lazo

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Preferential Enhancement of Tumor Radioresponse by a Cyclooxygenase-2 Inhibitor

Kazushi Kishi; Sven Petersen; Cordula Petersen; Nancy Hunter; Kathryn Mason; Jaime L. Masferrer; Philip J. Tofilon; Luka Milas

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Molecular Biology and Genetics

A Role for Id-1 in the Aggressive Phenotype and Steroid Hormone Response of Human Breast Cancer Cells 1

Claudia Qiao Lin; Jarnail Singh; Kenji Murata; Yoko Itahana; Simona Parrinello; Scott H. Liang; Cheryl E. Gillett; Judith Campisi; Pierre-Yves Desprez

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A Minimal Critical Region of the 8p22–23 Amplicon in Esophageal Adenocarcinomas Defined Using Sequence Tagged Site-Amplification Mapping and Quantitative Polymerase Chain Reaction Includes the GATA-4 Gene 1

Lin Lin; Sanjeev Aggarwal; Thomas W. Glover; Mark B. Orringer; Samir Hanash; David G. Beer

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Prostate-specific Transcription Factor hPSE Is Translated Only in Normal Prostate Epithelial Cells

Masahiro Nozawa; Kentaro Yomogida; Nobufumi Kanno; Norio Nonomura; Tsuneharu Miki; Akihiko Okuyama; Yoshitake Nishimune; Masami Nozaki

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Identification of a Human Glioma-associated Growth Factor Gene, granulin, Using Differential Immuno-absorption 1

Linda M. Liau; Roger L. Lallone; Robert S. Seitz; Alexei Buznikov; Jeff P. Gregg; Harley I. Kornblum; Stanley F. Nelson; Jeff M. Bronstein

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BRCA1-related Papillary Serous Carcinoma of the Peritoneum Has a Unique Molecular Pathogenesis 1

John O. Schorge; Michael G. Muto; Sandra J. Lee; Lee-Wen Huang; William R. Welch; Debra A. Bell; Emily Z. Keung; Ross S. Berkowitz; Samuel C. Mok

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High Levels of Tyrosine Phosphorylated Proto-Ret in Sporadic Pheochromocytomas 1

Hervé Le Hir; Luca G. Colucci-D’Amato; Nicolas Charlet-Berguerand; Pierre-François Plouin; Xavier Bertagna; Vittorio de Franciscis; Claude Thermes

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BRCA1 and BRCA2 Have a Limited Role in Familial Prostate Cancer 1

Colleen Schehl Sinclair; Rebecca Berry; Daniel Schaid; Stephen N. Thibodeau; Fergus J. Couch

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Class A Helix-Loop-Helix Proteins Are Positive Regulators of Several Cyclin-dependent Kinase Inhibitors’ Promoter Activity and Negatively Affect Cell Growth 1

Alfredo Pagliuca; Pasquale Gallo; Pasquale De Luca; Luigi Lania

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Diversity and Frequency of Epidermal Growth Factor Receptor Mutations in Human Glioblastomas 1

Lori Frederick; Xiao-Yang Wang; Greg Eley; C. David James

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Tumor Biology

Heterogeneity of Angiogenesis and Blood Vessel Maturation in Human Tumors: Implications for Antiangiogenic Tumor Therapies 1

Anne Eberhard; Sebastian Kahlert; Valentin Goede; Bernhard Hemmerlein; Karl H. Plate; Hellmut G. Augustin

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Autocrine Stimulatory Mechanism by Transforming Growth Factor β in Human Hepatocellular Carcinoma 1

Koichi Matsuzaki; Masataka Date; Fukiko Furukawa; Yoshiya Tahashi; Masanori Matsushita; Kazushige Sakitani; Noriyo Yamashiki; Toshihito Seki; Hidetsugu Saito; Mikio Nishizawa; Junichi Fujisawa; Kyoichi Inoue

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Identification of the Putative Brain Tumor Antigen BF7/GE2 as the (De)Toxifying Enzyme Microsomal Epoxide Hydrolase 1

Reto Kessler; Marie-France Hamou; Michele Albertoni; Nicolas de Tribolet; Michael Arand; Erwin G. Van Meir

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Expression of Sialyl 6-Sulfo Lewis X Is Inversely Correlated with Conventional Sialyl Lewis X Expression in Human Colorectal Cancer 1

Mineko Izawa; Kensuke Kumamoto; Chikako Mitsuoka; Akiko Kanamori; Katsuyuki Ohmori; Hiroji Ishida; Shigeo Nakamura; Kazumi Kurata-Miura; Katsutoshi Sasaki; Tatsunari Nishi; Reiji Kannagi

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A Mechanistic, Predictive Model of Dose-Response Curves for Cell Cycle Phase-specific and -nonspecific Drugs 1

Shea N. Gardner

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Sulforaphane, a Naturally Occurring Isothiocyanate, Induces Cell Cycle Arrest and Apoptosis in HT29 Human Colon Cancer Cells

Laurence Gamet-Payrastre; Pengfei Li; Solange Lumeau; Georges Cassar; Marie-Ange Dupont; Sylvie Chevolleau; Nicole Gasc; Jacques Tulliez; François Tercé

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Estrogen Receptors in Human Myeloma Cells 1

Takemi Otsuki; Osamu Yamada; Junichi Kurebayashi; Takuya Moriya; Haruko Sakaguchi; Hironori Kunisue; Kenichiro Yata; Masako Uno; Yoshihito Yawata; Ayako Ueki

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Local Imbalance of Proangiogenic and Antiangiogenic Factors: A Potential Mechanism of Focal Necrosis and Dormancy in Tumors 1

Saroja Ramanujan; Gerald C. Koenig; Timothy P. Padera; Brian R. Stoll; Rakesh K. Jain

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Restoration of α(1,2) Fucosyltransferase Activity Decreases Adhesive and Metastatic Properties of Human Pancreatic Cancer Cells 1

Muriel Aubert; Laurence Panicot; Christian Crotte; Patrick Gibier; Dominique Lombardo; Marie-Odile Sadoulet; Eric Mas

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Virology

Overexpression of PTEN/MMAC1 and Decreased Activation of Akt in Human Papillomavirus-infected Laryngeal Papillomas 1

Ping Zhang; Bettie M. Steinberg

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Letters to the Editor

Correspondence re: Q-R. Chen et al., Liposomes Complexed to Plasmids Encoding Angiostatin and Endostatin Inhibit Breast Cancer in Nude Mice. Cancer Res., 59: 3308–3312,1999.

Andrew L. Feldman; Steven K. Libutti

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Meeting Reports

Summary of the International Cancer Microenvironment from Meeting in Pittsburgh, Pennsylvania on October 3–6, 1999

Ronald B. Herberman; Theresa L. Whiteside

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Errata

A. Bonati et al. 60: 728–732

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A. P. McGlynn et al. 59: 5912–5916

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Correction

S. Bettuzi et al. 60: 28–34

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Table of Contents

Advances in Brief

Biochemistry and Biophysics

Carcinogenesis

Clinical Investigations

Experimental Therapeutics

Molecular Biology and Genetics

Tumor Biology

Virology

Letters to the Editor

Meeting Reports

Errata

Correction

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