(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Editorial

Cancer Research for the New Millennium

Frank J. Rauscher, III

Extract

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Advances in Brief

Therapy of Human Pancreatic Carcinoma Implants by Irinotecan and the Oral Immunomodulator JBT 3002 Is Associated with Enhanced Expression of Inducible Nitric Oxide Synthase in Tumor-infiltrating Macrophages 1

Christiane J. Bruns; Hisashi Shinohara; Matthew T. Harbison; Darren W. Davis; Gina Nelkin; Jerald J. Killion; David J. McConkey; Zhongyun Dong; Isaiah J. Fidler

Abstract

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Mutations in the Retinoblastoma-related Gene RB2/p130 in Primary Nasopharyngeal Carcinoma 1

Pier Paolo Claudio; Candace M. Howard; Yan Fu; Caterina Cinti; Luigi Califano; Pietro Micheli; Edward W. Mercer; Mario Caputi; Antonio Giordano

Abstract

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Molecular Cloning and Characterization of Human MAWD, a Novel Protein Containing WD-40 Repeats Frequently Overexpressed in Breast Cancer 1

Satoru Matsuda; Ryu Katsumata; Takahito Okuda; Tatsuyoshi Yamamoto; Kou Miyazaki; Takeshi Senga; Kazuya Machida; Aye Aye Thant; Shigekazu Nakatsugawa; Michinari Hamaguchi

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Loss of Fragile Histidine Triad Expression in Colorectal Carcinomas and Premalignant Lesions 1³

Xing Pei Hao; Joseph E. Willis; Thomas G. Pretlow; J. Sunil Rao; Gregory T. MacLennan; Ian C. Talbot; Theresa P. Pretlow

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Increased p53-dependent Apoptosis by the Insulin-like Growth Factor Binding Protein IGFBP-3 in Human Colonic Adenoma-derived Cells 1

Ann C. Williams; Tracey J. Collard; Claire M. Perks; Paul Newcomb; Moganaden Moorghen; Jeff M. P. Holly; Chris Paraskeva

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Tumor Progression Is Accompanied by Significant Changes in the Levels of Expression of Polyamine Metabolism Regulatory Genes and Clusterin (Sulfated Glycoprotein 2) in Human Prostate Cancer Specimens 1

Bettuzzi Saverio; Davalli Pierpaola; Astancolle Serenella; Carani Cesare; Madeo Bruno; Tampieri Auro; Corti Arnaldo

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Threonine Phosphorylation of the MMAC1/PTEN PDZ Binding Domain Both Inhibits and Stimulates PDZ Binding

Nils B. Adey; Liwen Huang; Patricia A. Ormonde; Michelle L. Baumgard; Ralph Pero; Deepthi V. Byreddy; Sean V. Tavtigian; Paul L. Bartel

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Carcinogenic Nickel Induces Genes Involved with Hypoxic Stress 1

Konstantin Salnikow; Mikhail V. Blagosklonny; Heather Ryan; Randall Johnson; Max Costa

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Tumor Suppression and Sensitization to Tumor Necrosis Factor α-induced Apoptosis by an Interferon-inducible Protein, p202, in Breast Cancer Cells 1

Yong Wen; Duen-Hwa Yan; Bill Spohn; Jiong Deng; Shiaw-Yih Lin; Mien-Chie Hung

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Fumitremorgin C Reverses Multidrug Resistance in Cells Transfected with the Breast Cancer Resistance Protein 1

Sridhar K. Rabindran; Douglas D. Ross; L. Austin Doyle; Weidong Yang; Lee M. Greenberger

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Enhancement of Tumor-specific Immune Response with Plasmid DNA Replicon Vectors

Wolfgang W. Leitner; Han Ying; David A. Driver; Thomas W. Dubensky; Nicholas P. Restifo

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A Novel Form of Prostate-specific Antigen Transcript Produced by Alternative Splicing 1

Tsutomu Tanaka; Takahiro Isono; Tatsuhiro Yoshiki; Takeshi Yuasa; Yusaku Okada

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Identical Clonality of Sporadic Gastrinomas at Multiple Sites

Stephan U. Goebel; Alexander O. Vortmeyer; Zhengping Zhuang; Jose Serrano; Robert T. Jensen; Irina A. Lubensky

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N-Myc Induction Stimulated by Insulin-like Growth Factor I through Mitogen-activated Protein Kinase Signaling Pathway in Human Neuroblastoma Cells 1

Akiko Misawa; Hajime Hosoi; Akiko Arimoto; Takuma Shikata; Shinji Akioka; Takafumi Matsumura; Peter J. Houghton; Tadashi Sawada

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A Distinct Tumor Suppressor Gene Locus on Chromosome 15q21.1 in Sporadic Form of Colorectal Cancer 1

Won Sang Park; Jik Young Park; Ro Ra Oh; Nam Jin Yoo; Sug Hyung Lee; Min Sun Shin; Hun Kyung Lee; Seoyoung Han; Sungjoo Kim Yoon; Su Young Kim; Chan Choi; Pum Joon Kim; Seong Taek Oh; Jung Young Lee

Abstract

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Carcinogenesis

Organ-specific, Carcinogen-induced Increases in Cell Proliferation in p53-deficient Mice 1

Tokuo Sukata; Keisuke Ozaki; Satoshi Uwagawa; Takaki Seki; Hideki Wanibuchi; Shinji Yamamoto; Yasuyoshi Okuno; Shoji Fukushima

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Endocrinology

Polysialylated-Neural Cell Adhesion Molecule Expression in Rat Pituitary Transplantable Tumors (Spontaneous Mammotropic Transplantable Tumor in Wistar-Furth Rats) Is Related to Growth Rate and Malignancy 1

Laurent Daniel; Jacqueline Trouillas; Wanda Renaud; Pascale Chevallier; Joanny Gouvernet; Geneviève Rougon; Dominique Figarella-Branger

Abstract

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Experimental Therapeutics

Re-Evaluating Gadolinium(III) Texaphyrin as a Radiosensitizing Agent 1

Eric J. Bernhard; James B. Mitchell; Dennis Deen; Monika Cardell; David I. Rosenthal; J. Martin Brown

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Radiosensitivity of Thymidylate Synthase-deficient Human Tumor Cells Is Affected by Progression through the G₁ Restriction Point into S-Phase: Implications for Fluoropyrimidine Radiosensitization 1

Hwa-Shin Hwang; Thomas W. Davis; Janet A. Houghton; Timothy J. Kinsella

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Molecular Biology and Genetics

APCL, a Central Nervous System-specific Homologue of Adenomatous Polyposis Coli Tumor Suppressor, Binds to p53-binding Protein 2 and Translocates it to the Perinucleus 1

Hidewaki Nakagawa; Kumiko Koyama; Yoji Murata; Monden Morito; Tetsu Akiyama; Yusuke Nakamura

Abstract

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PLAG1, the Main Translocation Target in Pleomorphic Adenoma of the Salivary Glands, Is a Positive Regulator of IGF-II1

Marianne L. Voz; Nancy S. Agten; Wim J. M. Van de Ven; Koen Kas

Abstract

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Frequent Genetic Heterogeneity in the Clonal Evolution of Gynecological Carcinosarcoma and Its Influence on Phenotypic Diversity 1

Hiroaki Fujii; Manabu Yoshida; Zhu Xue Gong; Toshiharu Matsumoto; Yoshitomo Hamano; Masaharu Fukunaga; Ralph H. Hruban; Edward Gabrielson; Toshikazu Shirai

Abstract

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ICBP90, a Novel Human CCAAT Binding Protein, Involved in the Regulation of Topoisomerase IIα Expression 1

Raphaël Hopfner; Marc Mousli; Jean-Marc Jeltsch; Angélique Voulgaris; Yves Lutz; Cristi Marin; Jean-Pierre Bellocq; Pierre Oudet; Christian Bronner

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Hypermethylation-associated Inactivation of p14^ARF Is Independent of p16^INK4a Methylation and p53 Mutational Status 1

Manel Esteller; Silvia Tortola; Minoru Toyota; Gabriel Capella; Miguel Angel Peinado; Stephen B. Baylin; James G. Herman

Abstract

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Tumor Biology

β1,6-N-Acetylglucosamine-bearing N-Glycans in Human Gliomas: Implications for a Role in Regulating Invasivity 1

Hirotaka Yamamoto; Jason Swoger; Suzanne Greene; Tasuku Saito; Jay Hurh; Charla Sweeley; Jan Leestma; Edward Mkrdichian; Leonard Cerullo; Atsushi Nishikawa; Yoshito Ihara; Naoyuki Taniguchi; Joseph R. Moskal

Abstract

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c-Myc Suppresses the Tumorigenicity of Lung Cancer Cells and Down-Regulates Vascular Endothelial Growth Factor Expression 1

Linda F. Barr; Susan E. Campbell; Gregory B. Diette; Edward W. Gabrielson; Sunkyu Kim; Hyunsuk Shim; Chi V. Dang

Abstract

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High Levels of Stromal Hyaluronan Predict Poor Disease Outcome in Epithelial Ovarian Cancer 1

Maarit A. Anttila; Raija H. Tammi; Markku I. Tammi; Kari J. Syrjänen; Seppo V. Saarikoski; Veli-Matti Kosma

Abstract

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p21^WAF1 Regulates Anchorage-independent Growth of HCT116 Colon Carcinoma Cells via E-Cadherin Expression 1

Sebastian Mueller; Enrique Cadenas; Axel H. Schönthal

Abstract

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Source of Oncofetal ED-B-containing Fibronectin: Implications of Production by Both Tumor and Endothelial Cells 1

Marta Midulla; Rakesh Verma; Massimo Pignatelli; Mary A. Ritter; Nigel S. Courtenay-Luck; Andrew J. T. George

Abstract

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Testosterone-repressed Prostate Message-2 Is an Antiapoptotic Gene Involved in Progression to Androgen Independence in Prostate Cancer 1

Hideaki Miyake; Colleen Nelson; Paul S. Rennie; Martin E. Gleave

Abstract

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E-Cadherin Promotes Intraepithelial Expansion of Bladder Carcinoma Cells in an in Vitro Model of Carcinoma in Situ

Eric M. J. Bindels; Marcel Vermey; René van den Beemd; Winand N. M. Dinjens; Theodorus H. Van Der Kwast

Abstract

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Inflammatory Cytokines Induce DNA damage and Inhibit DNA repair in Cholangiocarcinoma Cells by a Nitric Oxide-dependent Mechanism 1

Meeta Jaiswal; Nicholas F. LaRusso; Lawrence J. Burgart; Gregory J. Gores

Abstract

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