(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Advances in Brief

Carboxymethyl Benzylamide Dextran Blocks Angiogenesis of MDA-MB435 Breast Carcinoma Xenografted in Fat Pad and Its Lung Metastases in Nude Mice 1

Rozita Bagheri-Yarmand; Yamina Kourbali; Ana Maria Rath; Roger Vassy; Antoine Martin; Jacqueline Jozefonvicz; Claudine Soria; He Lu; Michel Crépin

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Identification of a Novel Gene, MASL1 within an Amplicon at 8p23.1 Detected in Malignant Fibrous Histiocytomas by Comparative Genomic Hybridization 1

Tomoya Sakabe; Takashi Shinomiya; Toshiki Mori; Yoji Ariyama; Yoji Fukuda; Tsutomu Fujiwara; Yusuke Nakamura; Johji Inazawa

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Functional Evidence of Novel Tumor Suppressor Genes for Cutaneous Malignant Melanoma 1

Christopher N. Parris; Julian D. Harris; Darren K. Griffin; Andrew P. Cuthbert; Andrew J. R. Silver; Robert F. Newbold

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Chemoprevention of Rat Prostate Carcinogenesis by 9-cis-Retinoic Acid 1

David L. McCormick; K. V. N. Rao; Vernon E. Steele; Ronald A. Lubet; Gary J. Kelloff; Maarten C. Bosland

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Coexpression of Estrogen Receptor α and β: Poor Prognostic Factors in Human Breast Cancer?1

Valerie Speirs; Alicia T. Parkes; Michael J. Kerin; David S. Walton; Peter J. Carleton; John N. Fox; Stephen L. Atkin

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Estrogen Receptor-β Messenger RNA Expression in Human Breast Tumor Biopsies: Relationship to Steroid Receptor Status and Regulation by Progestins 1

Helmut Dotzlaw; Etienne Leygue; Peter H. Watson; Leigh C. Murphy

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BNIP3α: A Human Homolog of Mitochondrial Proapoptotic Protein BNIP3 1

Motoaki Yasuda; Jia-wen Han; Cheryl A. Dionne; Janice M. Boyd; G. Chinnadurai

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The Human MLH1 cDNA Complements DNA Mismatch Repair Defects in Mlh1-deficient Mouse Embryonic Fibroblasts 1

Andrew B. Buermeyer; Carmell Wilson-Van Patten; Sean M. Baker; R. Michael Liskay

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Phosphoinositide 3-Kinase Activity Is Essential for all-trans-Retinoic Acid-induced Granulocytic Differentiation of HL-60 Cells 1

Valeria Bertagnolo; Luca Maria Neri; Marco Marchisio; Carlo Mischiati; Silvano Capitani

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Independent Regulation of Growth and SMAD-mediated Transcription by Transforming Growth Factor β in Human Melanoma Cells 1

Ulrich Rodeck; Takafumi Nishiyama; Alain Mauviel

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Cloning of Human Telomerase Catalytic Subunit (hTERT) Gene Promoter and Identification of Proximal Core Promoter Sequences Essential for Transcriptional Activation in Immortalized and Cancer Cells

Masahiro Takakura; Satoru Kyo; Taro Kanaya; Hisao Hirano; Jun Takeda; Masuo Yutsudo; Masaki Inoue

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Biochemistry

Identification of Functional Elements of p18^INK4C Essential for Binding and Inhibition of Cyclin-dependent Kinase (CDK) 4 and CDK6 1

Seong J. Noh; Yan Li; Yue Xiong; Kun-Liang Guan

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Transcription of the Bone Sialoprotein Gene Is Stimulated by v-Src Acting through an Inverted CCAAT Box 1

Richard H. Kim; Jaro Sodek

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Protein Kinase D in Small Cell Lung Cancer Cells: Rapid Activation through Protein Kinase C 1

Lina Paolucci; Enrique Rozengurt

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Carcinogenesis

Cancer Chemopreventive Activity Mediated by 4′-Bromoflavone, a Potent Inducer of Phase II Detoxification Enzymes 1

Lynda L. Song; Jerome W. Kosmeder, II; Sang Kook Lee; Clarissa Gerhäuser; Daniel Lantvit; Richard C. Moon; Robert M. Moriarty; John M. Pezzuto

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Polymorphic Expression of the Glutathione Polymorphic Expression of the Glutathione S-Transferase P1 Gene and Its Susceptibility to Barrett’s Esophagus and Esophageal Carcinoma 1

Esther M. M. van Lieshout; Hennie M. J. Roelofs; Simone Dekker; Chris J. J. Mulder; Theo Wobbes; Jan B. M. J. Jansen; Wilbert H. M. Peters

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Quantitation of Urinary Metabolites of a Tobacco-specific Lung Carcinogen after Smoking Cessation 1

Stephen S. Hecht; Steven G. Carmella; Menglan Chen; J. F. Dor Koch; Andrew T. Miller; Sharon E. Murphy; Joni A. Jensen; Cheryl L. Zimmerman; Dorothy K. Hatsukami

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Chemopreventive Effect of Curcumin, a Naturally Occurring Anti-Inflammatory Agent, during the Promotion/Progression Stages of Colon Cancer 1

Toshihiko Kawamori; Ronald Lubet; Vernon E. Steele; Gary J. Kelloff; Robert B. Kaskey; Chinthalapally V. Rao; Bandaru S. Reddy

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Manganese Superoxide Dismutase (MnSOD) Genetic Polymorphisms, Dietary Antioxidants, and Risk of Breast Cancer 1

Christine B. Ambrosone; Jo L. Freudenheim; Patricia A. Thompson; Elise Bowman; John E. Vena; James R. Marshall; Saxon Graham; Rosemary Laughlin; Takuma Nemoto; Peter G. Shields

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Isoform-specific Induction of a Human Aldo-Keto Reductase by Polycyclic Aromatic Hydrocarbons (PAHs), Electrophiles, and Oxidative Stress: Implications for the Alternative Pathway of PAH Activation Catalyzed by Human Dihydrodiol Dehydrogenase 1

Michael E. Burczynski; Hseuh-Kung Lin; Trevor M. Penning

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Clinical Investigations

2-[C-11]Thymidine Imaging of Malignant Brain Tumors 1

Janet F. Eary; David A. Mankoff; Alexander M. Spence; Mitchel S. Berger; Adam Olshen; Jeanne M. Link; Finbarr O’Sullivan; Kenneth A. Krohn

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Epidemiology and Prevention

A Flavonoid Antioxidant, Silymarin, Affords Exceptionally High Protection against Tumor Promotion in the SENCAR Mouse Skin Tumorigenesis Model 1

Moushumi Lahiri-Chatterjee; Santosh K. Katiyar; Rajiv R. Mohan; Rajesh Agarwal

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Experimental Therapeutics

Stimulation of Tumors to Synthesize Tumor Necrosis Factor-α in Situ Using 5,6-Dimethylxanthenone-4-acetic Acid: A Novel Approach to Cancer Therapy 1

Wayne R. Joseph; Zhihui Cao; Kathleen G. Mountjoy; Elaine S. Marshall; Bruce C. Baguley; Lai-Ming Ching

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Effects of Cationic Porphyrins as G-Quadruplex Interactive Agents in Human Tumor Cells 1

Elzbieta Izbicka; Richard T. Wheelhouse; Eric Raymond; Karen K. Davidson; Richard A. Lawrence; Daekyu Sun; Bradford E. Windle; Laurence H. Hurley; Daniel D. Von Hoff

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Eradication of Rat Malignant Gliomas by Retroviral-mediated, in Vivo Delivery of the Interleukin 4 Gene 1

Sara Benedetti; Maria Grazia Bruzzone; Bianca Pollo; Francesco DiMeco; Lorenzo Magrassi; Barbara Pirola; Nicola Cirenei; Mario P. Colombo; Gaetano Finocchiaro

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Laulimalide and Isolaulimalide, New Paclitaxel-Like Microtubule-Stabilizing Agents 1

Susan L. Mooberry; Georgia Tien; Anne H. Hernandez; Anuchit Plubrukarn; Bradley S. Davidson

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Radioisotope Concentrator Gene Therapy Using the Sodium/Iodide Symporter Gene

Robert B. Mandell; Leisa Z. Mandell; Charles J. Link, Jr.

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Cytotoxicity and Accumulation of Ganciclovir Triphosphate in Bystander Cells Cocultured with Herpes Simplex Virus Type 1 Thymidine Kinase-expressing Human Glioblastoma Cells 1

Laura Z. Rubsam; Paul D. Boucher; Patrick J. Murphy; Mark KuKuruga; Donna S. Shewach

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Immunology

Induction of Protective Host Immunity to Carcinoembryonic Antigen (CEA), a Self-Antigen in CEA Transgenic Mice, by Immunizing with a Recombinant Vaccinia-CEA Virus

Erik Kass; Jeffrey Schlom; John Thompson; Fiorella Guadagni; Paolo Graziano; John W. Greiner

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Molecular Biology and Genetics

Reduced Expression of the Cell Cycle Inhibitor p27^Kip1 in Non-Small Cell Lung Carcinoma: A Prognostic Factor Independent of Ras1

Charles Catzavelos; Ming-Sound Tsao; Gerrit DeBoer; Nandita Bhattacharya; Frances A. Shepherd; Joyce M. Slingerland

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N-(2-Chloroethyl)-N-nitrosourea Tethered to Lexitropsin Induces Minor Groove Lesions at the p53 cDNA That Are More Cytotoxic than Mutagenic 1

Alberto Inga; Fa-Xian Chen; Paola Monti; Anna Aprile; Paola Campomenosi; Paola Menichini; Laura Ottaggio; Silvia Viaggi; Angelo Abbondandolo; Barry Gold; Gilberto Fronza

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Bax Is Frequently Compromised in Burkitt’s Lymphomas with Irreversible Resistance to Fas-induced Apoptosis

Marina I. Gutiérrez; Barry Cherney; Azhar Hussain; Howard Mostowski; Giovanna Tosato; Ian Magrath; Kishor Bhatia

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Yeast Proteins Related to the p40/Laminin Receptor Precursor Are Required for 20S Ribosomal RNA Processing and the Maturation of 40S Ribosomal Subunits 1

Christine L. Ford; Leslie Randal-Whitis; Steven R. Ellis

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Tumor Biology

Activation of Neurotrophin-3 Receptor TrkC Induces Apoptosis in Medulloblastomas 1

John Y. H. Kim; Mary E. Sutton; Diane J. Lu; Tracey A. Cho; Liliana C. Goumnerova; Lyuda Goritchenko; Jill R. Kaufman; K. K. Lam; Amy L. Billet; Nancy J. Tarbell; Julian Wu; Jeffrey C. Allen; Charles D. Stiles; Rosalind A. Segal; Scott L. Pomeroy

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Expression of Endothelin 1 and Endothelin A Receptor in Ovarian Carcinoma: Evidence for an Autocrine Role in Tumor Growth 1

Anna Bagnato; Debora Salani; Valeriana Di Castro; Jinshyun R. Wu-Wong; Raffaele Tecce; Maria Rita Nicotra; Aldo Venuti; Pier Giorgio Natali

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Expression of Vascular Endothelial Growth Factor and Its Receptors in Hematopoietic Malignancies 1

William T. Bellamy; Lynne Richter; Yvette Frutiger; Thomas M. Grogan

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Chemotherapy Augments TRAIL-induced Apoptosis in Breast Cell Lines

Maccon M. Keane; Seth A. Ettenberg; Marion M. Nau; Edward K. Russell; Stan Lipkowitz

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Stimulation of Breast Cancer Invasion and Metastasis by Synuclein γ 1

Tongli Jia; Yiliang E. Liu; Jingwen Liu; Y. Eric Shi

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Comparative Genomic Hybridization of Cancer of the Gastroesophageal Junction: Deletion of 14Q31–32.1 Discriminates between Esophageal (Barrett’s) and Gastric Cardia Adenocarcinomas 1

Herman van Dekken; Eric Geelen; Winand N. M. Dinjens; B. P. L. Wijnhoven; Hugo W. Tilanus; Hans J. Tanke; Carla Rosenberg

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Variants of Squamous Cell Carcinoma of the Anal Canal and Perianal Skin and Their Relation to Human Papillomaviruses 1

Morten Frisch; Claus Fenger; Adriaan J. C. van den Brule; Per Sørensen; Chris J. L. M. Meijer; Jan M. M. Walboomers; Hans-Olov Adami; Mads Melbye; Bengt Glimelius

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Focal Adhesion Kinase-dependent Apoptosis of Melanoma Induced by Tyrosine and Phenylalanine Deficiency 1

Ya-Min Fu; Zu-Xi Yu; Bertha A. Pelayo; Victor J. Ferrans; Gary G. Meadows

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