(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Advances in Brief

Induction of Apoptotic Cell Death and in Vivo Growth Inhibition of Human Cancer Cells by a Saturated Branched-Chain Fatty Acid, 13-Methyltetradecanoic Acid 1

Zhenhua Yang; Shangpei Liu; Xudong Chen; Hang Chen; Mei Huang; Jianping Zheng

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Expression of a Highly Conserved Protein, p27^BBP, during the Progression of Human Colorectal Cancer 1

Francesca Sanvito; Federica Vivoli; Stefania Gambini; Graziella Santambrogio; Marco Catena; Edi Viale; Fabrizio Veglia; Alessandra Donadini; Stefano Biffo; Pier Carlo Marchisio

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p53-dependent Global Genomic Repair of Benzo[a]pyrene-7,8-diol-9,10-epoxide Adducts in Human Cells 1

Daniel R. Lloyd; Philip C. Hanawalt

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High Frequency of K-ras Mutations in Biliary Duct Carcinomas of Cases with a Long Common Channel in the Papilla of Vater 1

Eiji Hidaka; Akio Yanagisawa; Makoto Seki; Kouichi Takano; Toshiaki Setoguchi; Yo Kato

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Photofrin Photodynamic Therapy Can Significantly Deplete or Preserve Oxygenation in Human Basal Cell Carcinomas during Treatment, Depending on Fluence Rate 1

Barbara W. Henderson; Theresa M. Busch; Lurine A. Vaughan; Noreen P. Frawley; Debra Babich; Tara A. Sosa; Joseph D. Zollo; Anthony S. Dee; Michele T. Cooper; David A. Bellnier; William R. Greco; Allan R. Oseroff

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Differences in Estrogen Receptor α Variant Messenger RNAs between Normal Human Breast Tissue and Primary Breast Carcinomas 1

Mariska A. J. van Dijk; Augustinus A. M. Hart; Laura J. van’t Veer

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High-Activity Microsomal Epoxide Hydrolase Genotypes and the Risk of Oral, Pharynx, and Larynx Cancers 1

Nadejda Jourenkova-Mironova; Katja Mitrunen; Christine Bouchardy; Pierre Dayer; Simone Benhamou; Ari Hirvonen

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Methylation of the Human Telomerase Gene CpG Island 1

Scott K. Dessain; Hua-yin Yu; Roger R. Reddel; Roderick L. Beijersbergen; Robert A. Weinberg

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Constitutive Activation of Cyclin B1-associated cdc2 Kinase Overrides p53-mediated G₂-M Arrest 1

Misoon Park; Hee-Don Chae; Jeanho Yun; Moonsu Jung; Yeon-Soo Kim; Sung-Ho Kim; Moon Hi Han; Deug Y. Shin

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No Evidence of Peutz-Jeghers Syndrome Gene LKB1 Involvement in Left-sided Colorectal Carcinomas 1

Virpi Launonen; Egle Avizienyte; Anu Loukola; Päivi Laiho; Reijo Salovaara; Heikki Järvinen; Jukka-Pekka Mecklin; Asuka Oku; Miyuki Shimane; Hee C. Kim; Jin C. Kim; Jun-ichi Nezu; Lauri A. Aaltonen

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Genomic Imbalances Including Amplification of the Tyrosine Kinase Gene JAK2 in CD30⁺ Hodgkin Cells 1

Stefan Joos; Manfred Küpper; Sibylle Ohl; Frederike von Bonin; Gunhild Mechtersheimer; Martin Bentz; Peter Marynen; Peter Möller; Michael Pfreundschuh; Lorenz Trümper; Peter Lichter

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Regulation of Tumor Necrosis Factor-related Apoptosis-inducing Ligand Sensitivity in Primary and Transformed Human Keratinocytes 1

Martin Leverkus; Manfred Neumann; Thilo Mengling; Charles T. Rauch; Eva-Bettina Bröcker; Peter H. Krammer; Henning Walczak

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Down-Regulation of HER2/neu Expression Induces Apoptosis in Human Cancer Cells That Overexpress HER2/neu1

Haeri Roh; James Pippin; Jeffrey A. Drebin

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Biochemistry

An Indolocarbazole Inhibitor of Human Checkpoint Kinase (Chk1) Abrogates Cell Cycle Arrest Caused by DNA Damage

Jeffrey R. Jackson; Aidan Gilmartin; Christina Imburgia; James D. Winkler; Lisa A. Marshall; Amy Roshak

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Quantitative Analysis of Interindividual Variation of Glutathione S-Transferase Expression in Human Pancreas and the Ambiguity of Correlating Genotype with Phenotype 1

Brian F. Coles; Kristin E. Anderson; Daniel R. Doerge; Mona I. Churchwell; Nicholas P. Lang; Fred F. Kadlubar

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Carcinogenesis

Differentiation of Rat Oval Cells after Activation of Peroxisome Proliferator-activated Receptor α43

Catherine Kaplanski; Cindy J. Pauley; Thomas G. Griffiths; Thomas T. Kawabata; Brian J. Ledwith

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Single-Site Methylation within the p53 Promoter Region Reduces Gene Expression in a Reporter Gene Construct: Possible in Vivo Relevance during Tumorigenesis 1

Igor P. Pogribny; Marta Pogribna; Judith K. Christman; S. Jill James

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Transgenic Mice Overexpressing Protein Kinase Cε in Their Epidermis Exhibit Reduced Papilloma Burden but Enhanced Carcinoma Formation after Tumor Promotion 1

Peter J. Reddig; Nancy E. Dreckschmidt; Jun Zou; Sarah E. Bourguignon; Terry D. Oberley; Ajit K. Verma

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Cell Proliferation Induced by Triiodothyronine in Rat Liver Is Associated with Nodule Regression and Reduction of Hepatocellular Carcinomas 1

Giovanna M. Ledda-Columbano; Andrea Perra; Roberto Loi; Hisashi Shinozuka; Amedeo Columbano

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Clinical Investigations

Telomerase Activity and Telomere Length in Acute and Chronic Leukemia, Pre- and Post-ex Vivo Culture 1

Monika Engelhardt; Karen Mackenzie; Pamela Drullinsky; Richard T. Silver; Malcolm A. S. Moore

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Altered Hepatic Gluconeogenesis during l-Alanine Infusion in Weight-losing Lung Cancer Patients as Observed by Phosphorus Magnetic Resonance Spectroscopy and Turnover Measurements 1

Susanne Leij-Halfwerk; J. Willem O. van den Berg; Paul E. Sijens; J. H. Paul Wilson; Matthijs Oudkerk; Pieter C. Dagnelie

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Imaging Brain Tumor Proliferative Activity with [¹²⁴I]Iododeoxyuridine 1

Ronald G. Blasberg; Ulrich Roelcke; Regin Weinreich; Bradley Beattie; Klaus von Ammon; Yasuhiro Yonekawa; Hans Landolt; Ilonka Guenther; Nigel E. A. Crompton; Peter Vontobel; John Missimer; Ralph P. Maguire; Jacek Koziorowski; E. Joachim Knust; Ronald D. Finn; Klaus L. Leenders

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The Urokinase System of Plasminogen Activation and Prognosis in 2780 Breast Cancer Patients 1

John A. Foekens; Harry A. Peters; Maxime P. Look; Henk Portengen; Manfred Schmitt; Michael D. Kramer; Nils Brünner; Fritz Jänicke; Marion E. Meijer-van Gelder; Sonja C. Henzen-Logmans; Wim L. J. van Putten; Jan G. M. Klijn

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Epidemiology and Prevention

Substantially Reduced Risk of Cancer of the Aerodigestive Tract in Subjects with Variant −463A of the Myeloperoxidase Gene 1

Ingolf Cascorbi; Stefan Henning; Jürgen Brockmöller; Jürgen Gephart; Christian Meisel; Joachim M. Müller; Robert Loddenkemper; Ivar Roots

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Experimental Therapeutics

Manumycin Enhances the Cytotoxic Effect of Paclitaxel on Anaplastic Thyroid Carcinoma Cells 1

Sai-Ching Jim Yeung; Guangpu Xu; Jingxuan Pan; Michelle Christgen; Alexander Bamiagis

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Expression of Endogenously Activated Secreted or Cell Surface Carboxypeptidase A Sensitizes Tumor Cells to Methotrexate-α-Peptide Prodrugs 1

Daniel A. Hamstra; Michel Pagé; Jonathan Maybaum; Alnawaz Rehemtulla

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Tumor-targeting Chemotherapy by a Xanthine Oxidase-Polymer Conjugate That Generates Oxygen-free Radicals in Tumor Tissue 1

Tomohiro Sawa; Jun Wu; Takaaki Akaike; Hiroshi Maeda

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Functional Interactions between Bile Acids, All-Trans Retinoic Acid, and 1,25-Dihydroxy-Vitamin D₃ on Monocytic Differentiation and Myeloblastin Gene Down-Regulation in HL60 and THP-1 Human Leukemia Cells 1

Amazia Zimber; Annick Chedeville; Jean-Pierre Abita; Veronique Barbu; Christian Gespach

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p21^WAF1/CIP1 Antisense Therapy Radiosensitizes Human Colon Cancer by Converting Growth Arrest to Apoptosis 1

Hui Tian; Ellen K. Wittmack; Timothy J. Jorgensen

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Immunology

Interleukin-7/B7.1-encoding Adenoviruses Induce Rejection of Transplanted but not Nontransplanted Tumors 1

Gerald Willimsky; Thomas Blankenstein

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Targeting of Human p53-overexpressing Tumor Cells by an HLA A*0201-restricted Murine T-Cell Receptor Expressed in Jurkat T Cells 1

Xiping Liu; Elizabeth A. Peralta; Joshua D. I. Ellenhorn; Don J. Diamond

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Molecular Biology and Genetics

Frequent Methylation of Estrogen Receptor in Prostate Cancer: Correlation with Tumor Progression 1

Long-Cheng Li; Richard Chui; Koichi Nakajima; Bong Ryoul Oh; Harry C. Au; Rajvir Dahiya

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Detection of Plasma Tumor DNA in Head and Neck Squamous Cell Carcinoma by Microsatellite Typing and p53 Mutation Analysis 1

Florence Coulet; Helene Blons; Arnauld Cabelguenne; Thierry Lecomte; Olivier Laccourreye; Daniel Brasnu; Philippe Beaune; Jessica Zucman; Pierre Laurent-Puig

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Tumor Biology

Integrins α_vβ₃ and α_vβ₅ Are Expressed by Endothelium of High-Risk Neuroblastoma and Their Inhibition Is Associated with Increased Endogenous Ceramide 1

Anat Erdreich-Epstein; Hiroyuki Shimada; Susan Groshen; Ming Liu; Leonid S. Metelitsa; Kwang Sik Kim; Monique F. Stins; Robert C. Seeger; Donald L. Durden

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Aminopeptidase N Is a Receptor for Tumor-homing Peptides and a Target for Inhibiting Angiogenesis 1

Renata Pasqualini; Erkki Koivunen; Renate Kain; Johanna Lahdenranta; Michiie Sakamoto; Anette Stryhn; Richard A. Ashmun; Linda H. Shapiro; Wadih Arap; Erkki Ruoslahti

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Selective Expression and Constitutive Phosphorylation of SHC Proteins in the CD34⁺ Fraction of Chronic Myelogenous Leukemias 1

Antonio Bonati; Carmelo Carlo-Stella; Paolo Lunghi; Roberto Albertini; Silvana Pinelli; Enrica Migliaccio; Gabriella Sammarelli; Barbara Savoldo; Antonio Tabilio; Pier Paolo Dall’Aglio; Pier Giuseppe Pelicci

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Basic Fibroblast Growth Factor Confers a Less Malignant Phenotype in MDA-MB-231 Human Breast Cancer Cells 1

Reju M. Korah; Vilayvanh Sysounthone; Yosef Golowa; Robert Wieder

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Androgen Deprivation of the Prohormone Convertase-310 Human Prostate Cancer Model System Induces Neuroendocrine Differentiation 1

Johan Jongsma; Monique H. Oomen; Marinus A. Noordzij; Wytske M. Van Weerden; Gerard J. M. Martens; Theodorus H. van der Kwast; Fritz H. Schröder; Gert J. van Steenbrugge

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Drg-1 as a Differentiation-related, Putative Metastatic Suppressor Gene in Human Colon Cancer 1

Rong J. Guan; Heide L. Ford; Yineng Fu; Youzhi Li; Leslie M. Shaw; Arthur B. Pardee

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A Precursor Form of Prostate-specific Antigen Is More Highly Elevated in Prostate Cancer Compared with Benign Transition Zone Prostate Tissue

Stephen D. Mikolajczyk; Lisa S. Millar; Tang J. Wang; Harry G. Rittenhouse; Leonard S. Marks; Weitao Song; Thomas M. Wheeler; Kevin M. Slawin

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Down-Regulation of the Insulin-like Growth Factor I Receptor by Antisense RNA Can Reverse the Transformed Phenotype of Human Cervical Cancer Cell Lines 1

Keiichiro Nakamura; Atsushi Hongo; Junichi Kodama; Yasunari Miyagi; Mitsuo Yoshinouchi; Takafumi Kudo

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Letters to the Editor

Correspondence re: S. Shintani et al., Intragenic Mutation Analysis of the Human Epidermal Growth Factor Receptor (EGFR)Gene in Malignant Human Oral Keratinocytes. Cancer Res.,59: 4142–4147, 1999.

Jill L. Reiter; Greg Eley; C. David James; Nita J. Maihle

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Meeting Report

Eleventh Annual Pezcoller Symposium: Molecular Horizons in Cancer Therapeutics 1

Enrico Mihich; David Livingston

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