(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Perspectives in Cancer Research

Fractals and Cancer 1

James W. Baish; Rakesh K. Jain

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Special Lecture

The Pezcoller Lecture: Cancer Cell Cycles Revisited

Charles J. Sherr

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Advances in Brief

Human Mesothelioma Samples Overexpress Both Cyclooxygenase-2 (COX-2) and Inducible Nitric Oxide Synthase (NOS2): In Vitro Antiproliferative Effects of a COX-2 Inhibitor

Aizen Marrogi; Harvey I. Pass; Mohammed Khan; Linda J. Metheny-Barlow; Curtis C. Harris; Brenda I. Gerwin

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Vaccination against Gonadotropin-releasing Hormone (GnRH) Using Toxin Receptor-binding Domain-conjugated GnRH Repeats 1

Chia-Tse Hsu; Chun-Yuan Ting; Chun-Jen Ting; Tzong-Yueh Chen; Chia-Po Lin; Jacqueline Whang-Peng; Jaulang Hwang

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A Genome-wide Map Showing Common Regions of Loss of Heterozygosity/Allelic Imbalance in Breast Cancer 1

Robert J. Osborne; Marion G. Hamshere

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Suppressing Effects of Dietary Supplementation of the Organoselenium 1,4-Phenylenebis(methylene)selenocyanate and the Citrus Antioxidant Auraptene on Lung Metastasis of Melanoma Cells in Mice 1

Takuji Tanaka; Hiroyuki Kohno; Manabu Murakami; Seiko Kagami; Karam El-Bayoumy

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Synergistic Antitumor Activity of Irinotecan in Combination with 5-Fluorouracil in Rats Bearing Advanced Colorectal Cancer: Role of Drug Sequence and Dose 1

Shousong Cao; Youcef M. Rustum

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Identification of Fractalkine, a CX3C-type Chemokine, as a Direct Target of p53 1

Kenji Shiraishi; Seisuke Fukuda; Toshiki Mori; Koichi Matsuda; Tatsuya Yamaguchi; Chizu Tanikawa; Michio Ogawa; Yusuke Nakamura; Hirofumi Arakawa

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Tyrosine 1062 of RET-MEN2A Mediates Activation of Akt (Protein Kinase B) and Mitogen-activated Protein Kinase Pathways Leading to PC12 Cell Survival 1

Gabriella De Vita; Rosa Marina Melillo; Francesca Carlomagno; Roberta Visconti; Maria Domenica Castellone; Alfonso Bellacosa; Marc Billaud; Alfredo Fusco; Philip N. Tsichlis; Massimo Santoro

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Biochemistry and Biophysics

Highly Selective Isolation of Unknown Mutations in Diverse DNA Fragments: Toward New Multiplex Screening in Cancer 1

Subrata Chakrabarti; Brendan D. Price; Sotirios Tetradis; Edward A. Fox; Yuzhi Zhang; Gautam Maulik; G. Mike Makrigiorgos

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Carcinogenesis

Accelerated Ultraviolet Radiation-induced Carcinogenesis in Hepatocyte Growth Factor/Scatter Factor Transgenic Mice 1

Frances P. Noonan; Toshiyuki Otsuka; Stacey Bang; Miriam R. Anver; Glenn Merlino

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Epidemiology

Plasma Insulin-like Growth Factor (IGF) I, IGF-binding Protein 3, and Mammographic Density 1

Celia Byrne; Graham A. Colditz; Walter C. Willett; Frank E. Speizer; Michael Pollak; Susan E. Hankinson

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Experimental Therapeutics

Combination of the Bioreductive Drug Tirapazamine with the Chemotherapeutic Prodrug Cyclophosphamide for P450/P450-Reductase-based Cancer Gene Therapy 1

Youssef Jounaidi; David J. Waxman

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In Vivo Site Specificity and Human Isoenzyme Selectivity of Two Topoisomerase II-poisoning Anthracyclines 1

Monica Binaschi; Rosalba Farinosi; M. Evelina Borgnetto; Giovanni Capranico

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Cooperative Effects of Mycobacterium tuberculosis Ag38 Gene Transduction and Interleukin 12 in Vaccination against Spontaneous Tumor Development in Proto-neu Transgenic Mice 1

Lucia Sfondrini; Monica Rodolfo; Mahavir Singh; Mario P. Colombo; Maria I. Colnaghi; Sylvie Ménard; Andrea Balsari

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Prevention of Mammary Tumors with a Chimeric HER-2 B-cell Epitope Peptide Vaccine 1

Naveen K. Dakappagari; Donna B. Douglas; Pierre L. Triozzi; Vernon C. Stevens; Pravin T. P. Kaumaya

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Antigene and Antiproliferative Effects of a c-myc-targeting Phosphorothioate Triple Helix-forming Oligonucleotide in Human Leukemia Cells 1

Eileen M. McGuffie; Daniel Pacheco; Giuseppina M. R. Carbone; Carlo V. Catapano

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Use of Phosphorous-31 Nuclear Magnetic Resonance Spectroscopy to Determine Safe Timing of Chemotherapy after Hepatic Resection 1

David A. Kooby; Kristen L. Zakian; Surya N. Challa; Cornelia Matei; Henrik Petrowsky; Hyok-Hee Yoo; Jason A. Koutcher; Yuman Fong

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Cardiac Glycosides Stimulate Ca²⁺ Increases and Apoptosis in Androgen-independent, Metastatic Human Prostate Adenocarcinoma Cells

David J. McConkey; Yun Lin; Leta K. Nutt; Huseyin Z. Ozel; Robert A. Newman

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In Vivo Cancer Gene Therapy by Adenovirus-mediated Transfer of a Bifunctional Yeast Cytosine Deaminase/Uracil Phosphoribosyltransferase Fusion Gene

Philippe Erbs; Etienne Regulier; Jacqueline Kintz; Pierre Leroy; Yves Poitevin; Françoise Exinger; Richard Jund; Majid Mehtali

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Dietary Flavone Is a Potent Apoptosis Inducer in Human Colon Carcinoma Cells

Uwe Wenzel; Sabine Kuntz; Mathias D. Brendel; Hannelore Daniel

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In Situ Tumor Vaccination with Interleukin-12-encapsulated Biodegradable Microspheres: Induction of Tumor Regression and Potent Antitumor Immunity 1

Nejat K. Egilmez; Yong S. Jong; Michael S. Sabel; Jules S. Jacob; Edith Mathiowitz; Richard B. Bankert

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Immunology

Oleandrin Suppresses Activation of Nuclear Transcription Factor-κB, Activator Protein-1, and c-Jun NH₂-Terminal Kinase 1

Sunil K. Manna; Nand K. Sah; Robert A. Newman; Angela Cisneros; Bharat B. Aggarwal

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Identification on a Human Sarcoma of Two New Genes with Tumor-specific Expression 1

Valérie Martelange; Charles De Smet; Etienne De Plaen; Christophe Lurquin; Thierry Boon

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Molecular Biology and Genetics

The Extracellular Region of Heregulin Is Sufficient to Promote Mammary Gland Proliferation and Tumorigenesis but not Apoptosis

Edward J. Weinstein; Philip Leder

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Different Combinations of Genetic/Epigenetic Alterations Inactivate the p53 and pRb Pathways in Invasive Human Bladder Cancers 1

Somdatta Sarkar; Knut P. Jülicher; Melissa S. Burger; Véronique Della Valle; Christian-Jacques Larsen; Thomas R. Yeager; Timothy B. Grossman; Robert W. Nickells; Chris Protzel; David F. Jarrard; Catherine A. Reznikoff

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The Human T-Cell Transcription Factor-4 Gene: Structure, Extensive Characterization of Alternative Splicings, and Mutational Analysis in Colorectal Cancer Cell Lines 1

Alex Duval; Sandra Rolland; Emmanuel Tubacher; Hung Bui; Gilles Thomas; Richard Hamelin

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Deletion at 13q21 Is Associated with Aggressive Prostate Cancers 1

Jin-Tang Dong; Ceshi Chen; Brian G. Stultz; John T. Isaacs; Henry F. Frierson, Jr.

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Genome-wide Search for Loss of Heterozygosity Using Laser Capture Microdissected Tissue of Breast Carcinoma: An Implication for Mutator Phenotype and Breast Cancer Pathogenesis

Chen-Yang Shen; Jyh-Cherng Yu; Yen-Li Lo; Chia-Hui Kuo; Chung-Tai Yue; Yuh-Shan Jou; Chiun-Sheng Huang; Jia-Chyi Lung; Cheng-Wen Wu

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A Case-Control Study Confirms That Microsatellite Assay Can Identify Patients at Risk of Developing Oral Squamous Cell Carcinoma within a Field of Cancerization 1

Maxine Partridge; Stelios Pateromichelakis; Elaine Phillips; Gracy G. Emilion; Roger P. A’Hern; John D. Langdon

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Tumor Biology

DNA Sequence Copy Number Changes in Gastrointestinal Stromal Tumors: Tumor Progression and Prognostic Significance 1

Wa’el El-Rifai; Maarit Sarlomo-Rikala; Leif C. Andersson; Sakari Knuutila; Markku Miettinen

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Down-Regulation of neu/HER-2 by Interferon-γ in Prostate Cancer Cells 1

Scott L. Kominsky; Amy C. Hobeika; Faith A. Lake; Barbara A. Torres; Howard M. Johnson

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Activation of Insulin-like Growth Factor I Receptor Signaling Pathway Is Critical for Mouse Plasma Cell Tumor Growth

Weiqun Li; Teresa Hyun; Mary Heller; Alan Yam; Lawrence Flechner; Jacalyn H. Pierce; Stuart Rudikoff

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Akt/Protein Kinase B Promotes Survival and Hormone-independent Proliferation of Thyroid Cells in the Absence of Dedifferentiating and Transforming Effects 1

Gabriella De Vita; Maria Teresa Berlingieri; Roberta Visconti; Maria Domenica Castellone; Giuseppe Viglietto; Gustavo Baldassarre; Mariastella Zannini; Alfonso Bellacosa; Philip N. Tsichlis; Alfredo Fusco; Massimo Santoro

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Histone H3 and Heat Shock Protein GRP78 Are Selectively Cross-Linked to DNA by Photoactivated Gilvocarcin V in Human Fibroblasts 1

Akira Matsumoto; Philip C. Hanawalt

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The Role of Cellular Glutathione Peroxidase Redox Regulation in the Suppression of Tumor Cell Growth by Manganese Superoxide Dismutase 1

Shijun Li; Tao Yan; Ji-Qin Yang; Terry D. Oberley; Larry W. Oberley

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Inhibition of Hsp90 Function by Ansamycins Causes Retinoblastoma Gene Product-dependent G₁ Arrest 1

Mary Srethapakdi; Franklin Liu; Ranjana Tavorath; Neal Rosen

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Metabolic Inhibitors Sensitize for CD95 (APO-1/Fas)-induced Apoptosis by Down-Regulating Fas-associated Death Domain-like Interleukin 1-Converting Enzyme Inhibitory Protein Expression 1

Simone Fulda; Eric Meyer; Klaus-Michael Debatin

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E1A Overcomes the Apoptosis Block in BCR-ABL+ Leukemia Cells and Renders Cells Susceptible to Induction of Apoptosis by Chemotherapeutic Agents 1

Thorsten Stiewe; Keiarasch Parssanedjad; Helmut Esche; Bertram Opalka; Brigitte M. Pützer

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Dnmt1^N/+ Reduces the Net Growth Rate and Multiplicity of Intestinal Adenomas in C57BL/6-Multiple Intestinal Neoplasia (Min)/+ Mice Independently of p53 but Demonstrates Strong Synergy with the Modifier of Min 1^AKR Resistance Allele 1

Robert T. Cormier; William F. Dove

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STAT5 Activation Is Required for Interleukin-9-dependent Growth and Transformation of Lymphoid Cells 1

Jean-Baptiste Demoulin; Catherine Uyttenhove; Diane Lejeune; Alice Mui; Bernd Groner; Jean-Christophe Renauld

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Cimetidine Inhibits Cancer Cell Adhesion to Endothelial Cells and Prevents Metastasis by Blocking E-selectin Expression 1

Ken-ichi Kobayashi; Sumio Matsumoto; Takashi Morishima; Takumi Kawabe; Takashi Okamoto

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Journal Archive

Table of Contents

Perspectives in Cancer Research

Special Lecture

Advances in Brief

Biochemistry and Biophysics

Carcinogenesis

Epidemiology

Experimental Therapeutics

Immunology

Molecular Biology and Genetics

Tumor Biology

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