(ISSN 0099-7013) Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.

Editorial

Reflections of the Editor-in-Chief

Carlo M. Croce

Extract

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Advances in Brief

Flt3-Ligand Administration after Radiation Therapy Prolongs Survival in a Murine Model of Metastatic Lung Cancer

Prabir K. Chakravarty; Alan Alfieri; Elaine K. Thomas; Vivek Beri; Kathryn E. Tanaka; Bhadrasain Vikram; Chandan Guha

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Arsenic Trioxide Causes Selective Necrosis in Solid Murine Tumors by Vascular Shutdown 1

Young S. Lew; Stephen L. Brown; Robert J. Griffin; Chang W. Song; Jae Ho Kim

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Down-Regulation of Nuclear Factor κB Is Required for p53-dependent Apoptosis in X-Ray-irradiated Mouse Lymphoma Cells and Thymocytes 1

Hidehiko Kawai; Yukiko Yamada; Masaaki Tatsuka; Ohtsura Niwa; Ken-ichi Yamamoto; Fumio Suzuki

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E7-transduced Human Breast Epithelial Cells Show Partial Differentiation in Three-dimensional Culture 1

Kimberly M. Spancake; Christine B. Anderson; Valerie M. Weaver; Norisada Matsunami; Mina J. Bissell; Raymond L. White

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Hypoxia Induces p53 Accumulation through MDM2 Down-Regulation and Inhibition of E6-mediated Degradation 1

Rodolfo Alarcón; Constantinos Koumenis; Rory K. Geyer; Carl G. Maki; Amato J. Giaccia

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The Generation of Endostatin Is Mediated by Elastase 1

Wei Wen; Marsha A. Moses; Dmitri Wiederschain; Jack L. Arbiser; Judah Folkman

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Ras Oncogene-Induced Sensitization to 1-β-d-Arabinofuranosylcytosine 1

Han-Mo Koo; Mary Jane McWilliams; W. Gregory Alvord; George F. Vande Woude

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Growth Suppression of Human Ovarian Cancer Cells by Adenovirus-mediated Transfer of the PTEN Gene

Takeo Minaguchi; Toshiki Mori; Yasunobu Kanamori; Mieko Matsushima; Hiroyuki Yoshikawa; Yuji Taketani; Yusuke Nakamura

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Antisense to SV40 Early Gene Region Induces Growth Arrest and Apoptosis in T-Antigen-positive Human Pleural Mesothelioma Cells

Ishrat Waheed; Z. Sheng Guo; G. Aaron Chen; Todd S. Weiser; Dao M. Nguyen; David S. Schrump

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Tissue-specific Expression of Functional Isoforms of Mouse Folylpoly-γ-glutamate Synthetase: A Basis for Targeting Folate Antimetabolites 1

Fiona B. Turner; John L. Andreassi, II; Jennifer Ferguson; Steven Titus; Archie Tse; Shirley M. Taylor; Richard G. Moran

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Deletion of the Carboxyl-Terminal Exons of K-sam/FGFR2 by Short Homology-mediated Recombination, Generating Preferential Expression ofSpecific Messenger RNAs 1

Tetsuya Ueda; Hiroki Sasaki; Yoshitaka Kuwahara; Masahiko Nezu; Tetsuo Shibuya; Hiromi Sakamoto; Hideshi Ishii; Kazuyoshi Yanagihara; Ken-ichi Mafune; Masatoshi Makuuchi; Masaaki Terada

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DNA Methylation Analysis of the Promoter Region of the Human Telomerase Reverse Transcriptase (hTERT) Gene

Theodora R. Devereux; Izumi Horikawa; Colleen H. Anna; Lois A. Annab; Cynthia A. Afshari; J. Carl Barrett

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Amplification and Overexpression of the MDM4 (MDMX) Gene from 1q32 in a Subset of Malignant Gliomas without TP53 Mutation or MDM2 Amplification 1

Markus J. Riemenschneider; Rainer Büschges; Marietta Wolter; Julia Reifenberger; Jan Boström; Jürgen A. Kraus; Uwe Schlegel; Guido Reifenberger

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Survivin-ΔEx3 and Survivin-2B: Two Novel Splice Variants of the Apoptosis Inhibitor Survivin with Different Antiapoptotic Properties 1

Csaba Mahotka; Michael Wenzel; Erik Springer; Helmut E. Gabbert; Claus D. Gerharz

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Unique Strains of SV40 in Commercial Poliovaccines from 1955 Not Readily Identifiable with Current Testing for SV40 Infection 1

Paola Rizzo; Ilaria Di Resta; Amy Powers; Herbert Ratner; Michele Carbone

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Sensitivity to Polyamine-induced Growth Arrest Correlates with Antizyme Induction in Prostate Carcinoma Cells

Cheiko Koike; Debra T. Chao; Bruce R. Zetter

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Gastric and Duodenal Polyps in Smad4 (Dpc4) Knockout Mice 1

Kazuaki Takaku; Hiroyuki Miyoshi; Akihiro Matsunaga; Masanobu Oshima; Nobuya Sasaki; Makoto M. Taketo

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Carcinogenesis

High Susceptibility of a Human Breast Epithelial Cell Type with Stem Cell Characteristics to Telomerase Activation and Immortalization 1

Wei Sun; Kyung-Sun Kang; Ikue Morita; James E. Trosko; Chia-Cheng Chang

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Helicobacter pylori Strain-specific Genotypes and Modulation of the Gastric Epithelial Cell Cycle 1

Richard M. Peek, Jr.; Martin J. Blaser; Deborah J. Mays; Mark H. Forsyth; Timothy L. Cover; Si Young Song; Uma Krishna; Jennifer A. Pietenpol

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Clinical Investigations

Detection of High-Risk Cervical Intraepithelial Neoplasia and Cervical Cancer by Amplification of Transcripts Derived from Integrated Papillomavirus Oncogenes 1

Ruediger Klaes; Stefan M. Woerner; Ruediger Ridder; Nicolas Wentzensen; Matthias Duerst; Achim Schneider; Beatrix Lotz; Peter Melsheimer; Magnus von Knebel Doeberitz

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Experimental Therapeutics

Differential Roles of the Tandem C1 Domains of Protein Kinase C δ in the Biphasic Down-Regulation Induced by Bryostatin 1

Patricia S. Lorenzo; Krisztina Bögi; Kathleen M. Hughes; Maryam Beheshti; Dipak Bhattacharyya; Susan H. Garfield; George R. Pettit; Peter M. Blumberg

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Inhibition of Src Kinases by a Selective Tyrosine Kinase Inhibitor Causes Mitotic Arrest 1

Mark M. Moasser; Mary Srethapakdi; Komal S. Sachar; Alan J. Kraker; Neal Rosen

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Tumor Necrosis Factor-related Apoptosis-inducing Ligand’s Antitumor Activity in Vivo Is Enhanced by the Chemotherapeutic Agent CPT-11

Brian Gliniak; Tiep Le

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Imaging Brain Tumors by Targeting Peptide Radiopharmaceuticals through the Blood-Brain Barrier 1

Atsushi Kurihara; William M. Pardridge

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In Vivo Fluence Rate and Fractionation Effects on Tumor Response and Photobleaching: Photodynamic Therapy with Two Photosensitizers in an Orthotopic Rat Tumor Model 1

Seiichi Iinuma; Kevin T. Schomacker; Georges Wagnieres; Milind Rajadhyaksha; Michael Bamberg; Tetsuo Momma; Tayyaba Hasan

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Influence of Coenzyme A-independent Transacylase and Cyclooxygenase Inhibitors on the Proliferation of Breast Cancer Cells 1

Anthony J. Trimboli; B. Moseley Waite; Gen-ichi Atsumi; Alfred N. Fonteh; Andrew M. Namen; Carl E. Clay; Tim E. Kute; Kevin P. High; Mark C. Willingham; Floyd H. Chilton

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Synergistic Effects of New Chemopreventive Agents and Conventional Cytotoxic Agents against Human Lung Cancer Cell Lines 1

Ariel F. Soriano; Barbara Helfrich; Daniel C. Chan; Lynn E. Heasley; Paul A. Bunn, Jr.; Ting-Chao Chou

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Sphingosine-1-phosphate Inhibits Motility of Human Breast Cancer Cells Independently of Cell Surface Receptors 1

Fang Wang; James R. Van Brocklyn; Lisa Edsall; Victor E. Nava; Sarah Spiegel

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In Vitro Growth Inhibition of Ovarian Cancer Cells by Decorin: Synergism of Action between Decorin and Carboplatin 1

Micheal A. Nash; Amy E. Loercher; Ralph S. Freedman

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Immunology

Cancer-Testis Antigens and ING1 Tumor Suppressor Gene Product Are Breast Cancer Antigens: Characterization of Tissue-specific ING1 Transcripts and a Homologue Gene 1

Dirk Jäger; Elisabeth Stockert; Matthew J. Scanlan; Ali O. Güre; Elke Jäger; Alexander Knuth; Lloyd J. Old; Yao-Tseng Chen

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Molecular Biology and Genetics

Breakpoints of the t(11;18)(q21;q21) in Mucosa-associated Lymphoid Tissue (MALT) Lymphoma Lie within or near the Previously Undescribed Gene MALT1 in Chromosome 18 1

Jeffrey A. Morgan; Yi Yin; Alexander D. Borowsky; Frank Kuo; Nicole Nourmand; Jason I. Koontz; Carol Reynolds; Lee Soreng; Constance A. Griffin; Fiona Graeme-Cook; Nancy L. Harris; Dennis Weisenburger; Geraldine S. Pinkus; Jonathan A. Fletcher; Jeffrey Sklar

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Structural Basis for the Regulation of UDP-N-Acetyl-α-d-galactosamine: Polypeptide N-Acetylgalactosaminyl Transferase-3 Gene Expression in Adenocarcinoma Cells 1

Minoru Nomoto; Hiroto Izumi; Tomoko Ise; Ken Kato; Hiroshi Takano; Gunji Nagatani; Kazunori Shibao; Ryo Ohta; Toshihiro Imamura; Michihiko Kuwano; Ken-ichi Matsuo; Yuji Yamada; Hideaki Itoh; Kimitoshi Kohno

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CTp11, a Novel Member of the Family of Human Cancer/Testis Antigens 1

Albert J. W. Zendman; Ine M. H. A. Cornelissen; Ulrich H. Weidle; Dirk J. Ruiter; Goos N. P. van Muijen

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MHC Class I-restricted Recognition of a Melanoma Antigen by a Human CD4⁺ Tumor Infiltrating Lymphocyte

Michael I. Nishimura; Dody Avichezer; Mary C. Custer; Catherine S. Lee; Christine Chen; Maria R. Parkhurst; Rochelle A. Diamond; Paul F. Robbins; Douglas J. Schwartzentruber; Steven A. Rosenberg

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Tumor Biology

The NH₂ Terminus of Galectin-3 Governs Cellular Compartmentalization and Functions in Cancer Cells 1

Hua Chang Gong; Yuichiro Honjo; Pratima Nangia-Makker; Victor Hogan; Nachman Mazurak; Robert S. Bresalier; Avraham Raz

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Hyaluronidase-2 Overexpression Accelerates Intracerebral but not Subcutaneous Tumor Formation of Murine Astrocytoma Cells 1

Ulrike Novak; Stanley S. Stylli; Andrew H. Kaye; Guenter Lepperdingerm

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Mouse Endostatin Inhibits the Formation of Lung and Liver Metastases 1

Sam S. Yoon; Hiroshi Eto; Cheng-mao Lin; Hideo Nakamura; Timothy M. Pawlik; Sun U. Song; Kenneth K. Tanabe

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The Novel Retinoid 6-[3-(1-adamantyl)-4-hydroxyphenyl]-2-naphtalene Carboxylic Acid Can Trigger Apoptosis through a Mitochondrial Pathway Independent of the Nucleus 1

Philippe Marchetti; Naoufal Zamzami; Bertrand Joseph; Susanna Schraen-Maschke; Claude Méreau-Richard; Paola Costantini; Didier Métivier; Santos A. Susin; Guido Kroemer; Pierre Formstecher

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Tissue Inhibitor of Metalloproteinase-1 Inhibits Apoptosis of Human Breast Epithelial Cells 1

Gangyong Li; Rafael Fridman; Hyeong-Reh Choi Kim

Abstract

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Comparison of Effects of Two Polymorphic Variants of Manganese Superoxide Dismutase on Human Breast MCF-7 Cancer Cell Phenotype 1

Hannah J. Zhang; Tao Yan; Terry D. Oberley; Larry W. Oberley

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