Skip to Main Content

Advertisement

American Association for Cancer Research Logo
header search
Search
Advanced Search
Skip Nav Destination

Issues

Volume 59, Issue 22
15 November 1999
Cancer Research Cover Image for Volume 59, Issue 22
All Issues
ISSN 0008-5472
EISSN 1538-7445

Cancer Research

Table of Contents


Advances in Brief

Expression of Cyclooxygenase-2 (COX-2) in Human Invasive Transitional Cell Carcinoma (TCC) of the Urinary Bladder1
Sulma I. Mohammed; Deborah W. Knapp; David G. Bostwick; Richard S. Foster; Kanwar Nasir M. Khan; Jaime L. Masferrer; Bryan M. Woerner; Paul W. Snyder; Alane T. Koki
View articletitled, Expression of Cyclooxygenase-2 (COX-2) in Human Invasive Transitional Cell Carcinoma (TCC) of the Urinary Bladder<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
Open the PDF for in another window
NH2-Terminal Pentapeptide of Endothelial Interleukin 8 Is Responsible for the Induction of Apoptosis in Leukemic Cells and Has an Antitumor Effect in Vivo1
Yasuhito Terui; Hiroshi Tomizuka; Yuji Mishima; Masayuki Ikeda; Tadashi Kasahara; Masaya Uwai; Masaki Mori; Takehito Itoh; Miyuki Tanaka; Muneo Yamada; Seiichi Shimamura; Yukihito Ishizaka; Keiya Ozawa; Kiyohiko Hatake
View articletitled, NH<sub>2</sub>-Terminal Pentapeptide of Endothelial Interleukin 8 Is Responsible for the Induction of Apoptosis in Leukemic Cells and Has an Antitumor Effect <em>in Vivo</em><sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
Open the PDF for in another window
In Vivo Gene Expression Profile Analysis of Human Breast Cancer Progression1
Dennis C. Sgroi; Sarena Teng; Greg Robinson; Rebbecca LeVangie; James R. Hudson, Jr.; Abdel G. Elkahloun
View articletitled, <em>In Vivo</em> Gene Expression Profile Analysis of Human Breast Cancer Progression<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
Open the PDF for in another window
The Association of Chromosome 8p Deletion and Tumor Metastasis in Human Hepatocellular Carcinoma1
Lun-Xiu Qin; Zhao-You Tang; Jonathan S. T. Sham; Zeng-Chen Ma; Sheng-Long Ye; Xin-Da Zhou; Zhi-Quan Wu; Jeffrey M. Trent; Xin-Yuan Guan
View articletitled, The Association of Chromosome 8p Deletion and Tumor Metastasis in Human Hepatocellular Carcinoma<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
Open the PDF for in another window
Gender Differences in p53 Mutational Status in Small Cell Lung Cancer1
Jennifer E. Tseng; Marivonne Rodriguez; Jae Ro; Diane Liu; Waun Ki Hong; Li Mao
View articletitled, Gender Differences in <em>p53</em> Mutational Status in Small Cell Lung Cancer<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
Open the PDF for in another window
A New Ligand for the Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ), GW7845, Inhibits Rat Mammary Carcinogenesis1
Nanjoo Suh; Yongping Wang; Charlotte R. Williams; Renee Risingsong; Tona Gilmer; Timothy M. Willson; Michael B. Sporn
View articletitled, A New Ligand for the Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ), GW7845, Inhibits Rat Mammary Carcinogenesis<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
Open the PDF for in another window
Point Mutations and Deletions of the Bcl10 Gene in Solid Tumors andMalignant Lymphomas1
Sug Hyung Lee; Min Sun Shin; Hong Sug Kim; Won Sang Park; Su Young Kim; Hun Kyung Lee; Jik Young Park; Ro Ra Oh; Ja June Jang; Kyung Mi Park; Ji Youn Han; Chang Suk Kang; Jung Young Lee; Nam Jin Yoo
View articletitled, Point Mutations and Deletions of the <em>Bcl10</em> Gene in Solid Tumors andMalignant Lymphomas<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
Open the PDF for in another window
TβR-I(6A) Is a Candidate Tumor Susceptibility Allele1
Boris Pasche; Prema Kolachana; Khedoudja Nafa; Jaya Satagopan; Ye-Guang Chen; Roger S. Lo; Dara Brener; Diana Yang; Laurie Kirstein; Carole Oddoux; Harry Ostrer; Paolo Vineis; Liliana Varesco; Suresh Jhanwar; Lucio Luzzatto; Joan Massagué; Kenneth Offit
View articletitled, <em>TβR-I(6A)</em> Is a Candidate Tumor Susceptibility Allele<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
Open the PDF for in another window
Alterations of the DR5/TRAIL Receptor 2 Gene in Non-Small Cell Lung Cancers1
Sug Hyung Lee; Min Sun Shin; Hong Sug Kim; Hun Kyung Lee; Won Sang Park; Su Young Kim; Jong Heun Lee; Seo Young Han; Jik Young Park; Ro Ra Oh; Ja June Jang; Ji Youn Han; Jung Young Lee; Nam Jin Yoo
View articletitled, Alterations of the <em>DR5/TRAIL Receptor 2</em> Gene in Non-Small Cell Lung Cancers<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
Open the PDF for in another window
Chromosomal Imbalances Are Associated with a High Risk of Progression in Early Invasive (pT1) Urinary Bladder Cancer1
Jan Richter; Urs Wagner; Peter Schraml; Robert Maurer; Göran Alund; Hartmut Knönagel; Holger Moch; Michael J. Mihatsch; Thomas C. Gasser; Guido Sauter
View articletitled, Chromosomal Imbalances Are Associated with a High Risk of Progression in Early Invasive (pT<sub>1</sub>) Urinary Bladder Cancer<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
Open the PDF for in another window
Decreased Insulin-like Growth Factor-II/Mannose 6-Phosphate Receptor Expression Enhances Tumorigenicity in JEG-3 Cells
David B. O’Gorman; Michael Costello; Jocelyn Weiss; Sue M. Firth; Carolyn D. Scott
View articletitled, Decreased Insulin-like Growth Factor-II/Mannose 6-Phosphate Receptor Expression Enhances Tumorigenicity in JEG-3 Cells
Open the PDF for in another window

Biochemistry and Biophysics

HMG-I(Y) Recognizes Base-unpairing Regions of Matrix Attachment Sequences and Its Increased Expression Is Directly Linked to Metastatic Breast Cancer Phenotype1
Wen-Man Liu; Fabiana K. Guerra-Vladusic; Shinichi Kurakata; Ruth Lupu; Terumi Kohwi-Shigematsu
View articletitled, HMG-I(Y) Recognizes Base-unpairing Regions of Matrix Attachment Sequences and Its Increased Expression Is Directly Linked to Metastatic Breast Cancer Phenotype<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
Open the PDF for in another window

Carcinogenesis

Red Meat and Colon Cancer: The Cytotoxic and Hyperproliferative Effects of Dietary Heme1
Aloys L. A. Sesink; Denise S. M. L. Termont; Jan H. Kleibeuker; Roelof Van der Meer
View articletitled, Red Meat and Colon Cancer<span class="subtitle-colon">: </span><span class="subtitle">The Cytotoxic and Hyperproliferative Effects of Dietary Heme<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup></span>
Open the PDF for in another window
Transgenic Mice Overexpressing Protein Kinase Cδ in the Epidermis Are Resistant to Skin Tumor Promotion by 12-O-Tetradecanoylphorbol-13-acetate1
Peter J. Reddig; Nancy E. Dreckschimdt; Helga Ahrens; Robita Simsiman; Ching-Ping Tseng; Jun Zou; Terry D. Oberley; Ajit K. Verma
View articletitled, Transgenic Mice Overexpressing Protein Kinase Cδ in the Epidermis Are Resistant to Skin Tumor Promotion by 12-<em>O</em>-Tetradecanoylphorbol-13-acetate<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
Open the PDF for in another window

Clinical Investigations

Caveolin-1 Expression in Clinically Confined Human Prostate Cancer: A Novel Prognostic Marker1
Guang Yang; Luan D. Truong; Thomas M. Wheeler; Timothy C. Thompson
View articletitled, Caveolin-1 Expression in Clinically Confined Human Prostate Cancer<span class="subtitle-colon">: </span><span class="subtitle">A Novel Prognostic Marker<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup></span>
Open the PDF for in another window
Loss of KAI1 Expression in the Progression of Colorectal Cancer1
Donald P. Lombardi; Joseph Geradts; Julie F. Foley; Chia Chiao; Pattie W. Lamb; J. Carl Barrett
View articletitled, Loss of KAI1 Expression in the Progression of Colorectal Cancer<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
Open the PDF for in another window
Differential Diagnosis of Chronic Pancreatitis and Pancreatic Cancer in Brush Cytology Specimens
Bernard E. M. Van Driel; Thomas M. Van Gulik; Patrick D. J. Sturm; G. Johan A. Offerhaus; Dirk J. Gouma; Cornelis J. F. Van Noorden
View articletitled, Differential Diagnosis of Chronic Pancreatitis and Pancreatic Cancer in Brush Cytology Specimens
Open the PDF for in another window

Endocrinology

Human Uterine Leiomyomata Express Higher Levels of Peroxisome Proliferator-activated Receptor γ, Retinoid X Receptor α, and all-trans Retinoic Acid Than Myometrium
John C. M. Tsibris; Kathy B. Porter; Allahyar Jazayeri; Georg Tzimas; Heinz Nau; Hong Huang; Khatuna Kuparadze; Gregory W. Porter; William F. O’Brien; William N. Spellacy
View articletitled, Human Uterine Leiomyomata Express Higher Levels of Peroxisome Proliferator-activated Receptor γ, Retinoid X Receptor α, and all-<em>trans</em> Retinoic Acid Than Myometrium
Open the PDF for in another window

Experimental Therapeutics

Phosphoinositide 3-Hydroxide Kinase Blockade Enhances Apoptosis in the Ewing’s Sarcoma Family of Tumors1
Jeffrey A. Toretsky; Manjusha Thakar; Allen E. Eskenazi; Christopher N. Frantz
View articletitled, Phosphoinositide 3-Hydroxide Kinase Blockade Enhances Apoptosis in the Ewing’s Sarcoma Family of Tumors<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
Open the PDF for in another window
CHS 828, a Novel Pyridyl Cyanoguanidine with Potent Antitumor Activity in Vitro and in Vivo
Pernille-Julia Vig Hjarnaa; Elin Jonsson; Scilla Latini; Sumeer Dhar; Rolf Larsson; Erik Bramm; Torsten Skov; Lise Binderup
View articletitled, CHS 828, a Novel Pyridyl Cyanoguanidine with Potent Antitumor Activity <em>in Vitro</em> and <em>in Vivo</em>
Open the PDF for in another window
High Thermal Stability Is Essential for Tumor Targeting of Antibody Fragments: Engineering of a Humanized Anti-epithelial Glycoprotein-2 (Epithelial Cell Adhesion Molecule) Single-Chain Fv Fragment1
Jörg Willuda; Annemarie Honegger; Robert Waibel; P. August Schubiger; Rolf Stahel; Uwe Zangemeister-Wittke; Andreas Plückthun
View articletitled, High Thermal Stability Is Essential for Tumor Targeting of Antibody Fragments<span class="subtitle-colon">: </span><span class="subtitle">Engineering of a Humanized Anti-epithelial Glycoprotein-2 (Epithelial Cell Adhesion Molecule) Single-Chain Fv Fragment<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup></span>
Open the PDF for in another window
Ceramide-β-d-Glucuronide: Synthesis, Digestion, and Suppression of Early Markers of Colon Carcinogenesis1
Eva M. Schmelz; Anatoliy S. Bushnev; Dirck L. Dillehay; M. Cameron Sullards; Dennis C. Liotta; Alfred H. Merrill, Jr.
View articletitled, Ceramide-β-<span class="small-caps">d</span>-Glucuronide<span class="subtitle-colon">: </span><span class="subtitle">Synthesis, Digestion, and Suppression of Early Markers of Colon Carcinogenesis<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup></span>
Open the PDF for in another window
Inhibition of Tumor Growth Correlates with the Expression Level of a Human Angiostatin Transgene in Transfected B16F10 Melanoma Cells
Stefan Ambs; Steven Dennis; Jeff Fairman; Meredith Wright; Jacqueline Papkoff
View articletitled, Inhibition of Tumor Growth Correlates with the Expression Level of a Human Angiostatin Transgene in Transfected B16F10 Melanoma Cells
Open the PDF for in another window

Immunology

Antitumor Immune Effector Mechanisms Recruited by Phage Display-derived Fully Human IgG1 and IgA1 Monoclonal Antibodies1
Gerwin Huls; Ingmar A. F. M. Heijnen; Emanuela Cuomo; Joke van der Linden; Edwin Boel; Jan G. J. van de Winkel; Ton Logtenberg
View articletitled, Antitumor Immune Effector Mechanisms Recruited by Phage Display-derived Fully Human IgG1 and IgA1 Monoclonal Antibodies<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
Open the PDF for in another window
Two Antigens Recognized by Autologous Cytolytic T Lymphocytes on a Melanoma Result from a Single Point Mutation in an Essential Housekeeping Gene1
Rita Chiari; Françoise Foury; Eienne De Plaen; Jean-François Baurain; Joëlle Thonnard; Pierre G. Coulie
View articletitled, Two Antigens Recognized by Autologous Cytolytic T Lymphocytes on a Melanoma Result from a Single Point Mutation in an Essential Housekeeping Gene<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
Open the PDF for in another window
Human Leukocyte Antigen Class I Expression on Squamous Cell Carcinoma Cells Regulates Natural Killer Cell Activity1
Charles T. Lutz; Zoya B. Kurago
View articletitled, Human Leukocyte Antigen Class I Expression on Squamous Cell Carcinoma Cells Regulates Natural Killer Cell Activity<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
Open the PDF for in another window
A Triad of Costimulatory Molecules Synergize to Amplify T-Cell Activation
James W. Hodge; Helen Sabzevari; Alicia Gómez Yafal; Linda Gritz; Matthias G. O. Lorenz; Jeffrey Schlom
View articletitled, A Triad of Costimulatory Molecules Synergize to Amplify T-Cell Activation
Open the PDF for in another window

Molecular Biology and Genetics

PTEN Suppresses Breast Cancer Cell Growth by Phosphatase Activity-dependent G1 Arrest followed by Cell Death1
Liang-Ping Weng; Wendy M. Smith; Patricia L. M. Dahia; Ulrike Ziebold; Elad Gil; Jacqueline A. Lees; Charis Eng
View articletitled, PTEN Suppresses Breast Cancer Cell Growth by Phosphatase Activity-dependent G<sub>1</sub> Arrest followed by Cell Death<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
Open the PDF for in another window

Tumor Biology

Bone Morphogenetic Protein-6 Is a Marker of Serous Acinar Cell Differentiation in Normal and Neoplastic Human Salivary Gland1
A. Kristiina Heikinheimo; Merja A. Laine; Olli V-P. Ritvos; Raimo J. Voutilainen; Brigid L. M. Hogan; Ilmo V. Leivo
View articletitled, Bone Morphogenetic Protein-6 Is a Marker of Serous Acinar Cell Differentiation in Normal and Neoplastic Human Salivary Gland<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
Open the PDF for in another window
Hypoxia-induced Elevation in Interleukin-8 Expression by Human Ovarian Carcinoma Cells1
Lei Xu; Keping Xie; Naofumi Mukaida; Kouji Matsushima; Isaiah J. Fidler
View articletitled, Hypoxia-induced Elevation in Interleukin-8 Expression by Human Ovarian Carcinoma Cells<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
Open the PDF for in another window
Overexpression of Hypoxia-inducible Factor 1α in Common Human Cancers and Their Metastases1
Hua Zhong; Angelo M. De Marzo; Erik Laughner; Michael Lim; David A. Hilton; David Zagzag; Peter Buechler; William B. Isaacs; Gregg L. Semenza; Jonathan W. Simons
View articletitled, Overexpression of Hypoxia-inducible Factor 1α in Common Human Cancers and Their Metastases<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
Open the PDF for in another window
Diminished Aqueous Microviscosity of Tumors in Murine Models Measured with in Vivo Radiofrequency Electron Paramagnetic Resonance1
Howard J. Halpern; G. V. R. Chandramouli; Eugene D. Barth; Cheng Yu; Miroslav Peric; David J. Grdina; Beverly A. Teicher
View articletitled, Diminished Aqueous Microviscosity of Tumors in Murine Models Measured with <em>in Vivo</em> Radiofrequency Electron Paramagnetic Resonance<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
Open the PDF for in another window
Aberrant Sphingolipid Signaling Is Involved in the Resistance of Prostate Cancer Cell Lines to Chemotherapy1
Xiao-Zhuo Wang; James R. Beebe; Leah Pwiti; Alicja Bielawska; Miriam J. Smyth
View articletitled, Aberrant Sphingolipid Signaling Is Involved in the Resistance of Prostate Cancer Cell Lines to Chemotherapy<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
Open the PDF for in another window
Identification of Breast Cancer Cell Line-derived Paracrine Factors That Stimulate Osteoclast Activity1
Larry Pederson; Bent Winding; Niels T. Foged; Thomas C. Spelsberg; Merry Jo Oursler
View articletitled, Identification of Breast Cancer Cell Line-derived Paracrine Factors That Stimulate Osteoclast Activity<sup><a href="javascript:;" reveal-id="FN1" data-open="FN1" class="link link-ref link-reveal xref-fn js-xref-fn split-view-modal">1</a></sup>
Open the PDF for in another window

Letters to the Editor

Correspondence re: N. N. Mahmoud et al., Genotype-Phenotype Correlation in Murine Apc Mutation: Differences in Enterocyte Migration and Response to Sulindac. Cancer Res., 59: 353–359, 1999.
Leonard H. Augenlicht
View articletitled, Correspondence re: N. N. Mahmoud <em>et al.</em>, Genotype-Phenotype Correlation in Murine <em>Apc</em> Mutation: Differences in Enterocyte Migration and Response to Sulindac. Cancer Res., <em>59:</em> 353–359, 1999.
Open the PDF for in another window

Errata

C.A. Eads et al., 2302–2306, 1999
View articletitled, C.A. Eads <em>et al.</em>, 2302–2306, 1999
Open the PDF for in another window

Journal Archive


Cancer Research

(1941-Present; volumes 1-current)

Published twice monthly since 1987. From 1941-1986, published monthly.
(ISSN 0008-5472)

The American Journal of Cancer

(1931-1940; volumes 15-40)

Published quarterly in 1931, bimonthly in 1932, and monthly from 1933 to 1940. The journal changed title to Cancer Research in 1941.
(ISSN 0099-7374)

The Journal of Cancer Research

(1916-1930); volumes 1-14)

Published quarterly from 1916 through 1930 (publication was suspended from November 1922 to March 1924). The journal changed title to The American Journal of Cancer in 1931.
(ISSN 0099-7013)

Advertisement

Email alerts

eTOC Alert
Close Modal
Latest News
How Unruly DNA Loops Are Shaping Cancer—and Treatments
Global Platform Delivering Kids’ Cancer Drugs to Countries in Need
Cancer Grand Challenges Throws Down Gauntlet
View more recent articles
Breaking
Ovarian Cancer Trial Brought to a Halt
New Nominee for CDC Director Named
23andMe Declares Bankruptcy; CEO Quits
View more recent articles
Research Watch
Synonymous Mutations in m6A-modified Sites Can Destabilize Tumor Suppressors
MIF–ACKR3 Signaling Drives Cancer Cachexia by Impairing Adipogenesis
Epithelial-to-Mesenchymal Transition Supports Pancreatic Cancer Evolution
View more recent articles

NOTICE: This notice serves to inform the reader that, in 2023, AACR received a donation by Pfizer of the rights to royalties from the sale—within the United States—of Bavencio® (avelumab), a pharmaceutical owned by Merck.  None of these funds are being, or will be, used to directly support any specific publication or author. If an individual article is published that deals with this particular drug, such article will include standard financial disclosures per AACR journal policy. For more detail regarding AACR’s established policies for authors, please go to https://aacrjournals.org/pages/editorial-policies#coi.

  • Online ISSN 1538-7445
  • Print ISSN 0008-5472

AACR Journals

 

 

  • Copyright © 2025 by the American Association for Cancer Research.
Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal
This site uses cookies. By continuing to use our website, you are agreeing to our privacy policy.
Accept