(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Advances in Brief

HRad17, a Human Homologue of the Schizosaccharomyces pombe Checkpoint Gene rad17, Is Overexpressed in Colon Carcinoma 1

Shideng Bao; Mau-Sun Chang; Daniel Auclair; Yapin Sun; Youbin Wang; Wei-Kong Wong; Jinyang Zhang; Yuan Liu; Xiuqi Qian; Rebecca Sutherland; Cristina Magi-Galluzi; Ellen Weisberg; Edmond Y. S. Cheng; Luning Hao; Hidefumi Sasaki; Michael S. Campbell; Stine-Kathrein Kraeft; Massimo Loda; Kin-Ming Lo; LanBo Chen

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Methylation of CpG in a Small Region of the hMLH1 Promoter Invariably Correlates with the Absence of Gene Expression 1

Guoren Deng; Ada Chen; Joe Hong; Hiun Suk Chae; Young S. Kim

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Impairment of the Proapoptotic Activity of Bax by Missense Mutations Found in Gastrointestinal Cancers 1

Joan Gil; Hiroyuki Yamamoto; Juan M. Zapata; John C. Reed; Manuel Perucho

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Genetic and Functional Analyses Exclude Mortality Factor 4 (MORF4) as a Keratinocyte Senescence Gene 1

Steven D. Bryce; Nicholas R. Forsyth; Sara A. Fitzsimmons; Louise J. Clark; Michael J. Bertram; Andrew P. Cuthbert; Robert F. Newbold; Olivia M. Pereira-Smith; E. Kenneth Parkinson

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Centrosomal Kinase AIK1 Is Overexpressed in Invasive Ductal Carcinoma of the Breast 1

Takuji Tanaka; Masashi Kimura; Kengo Matsunaga; Daizo Fukada; Hideki Mori; Yukio Okano

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Promoting Effects of 3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone on Rat Glandular Stomach Carcinogenesis Initiated with N-Methyl-N′-nitro-N-nitrosoguanidine 1

Akiyoshi Nishikawa; Fumio Furukawa; In-Seon Lee; Ken-ichiro Kasahara; Zen-yo Tanakamaru; Hideaki Nakamura; Makoto Miyauchi; Naohide Kinae; Masao Hirose

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Genetic Deletion of p21^WAF1 Enhances Papilloma Formation but not Malignant Conversion in Experimental Mouse Skin Carcinogenesis

Wendy C. Weinberg; Ester Fernandez-Salas; David L. Morgan; Aryaman Shalizi; Elena Mirosh; Eric Stanulis; Chuxia Deng; Henry Hennings; Stuart H. Yuspa

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Replication-competent, Nonneuroinvasive Genetically Engineered Herpes Virus Is Highly Effective in the Treatment of Therapy-resistant Experimental Human Tumors 1

Sunil J. Advani; Su-Mi Chung; Sze Y. Yan; G. Yancey Gillespie; James M. Markert; Richard J. Whitley; Bernard Roizman; Ralph R. Weichselbaum

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Elevation of α2(I) Collagen, a Suppressor of Ras Transformation, Is Required for Stable Phenotypic Reversion by Farnesyltransferase Inhibitors 1

Wei Du; Peter F. Lebowitz; George C. Prendergast

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The Pathway Regulating MDM2 Protein Degradation Can Be Altered in Human Leukemic Cells 1

Yi Pan; Dale S. Haines

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Mouse p73 Gene Maps to the Distal Part of Chromosome 4 and Might Be Involved in the Progression of γ-Radiation-induced T-cell Lymphomas 1

Michel Herranz; Javier Santos; Eduardo Salido; José Ferná ndez-Piqueras; Manuel Serrano

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Direct Correlation between Nitric Oxide Synthase II Inducibility and Metastatic Ability of UV-2237 Murine Fibrosarcoma Cells Carrying Mutant p53 1

Qian Shi; Suyun Huang; Weidong Jiang; Laura S. Kutach; Honnavara N. Ananthaswamy; Keping Xie

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Biochemistry

Glioma Migration Can Be Blocked by Nontoxic Inhibitors of Myosin II 1

G. Yancey Gillespie; Liliana Soroceanu; Timothy J. Manning, Jr.; Candece L. Gladson; Steven S. Rosenfeld

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Mistletoe Lectin Activates Caspase-8/FLICE Independently of Death Receptor Signaling and Enhances Anticancer Drug-induced Apoptosis 1

Heike Bantel; Ingo H. Engels; Wolfgang Voelter; Klaus Schulze-Osthoff; Sebastian Wesselborg

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Carcinogenesis

Mutagenic Potential of α-(N²-Deoxyguanosinyl)tamoxifen Lesions, the Major DNA Adducts Detected in Endometrial Tissues of Patients Treated with Tamoxifen 1

Isamu Terashima; Naomi Suzuki; Shinya Shibutani

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Clinical Investigations

Phase I Evaluation of Humanized OKT3: Toxicity and Immunomodulatory Effects of hOKT3γ₄

Jon Richards; Julie Auger; Donna Peace; Danielle Gale; Judy Michel; Ann Koons; Tom Haverty; Robert Zivin; Linda Jolliffe; Jeffrey A. Bluestone

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Experimental Therapeutics

Modulation of Drug Resistance Mediated by Loss of Mismatch Repair by the DNA Polymerase Inhibitor Aphidicolin 1

Nicole J. Moreland; Maureen Illand; Young Tae Kim; Jim Paul; Robert Brown

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Paracrine Immunotherapy with Interleukin-2 and Local Chemotherapy Is Synergistic in the Treatment of Experimental Brain Tumors 1

Prakash Sampath; Justin Hanes; Francesco DiMeco; Betty M. Tyler; Daniel Brat; Drew M. Pardoll; Henry Brem

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Prostate Cancer Chemoprevention by Green Tea: In Vitro and in Vivo Inhibition of Testosterone-mediated Induction of Ornithine Decarboxylase 1

Sanjay Gupta; Nihal Ahmad; Rajiv R. Mohan; Mirza M. Husain; Hasan Mukhtar

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In Vivo Cytotoxicity of Ovarian Cancer Cells through Tumor-selective Expression of the BAX Gene 1

Yu-Tzu Tai; Thomas Strobel; Donald Kufe; Stephen A. Cannistra

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Expression of Human α(1,3)Fucosyltransferase Antisense Sequences Inhibits Selectin-mediated Adhesion and Liver Metastasis of Colon Carcinoma Cells 1

Brent W. Weston; Kara M. Hiller; John P. Mayben; George A. Manousos; Katharine M. Bendt; Rong Liu; James C. Cusack, Jr.

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Prostate-specific Antigen (PSA) Promoter-driven Androgen-inducible Expression of Sodium Iodide Symporter in Prostate Cancer Cell Lines 1

Christine Spitzweg; Shaobo Zhang; Elizabeth R. Bergert; Maria R. Castro; Bryan McIver; Armin E. Heufelder; Donald J. Tindall; Charles Y. F. Young; John C. Morris

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Immunology

Regulation of Transforming Growth Factor β1 by Nitric Oxide

Yoram Vodovotz; Louis Chesler; Hyonkyong Chong; Seong-Jin Kim; John T. Simpson; William DeGraff; George W. Cox; Anita B. Roberts; David A. Wink; Mary Helen Barcellos-Hoff

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Presentation of Tumor Antigens by Phagocytic Dendritic Cell Clusters Generated from Human CD34⁺ Hematopoietic Progenitor Cells: Induction of Autologous Cytotoxic T Lymphocytes against Leukemic Cells in Acute Myelogenous Leukemia Patients 1

Shin-ichiro Fujii; Koji Fujimoto; Kanako Shimizu; Taichi Ezaki; Fumio Kawano; Kiyoshi Takatsuki; Makoto Kawakita; Kenjiro Matsuno

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Improving the Efficacy of Antibody-Interleukin 2 Fusion Proteins by Reducing Their Interaction with Fc Receptors

Stephen D. Gillies; Yan Lan; Kin-Ming Lo; Michael Super; John Wesolowski

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An Antigen-targeted Approach to Adoptive Transfer Therapy of Cancer 1

Danila Valmori; Mikaël J. Pittet; Donata Rimoldi; Danielle Liénard; Rod Dunbar; Vincenzo Cerundolo; Ferdy Lejeune; Jean-Charles Cerottini; Pedro Romero

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Molecular Biology and Genetics

ATP-dependent Steps in Apoptotic Signal Transduction 1

Yutaka Eguchi; Anu Srinivasan; Kevin J. Tomaselli; Shigeomi Shimizu; Yoshihide Tsujimoto

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The Genetic Locus NRC-1 within Chromosome 3p12 Mediates Tumor Suppression in Renal Cell Carcinoma Independently of Histological Type, Tumor Microenvironment, and VHL Mutation 1

Mercedes Lovell; Steven Trent Lott; Patricia Wong; Adel El-Naggar; Susan Tucker; Ann McNeill Killary

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Poly(ADP-ribosyl)ation of p53 during Apoptosis in Human Osteosarcoma Cells 1

Cynthia M. Simbulan-Rosenthal; Dean S. Rosenthal; RuiBai Luo; Mark E. Smulson

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The JNK/SAPK Activator Mixed Lineage Kinase 3 (MLK3) Transforms NIH 3T3 Cells in a MEK-dependent Fashion 1

Jörg Hartkamp; Jakob Troppmair; Ulf R. Rapp

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Tumor Biology

The Insulin-like Growth Factor Axis and Prostate Cancer: Lessons from the Transgenic Adenocarcinoma of Mouse Prostate (TRAMP) Model 1

Paula J. Kaplan; Subburaman Mohan; Pinchas Cohen; Barbara A. Foster; Norman M. Greenberg

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Transforming Growth Factor β1 Is a Target for the von Hippel-Lindau Tumor Suppressor and a Critical Growth Factor for Clear Cell Renal Carcinoma 1

Subbian Ananth; Bertrand Knebelmann; Wolfram Grüning; Mohanraj Dhanabal; Gerd Walz; Isaac E. Stillman; Vikas P. Sukhatme

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Tumor Spectrum in ARF-deficient Mice 1

Takehiko Kamijo; Sara Bodner; Esther van de Kamp; David H. Randle; Charles J. Sherr

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Relationship of Arachidonic Acid Metabolizing Enzyme Expression in Epithelial Cancer Cell Lines to the Growth Effect of Selective Biochemical Inhibitors

Sung H. Hong; Ingalill Avis; Michele D. Vos; Alfredo Martínez; Anthony M. Treston; James L. Mulshine

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Overexpression of Sialomucin Complex, a Rat Homologue of MUC4, Inhibits Tumor Killing by Lymphokine-activated Killer Cells 1

Masanobu Komatsu; Lisa Yee; Kermit L. Carraway

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Overexpression of α1-6 Fucosyltransferase in Hepatoma Cells Suppresses Intrahepatic Metastasis after Splenic Injection in Athymic Mice 1

Eiji Miyoshi; Katsuhisa Noda; Jeong Heon Ko; Atsuko Ekuni; Takatoshi Kitada; Naofumi Uozumi; Yoshitaka Ikeda; Nariaki Matsuura; Yutaka Sasaki; Norio Hayashi; Masatsugu Hori; Naoyuki Taniguchi

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Deficient Activity of von Willebrand’s Factor-cleaving Protease in Patients with Disseminated Malignancies 1

Leslie Oleksowicz; Niyati Bhagwati; Margie DeLeon-Fernandez

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Meeting Report

Third International Meeting on van Hippel-Lindau Disease

Berton Zbar; William Kaelin; Eamonn Maher; Stephane Richard

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Obituary

Raymond Latarjet

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